4 results on '"Goldstein, Michaella"'
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2. Additional file 1 of Evaluation of a self-imaging SD-OCT system designed for remote home monitoring
- Author
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Kim, Judy E., Tomkins-Netzer, Oren, Elman, Michael J., Lally, David R., Goldstein, Michaella, Goldenberg, Dafna, Shulman, Shiri, Benyamini, Gidi, and Loewenstein, Anat
- Subjects
Data_FILES - Abstract
Additional file 1.
- Published
- 2022
- Full Text
- View/download PDF
3. A Collaborative Retrospective Study on the Efficacy and Safety of Intravitreal Dexamethasone Implant (Ozurdex) in Patients with Diabetic Macular Edema
- Author
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Amir Rosenblatt, Patricia Udaondo, José Cunha-Vaz, Sobha Sivaprasad, Francesco Bandello, Paolo Lanzetta, Laurent Kodjikian, Michaella Goldstein, Zohar Habot-Wilner, Anat Loewenstein, Jose Juan Escobar, Geeta Menon, Borja Corcostegui, Urban Eriksson, Anna Boixadera, Laura Sararols, Sebastien Guigou, Monica Varano, João Figueira, Ayalla Pollack, Pascale Massin, Paolo Carpineto, Nicola Recchimurzo, Frederic Matonti, Kati Kinnunen, Florence Coscas, Edoardo Midena, João Nascimento, Felix Armada, Nir Sorkin, Zohar Habot- Wilner, Rosenblatt, Amir, Udaondo, Patricia, Cunha-Vaz, José, Sivaprasad, Sobha, Bandello, Francesco, Lanzetta, Paolo, Kodjikian, Laurent, Goldstein, Michaella, Habot-Wilner, Zohar, Loewenstein, Anat, Escobar, Jose Juan, Menon, Geeta, Corcostegui, Borja, Eriksson, Urban, Boixadera, Anna, Sararols, Laura, Guigou, Sebastien, Varano, Monica, Figueira, João, Pollack, Ayalla, Massin, Pascale, Carpineto, Paolo, Recchimurzo, Nicola, Matonti, Frederic, Kinnunen, Kati, Coscas, Florence, Midena, Edoardo, Nascimento, João, Armada, Felix, Sorkin, Nir, and Habot- Wilner, Zohar
- Subjects
Retina detachment ,0303 health sciences ,medicine.medical_specialty ,Intraocular pressure ,Visual acuity ,genetic structures ,business.industry ,Retrospective cohort study ,Diabetic retinopathy ,medicine.disease ,eye diseases ,3. Good health ,03 medical and health sciences ,Ophthalmology ,0302 clinical medicine ,Endophthalmitis ,030221 ophthalmology & optometry ,medicine ,medicine.symptom ,business ,Macular edema ,Dexamethasone ,030304 developmental biology ,medicine.drug - Abstract
Purpose To evaluate the efficacy, effect profile, and safety of dexamethasone implant on diabetic macular edema (DME) in a real-life setting, further comparing results by DME duration, previous treatment status, and diabetic control. Design A multicenter, retrospective cohort of 340 DME eyes of 287 patients from 25 clinical sites from 8 countries. Methods Data were analyzed in 2 perspectives: per injection, in which all measurements were grouped and baseline was defined as the day of injection, and thus the pharmacodynamics of single injections could be assessed; and injection series, defined as 2 or more injections with 3 to 6 months between injections analyzing the outcome 3 to 6 months after the last injection. Main Outcome Measures Primary outcome was improvement of 15 or more letters in best-corrected visual acuity (BCVA) from baseline. Secondary outcomes included improvement of 10 letters or more in BCVA, change in central macular thickness (CMT), and time to maximum improvement and safety. Results Overall, 762 injections were administered to 340 eyes of 287 patients. Injection series analysis included 171 series in 171 eyes of 150 patients, for a total of 444 injections, with a mean follow-up of 1.7±0.8 years. Of the 762 injections analyzed per injection, 22.7% achieved a 15-letter or more improvement, and 37.8% achieved a 10-letter or more improvement. Mean time to peak improvement was 81.9±39.7 days. Mean maximum change in CMT was –174±171 μm. Overall, 7.6% lost 15 or more letters. More eyes with early DME gained 10 or more letters and fewer eyes lost 10 or more letters compared with eyes with late DME (47.4% vs. 33.9% [P = 0.001] and 8.2% vs. 13.5% [P = 0.029], respectively). Patients with controlled diabetes showed greater CMT reduction (P = 0.0002). A higher percentage of treatment-naive patients gained 10 or 15 letter or more in BCVA (P = 0.001 and P = 0.006, respectively). Intraocular pressure elevation of more than 25 mmHg was found following 7.9% of injections; no endophthalmitis was reported. Conclusions Dexamethasone implant is an effective and safe treatment for DME. Peak improvement was achieved 3 months after injection and dissipated thereafter. Clinicians and providers may consider shortening treatment intervals.
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- 2020
4. MICROPERIMETRY IN BEST VITELLIFORM MACULAR DYSTROPHY
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Theodoros Empeslidis, Niccolò Castellino, Michaella Goldstein, Pierluigi Iacono, Francesco Bandello, Maurizio Battaglia Parodi, Itay Chowers, Battaglia Parodi, Maurizio, Castellino, Niccolò, Iacono, Pierluigi, Chowers, Itay, Empeslidis, Theodoro, Goldstein, Michaella, and Bandello, Francesco
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Visual acuity ,genetic structures ,Adolescent ,Visual Acuity ,Vitelliform macular dystrophy ,Fixation, Ocular ,03 medical and health sciences ,chemistry.chemical_compound ,Young Adult ,0302 clinical medicine ,Ophthalmology ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Scotoma ,Aged ,Aged, 80 and over ,business.industry ,Blind spot ,Retinal ,General Medicine ,Middle Aged ,medicine.disease ,eye diseases ,Vitelliform Macular Dystrophy ,Best Vitelliform Macular Dystrophy ,030104 developmental biology ,Cross-Sectional Studies ,chemistry ,Fixation (visual) ,030221 ophthalmology & optometry ,Optometry ,Visual Field Tests ,Female ,medicine.symptom ,business ,Microperimetry - Abstract
Purpose To investigate retinal sensitivity in eyes with all the clinical stages of Best vitelliform macular dystrophy (VMD). Methods Thirty-two patients affected by VMD in subclinical, vitelliform, pseudohypopyon, vitelliruptive, and atrophic stages were enrolled in this prospective cross-sectional study. Patients underwent a complete ophthalmologic examination, including determination of best-corrected visual acuity (BCVA), staging of the disease (Gass's classification), and microperimetry by means of the macular integrity assessment microperimeter. The primary outcome measure was to describe the alterations in the retinal sensitivity of eyes affected by VMD in different stages. Secondary outcome measures included correlations between retinal sensitivity and best-corrected visual acuity and the correlation between the VMD stage and the specific microperimetry pattern. Results Mean retinal sensitivity was reduced in all the VMD stages. Nevertheless, vitelliform, pseudohypopyon, and vitelliruptive stages turned out to be very similar, especially within 10°. Fixation was classified as stable in 27 eyes (44.2%), relatively unstable in 16 eyes (26.2%), and unstable in 18 eyes (29.5%). Fixation stability correlated both with the disease stage and best-corrected visual acuity. Conclusion VMD is characterized by complex microperimetric abnormalities, involving the whole macular area. Microperimetry may contribute to the global clinical assessment of patients affected by VMD and could be used in future therapeutic approaches.
- Published
- 2017
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