1. MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy
- Author
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Henrik J. Ditzel, Behzad Baradaran, Elham Safarzadeh, William C. Cho, Morten F. Gjerstorff, Behzad Mansoori, Pascal H.G. Duijf, Ali Mohammadi, Mansoori, Behzad, Duijf, Pascal HG, Mohammadi, Ali, Safarzadeh, Elham, Ditzel, Henrik J, Gjerstorff, Morten F, Cho, William Chi-Shing, and Baradaran, Behzad
- Subjects
Untranslated region ,HMGA2 ,miR-142-3p ,Breast Neoplasms ,Apoptosis ,Breast Neoplasms/genetics ,Malignancy ,General Biochemistry, Genetics and Molecular Biology ,STAT3 ,Breast cancer ,Cell Movement ,Cancer stem cell ,Gene expression ,microRNA ,Biomarkers, Tumor ,Tumor Cells, Cultured ,medicine ,Humans ,General Pharmacology, Toxicology and Pharmaceutics ,Cell Proliferation ,biology ,Cancer stem cells ,business.industry ,AKT ,HMGA2 Protein ,Cell Cycle ,General Medicine ,Cell cycle ,Prognosis ,medicine.disease ,HMGA2 Protein/genetics ,Gene Expression Regulation, Neoplastic ,Survival Rate ,MicroRNAs ,ERK ,MicroRNAs/genetics ,biology.protein ,Cancer research ,Female ,Biomarkers, Tumor/genetics ,business - Abstract
MicroRNAs (miRNAs) have the ability to regulate gene expression programs in cells. Hence, altered expression of miRNAs significantly contributes to breast cancer development and progression. Here, we demonstrate that the miRNA miR-142-3p directly targets the 3′ untranslated region of HMGA2, which encodes an onco-embryonic protein that is overexpressed in most cancers, including breast cancer. Down regulation of miR-142-3p predicting poor patient survival in grade 3 breast cancer (P-value = 0.045). MiR-142-3p downregulates HMGA2 mRNA and protein levels. Higher miR-142-3p and lower HMGA2 expressed are found in breast cancer versus normal breast tissue (P-value
- Published
- 2021
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