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1. Event-related potentials as an index of cognitive function during recovery from severe closed head injury

Author

Zeev Groswasser, Keren O, Goldberg G, Stern Mj, and Ben-Dror S

Subjects
Adult, Male, Longitudinal study, Adolescent, Physical Therapy, Sports Therapy and Rehabilitation, Neuropsychological Tests, Rehabilitation Centers, Sensitivity and Specificity, Event-related potential, Head Injuries, Closed, medicine, Reaction Time, Humans, Glasgow Coma Scale, Effects of sleep deprivation on cognitive performance, Longitudinal Studies, Prospective Studies, Recall, medicine.diagnostic_test, business.industry, Rehabilitation, Neuropsychology, Electroencephalography, Neuropsychological test, medicine.disease, Prognosis, Event-Related Potentials, P300, Neurobehavioral Manifestations, Anesthesia, Closed head injury, Female, Neurology (clinical), business, Cognition Disorders
Abstract

OBJECTIVE To evaluate the utility and neuropsychological correlates of serially performed recordings of event-related potentials (ERPs) in patients recovering from a severe closed head injury (CHI). DESIGN Prospective longitudinal study. SETTING Brain injury rehabilitation unit based in a national rehabilitation hospital. SUBJECTS Sixteen patients with severe CHI (significant degree of impaired consciousness greater than 24 hours) subclassified into two severity groups according to initial Glasgow Coma Scale (GCS) score: those with initial GCS score 8, indicating a less severe injury. METHODS ERPs were elicited using the standard auditory P300 "oddball" detection paradigm. ERP recordings were carried out three times: 2 months after injury, 1 month later, and 2.5 months or more after the initial study. Parameters analyzed included latencies and amplitudes of the P3, N2, P2, and N1 components of the ERPs. Correlations between changes in these ERP parameters and specific neuropsychological test results were evaluated. RESULTS Initial P3 latencies in the more severely injured group were significantly longer (P < .05) than those recorded in the less severely injured patients. In subsequent recordings, P3 latency was found to be significantly shorter compared with the initial P3 latency, and the difference in P3 latency between the two patient groups was no longer statistically significant by the time of the third recording. For the group as a whole, P3 latency decreased significantly on each repeated recording. N2 latency was found to be significantly shorter (P < .05) between the first and third recordings. Cognitive performance significantly improved between the first and third recordings. P3 latency shortening was correlated with improvement in neuropsychological test scores for short-term and long-term story recall and for word recall. N2 latency shortening was correlated with improvement in the neuropsychological test scores for word recall only. CONCLUSION ERP recordings performed in the subacute stage after CHI may assist in evaluating injury severity. Moreover, serially performed recordings of P3 latency may be used as a physiologic index of brain activity that correlates with recovery from CHI.

Published
1998

11. Effect of metoprolol CR XL in chronic heart failure: Metoprolol CR XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)

Author

Hjalmarson, A., Goldstein, S., Fagerberg, B., Wedel, H., Waagstein, F., Kjekshus, J., Wikstrand, J., Westergren, G., Hassle, A., Thimell, M., El Allaf, D., Vitovec, J., Aldershvile, J., Halinen, M., Dietz, R., Neuhaus, Kl, Janosi, A., Thorgeirsson, G., Dunselman, P., Gullestad, L., Kuch, J., Herlitz, J., Rickenbacher, P., Ball, S., Gottlieb, S., Deedwania, P., Vandenhoven, G., Novakova, I., Danker, S., Lundstrom, M., Meyer-Sabellek, W., Balla, I., Sveinsdottir, M., Dorhout, B., Hildebrandt, A., Szczurko, I., Larsson, C., Bucher, E., Scott, E., Dwyer, D., Julian, Dg, Demets, Dl, Chatterjee, K., Feyzi, J., Lehto, S., Karpati, P., Motz, W., Samuelsson, O., Viersma, Jw, Andersson, B., Berthe, C., Boutefeu, Jm, Boxho, G., Decroly, P., Derbaudrenghien, Jp, Pirlet, J., Henry, P., Heyndrickx, G., Missault, L., Nannan, M., Timmermans, P., Vachiery, Jl, Mieghem, W., Vandenbossche, Jl, Dvorak, K., Herold, M., Hradec, J., Kana, A., Petr, P., Rybka, J., Smid, J., Svitil, P., Toman, J., Agner, E., Amtorp, O., Egstrup, K., Eliasen, P., Gotzsche, Co, Hildebrandt, P., Johannesen, A., Kaiser-Nielsen, P., Nielsen, H., Nielsen, Pe, Pedersen, F., Nielsen, Jr, Skagen, K., Honkanen, T., Hussi, E., Juvonen, J., Jaaskelainen, H., Rinne, J., Salonen, T., Andresen, D., Berwing, H., Forster, A., Hauf, Gf, Krosse, B., Luderitz, B., Olshausen, Ke, Schmailzl, Kjg, Schwimmbeck, Pl, Sigmund, M., Voller, H., Czuriga, I., Hetey, M., Katona, A., Lengyel, M., Nyaradi, A., Rednik, A., Sandori, K., Szabo, P., Tarjan, J., Tenczer, J., Timar, S., Valyi, P., Veress, G., Zamolyi, K., Oze, B., Bernink, Pjlm, Bredero, Ac, Breedveld, Rw, Breuls, Pnwm, Bucx, Jjj, jan cornel, Milliano, Par, Dunselman, Phjm, Hamer, Bjb, Holwerda, Nl, Hoogsteen, J., Hoorntje, Jca, Kragten, Ja, Liem, Ah, Linssen, Gcm, Michels, Hr, Misier, Arr, Schaafsma, Hj, Sijbring, P., Taverne, Rjt, Kempen, Lhj, Stralen, R., Veldhuisen, Dj, Veerhoek, Mj, Werter, Cjpj, Wesdorp, Jcl, Willems, Ar, Withagen, Ajam, Zwart, Pag, Bjornerheim, R., Dahle, M., Dickstein, K., Froland, Gs, Gundersen, T., Hofsoy, K., Hole, Tl, Johansen, T., Mannsverk, J., Nesje, P., Omland, Tm, Sjodin, C., Smith, P., Tjonndal, Ha, Vikesdal, O., Waage, K., Jaworska, K., Kolodziej, P., Kornacewicz-Jach, Z., Krzeminska-Pakula, M., Piotrowski, Jw, Piwowarska, W., Stogowski, A., Wodniecki, J., Wrabec, K., Ahlstrom, P., Ekdahl, S., Hemmingson, Lo, Holmberg, L., Lernfelt, B., Nilsson, H., Widgren, B., Angman, K., Erne, P., Mohacsi, P., Polikar, R., Schlapfer, H., Batin, P., Berkin, Ke, Callaghan, Ts, Forfar, J., Frenneaux, M., Greenbaum, Ra, Maltz, M., Murdoch, D., Reynolds, G., Stephens, J., Struthers, A., Swan, J., Tildesley, G., Abbasi, A., Alagona, P., Alderman, J., Alipour, M., Anderson, Jl, Ansari, Z., Ashraf, M., Beanblossom, Bt, Bennett, S., Benvenuti, D., Berk, MR, Bhalla, R., Bilazarian, Sd, Browne, Kf, Buchter, Cm, Carlson, R., Carlson, Cj, Danisa, K., Dauber, I., Dewood, Ma, Dennish, G., Denny, Dm, Dibianco, R., Diller, Pm, Dunlap, M., Dowd, K., Edmiston, A., El Shahawy, M., Elkayam, U., Farnham, J., Fenster, P., Friedman, S., Heywood, T., Galichia, Jp, Geller, M., Ghali, Jk, Gheorghiade, M., Giles, T., Gillespe, R., Goldberg, G., Goldberg, Mc, Goldscher, Da, Gooden, Gp, Goodman, M., Goodman, L., Gorwit, J., Gottlieb, Ss, Gradman, A., Grech, D., Hack, T., Hall, Jh, Hattenhauer, Mt, Higginbotham, Mb, Hutchins, S., Imburgia, M., Iteld, Bj, Jackson, B., Jafri, S., Jauch, W., Jennison, S., Kahn, Bh, Kao, W., Kaplan, K., Karlsberg, R., Kennedy, Hl, Kennedy, Jj, Kirkegaard, L., Kraus, Dh, Labresh, K., Lalonde, L., Lesser, Mf, Levites, R., Levy, M., Lewis, Rk, Loh, Ik, Madyoon, H., Maislos, F., Mann, D., Maurice, Gl, Nisar, A., Old, W., Pappas, Jd, Phadke, K., Promisloff, S., Rashkow, Am, Reeves, B., Rosen, Jh, Rotman, M., Saleem, T., Savran, Sv, Shah, R., Shalev, Y., Shanes, Jg, O Shaughnessy, M., Silverman, B., Steingart, Rm, Swenson, L., Syed, K., Thadani, U., Thorsen, Rd, Tonkon, Mj, Touchon, R., Uhl, G., Vaska, Kj, Wagner, Sg, Weaver, Cj, Weiss, Rj, Wickemeyer, Wj, Willens, Hj, Wilson, Jr, Wright, R., and Yellen, L.

13. Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Author

Lorenzo Memeo, Jayadev Raju, Amedeo Amedei, Dustin G. Brown, Rafaela Andrade-Vieira, Jordan Woodrick, Dale W. Laird, Fahd Al-Mulla, Neetu Singh, Gary S. Goldberg, Debasish Roy, Rabeah Al-Temaimi, Paul Dent, William H. Bisson, Paola A. Marignani, Jan Vondráček, Gloria M. Calaf, Richard Ponce-Cusi, Karine A. Cohen-Solal, Riccardo Di Fiore, Rita Nahta, Annamaria Colacci, Hosni Salem, Robert C. Castellino, Elizabeth P. Ryan, Nichola Cruickshanks, Harini Krishnan, Chiara Mondello, Christian C. Naus, Mark Wade, Rabindra Roy, Monica Vaccari, Stefano Forte, Sarah N Bay, Roslida Abd Hamid, Ahmed Lasfar, A. Ivana Scovassi, Renza Vento, Nahta, R., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Andrade-Vieira, R., Bay, S., Brown, D., Calaf, G., Castellino, R., Cohen-Solal, K., Colacci, A., Cruickshanks, N., Dent, P., Di Fiore, R., Forte, S., Goldberg, G., Hamid, R., Krishnan, H., Laird, D., Lasfar, A., Marignani, P., Memeo, L., Mondello, C., Naus, C., Ponce-Cusi, R., Raju, J., Roy, D., Roy, R., Ryan, E., Salem, H., Ivana Scovassi, A., Singh, N., Vaccari, M., Vento, R., Vondráček, J., Wade, M., Woodrick, J., and Bisson, W.

Subjects
Cancer Research, Review, Hazardous Substances, chemistry.chemical_compound, Neoplasms, Animals, Humans, Medicine, biology, Animal, business.industry, Medicine (all), Retinoblastoma protein, Contact inhibition, Cancer, Environmental Exposure, General Medicine, Environmental exposure, Evasion (ethics), medicine.disease, Cell biology, chemistry, Hazardous Substance, Immunology, Cancer cell, biology.protein, Neoplasm, Signal transduction, Growth inhibition, business, Human, Signal Transduction
Abstract

As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.

Published
2015
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14. Breast-feeding : early influences on later health

Author

Bork Simondon, Kirsten, Goldberg, G., Prentice, A., Filteau, S., and Simondon, Kirsten

Abstract

The importance of breast-feeding for infant and child health and survival in less developed countries has been the subject of a number of studies over the last 25 years.1_9 However, the epidemic of AIDS in low-income countries, together with the discovery of an important risk of mother-to-child transmission of HIV-1 through breast-milk,10 has prompted renewed interest in this subject. Indeed, in order to weigh the mortality risks associated with different infant feeding practices against the risk of mother-to-child transmission of the virus, it is essential to have precise estimates of relative risk of death of non-breastfed infants within narrow age intervals.

Published
2009

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