136,615 results on '"Heinz, A."'
Search Results
2. Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study
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Patricia Perez Schmidt, Tanja Luedtke, Paolo Moretti, Paolo Di Gianvincenzo, Marcos Fernandez Leyes, Bruno Espuche, Heinz Amenitsch, Guocheng Wang, Hernan Ritacco, Laura Polito, M. Grazia Ortore, and S.E. Moya
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Biomaterials ,Colloid and Surface Chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2023
3. Science objectives of the MMX rover
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Stephan Ulamec, Patrick Michel, Matthias Grott, Ute Böttger, Susanne Schröder, Heinz-Wilhelm Hübers, Yuichiro Cho, Fernando Rull, Naomi Murdoch, Pierre Vernazza, Olga Prieto-Ballesteros, Jens Biele, Simon Tardivel, Denis Arrat, Till Hagelschuer, Jörg Knollenberg, Damien Vivet, Cecily Sunday, Laurent Jorda, Olivier Groussin, Colas Robin, and Hirdy Miyamoto
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Phobos ,Martian moons eXploration MMX ,Rover ,Aerospace Engineering - Published
- 2023
4. Combined Chronic Oral Methylphenidate and Fluoxetine Treatment During Adolescence: Effects on Behavior
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Panayotis K, Thanos, Madison, McCarthy, Daniela, Senior, Samantha, Watts, Carly, Connor, Nikki, Hammond, Kenneth, Blum, Michael, Hadjiargyrou, David, Komatsu, and Heinz, Steiner
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Pharmaceutical Science ,Biotechnology - Abstract
Background: Attention Deficit Hyperactivity Disorder (ADHD) can be comorbid with depression, often leading to the prescription of both methylphenidate (MP) and selective serotonin reuptake inhibitor (SSRI) antidepressants, such as fluoxetine (FLX). Moreover, these drugs are often misused as cognitive enhancers. This study examined the effects of chronic oral co-administration of MP and FLX on depressive- and anxiety-like behaviors. Methods: Adolescent rats received daily either water (control), MP, FLX, or the combination of MP plus FLX in their drinking water over the course of 4 weeks. Results: Data analysis shows a decrease in food consumption and body weight for rats exposed to FLX or the combination of MP and FLX. Sucrose consumption was significantly greater in FLX or MP+FLX groups compared to controls. FLX-treated rats showed no effect in the elevated plus maze (EPM; open arm time) and forced swim test (FST; latency to immobility). However, rats treated with the combination (MP+FLX) showed significant anxiolytic-like and anti-depressive-like behaviors (as measured by EPM and FST), as well as significant increases in overall activity (distance traveled in open field test). Finally, the combined MP+FLX treatment induced a decrease in anxiety and depressive- like behaviors significantly greater than the response from either of these drugs alone. Conclusion: These behavioral results characterize the long-term effects of these drugs (orally administered) that are widely co-administered and co-misused and provide important insight into the potential neurobiological and neurochemical effects. Future research will determine the potential risks of the long-term use of MP and FLX together.
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- 2023
5. In-flight separation of rare heavy transfer products with a velocity filter
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S. Heinz and H.M. Devaraja
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Nuclear and High Energy Physics ,Instrumentation - Published
- 2023
6. Targeting 1.5 degrees with the global carbon footprint of the Australian Capital Territory
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Kylie Goodwin, Cameron Allen, Soo Huey Teh, Mengyu Li, Jacob Fry, Manfred Lenzen, Serena Farrelly, Constanza Leon, Sophie Lewis, Guangwu Chen, Heinz Schandl, and Thomas Wiedmann
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Geography, Planning and Development ,Management, Monitoring, Policy and Law - Published
- 2023
7. Optimizing surfactant removal from a soft-templated ordered mesoporous carbon precursor: an in situ SAXS study
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Max Valentin Rauscher, Malina Seyffertitz, Richard Kohns, Sebastian Stock, Heinz Amenitsch, Nicola Huesing, and Oskar Paris
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General Biochemistry, Genetics and Molecular Biology - Abstract
In situ small-angle X-ray scattering (SAXS) was employed to identify critical parameters during thermal treatment for template removal of an ordered mesoporous carbon precursor synthesized via a direct soft-templating route. The structural parameters obtained from the SAXS data as a function of time were the lattice parameter of the 2D hexagonal structure, the diameter of the cylindrical mesostructures and a power-law exponent characterizing the interface roughness. Moreover, detailed information on contrast changes and pore lattice order was obtained from analysis of the integrated SAXS intensity of the Bragg and diffuse scattering separately. Five characteristic regions during heat treatment were identified and discussed regarding the underlying dominant processes. The influence of temperature and O2/N2 ratio on the final structure was analyzed, and parameter ranges were identified for an optimized template removal without strongly affecting the matrix. The results indicate that the final structure and controllability of the process are optimum for temperatures between 260 and 300°C with a gas flow containing 2 mol% of O2.
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- 2023
8. Radiation protection challenges for the Large Hadron Collider upgrade
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Lucie Elie, Patrycja Dyrcz, Angelo Infantino, Christophe Tromel, and Heinz Vincke
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Radiation ,Radiological and Ultrasound Technology ,Public Health, Environmental and Occupational Health ,Radiology, Nuclear Medicine and imaging ,General Medicine - Abstract
In the context of the so-called Long Shutdown 3 (2026–2028), the Large Hadron Collider will be upgraded to the High-Luminosity Large Hadron Collider, allowing for approximately five more instantaneous collisions. The upgrade, maintenance and decommissioning of equipment will be mainly performed in the experimental insertions of Points 1 and 5, requiring to perform multiple interventions in high-residual radiation environment. This poses complex radiological challenges that the CERN Radiation Protection group is called to address. Radiation protection studies are performed to plan and optimise (ALARA) these future interventions using the advanced Monte Carlo techniques and tools such as FLUKA, ActiWiz, SESAME and the FCC method. This paper aims to provide an overview of the studies conducted to estimate the residual radiation field in the experimental insertions, the activation levels in terms of multiple of the Swiss clearance limits/specific activity and to provide preliminary considerations on the upgrade/decommissioning of key equipment.
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- 2023
9. Radiation protection challenges in the upgrade, autopsy and disposal of the LHC beam dump
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Angelo Infantino, Ana-Paula Bernardes, Marco Calviani, Gerald Dumont, Safouane El-Idrissi, Renaud Mouret, Christophe Tromel, and Heinz Vincke
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Radiation ,Radiological and Ultrasound Technology ,Public Health, Environmental and Occupational Health ,Radiology, Nuclear Medicine and imaging ,General Medicine - Abstract
The upgrade of the Large Hadron Collider spare beam dumps (Target Dump External, TDE) and the autopsy of the old operational TDE required to perform several activities in a high-radiation environment posing significant radiation protection challenges due to the residual activation of the equipment. To ensure high safety standards and to respect the ALARA principle, these challenges were addressed using the advanced Monte Carlo techniques to predict the residual ambient dose equivalent rate and the radionuclide inventory at different steps of the interventions. The CERN HSE-RP group makes extensive use of the FLUKA and ActiWiz codes to produce accurate estimates. This work aims to provide an overview of the radiation protection studies to optimise the interventions (ALARA) and to reduce the radiological risk for personnel and environment.
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- 2023
10. Automated trackspinning of aligned lignin fibers as precursors of green carbon nanofibers
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Dave Jao, Abigail Heinz, Joseph F Stanzione, and Vince Z Beachley
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Polymers and Plastics ,Materials Chemistry ,Pollution - Abstract
At present, most carbon fibers are made from non-renewable polyacrylonitrile. Substantial efforts have been made to replace petroleum-based precursors for carbon fiber production. Interestingly, lignin is a carbon fiber precursor material that is cheap, highly available and sustainable. Submicron-scale lignin-based carbon nanofibers are used in numerous areas, such as electronic devices, batteries, supercapacitors and low-cost, high-performance structural composite materials. Trackspinning (TS) technology offers a way to scale up the versatile, but inefficient contact drawing technique to produce small-diameter lignin fibers from environmentally friendly aqueous solutions. In this study, the effects of TS based on probe drawing of low-concentration lignin nanofibers blended with poly(ethylene oxide) and glycerol in sodium hydroxide (NaOH) solution were investigated. The TS lignin fibers were well aligned and reached diameters as small as 500–1000 nm as the drawing length was increased. Lignin fiber macromolecular alignment was isotropic at low levels of draw, and the dichroic ratio increased from 1 to 2.25 with doubling of the drawing length. The most highly drawn trackspun lignin fibers had a mechanical strength of 3.92 MPa and a Young’s modulus of 2.15 GPa, which were similar to reported values for solvent-electrospun lignin nanofibers. These findings support the potential to utilize TS to produce small-diameter lignin fibers using a simple aqueous solvent approach.
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- 2023
11. Radiological Characterization Studies for the CNGS Dismantling
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Claudia Ahdida, Elzbieta Nowak, Christelle Saury, Heinz Vincke, and Helmut Vincke
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Nuclear Energy and Engineering - Published
- 2023
12. Drone-Based Thermal Imaging in the Detection of Wildlife Carcasses and Disease Management
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Janine Rietz, Suzanne T. S. van Beeck Calkoen, Nicolas Ferry, Jens Schlüter, Helena Wehner, Karl-Heinz Schindlatz, Tomáš Lackner, Christian von Hoermann, Franz J. Conraths, Jörg Müller, and Marco Heurich
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General Veterinary ,General Immunology and Microbiology ,General Medicine - Abstract
Because animal carcasses often serve as reservoirs for pathogens, their location and removal are crucial in controlling the spread of diseases. During carcass decomposition, heat is emitted due to microbial activity and the development of maggots. Recent studies have shown that infrared sensors can be used to locate animal carcasses, but little is known about the factors influencing detection success. In this study, we investigated the potential of infrared technology to locate wild boar carcasses, as they play an important role in the spread of African swine fever. Specifically, we tested the effects of environmental and carcass conditions on the detection probability. A drone-based thermal camera was used to collect data during 379 flyovers of 42 wild boar carcasses in different stages of decomposition between September 2020 and July 2021. Generalized mixed-effect models and conditional inference trees were used to identify the environmental and carcass conditions that influenced the detection probability. Our results showed that the thermal camera accurately measured carcass temperature (R2 = 0.75, RMSE = 5.89°C). The probability of finding carcasses was higher in open habitats with air temperatures >3.0°C and thus conducive to maggot development (detection rate ≤80%). A forest canopy openness >29.3% and cloudy conditions or flights at dawn increased the detection rate. Moreover, carcasses infested with large amounts of maggots could be detected even in habitats with a more extensive canopy cover, whereas in dense forests, the detection probability was limited (6.4°C (≤62%). Our study demonstrates the utility of thermal imaging in searching for wild boar carcasses under specific environmental and carcass conditions and thus its use in supporting ground searches.
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- 2023
13. In Vitro and In Vivo Evaluation of ABCG2 (BCRP) Inhibitors Derived from Ko143
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Melanie Zechner, Claudia A. Castro Jaramillo, Nadine S. Zubler, Marco F. Taddio, Linjing Mu, Karl-Heinz Altmann, and Stefanie D. Krämer
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Drug Discovery ,Molecular Medicine - Published
- 2023
14. Blood Kallikrein-8 and Non-Amnestic Mild Cognitive Impairment: An Exploratory Study
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Schramm, Sara, Krizanovic, Nela, Roggenbuck, Ulla, Jöckel, Karl-Heinz, Herring, Arne, Keyvani, Kathy, and Jokisch, Martha
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Psychiatry and Mental health ,Clinical Psychology ,General Neuroscience ,Medizin ,Geriatrics and Gerontology - Abstract
Background: Blood kallikrein-8 is supposed to be a biomarker for mild cognitive impairment (MCI) due to Alzheimer's disease (AD), a precursor of AD dementia. Little is known about the association of kallikrein-8 and non-AD type dementias. Objective: To investigate whether blood kallikrein-8 is elevated in individuals with non-amnestic MCI (naMCI), which has a higher probability to progress to a non-AD type dementia, compared with cognitively unimpaired (CU) controls. Methods: We measured blood kallikrein-8 at ten-year follow-up (T2) in 75 cases and 75 controls matched for age and sex who were participants of the population-based Heinz Nixdorf Recall study (baseline: 2000-2003). Cognitive performance was assessed in a standardized manner at five (T1) and ten-year follow-up. Cases were CU or had subjective cognitive decline (SCD) at T1 and had naMCI at T2. Controls were CU at both follow-ups. The association between kallikrein-8 (per 500 pg/ml increase) and naMCI was estimated using conditional logistic regression: odds ratios (OR) and 95% confidence intervals (95%CI) were determined, adjusted for inter-assay variability and freezing duration. Results: Valid kallikrein-8 values were measured in 121 participants (45% cases, 54.5% women, 70.5 +/- 7.1 years). In cases, the mean kallikrein-8 was higher than in controls (922 +/- 797 pg/ml versus 884 +/- 782 pg/ml). Kallikrein-8 was not associated with having naMCI compared to being CU (adjusted; OR: 1.03 [95%CI: 0.80-1.32]). Conclusion: This is the first population-based study that shows that blood kallikrein-8 tends not to be elevated in individuals with naMCI compared with CU. This adds to the evidence of the possible AD specificity of kallikrein-8. CA Schramm
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- 2023
15. Muscle Ultrasound Abnormalities in Individuals with RYR1-Related Malignant Hyperthermia Susceptibility
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Luuk R. van den Bersselaar, Nens van Alfen, Nick Kruijt, Erik-Jan Kamsteeg, Miguel A. Fernandez-Garcia, Susan Treves, Sheila Riazi, Chu-Ya Yang, Ignacio Malagon, Lucas T. van Eijk, Baziel G.M. van Engelen, Gert-Jan Scheffer, Heinz Jungbluth, Marc M.J. Snoeck, and Nicol C. Voermans
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Neurology ,Neurology (clinical) - Abstract
Background: Variants in RYR1, the gene encoding the ryanodine receptor-1, can give rise to a wide spectrum of neuromuscular conditions. Muscle imaging abnormalities have been demonstrated in isolated cases of patients with a history of RYR1-related malignant hyperthermia (MH) susceptibility. Objective: To provide insights into the type and prevalence of muscle ultrasound abnormalities and muscle hypertrophy in patients carrying gain-of-function RYR1 variants associated with MH susceptibility and to contribute to delineating the wider phenotype, optimizing the diagnostic work-up and care for of MH susceptible patients. Methods: We performed a prospective cross-sectional observational muscle ultrasound study in patients with a history of RYR1-related MH susceptibility (n = 40). Study procedures included a standardized history of neuromuscular symptoms and a muscle ultrasound assessment. Muscle ultrasound images were analyzed using a quantitative and qualitative approach and compared to reference values and subsequently subjected to a screening protocol for neuromuscular disorders. Results: A total of 15 (38%) patients had an abnormal muscle ultrasound result, 4 (10%) had a borderline muscle ultrasound screening result, and 21 (53%) had a normal muscle ultrasound screening result. The proportion of symptomatic patients with an abnormal result (11 of 24; 46%) was not significantly higher compared to the proportion of asymptomatic patients with an abnormal ultrasound result (4 of 16; 25%) (P = 0.182). The mean z-scores of the biceps brachii (z = 1.45; P < 0.001), biceps femoris (z = 0.43; P = 0.002), deltoid (z = 0.31; P = 0.009), trapezius (z = 0.38; P = 0.010) and the sum of all muscles (z = 0.40; P < 0.001) were significantly higher compared to 0, indicating hypertrophy. Conclusions: Patients with RYR1 variants resulting in MH susceptibility often have muscle ultrasound abnormalities. Frequently observed muscle ultrasound abnormalities include muscle hypertrophy and increased echogenicity.
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- 2023
16. Simulating the shrinkage-induced interfacial damage around Class I composite resin restorations with damage mechanics
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Po-Chun Tseng, Shu-Fen Chuang, Dalia Kaisarly, and Karl-Heinz Kunzelmann
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Mechanics of Materials ,General Materials Science ,General Dentistry - Published
- 2023
17. Leveraging deep learning models to understand the daily experience of anxiety in teenagers over the course of a year
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Brian Wang, Matthew David Nemesure, Chloe Park, George Price, Michael V. Heinz, and Nicholas C. Jacobson
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Psychiatry and Mental health ,Clinical Psychology - Abstract
Anxiety disorders are a prevalent and severe problem that are often developed early in life and can disrupt the daily lives of affected individuals for many years into adulthood. Given the persistent negative aspects of anxiety, accurate and early assessment is critical for long term outcomes. Currently, the most common method for anxiety assessment is through point-in-time measures like the GAD-7. Unfortunately, this survey and others like it can be subject to recall bias and do not fully capture the variability in an individual’s day-to-day symptom experience. The current work aims to evaluate how point-in-time assessments like the GAD-7 relate to daily measurements of anxiety in a teenage population. To evaluate this relationship, we leveraged data collected at four separate three week intervals from 30 teenagers over the course of a year. The specific items of interest were a single item anxiety severity measure collected three times per day and end-of-month GAD-7 assessments. Within this sample, 40% of individuals reported clinical levels of generalized anxiety disorder symptoms at some point during the study. The first component of analysis was a visual inspection assessing how daily anxiety severity fluctuated around end-of-month reporting via the GAD-7. The second component was a between-subjects comparison assessing whether individuals with similar GAD-7 scores experienced similar symptom dynamics across the month as represented by latent features derived from a deep learning model. With this approach, similarity was operationalized by hierarchical clustering of the latent features. The aim clearly indicated that an individual’s daily experience of anxiety varied widely around what was captured by the GAD-7. Additionally, when hierarchical clustering was applied to the three latent features derived from the (LSTM) encoder (r=0.624 for feature reconstruction), it was clear that individuals with similar GAD-7 outcomes were experiencing different symptom dynamics. Upon further inspection of the latent features, the LSTM model appeared to rely as much on anxiety variability over the course of the month as it did on anxiety severity (p
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- 2023
18. Faith development as change in religious types: Results from three-wave longitudinal data with faith development interviews
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Ralph W. Hood, Heinz Streib, and Zhuo Job Chen
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Social Psychology ,Longitudinal data ,media_common.quotation_subject ,Religious studies ,Sample (statistics) ,PsycINFO ,religious change ,spirituality ,religious types ,Religious development ,Faith ,Adult life ,religion ,Schema (psychology) ,Openness to experience ,Faith development ,Sociology ,Meaning (existential) ,Social science ,Psychology ,Social psychology ,Applied Psychology ,media_common - Abstract
Faith, as a way of how people understand God and the world and make or discover meaning in their life, is characterized by individual differences and changes over the lifetime. Our research investigates these changes over the life span in terms of hierarchically ordered types that are the elements in our developmental model, which is a critical advancement and modification of Fowler’s theory of faith development. This study is the first to investigate whether there is development in faith over the adult life span and to identify predictors of developmental change. Our mixed-method design used three-wave longitudinal data (mean lag time 10.47 years from Wave 1 to Wave 3). A sample of N = 75 participants were interviewed with the faith development interview three times and each time answered comprehensive questionnaires. Results evidenced faith development over the life span: a majority in our data moved to a higher type, while change to a lower type did occur. Openness to experience and the religious schema truth of text and teachings were potential antecedents for faith development. (PsycInfo Database Record (c) 2021 APA, all rights reserved)
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- 2023
19. Navigator-based slice tracking for prospective motion correction in kidney vessel architecture imaging
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Ke, Zhang, Simon M F, Triphan, Felix T, Kurz, Christian H, Ziener, Hans-Ulrich, Kauczor, Heinz-Peter, Schlemmer, and Oliver, Sedlaczek
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Biomedical Engineering ,Biophysics ,Radiology, Nuclear Medicine and imaging - Abstract
To apply a navigator-based slice tracking method to prospectively compensate the respiratory motion for kidney vessel architecture imaging (VAI).A dual gradient echo (GE)/spin echo (SE) 2D EPI sequence was developed for kidney VAI. A single gradient-echo slice selection and projection readout at the location of the diaphragm along the inferior-superior direction was applied as a navigator. Navigator acquisition and fat suppression were inserted before each transverse imaging slice. Motion information was calculated after exclusion of the signal saturation in the navigator signal caused by imaging slices. The motion information was then directly sent back to the sequence and slice positioning was adjusted in real-time. The whole sequence was applied during a contrast agent pass-through.VAI parametric maps show the structural heterogeneity of the renal vasculature. The respiratory motion from the navigator signal was precisely calculated and slice positioning was changed in real-time based on the motion information. The vibration amplitude of the signal intensity of the liver tissue at the liver-lung interface in the case of prospective motion correction (PMC) on is about 28% of the PMC off case. Compared to the case of PMC off, the coefficient of variation (CoV) was reduced 30% of the case of PMC on.This study demonstrates the feasibility of the motion-compensating technique in kidney VAI. The sequence may improve the evaluation of microvasculature in kidney diseases.
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- 2023
20. Comparative performance analysis of frontier-based efficiency measurement methods – A Monte Carlo simulation
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Heinz Ahn, Marcel Clermont, and Julia Langner
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Information Systems and Management ,General Computer Science ,Modeling and Simulation ,Management Science and Operations Research ,Industrial and Manufacturing Engineering - Published
- 2023
21. Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study
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John H Strickler, Andrea Cercek, Salvatore Siena, Thierry André, Kimmie Ng, Eric Van Cutsem, Christina Wu, Andrew S Paulson, Joleen M Hubbard, Andrew L Coveler, Christos Fountzilas, Adel Kardosh, Pashtoon M Kasi, Heinz-Josef Lenz, Kristen K Ciombor, Elena Elez, David L Bajor, Chiara Cremolini, Federico Sanchez, Michael Stecher, Wentao Feng, Tanios S Bekaii-Saab, Marc Peeters, Marc Van den Evnde, Christophe Borg, Matthieu Sarabi, Francois Ghiringhelli, Benoist Chibaudel, Maria G. Zampino, Susana R. Keranen, Ramon Salazar, Pilar Alfonso, John H. Strickler, Andrew S. Paulson, Joleen M. Hubbard, Andrew L. Coveler, Pashtoon M. Kasi, Kristen K. Ciombor, David L. Bajor, Tanios S. Bekaii-Saab, Olumide Gbolahan, Patrick Boland, Daniel Berg, Timothy Goggins, Anwar Saeed, Howard Burris, Johanna Bendell, Darryl Outlaw, Isaac Tafur, Ardaman Shergill, Daniel Catenacci, Jun Gong, Ignacio Garrido-Laguna, Gene Finley, Benjamin Weinberg, Anthony Shields, Philip Philip, Anita Turk, Anthony Nguyen, Fadi Braiteh, Vijay Patel, William Harwin, Ian Anderson, Ajay Kundra, Christopher Chen, James Ford, Madappa Kundranda, Danny Nguyen, Suresh Ratnam, Donald Richards, Sujatha Nallapareddy, Sridhar Beeram, Scott McKenney, and Spencer Shao
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Oncology - Published
- 2023
22. A 2D/3D implicit gradient-enhanced nonlocal meso-scale damage model for deformation and fracturing of brittle materials
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Guanglei Zhou, Jiangwei Liu, Tao Xu, Heinz Konietzky, Chuanwei Zang, Guangchao Zhang, and Miao Chen
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Computational Mathematics ,Applied Mathematics ,General Engineering ,Analysis - Published
- 2023
23. Safety and efficacy of rozanolixizumab in patients with generalised myasthenia gravis (MycarinG): a randomised, double-blind, placebo-controlled, adaptive phase 3 study
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Vera Bril, Artur Drużdż, Julian Grosskreutz, Ali A Habib, Renato Mantegazza, Sabrina Sacconi, Kimiaki Utsugisawa, John Vissing, Tuan Vu, Marion Boehnlein, Ali Bozorg, Maryam Gayfieva, Bernhard Greve, Franz Woltering, Henry J Kaminski, Angela Genge, Rami Massie, Maxime Berube, Lubna Daniyal, Shabber Mannan, Eduardo Ng, Ritesh Rohan Raghu Raman, Evelyn Sarpong, Monica Alcantara, Annie Dionne, Zaeem Siddiqi, Derrick Blackmore, Faraz Hussain, Genevieve Matte, Stephan Botez, Michaela Tyblova, Michala Jakubikova, Jana Junkerova, Nanna Witting, Sonja Holm-Yildiz, Mads Stemmerik, Henning Andersen, Izabella Obál, Guilhem Solé, Stéphane Mathis, Marie-Hélène Violleau, Christine Tranchant, Sihame Messai, Jean-Baptiste Chanson, Aleksandra Nadaj-Pakleza, Arnaud Verloes, Leila Zaidi, Manuela Gambella, Michele Cavalli, Tanya Stojkovic, Sophie Demeret, Loic Le Guennec, Giorgia Querin, Nicolas Weiss, Marion Masingue, Laurent Magy, Karima Ghorab, Ia Rukhadze, Alexander Tsiskaridze, Marina Janelidze, Temur Margania, Florian Then Bergh, Eike Hänsel, Andrea Kalb, Bianca Meilick, Mandy Reuschel, Lars-Malte Teußer, Astrid Unterlauft, Clemens Goedel, Tim Hagenacker, Andreas Totzeck, Benjamin Stolte, Franz Blaes, Christine Bindler, Vasilios Tsoutsikas, Annekathrin Roediger, Christian Geis, Jens Schmidt, Jana Zschüntzsch, Margret Schwarz, Stefanie Meyer, Karsten Kummer, Stefanie Glaubitz, Rachel Zeng, Heinz Wiendl, Luisa Klotz, Anna Lammerskitten, Jan Lünemann, Péter Diószeghy, Lorenzo Maggi, Elena Rinaldi, Matteo Gastaldi, Federico Mazzacane, Pietro Businaro, Raffaele Iorio, Giovanni Antonini, Laura Fionda, Rita Rinaldi, Simone Rossi, Francesco Habetswallner, Francesco Tuccillo, Haruna Umehara, Eiko Uenaka, Masanori Takahashi, Keiko Higashi, Makoto Kinoshita, Emika Yoneda, Noriko Nakamura, Saeka Fujita, Tomoya Kubota, Masami Ono, Sana Yamamoto, Taku Hatano, Kazuki Oikoshi, Kazumasa Yokoyama, Yutaka Oji, Yuji Tomizawa, Akiyuki Uzawa, Manato Yasuda, Sachiko Akita, Yukiko Ozawa, Yosuke Onishi, Miki Takaki, Hiromi Yamada, Kanako Minemoto, Miki Sanko, Nanae Izawa, Mayumi Nakayama, Masayuki Masuda, Rune Tsuji, Nobuhiro Ido, Yumi Hyodo, Yoshihiko Okubo, Akiko Minohara, Nana Haraguchi, Makiko Naito, Seiko Yoshida, Yuri Fukushige, Akira Tsujino, Atsushi Nagaoka, Teiichiro Miyazaki, Shunsuke Yoshimura, Takuro Hirayama, Tomoaki Shima, Naoko Okamoto, Riki Matsumoto, Kenji Sekiguchi, Takehiro Ueda, Norio Chihara, Mari Kirimura, Emi Sunagawa, Ayaka Suzuki, Shigeaki Suzuki, Aozora Wada, Kei Ishizuchi, Yasushi Suzuki, Mitsuo Yata, Yuka Komatsu, Kenichi Tsukita, Genya Watanabe, Kazuki Sato, Emiko Kawasaki, Naoki Yamamoto, Hirohiko Ono, Tomoko Tsuda, Shigeki Ohashi, Yuka Fujisawa, Yumiko Yokota, Yuriko Nagane, Kameda Ayumi, Yuka Takematsu, Hiroyuki Naito, Kumiko Kuwada, Konrad Rejdak, Sebastian Szklener, Monika Kitowska, Kandyda Derkacz, Tomasz Berkowicz, Paulina Budzinska, Marek Halas, Leonid Zaslavskiy, Evgeniya Skornyakova, Sergey Kotov, Ekaterina Novikova, Olga Sidorova, Vitalii Goldobin, Tatiana Alekseeva, Patimat Isabekova, Nadezhda Malkova, Denis Korobko, Gordana Djordjevic, Aleksandar Stojanov, Stojan Peric, Dragana Lavrnic, Ivo Bozovic, Aleksa Palibrk, Carlos Casasnovas, Velina Nedkova-Hristova, Nuria Vidal Fernández, Elena Cortés Vicente, Luis Querol Gutiérrez, Maria Salvadó Figueras, Anna Canovas Segura, Raúl Juntas Morales, Daniel Sanchez Tejerina, Albert Saiz, Yolanda Blanco Morgado, Sara Llufriú Durán, María Sepúlveda Gázquez, Eugenia María Martínez Hernández, Gerardo Gutiérrez Gutiérrez, Paqui Iniesta, José Meca Lallana, Yuh-Cherng Guo, Hou-Chang Chiu, Jiann-Horng Yeh, Ya Hui Chen, Mei Fen Lee, Yi-Chung Lee, Kuan Lin Lai, Said Beydoun, Salma Akhter, Lucy Lam, Alisha Thomas, Michael Rivner, Brandy Quarles, Dale Lange, Shara Holzberg, Pantelis Pavlakis, Ashwathy Goutham, Henry Kaminski, Radwa Aly, Lisa Ashworth, Kathryn Bender, Karie Bond, Joanne Buckner, Sara Byerly, James Caress, Jessyca Clemons, Asha Farmer, Catherine Franklin, Summer Harris, Meredith Hiatt, Rachana Gandhi Mehta, Gina Miller, Lynn Smith, Rose Smith, Brian Strittmatter, Tahseen Mozaffar, Isela Hernandez, Kelsey Moulton, Chafic Karam, Pranali Ravikumar, Catherine Lomen-Hoerth, Laura Rosow, Hannah George, Viktoriya Irodenko, Carol Denny, Bart Hanson, Sara Klein, Jennifer Martinez-Thompson, Elie Naddaf, Denny Padgett, Eric Sorenson, Jane L Sultze, Delena Weis, Kourosh Rezania, Jason Thonhoff, Sheetal Shroff, Robert Pascuzzi, Angela Micheels, Cynthia Bodkin, Adam Comer, Gelasio Baras, Renee Wagner, Zabeen Mahuwala, Stephen Ryan, Kai Su, Khema Sharma, Andrew Brown, and Kore Liow
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Neurology (clinical) - Published
- 2023
24. Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study
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Anja M. Sedlmeier, Vivian Viallon, Pietro Ferrari, Laia Peruchet-Noray, Emma Fontvieille, Amina Amadou, Nazlisadat Seyed Khoei, Andrea Weber, Hansjörg Baurecht, Alicia K. Heath, Kostas Tsilidis, Rudolf Kaaks, Verena Katzke, Elif Inan-Eroglu, Matthias B. Schulze, Kim Overvad, Catalina Bonet, Esther Ubago-Guisado, María-Dolores Chirlaque, Eva Ardanaz, Aurora Perez-Cornago, Valeria Pala, Rosario Tumino, Carlotta Sacerdote, Fabrizio Pasanisi, Kristin B. Borch, Charlotta Rylander, Elisabete Weiderpass, Marc J. Gunter, Béatrice Fervers, Michael F. Leitzmann, Heinz Freisling, [Sedlmeier, Anja M. M.] Univ Regensburg, Dept Epidemiol & Prevent Med, Regensburg, Germany, [Weber, Andrea] Univ Regensburg, Dept Epidemiol & Prevent Med, Regensburg, Germany, [Baurecht, Hansjoerg] Univ Regensburg, Dept Epidemiol & Prevent Med, Regensburg, Germany, [Leitzmann, Michael F. F.] Univ Regensburg, Dept Epidemiol & Prevent Med, Regensburg, Germany, [Viallon, Vivian] Int Agcy Res Canc IARC, Nutr & Metab Branch, Lyon, France, [Ferrari, Pietro] Int Agcy Res Canc IARC, Nutr & Metab Branch, Lyon, France, [Peruchet-Noray, Laia] Int Agcy Res Canc IARC, Nutr & Metab Branch, Lyon, France, [Fontvieille, Emma] Int Agcy Res Canc IARC, Nutr & Metab Branch, Lyon, France, [Weiderpass, Elisabete] Int Agcy Res Canc IARC, Nutr & Metab Branch, Lyon, France, [Gunter, Marc J. J.] Int Agcy Res Canc IARC, Nutr & Metab Branch, Lyon, France, [Freisling, Heinz] Int Agcy Res Canc IARC, Nutr & Metab Branch, Lyon, France, [Peruchet-Noray, Laia] Univ Barcelona, Fac Med, Dept Clin Sci, Barcelona, Spain, [Amadou, Amina] Ctr Leon Berard, Dept Prevent Canc Environm, Lyon, France, [Fervers, Beatrice] Ctr Leon Berard, Dept Prevent Canc Environm, Lyon, France, [Amadou, Amina] INSERM, UMR1296 Radiat Def, Hlth, Environm, Lyon, France, [Fervers, Beatrice] INSERM, UMR1296 Radiat Def, Hlth, Environm, Lyon, France, [Seyed Khoei, Nazlisadat] Univ Vienna, Fac Life Sci, Dept Nutr Sci, Vienna, Austria, [Heath, Alicia K. K.] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England, [Tsilidis, Kostas] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England, [Tsilidis, Kostas] Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece, [Kaaks, Rudolf] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany, [Katzke, Verena] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany, [Inan-Eroglu, Elif] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany, [Schulze, Matthias B. B.] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany, [Overvad, Kim] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark, [Bonet, Catalina] Catalan Inst Oncol ICO, Unit Nutr & Canc, Barcelona, Spain, [Bonet, Catalina] Bellvitge Biomed Res Inst IDIBELL, Canc Prevent & Palliat Care Program, Nutr & Canc Grp, Epidemiol,Publ Hlth, Barcelona, Spain, [Ubago-Guisado, Esther] Escuela Andaluza Salud Publ EASP, Granada, Spain, [Ubago-Guisado, Esther] Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain, [Ubago-Guisado, Esther] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Chirlaque, Maria-Dolores] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Ardanaz, Eva] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain, [Chirlaque, Maria-Dolores] Reg Hlth Council, Dept Epidemiol, Murcia, Spain, [Chirlaque, Maria-Dolores] Murcia Univ, IMIB Arrixaca, Murcia, Spain, [Ardanaz, Eva] IdiSNA, Navarra Publ Hlth Inst, Pamplona, Spain, [Perez-Cornago, Aurora] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England, [Pala, Valeria] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy, [Tumino, Rosario] AIRE ONLUS, Hyblean Assoc Epidemiol Res, Ragusa, Italy, [Sacerdote, Carlotta] Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy, [Pasanisi, Fabrizio] Feder II Univ Hosp, Dept Clin Med & Surg, Clin Nutr Unit, Naples, Italy, [Borch, Kristin B. B.] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Commun Med, Tromso, Norway, [Rylander, Charlotta] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Commun Med, Tromso, Norway, French National Cancer Institute (l'Institut National du Cancer), International Agency for Research on Cancer (IARC), Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Danish Cancer Society (Denmark), Ligue Contre le Cancer (France), Institut Gustave Roussy (France), Mutuelle Generale de l'Education Nationale (France), Institut National de la Sante et de la Recherche Medicale (INSERM) (France), German Cancer Aid (Germany), German Cancer Research Center (DKFZ) (Germany), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) (Germany), Federal Ministry of Education and Research (BMBF) (Germany), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy (Italy), Compagnia di San Paolo (Italy), National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports (VWS) (The Netherlands), Netherlands Cancer Registry (NKR) (The Netherlands), LK Research Funds (The Netherlands), Dutch Prevention Funds (The Netherlands), Dutch ZON (Zorg Onderzoek Nederland) (The Netherlands), World Cancer Research Fund (WCRF) (The Netherlands), Statistics Netherlands (The Netherlands), Health Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII) (Spain), Regional Government of Andalucia (Spain), Regional Government of Asturias (Spain), Regional Government of Basque Country (Spain), Regional Government of Murcia (Spain), Regional Government of Navarra (Spain), Catalan Institute of Oncology-ICO (Spain), Swedish Cancer Society (Sweden), Swedish Research Council (Sweden), County Council of Skane (Sweden), County Council of Vaesterbotten (Sweden), Cancer Research UK (United Kingdom), and Medical Research Council (United Kingdom)
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Cancer Research ,Oncology ,Height ,Fat ,Physical-activity ,Obesity ,Esophageal ,Adenocarcinoma ,Metaanalysis ,Weight ,Nutrition ,Validity - Abstract
Background Classical anthropometric traits may fail to fully represent the relationship of weight, adiposity, and height with cancer risk. We investigated the associations of body shape phenotypes with the risk of overall and site-specific cancers. Methods We derived four distinct body shape phenotypes from principal component (PC) analysis on height, weight, body mass index (BMI), waist (WC) and hip circumferences (HC), and waist-to-hip ratio (WHR). The study included 340,152 men and women from 9 European countries, aged mostly 35–65 years at recruitment (1990–2000) in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results After a median follow-up of 15.3 years, 47,110 incident cancer cases were recorded. PC1 (overall adiposity) was positively associated with the risk of overall cancer, with a HR per 1 standard deviation (SD) increment equal to 1.07 (95% confidence interval 1.05 to 1.08). Positive associations were observed with 10 cancer types, with HRs (per 1 SD) ranging from 1.36 (1.30–1.42) for endometrial cancer to 1.08 (1.03–1.13) for rectal cancer. PC2 (tall stature with low WHR) was positively associated with the risk of overall cancer (1.03; 1.02–1.04) and five cancer types which were not associated with PC1. PC3 (tall stature with high WHR) was positively associated with the risk of overall cancer (1.04; 1.03–1.05) and 12 cancer types. PC4 (high BMI and weight with low WC and HC) was not associated with overall risk of cancer (1.00; 0.99–1.01). Conclusions In this multi-national study, distinct body shape phenotypes were positively associated with the incidence of 17 different cancers and overall cancer.
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- 2022
25. Five-Year Results of Coronary Artery Bypass Grafting With or Without Carotid Endarterectomy in Patients With Asymptomatic Carotid Artery Stenosis: CABACS RCT
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Stephan C. Knipp, Torulv Holst, Konstantinos Bilbilis, Otgonzul von Velsen, Claudia Ose, Hans-Christoph Diener, Heinz Jakob, Arjang Ruhparwar, Karl-Heinz Jöckel, Christian Weimar, Friedhelm Beyersdorf, Martin Breuer, Manfred Dahm, Anno Diegeler, Arne Kowalski, Sven Martens, Friedrich-Wilhelm Mohr, Anton Moritz, Jiri Ondrášek, Beate Reiter, Peter Roth, Ralf Seipelt, Markus Siggelkow, Gustav Steinhoff, Ulrich Stock, Mathias Wilhelmi, and Gerhard Wimmer-Greinecker
- Subjects
Stroke ,Advanced and Specialized Nursing ,Endarterectomy, Carotid ,Treatment Outcome ,Risk Factors ,Medizin ,Humans ,Carotid Stenosis ,Neurology (clinical) ,Coronary Artery Bypass ,Cardiology and Cardiovascular Medicine - Abstract
Background: In patients with coronary artery disease and concomitant asymptomatic severe carotid stenosis, combined simultaneous coronary artery bypass grafting (CABG) and carotid endarterectomy (CEA) has been widely performed despite lack of evidence from randomized trials. We recently showed that the risk of stroke or death within 30 days was higher following CABG+CEA compared with CABG alone. Here, we report long-term outcomes following CABG with versus without CEA. Methods: The CABACS (Coronary Artery Bypass Graft Surgery in Patients With Asymptomatic Carotid Stenosis Study) is a randomized, controlled, multicenter, open trial. Patients with asymptomatic severe (≥70%) carotid stenosis undergoing CABG were allocated either CABG+CEA or CABG alone, and follow-up was 5 years. Major secondary end points included nonfatal stroke or death, any death and any nonfatal stroke. Due to low recruitment, the study was stopped prematurely after randomization of 127 patients in 17 centers. Results: By 5 years, the rate of stroke or death did not significantly differ between groups (CABG+CEA 40.6% [95% CI, 0.285–0.536], CABG alone 35.0% [95% CI, 0.231–0.484]; P =0.58). Higher albeit statistically nonsignificant rates of nonfatal strokes occurred at any time following CABG+CEA versus CABG alone (1 year: 19.3% versus 7.1%, P =0.09; 5 years: 29.4% versus 18.8%, P =0.25). All-cause mortality up to 5 years was similar in both groups (CABG+CEA: 25.4% versus CABG alone: 23.3%, hazard ratio, 1.148 [95% CI, 0.560–2.353]; P =0.71). Subgroup analyses did not reveal any significant effect of age, sex, preoperative modified Rankin Scale and center on outcome events. Conclusions: During 5-years follow-up, combined simultaneous CABG+CEA was associated with a higher albeit statistically nonsignificant rate of stroke or death compared with CABG alone. This was mainly due to a nonsignificantly higher perioperative risk following CABG+CEA. Since the power of our study was not sufficient, no significant effect of either procedure could be observed at any time during follow-up. Registration: URL: http://www.controlled-trials.com ; Unique identifier: ISRCTN13486906.
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- 2022
26. Nieprzystosowanie społeczne nieletnich w Republice Federalnej Niemiec
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Heinz Schöch
- Subjects
Automotive Engineering - Published
- 2023
27. Sądownictwo dla nieletnich a zapobieganie nieprzystosowaniu społecznemu nieletnich w Republice Federalnej Niemiec. (Z uwzględnieniem procesów selekcji oraz diversion)
- Author
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Wolfgang Heinz
- Subjects
Automotive Engineering - Published
- 2023
28. Incentivizing centrally regulated units to improve performance: Pitfalls and requirements
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Mohsen Afsharian, Heinz Ahn, and Emmanuel Thanassoulis
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Marketing ,Strategy and Management ,Management Science and Operations Research ,Management Information Systems - Published
- 2023
29. Chaos analysis of the cortical boundary for the recognition of psychosis
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Alexandra I. Korda, Christina Andreou, Mihai Avram, Marina Frisman, Mariya Aliqadri, Anita Riecher-Rössler, Heinz Handels, Thomas Martinetz, and Stefan Borgwardt
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Psychiatry and Mental health ,Pharmacology (medical) ,Biological Psychiatry - Published
- 2023
30. Disorder-Induced Magnetotransport Anomalies in Amorphous and Textured Co1–xSix Semimetal Thin Films
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Alan Molinari, Federico Balduini, Lorenzo Rocchino, Rafał Wawrzyńczak, Marilyne Sousa, Holt Bui, Christian Lavoie, Vesna Stanic, Jean Jordan-Sweet, Marinus Hopstaken, Serguei Tchoumakov, Selma Franca, Johannes Gooth, Simone Fratini, Adolfo G. Grushin, Cezar Zota, Bernd Gotsmann, and Heinz Schmid
- Subjects
Materials Chemistry ,Electrochemistry ,Electronic, Optical and Magnetic Materials - Published
- 2023
31. On the need for financial and structural reform of long-term care insurance
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Heinz Rothgang
- Subjects
Public Health, Environmental and Occupational Health - Abstract
ZusammenfassungBei Einführung der Pflegeversicherung im Jahr 1994 wurden Ausgestaltungsentscheidungen getroffen, die das System bis heute prägen. In diesem Diskussionsbeitrag werden 3 dieser Entscheidungen untersucht. Jeweils wird ein Bewertungsmaßstab formuliert, um die aktuelle Situation zu beurteilen. Bei negativer Beurteilung werden Reformoptionen diskutiert.Die Ausgestaltung der Pflegeversicherung mit betraglich begrenzten Versicherungsleistungen und nach oben offenen Eigenanteilen hat zu Gesamteigenanteilen geführt, die von der Mehrheit der Heimbewohnenden nicht mehr aus dem laufenden Einkommen finanziert werden können. Um ihre ursprünglichen Ziele erfüllen zu können, müsste die Pflegeversicherung daher vom Kopf auf die Füße gestellt werden – durch eine absolute Begrenzung der Eigenanteile in Höhe und Dauer.Auch das „duale Versicherungssystem“ aus einer sozialen Pflegeversicherung und einer privaten Pflegepflichtversicherung hat sich als „Geburtsfehler“ des Systems erwiesen. Da das Kollektiv der Privatversicherten über eine wesentlich günstigere Risikostruktur und höhere Durchschnittseinkommen verfügt, ist die vom Bundesverfassungsgericht geforderte „gleichmäßige Lastenverteilung“ bei der Finanzierung nicht gegeben. Zur Behebung dieser Ungleichbehandlung ist die Überführung des dualen Systems in eine integrierte Pflegeversicherung oder zumindest ein Risikostrukturausgleich zwischen beiden Zweigen zu fordern.Dass die Pflegeversicherung als eigener Zweig der Sozialversicherung eingeführt wurde, lässt sich dagegen rechtfertigen. Allerdings wäre es zur Überwindung von Schnittstellenproblemen notwendig, die Finanzierungskompetenz für die geriatrische Rehabilitation bei der Pflegeversicherung und die für die medizinische Behandlungspflege in Pflegeheimen bei der Krankenversicherung anzusiedeln.
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- 2023
32. Stück Baden-Württemberg 'mittendrin in Berlin'
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Karl-Heinz Wiedner
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- 2023
33. Feasibility, acceptability, and behavioral outcomes of a multimodal intervention for prostate cancer patients: Experience from the MARTINI lifestyle program
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Imke Thederan, Aliaksandra Pott, Alexander Krueger, Thenappan Chandrasekar, Pierre Tennstedt, Sophie Knipper, Derya Tilki, Hans Heinzer, Karl‐Heinz Schulz, Nataliya Makarova, and Birgit‐Christiane Zyriax
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Oncology ,Urology - Published
- 2023
34. Bruton tyrosine kinase inhibitors for multiple sclerosis
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Julia Krämer, Amit Bar-Or, Timothy J. Turner, and Heinz Wiendl
- Subjects
Cellular and Molecular Neuroscience ,Neurology (clinical) - Published
- 2023
35. Hybridization into a Bitopic Ligand Increased Muscarinic Receptor Activation for Isopilocarpine but Not for Pilocarpine Derivatives
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Christine S. Heinz, Marcel Bermudez, Natasha Jaiswal, Carolin Große, Michael Kauk, Carsten Hoffmann, and Ulrike Holzgrabe
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Pharmacology ,Complementary and alternative medicine ,Organic Chemistry ,Drug Discovery ,Pharmaceutical Science ,Molecular Medicine ,Analytical Chemistry - Published
- 2023
36. Successful Repair of M. obliquus Internus Abdominis Avulsion at the Iliac Crest—Operative Technique in Professional Soccer Players
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Heinz Lohrer and Andreas Höferlin
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Orthopedics and Sports Medicine ,Surgery - Published
- 2023
37. Human appropriation of net primary production as driver of change in landscape‐scale vertebrate richness
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Karina Reiter, Christoph Plutzar, Dietmar Moser, Philipp Semenchuk, Karl‐Heinz Erb, Franz Essl, Andreas Gattringer, Helmut Haberl, Fridolin Krausmann, Bernd Lenzner, Johannes Wessely, Sarah Matej, Robin Pouteau, Stefan Dullinger, University of Vienna [Vienna], Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche] (BOKU), Botanique et Modélisation de l'Architecture des Plantes et des Végétations (UMR AMAP), and Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université de Montpellier (UM)
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Net primary production ,Human appropriation ,Global and Planetary Change ,Ecology ,Biodiversity loss ,Land use ,Species–energy relationship ,Extinction ,[SDE.BE]Environmental Sciences/Biodiversity and Ecology ,Ecology, Evolution, Behavior and Systematics ,Species richness ,Threatened species - Abstract
International audience; Aim: Land use is the most pervasive driver of biodiversity loss. Predicting its impact on species richness (SR) is often based on indicators of habitat loss. However, the degradation of habitats, especially through land-use intensification, also affects species. Here, we evaluate whether an integrative metric of land-use intensity, the human appropriation of net primary production, is correlated with the decline of SR in used landscapes across the globe. Location Global. Time period Present. Major taxa studied Birds, mammals and amphibians. Methods: Based on species range maps (spatial resolution: 20 km × 20 km) and an area-of-habitat approach, we calibrated a “species–energy model” by correlating the SR of three groups of vertebrates with net primary production and biogeographical covariables in “wilderness” areas (i.e., those where available energy is assumed to be still at pristine levels). We used this model to project the difference between pristine SR and the SR corresponding to the energy remaining in used landscapes (i.e., SR loss expected owing to human energy extraction outside wilderness areas). We validated the projected species loss by comparison with the realized and impending loss reconstructed from habitat conversion and documented by national Red Lists. Results Species–energy models largely explained landscape-scale variation of mapped SR in wilderness areas (adjusted R2-values: 0.79–0.93). Model-based projections of SR loss were lower, on average, than reconstructed and documented ones, but the spatial patterns were correlated significantly, with stronger correlation in mammals (Pearson's r = 0.68) than in amphibians (r = 0.60) and birds (r = 0.57). Main conclusions: Our results suggest that the human appropriation of net primary production is a useful indicator of heterotrophic species loss in used landscapes, hence we recommend its inclusion in models based on species–area relationships to improve predictions of land-use-driven biodiversity loss.
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- 2023
38. Galactosyl, alkyl, and acidic groups modify uptake and subcellular deposition of pyropheophorbide-a by epithelial tumor cells and determine photosensitizing efficacy
- Author
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Erin C. Tracy, Penny Joshi, Mykhaylo Dukh, Farukh A. Durrani, Ravindra K. Pandey, and Heinz Baumann
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General Chemistry - Abstract
Photosensitizers currently used for photodynamic therapy of cancer show enhanced accumulation in tumor tissue but lack cancer cell specificity. To augment cellular uptake, the targeting of pyropheophorbide-a to carbohydrate-binding components of cancer cells was explored. Galactose was attached to pyropheophorbide-a at positions 172 and 20. Since the modification at position 172 removed a carboxylic group, which is relevant for cell specificity, this study evaluated the relative contribution of galactosyl and carboxyl groups at either position 172 or 20, with or without a (hexyloxy)ethyl at position 3, to cellular uptake by human epithelial cancer cells. The subcellular deposition was monitored using fluorescence microscopy and the photoreaction was quantified using biomarkers. The results demonstrated that any galactose addition suppresses transmembrane diffusion and promotes endocytosis and lysosomal accumulation. An anionic group at position 172 or 20 enhances lysosomal retention. Neutralization of the carboxylic group at position 172 facilitates transfer to mitochondria/endoplasmatic reticulum and promotes tumor cell-specific retention. Replacing (hexyloxy)ethyl with an ethyl group at position 3 increased both cellular uptake and egress but did not alter subcellular localization. These findings suggest that specific neutral galactosylated pheophorbides may provide an enhanced therapeutic effect for those tumor types that do not retain unmodified pyropheophorbide. However, the galactose conjugates also serve as substrates for preferential uptake by liver cells resulting in hepatic sequestration, reduced systemic distribution, and lower accumulation in tumor tissue.
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- 2023
39. The clinical and biochemical significance of 11-oxygenated androgens in human health and disease
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Karl-Heinz Storbeck and Michael W O’Reilly
- Subjects
Endocrinology ,Endocrinology, Diabetes and Metabolism ,General Medicine - Abstract
For many decades, the prevailing paradigm in endocrinology was that testosterone and 5α-dihydrotestosterone are the only potent androgens in the context of human physiology. The more recent identification of adrenal derived 11-oxygenated androgens and particularly 11-ketotestosterone have challenged these established norms, prompting a revaluation of the androgen pool, particularly in women. Since being recognized as bone fide androgens in humans, numerous studies have focused their attention on understanding the role of 11-oxygenated androgens in human health and disease and have implicated them as role players in conditions such as castration resistant prostate cancer, congenital adrenal hyperplasia, polycystic ovary syndrome, Cushing's syndrome, and premature adrenarche. This review therefore provides an overview of our current knowledge on the biosynthesis and activity of 11-oxygenated androgens with a focus on their role in disease states. We also highlight important analytical considerations for measuring this unique class of steroid hormone.
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- 2023
40. Ärztliche Versorgung mit oder ohne Kooperationsvertrag? Eine Querschnittsuntersuchung in stationären Pflegeeinrichtungen in Bremen und Niedersachsen
- Author
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Anna-Carina Friedrich, Jonas Czwikla, Maike Schulz, Karin Wolf-Ostermann, and Heinz Rothgang
- Subjects
Health Policy ,Medicine (miscellaneous) ,Education - Published
- 2023
41. Combined Fault and DPA Protection for Lattice-Based Cryptography
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Daniel Heinz and Thomas Pöppelmann
- Subjects
Computational Theory and Mathematics ,Hardware and Architecture ,Software ,Theoretical Computer Science - Published
- 2023
42. Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling
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Felix T. Kurz, Miguel A. Aon, Heinz-Peter Schlemmer, Johann M.E. Jende, Brian O’Rourke, and Antonis A. Armoundas
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Biophysics - Published
- 2023
43. Ein Chatbot erklärt sich selbst
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Marcel Schorrlepp, Karl-Heinz Patzer, and Christopher Netsch
- Subjects
Complementary and alternative medicine ,Pharmaceutical Science ,Pharmacology (medical) - Published
- 2023
44. Investigating the neural correlates of affective mentalizing and their association with general intelligence in patients with schizophrenia
- Author
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Wladimir Tantchik, Melissa J. Green, Yann Quidé, Susanne Erk, Sebastian Mohnke, Carolin Wackerhagen, Nina Romanczuk-Seiferth, Heike Tost, Kristina Schwarz, Carolin Moessnang, Danilo Bzdok, Andreas Meyer-Lindenberg, Andreas Heinz, and Henrik Walter
- Subjects
Psychiatry and Mental health ,Biological Psychiatry - Published
- 2023
45. Johannes Burkhardt (1943–2022). Ein Nachruf
- Author
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Heinz Duchhardt
- Subjects
History - Published
- 2023
46. Natural History of Varicose Veins of the Legs
- Author
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Caroline Kern, Eberhard Rabe, Katrin Schuldt, Bernd Kowall, Andreas Stang, Eva Bock, Christopher Lattimer, Karl-Heinz Jöckel, and Felizitas Pannier
- Subjects
Cardiology and Cardiovascular Medicine - Abstract
Objective To assess the natural history of saphenous and non-saphenous varicose veins using the results of the Bonn Vein Studies and data published in literature. Methods We used the data of the Bonn Vein Studies (BVS) 1 and 2 to assess if preexisting non-saphenous varicose veins (NSVV) in persons who had no saphenous varicose veins (SVV) at baseline have an impact on the incidence of SVV during the follow-up of 6.6 years and vice versa. SVV where defined as tortuous or not-tortuous refluxing saphenous veins. The statistical evaluation was performed using SAS version 9.4 (SAS Institute, Cary, North Carolina). In addition, we performed a review of publications concerning the natural history of varicose veins (VV) using PubMed. Results In the BVS the overall incidence of SVV within the follow-up time of 6.6 years was 8.0 % (n = 133 of 1661; 95 % CI: 6.8–9.4). 7.2 % (n = 107 of 1492) without VV in BVS 1 and 19.8 % (n = 26) of patients with preexisting NSVV developed SVV. The relative risk for the development of SVV in patients with preexisting NSVV was 2.44 (95% CI: 1.64–3.64) adjusted for age and sex. The overall incidence of NSVV was markedly higher with 13.3 % (n = 226 of 1661; 95 % CI: 11.8–15.1). During follow-up 148 patients (9.9 %) without VV in BVS 1 developed NSVV. 48.5 % (n = 78) of patients with preexisting SVV developed NSVV during follow-up. The relative risk for the development of NSVV in patients with preexisting SVV was 4.10 (95% CI: 3.26–5.16), adjusted for age and sex.In published studies the development of VV is preceded by venous reflux. Initial VV may develop at any segment and the results from literature suggest that the location of VV and reflux at the time of the investigation depends on age. In younger individuals more distal location are reported with an ascending progression in the majority but also descending progression is possible. Conclusions Based on the results of the Bonn Vein Studies 1 and 2 we could demonstrate, that preexisting SVV increase the risk of developing NSVV and preexisting NSVV increase the risk of developing SVV in a similar way. Venous reflux may initially occur in any segment of the venous system and may progress in antegrade and/or retrograde fashion. In younger adults initial VV seem to be localized more often in distal parts of the legs with an antegrade progression over time.
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- 2023
47. Ist Stress am Arbeitsplatz ein Thema für den kardiologischen Alltag? Evidenz, Erkennung und Therapie aversiver Stressbedingungen im Arbeitsumfeld
- Author
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Karl-Heinz Ladwig and Karoline Lukaschek
- Subjects
General Medicine - Abstract
ZusammenfassungIn modernen Industriegesellschaften verbringen die Menschen die aktivste Zeit ihres Lebens in beruflicher Umgebung, die damit weitgehend Alltag und Lebensqualität bestimmt. Immer mehr verschwimmen die Grenzen zwischen Privatem und Beruflichem. Neben „klassischem“ Arbeitsstress – häufig definiert als Missverhältnis von hohen Anforderungen bei gleichzeitig geringen Entscheidungsmöglichkeiten oder als Missverhältnis zwischen Arbeitseinsatz und Belohnung – gehören u. a. Überarbeitung, Mobbing und Arbeitsplatzverlust sowie negative Arbeitsplatzbedingungen zu den Belastungen, die seelische und körperliche gesundheitliche Probleme auslösen können. Evidenz aus Megastudien mit > 100000 Teilnehmern belegt die Bedeutung von Arbeitsstress als Risikofaktor (RF) für Hypertonie, Schlafstörungen und Depressionen. Unter Arbeitsstress werden häufig gesundheitsgefährdende Verhaltensweisen als Kompensationsversuche eingesetzt. Andauernder Arbeitsstress wird damit zu einem signifikanten RF für ischämische Herzerkrankungen, zerebrovaskuläre Ereignisse und Diabetes mellitus. Arbeitsstress sollte daher in der kardiologischen Praxis exploriert werden. Grundzüge einer auf Arbeitsstress fokussierten Gesprächsführung für den Alltagseinsatz werden vorgestellt.
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- 2023
48. Kardiologische Rehabilitation als effektive Sekundärprävention
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Bernhard Schwaab, Rona K. Reibis, and Heinz Völler
- Subjects
General Medicine - Abstract
ZusammenfassungZiele der kardiologischen Rehabilitation (kurz: KardReha) sind die Wiederherstellung der individuell bestmöglichen physischen und psychischen Gesundheit kardiovaskulär erkrankter Patienten durch die Therapie in einem multidisziplinären Team, diese nachhaltig zu stabilisieren und die berufliche und soziale Re-Integration zu ermöglichen. Auf der Basis einer S3-Leitlinie zur KardReha im deutschsprachigen Raum Europas führt die Teilnahme an einer KardReha bei Patienten nach akutem Koronarsyndrom und nach Bypass-Operation zu einer signifikanten Reduktion der Gesamtmortalität. Bei Patienten mit systolischer Herzinsuffizienz werden die körperliche Belastbarkeit und die Lebensqualität signifikant verbessert. Nach operativer oder interventioneller Herzklappenkorrektur werden die körperliche Belastbarkeit sowie die Lebensqualität gesteigert, und in ersten Studien zeigen sich Signale für eine Mortalitätsreduktion. Daher sollte die KardReha ein integraler Bestandteil einer am langfristigen Erfolg orientierten Behandlung sein.
- Published
- 2023
49. Video analysis of Achilles tendon ruptures in professional male football (soccer) reveals underlying injury patterns and provides strategies for injury prevention
- Author
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Tim Hoenig, Thomas Gronwald, Karsten Hollander, Christian Klein, Karl-Heinz Frosch, Peter Ueblacker, and Tim Rolvien
- Subjects
Orthopedics and Sports Medicine ,Surgery - Abstract
Purpose In professional football (soccer), Achilles tendon ruptures are severe injuries. Video analysis promotes a better understanding of the underlying situational and biomechanical patterns, and provides a roadmap for future research to improve the management and prevention of Achilles tendon ruptures. The purpose of this study was to identify injury patterns contributing to acute Achilles tendon ruptures in professional male football players. Methods Professional male football players with an acute Achilles tendon rupture were identified using an online database. For every in-competition injury, the corresponding football match was detected. Video footage of the injury was accessed using Wyscout.com or publicly available video databases. Situational patterns and injury biomechanics of the injury frame were independently analysed by two reviewers using a standardised checklist and a motion analysis software. Finally, consensus was reached to describe the main injury patterns of Achilles tendon ruptures in professional male football players. Results The search identified video footage of 80 Achilles tendon ruptures in 78 players. Most injuries (94%) occurred through indirect or non-contact mechanisms. The kinematic analysis revealed characteristic joint positions at the time of injury consisting of hip extension, knee extension, ankle dorsiflexion, foot abduction, and foot pronation in most cases. The underlying direction of movement was from flexion to extension (knee) and from plantarflexion to dorsiflexion (ankle). Player actions identified as main injury patterns were stepping back (26%), landing (20%), running/sprinting (18%), jumping (13%), and starting (10%). Conclusion Most Achilles tendon ruptures in professional male football players are closed-chain indirect or non-contact injuries. Sudden loading to the plantarflexor musculotendinous unit remains to be the main component for most cases. By achieving a better understanding of underlying injury mechanisms, this study provides new strategies for the prevention of Achilles tendon ruptures. Level of evidence Level IV.
- Published
- 2023
50. Racialised identity, racism and the mental health of children and adolescents
- Author
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Felicia Boma Lazaridou, Andreas Heinz, Daniel Schulze, and Dinesh Bhugra
- Subjects
Psychiatry and Mental health - Published
- 2023
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