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Supplemental material, sj-docx-1-eso-10.1177_23969873231173282 for Sex differences in associations between creatinine and cystatin C-based kidney function measures with stroke and major bleeding by Jennifer Susan Lees, Nicole L De La Mata, Michael K Sullivan, Melanie L Wyld, Brenda M Rosales, Rachel Cutting, James Alan Hedley, Elaine Rutherford, Patrick Barry Mark and Angela C Webster in European Stroke Journal

Supplemental material, sj-docx-1-eso-10.1177_23969873231173282 for Sex differences in associations between creatinine and cystatin C-based kidney function measures with stroke and major bleeding by Jennifer Susan Lees, Nicole L De La Mata, Michael K Sullivan, Melanie L Wyld, Brenda M Rosales, Rachel Cutting, James Alan Hedley, Elaine Rutherford, Patrick Barry Mark and Angela C Webster in European Stroke Journal

Measures to control the COVID-19 pandemic have disrupted social networks and employment security worldwide. Longitudinal data in representative samples are required to understand the corresponding mental health impacts. We aimed to estimate the prevalence of depressive symptoms in Australian women raising young families during the first Victorian lockdown and to identify risk factors. Participants comprise 347 mothers of children aged 7 (mean age: 32·11 years [4·27]), from the Barwon Infant Study (BIS). Mothers had previously completed Edinburgh Postnatal Depression Scale (EPDS) at child ages zero, two, four. Following the lock down, mothers again completed EPDS along with questions regarding current household and employment demographics. Depressive symptoms were substantially more prevalent in the lockdown sample than at any prior assessment (EPDS10+; 30·6%); and were particularly high in women with previous poor mental health. Anticipated and actual job loss were twice as common relative to previous assessment (5% to 13%, p = 0 006) and (4% to 10%, p = 0 001) and were associated with depressive symptoms. While further studies are required to confirm causal associations, these findings highlight the need to support mental health during the COVID-19 pandemic, particularly in the context of employment insecurity and previous mental illness. KEY POINTS What is already known about this topic: Emerging reports from convenience samples demonstrate elevated depressive symptoms during the COVID-19 pandemic. Maternal mental health is important for child mental health. Representative, longitudinal data are needed to further improve targeting of policy and health service delivery to prevent a post-COVID-19 mental health crisis. What this topic adds: This early report from a population-derived cohort demonstrates high rates of depression symptomatology in mothers of school aged children following the first COVID-19 lockdown. A past history of depression and current threats to employment are identified as key risk factors for adverse mental health. Our findings are consistent with concerns regarding an increase in mental health burden in the wake of the COVID-19 pandemic but further studies are required to assess causality. Interventions and broader community resources to support the mental health of women of school aged children are required, and should target those with a history of depression and current threats to employment.

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