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The value of the TAG-72 (CA 72-4) serum marker in primary diagnosis was investigated in 110 patients with histologically diagnosed ovarian cancer. A reference group consisted of 103 patients with benign pelvic masses. Compared to the well-established CA-125, TAG-72 showed a low sensitivity of 42% in the detection of ovarian cancer. By contrast, when the cut-off level for TAG-72 was set at 6 U/ml, it showed a very high specificity of 99%. When the measurement of TAG-72 was combined to that of CA-125, improvements in both the specificity (as compared to a single CA-125 determination) and the sensitivity (as compared to a single TAG-72 assay) were observed. In such a combined assay, our results suggest that the best predictive value (positive and negative) was obtained if CA-125 is assigned a relatively high cut-off value (65 U/ml) in conjunction with a low cut-off level (3.2 U/ml or 4 U/ml) for TAG-72. In the present study, at threshold values of 65 U/ml respectively, a sensitivity of 86%, a specificity of 83% and a positive and negative predictive value of 85% were obtained. In mucinous carcinomas of the ovary, however, the additional TAG-72 determination did not lead to a better predictive power than did CA-125 measurement alone.

Im Rahmen einer prospektiven Studie wurde bei 91 Neugeborenen unmittelbar postpartal Nabelschnurblut in 10 ml EDTA-Rohrchen abgebommen und fol-gende Lipide untersucht: Cholesterin (enzymatisch mittels Cholesterin PAP MA-Kit 100 ROCHE auf COBAS-MIRA, Roche, Basel, Schweiz) Triglyzeride (enzymatisch mittels Triglyzeride PAP UNI-Kit III ROCHE auf COBAS-MIRA, Roche, Basel, Schweiz) HDL-, HDL2- und HDL3-Cholesterin (Fallung mit Dextransulfat, aus dem Uberstand Cholesterinbestimmung) (Patsch W, 1989) HDL-, HDL2- und HDL3-Triglyzeride (Fallung mit Dextransulfat, aus dem Uberstand Triglyzeridbestimmung) LDL-Cholesterin (Berechnung nach Friedewald-Formel) Apo-Lipoprotein A1 (Nephelometrie mit Bechman Array Protein System, Bechman, Berkeley, CA, USA). Die Kinder wurden eingeteilt in Gruppe 1: 26 Makrosome >4000 g (>90er Perzentile nach Hohenauer) Gruppe 2: 48 Normalgewichtige (10–90er Perzentile) Gruppe 3: 17 Dystrophe (

This study investigates the degree of effectiveness of post partum rubella vaccination, measured as percentage of true seroconversions. The vaccine used was RA 27/3. In the years 1983/84 the seronegative rate was 7% of the total number of births. The 270 seronegative women who had given birth during these two years had all been vaccinated post partum. 128 of them were controlled, and a seroconversion rate of 91.4% was obtained.

A hospital outbreak of Acinetobacter Calcoaceticus in a ward with patients with intravenous tokolysis is reported. Within 2 months 9 pregnant women who had tokolysis for premature labour developed septic fever that only subsisted after the administration of tokolysis was stopped. In 7 cases blood culture was positive for Acinetobacter Calcoaceticus. This endemic outbreak was responsible for premature deliveries in four cases, leading top post partum death of two infants. Source identification was inconclusive, no further outbreaks have occurred since the reported endemic occurrence. Dangers of nosocomial infections in patients with intravenous tokolysis are discussed.