Search

The purpose of regulatory data minimization obligations is to limit personal data to the absolute minimum necessary for a given context. Beyond the initial data collection, storage, and processing, data minimization is also required for subsequent data releases, as it is the case when data are provided using query-capable Web APIs. Data-providing Web APIs, however, typically lack sophisticated data minimization features, leaving the task open to manual and all too often missing implementations. In this paper, we address the problem of data minimization for data-providing, query-capable Web APIs. Based on a careful analysis of functional and non-functional requirements, we introduce Janus, an easy-to-use, highly configurable solution for implementing legally compliant data minimization in GraphQL Web APIs. Janus provides a rich set of information reduction functionalities that can be configured for different client roles accessing the API. We present a technical proof-of-concept along with experimental measurements that indicate reasonable overheads. Janus is thus a practical solution for implementing GraphQL APIs in line with the regulatory principle of data minimization., Comment: Preprint version (2022-03-18) This version of the contribution has been accepted for publication at the 22nd International Conference on Web Engineering (ICWE 2022), Bari, Italy

ispartof: Online proceedings of the International workshop on Fair, Effective And Sustainable Talent management using data science ispartof: International workshop on Fair, Effective And Sustainable Talent management using data science at European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases (ECML PKDD) location:Online date:13 Sep - 17 Sep 2021 status: accepted

Supplemental material, JCB900543 Supplemental Figures for Mild pericyte deficiency is associated with aberrant brain microvascular flow in aged PDGFRβ+/− mice by Ashley N Watson, Andree-Anne Berthiaume, Anna V Faino, Konnor P McDowell, Narayan R Bhat, David A Hartmann and Andy Y Shih in Journal of Cerebral Blood Flow & Metabolism

Includes supplementary material The thesis investigates the feasibility of duty cycling the GPS receiver onboard small satellites like NPSAT1 in order to repurpose power savings in ways that would better serve the satellite’s mission. Orbital propagation software run on onboard computer hardware produces accurate ephemeris data over short periods without continued GPS input. Longer periods relying on propagator ephemeris translate to greater power savings, but it also means increasing positional error. In order to better define the trade space between time and error of common propagators, Systems Tool Kit software was used to test the accuracy of the Two-Body and Simplified General Perturbations-4 propagators over time against positions measured by the Joint Space Operations Center. Two-Body propagators’ error response varies as a function of altitude and inclination, with the worst case requiring GPS updates up to twice an orbit. Simplified General Perturbations-4 propagators’ error depends strongly on the accuracy of the B* drag term, but is still sufficiently accurate to operate a day or more without a GPS update. Savings in the GPS power budget were found to exceed 96% and 99% for Two-Body and Simplified General Perturbations-4 propagators, respectively, and should be considered for use in future satellites. Lieutenant, United States Navy Approved for public release; distribution is unlimited.

Quaternized vinyl- and alkynyl-pyridine reagents were shown to react in an ultrafast and selective manner with several cysteine-tagged proteins at near-stoichiometric quantities. We have demonstrated that this method can effectively create a homogenous antibody-drug conjugate that features a precise drug-to-antibody ratio of 2, which was stable in human plasma and retained its specificity towards Her2+ cells. Finally, the developed warhead introduces a +1 charge to the overall net charge of the protein, which enabled us to show that the electrophoretic mobility of the protein may be tuned through the simple attachment of a quaternized vinyl pyridinium reagent at the cysteine residues. We anticipate the generalized use of quaternized vinyl- and alkynyl-pyridine reagents not only for bioconjugation, but also as warheads for covalent inhibition and as tools to profile cysteine reactivity.