1. Bronchial Thermoplasty Attenuates Cough Reflex Sensitivity in Severe Asthma: A Single-Center Retrospective Study with 2-year Follow-up
- Author
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Hara, Johsuke, Yamamura, Kenta, Sakai, Tamami, Takeda, Yoshihiro, Kobayashi, Takafumi, Ohkura, Noriyuki, Watanabe, Satoshi, Tambo, Yuichi, Kimura, Hideharu, Abo, Miki, Kasahara, Kazuo, and Yano, Seiji
- Subjects
cough-related quality of life ,bronchial thermoplasty ,otorhinolaryngologic diseases ,cough reflex sensitivity ,bronchial asthma ,General Medicine ,respiratory system ,General Biochemistry, Genetics and Molecular Biology - Abstract
Despite the relatively short follow-up period in our previous study, we had reported that increased cough reflex sensitivity (CRS) may predict the efficacy of bronchial thermoplasty (BT) for treating asthma. Herein, we examined whether CRS predicts the efficacy of BT 2 years after the final BT treatment. We also investigated the influence of BT on CRS. We reviewed 12 patients 2 years after their final BT treatment. CRS, asthma-related symptoms, asthma exacerbations, and cough-related quality of life were assessed at baseline and 2 years after BT. Six patients responded positively to BT (BT responders) and their asthma control improved. No significant difference in CRS at baseline was detected between the BT responders and nonresponders. In contrast, BT responders exhibited significant improvements in CRS 2 years after BT. CRS at baseline could not predict the BT efficacy after 2 years. This is the first report demonstrating BT desensitized CRS in consecutive case series.
- Published
- 2022