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The dataset contains variables used in the study of "Response-shift effects in childhood cancer survivors: A prospective study" reported in Huang et al., Psycho-Oncology 2023 (In Press). Please cite the appropriate publications in any communications or publications arising directly or indirectly from these data.&nbsp

Additional file 1. Supplementary Information.

Additional file 1: Table S1. Components and standards for scoring for Dietary Approaches to Stop Hypertension, Healthy Eating Index-2015, and Alternate Mediterranean diet. Figure S1. Radar plot showing the mean percentage of each component score received in men and women. Table S2. Characteristics of childhood cancer survivors by cardiovascular diseasestatus in the St. Jude Lifetime Cohort Study. Table S3. Characteristics of childhood cancer survivors by quintiles of DASH in the St. Jude Lifetime Cohort Study. Table S4. Characteristics of childhood cancer survivors by tertiles of Mediterranean Diet in the St. Jude Lifetime Cohort Study. Figure S2. Non-parametric regression curves1 for associations between DASH and risk of CVD in St. Jude Lifetime Cohort Study. Figure S3. Non-parametric regression curves1 for associations between Mediterranean diet and risk of CVD in St. JudeLifetime Cohort Study.

BackgroundGonadotoxic treatment-related infertility has a significant impact on quality of life in childhood cancer survivors. Genome-wide association analyses to delineate the risk of infertility in childhood cancer survivors have not been previously reported.MethodsLeveraging genotype data from a large survivor cohort, the Childhood Cancer Survivor Study (CCSS), we investigated the role of SNPs on future pregnancy or siring a pregnancy in survivors without pelvic, testicular, or brain radiation who had ever been married. We calculated sex-stratified hazard ratios, using Cox proportional hazards modeling, adjusting for birth cohort (before 1965 vs. 1965 or later) and doses of relevant chemotherapies; replication was attempted in the independent St. Jude Lifetime Cohort study (SJLIFE).ResultsIn the CCSS cohort, nine SNPs were found to be suggestive (P < 10-7) or statistically significantly (P < 5 × 10-8) associated with pregnancy, however, none of the SNPs were replicated in SJLIFE. Cohorts differed based on the overall pregnancy rate, frequency of sterilizing procedures, and birth cohort.ConclusionsWe were not able to replicate our findings of SNPs associated with pregnancy in childhood cancer survivors.ImpactFuture attempts at replication should be considered in cohorts treated in a comparable era. In addition, understanding the role of genetics in fertility in childhood cancer survivors may be better approached using more advanced sequencing techniques.

Educational achievement and employment outcomes are critical indicators of quality of life in survivors of childhood, adolescent, and young adult (CAYA) cancer. This review is aimed at providing an evidence-based clinical practice guideline (CPG) with internationally harmonized recommendations for the surveillance of education and employment outcomes in survivors of CAYA cancer diagnosed before the age of 30 years. The CPG was developed by a multidisciplinary panel under the umbrella of the International Late Effects of Childhood Cancer Guideline Harmonization Group. After evaluating concordances and discordances of 4 existing CPGs, the authors performed a systematic literature search through February 2021. They screened articles for eligibility, assessed quality, and extracted and summarized the data from included articles. The authors formulated recommendations based on the evidence and clinical judgment. There were 3930 articles identified, and 83 of them, originating from 17 countries, were included. On a group level, survivors were more likely to have lower educational achievement and more likely to be unemployed than comparisons. Key risk factors for poor outcomes included receiving a primary diagnosis of a central nervous system tumor and experiencing late effects. The authors recommend that health care providers be aware of the risk of educational and employment problems, implement regular surveillance, and refer survivors to specialists if problems are identified. In conclusion, this review presents a harmonized CPG that aims to facilitate evidence-based care, positively influence education and employment outcomes, and ultimately minimize the burden of disease and treatment-related late adverse effects for survivors of CAYA cancers. Lay Summary A multidisciplinary panel has developed guidelines for the surveillance of education and employment outcomes among survivors of childhood, adolescent, and young adult cancer. On the basis of evidence showing that survivors are at risk for lower educational achievement and unemployment, it is recommended that all survivors receive regular screening for educational and employment outcomes., + ID der Publikation: unilu_58956 + Sprache: Englisch + Letzte Aktualisierung: 2022-05-04 16:54:38

Additional file 1: Fig. S1. The scatter plots between chronological age and epigenetic age based on four epigenetic clocks. Fig. S2. QQ plots of EAA GWAS based on four epigenetic clocks. Fig. S3. Distribution of intrinsic epigenetic age acceleration (IEAA) across five quintiles of polygenic risk score (PRS) for IEAA. Fig. S4. Molecular mechanism for associations between rs732314, chest/abdominal/pelvic-RT and EAA-Horvath. Table S1. SNPs (except the top one) significantly associated with EAA-Horvath and EAA-Hannum among survivors (SJLIFE1, SJLIFE2) and controls. Table S2. Single nucleotide polymorphisms (SNPs) with significant associations with IEAA-Horvath and EEAA-Hannum among survivors (SJLIFE1, SJLIFE2) and controls. Table S3. Differentially methylated regions (DMR) between the SJLIFE1 data set of survivors and controls overlapping with rs28366133 (+/- 500 kb) in HLA region. Table S4. Multivariable linear regression models for the two top SNPs. Table S5. Estimated SNP heritability of EAA based on each of four clock methods using single-trait LD Score Regression of the GWAS of the SJLIFE1 data set. Table S6. Estimated genetic correlation between EAA-Horvath and other traits using LD Score Regression of the GWAS of the SJLIFE1 data set (P

Patients with childhood, adolescent, and young adult cancer who will be treated with gonadotoxic therapies are at increased risk for infertility. Many patients and their families desire biological children but effective communication about treatment-related infertility risk and procedures for fertility preservation does not always happen. The PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group reviewed the literature and developed a clinical practice guideline that provides recommendations for ongoing communication methods for fertility preservation for patients who were diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger and their families. Moreover, the guideline panel formulated considerations of the ethical implications that are associated with these procedures. Grading of Recommendations Assessment, Development and Evaluation methodology was used to grade the evidence and recommendations. In this clinical practice guideline, existing evidence and international expertise are combined to develop transparent recommendations that are easy to use to facilitate ongoing communication between health-care providers and patients with childhood, adolescent, and young adult cancer who might be at high risk for fertility impairment and their families.

Additional file 1 Supplementary material. The supplementary material includes (i) the histograms of the predicted AOF risk obtained from the prescribed-dose model and ovarian-dose model for individuals with and without AOF, respectively, (ii) the procedure of obtaining the true values of the IncV metrics under the distributional assumptions of the numerical study, (iii) the results of the numerical study scenarios in which neither of the working risk models is the true model, including plots of the values of each IncV metric for all the scenarios under different event rates, and the scatter plots of each pair of the IncV metrics, and (iv) the results for the scenarios where the two-marker model is the true model, including plots of the values of each IncV metric for all the scenarios under different event rates, plots of their summary statistics, and a table listing the Pearson correlation of each pair of the IncV metrics. (PDF file)

Additional file 1: Supplementary Methods. Bisulfite treatment, array hybridization, and scanning for DNA Methylation Profiling. Fig. S1. A flow diagram of the study population. Fig. S2. Q-Q plot showing the distribution of the observed versus expected association p-values. Fig. S3. Manhattan plot showing the treatment-specific association of DNA methylation. Fig. S4. The distributions of whole-array and significant treatment-associated CpG sites. Fig. S5. The distribution of beta-values for CpG mediators by groups of CHCs. Table S1. Pairwise correlations among eleven different treatments. Table S2. CpG hits associated with the specific treatment exposure (P

Purpose Cancer-related fatigue (CRF) negatively affects the lives of childhood, adolescent, and young adult (CAYA) cancer survivors. We aimed to provide an evidence-based clinical practice guideline (CPG) with internationally harmonized CRF surveillance recommendations for CAYA cancer survivors diagnosed

Post-treatment attention problems experienced by pediatric cancer survivors have been described as similar to symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) experienced in physically healthy children. Accordingly, the objectives of this study were to: (a) estimate the rate of occurrence of ADHD and secondary ADHD (SADHD) in a sample of pediatric cancer survivors, (b) compare the rate of ADHD/SADHD among survivors to the prevalence of ADHD in the general population, and (c) examine clinical correlates of ADHD/SADHD in this sample.Survivors of pediatric ALL or brain tumor (n = 100) participated in an assessment of attention including a Computerized Performance Measure [Conners' Continuous Performance test-II (CPT-II)], parent and self-report measures (Conners 3), and a structured diagnostic interview for ADHD and other psychological disorders [Diagnostic Interview for Children and Adolescents-IV (DICA-IV)].Binomial tests revealed that the rate of ADHD/SADHD in our sample (9%) was significantly greater than the lower limits of ADHD prevalence among children in the US (3%; P0.001), while no difference was identified compared to the upper limits of ADHD prevalence (7%; P0.05). Many additional survivors (25% of the sample) obtained clinical elevations on Conners 3 scales but did not meet ADHD/SADHD criteria.Attentional deficits experienced by pediatric cancer survivors do not appear to resemble the clinical presentation of ADHD or SADHD. Many survivors with cognitive and behavioral difficulties related to attention were not identified using this diagnostic approach. Findings offer needed clarification to guide researchers and clinicians in conceptualizing, assessing, and intervening on attentional late effects.

10055 Background: Childhood cancer survivors are a growing population who appear to be at higher risk for premature aging and age-related chronic health conditions than their peers with no history of cancer. Diet affects many hallmarks of aging, such as inflammation, metabolic dysfunctions, and molecular and epigenetic changes, leading to impairment in physical and cognitive functions and premature death. High consumption of animal foods that are high in protein and fat increase risk for many age-related chronic diseases. However, some studies found protein intake was beneficial for physical frailty in elderly and cancer survivors. Methods: Adult survivors (> = 18 years old) of childhood cancer survivors enrolled in the SJLIFE Cohort between 2007 and 2017 completed a 110-item food frequency questionnaire at study entry (n = 3,322). Survivors’ sociodemographic, cancer, cancer treatments, and medical history data were abstracted from medical records. Health conditions self-reported after cancer diagnosis were clinically validated. Premature aging was assessed using the Deficit Accumulation Index (DAI) based on 45 aging-related health conditions. DAI is categorized into low (< 0.2), medium (0.2-0.34) and high (> 0.35) aging risk groups. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multinomial logistic regressions adjusting for potential confounders. Results: The average age of survivors at baseline was 31 years. Approximately half of the survivors were women, and 82% were white, non-Hispanic. 20% and 8% of survivors were at medium and high risk for aging, respectively. Survivors at high risk for aging tended to be female, smokers, have low socioeconomic status, and received radiation therapy to head and neck, chest, spine or abdomen compared to those at low aging risk. Higher protein intake was associated with a less risk of premature aging (OR = 0.74, 95% CI: 0.58-0.95 for high aging risk group; OR = 0.91, 95% CI: 0.78-1.07 for medium aging risk group, per increment of 5% of total energy intake). On the other hand, higher fat intake was related to an increased risk of premature aging (OR = 1.14, 95% CI: 1.01-1.29 for high aging risk group; OR = 0.99, 95% CI: 0.91-1.08 for medium aging risk group, per increment of 5% of total energy intake). However, substituting monounsaturated fat for other types of fat was associated with a lower risk of premature aging (OR = 0.81 95% CI: 0.70-0.95 for high aging risk group). Red meat (OR = 1.11, 95% CI: 0.87-1.42 for high aging risk group) and dairy intake (OR = 0.99, 95% CI: 0.72-1.38 for high aging risk group) was not related to risk of premature aging. Conclusions: Consuming protein and fat from healthy foods may lower the risk of premature aging in childhood cancer survivors.