1. Potentiation of magnesium-induced neuromuscular weakness by gentamicin
- Author
-
Rasch Dk, Huber Pa, and L'Hommedieu Cs
- Subjects
Critical Care ,business.industry ,Respiratory arrest ,Muscular weakness ,Neuromuscular transmission ,Infant, Newborn ,Long-term potentiation ,Drug Synergism ,Neuromuscular weakness ,Neuromuscular Diseases ,Critical Care and Intensive Care Medicine ,Term neonates ,medicine.disease ,Anesthesia ,medicine ,Humans ,Gentamicin ,Female ,Magnesium ,medicine.symptom ,Hypermagnesemia ,Gentamicins ,business ,medicine.drug - Abstract
A term neonate with hypermagnesemia secondary to maternal administration of MgSO4 for pre-eclampsia had a respiratory arrest after receiving gentamicin im. The neuromuscular tracings and sequential physician exams done before and after administering gentamicin suggest aminoglycosides may potentiate a magnesium-induced impairment of neuromuscular transmission and cause muscular weakness in neonates.
- Published
- 1983