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5 results on '"Hwang, Yang-Ha"'

1. Factors Contributing to an Efficacious Endovascular Treatment for Acute Ischemic Stroke in Asian Population

Author

Lee, Jin Soo, Hwang, Yang-Ha, and Sohn, Sung-Il

Subjects
Medicine (General), medicine.medical_specialty, endovascular procedures, Neurosciences. Biological psychiatry. Neuropsychiatry, Review, intracranial atherosclerosis, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, R5-920, 0302 clinical medicine, Randomized controlled trial, law, Diabetes mellitus, medicine, Endovascular treatment, Intensive care medicine, Cerebral infarction, business.industry, Acute kidney injury, cerebral infarction, reperfusion injury, medicine.disease, acute kidney injury, diabetes mellitus, Asian population, Etiology, Intracranial Atherosclerosis, business, 030217 neurology & neurosurgery, RC321-571
Abstract

Although randomized control trials about endovascular treatment (EVT) of emergent large vessel occlusion (LVO) have demonstrated the success of mechanical thrombectomy as the choice of treatment, a wide range of caveats remain unaddressed. Asian patients were rarely included in the trials, thereby raising the question of whether the treatment could be generalized. In addition, there remains a concern on the feasibility of the method with respect to its application against intracranial atherosclerosis (ICAS)-related LVO, frequently observed in the Asian population. It is important to include evidence on ICAS LVO from Asian countries in the future for a comprehensive understanding of LVO etiology. Besides the issues with EVT, prognostic concerns in diabetes patients, acute kidney injury following EVT, neuroprotective management against reperfusion injury, and other peri-EVT issues should be considered in clinical practice. In the current article, we present an in-depth review of the literature that revises information pertaining to such concerns.

Published
2021
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2. A Case of Delayed Oculo-Palato-Brachial Tremor after Pontine Infarction

Author

Ryu, Ho-Sung, Cho, Minsub, Shin, Daeun, and Hwang, Yang-Ha

Subjects
medicine.medical_specialty, Pediatrics, Neurology, business.industry, MEDLINE, Neurosciences. Biological psychiatry. Neuropsychiatry, Pontine infarction, Text mining, Medicine, Neurology. Diseases of the nervous system, Neurology (clinical), RC346-429, business, Letter to the Editor, RC321-571
Published
2021
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3. Global impact of COVID-19 on stroke care

Author

Nogueira, Raul G., Abdalkader, Mohamad, Qureshi, Muhammed M., Frankel, Michael R., Mansour, Ossama Yassin, Yamagami, Hiroshi, Qiu, Zhongming, Farhoudi, Mehdi, Siegler, James E, Yaghi, Shadi, Raz, Eytan, Sakai, Nobuyuki, Ohara, Nobuyuki, Piotin, Michel, Mechtouff, Laura, Eker, Omer, Chalumeau, Vanessa, Kleinig, Timothy J., Pop, Raoul, Liu, Jianmin, Winters, Hugh S., Shang, Xianjin, Rodriguez Vasquez, Alejandro, Blasco, Jordi, Arenillas, Juan F, Martinez-Galdamez, Mario, Brehm, Alex, Psychogios, Marios-Nikos, Lylyk, Pedro, Haussen, Diogo C., Al-Bayati, Alhamza R., Mohammaden, Mahmoud H., Fonseca, Luísa, Luís Silva, M., Montalverne, Francisco, Renieri, Leonardo, Mangiafico, Salvatore, Fischer, Urs, Gralla, Jan, Frei, Donald, Chugh, Chandril, Mehta, Brijesh P., Nagel, Simon, Mohlenbruch, Markus, Ortega-Gutierrez, Santiago, Farooqui, Mudassir, Hassan, Ameer E, Taylor, Allan, Lapergue, Bertrand, Consoli, Arturo, Campbell, Bruce C.V., Sharma, Malveeka, Walker, Melanie, Van Horn, Noel, Fiehler, Jens, Nguyen, Huy Thang, Nguyen, Quoc T., Watanabe, Daisuke, Zhang, Hao, Le, Huynh V., Nguyen, Viet Q., Shah, Ruchir, Devlin, Thomas, Khandelwal, Priyank, Linfante, Italo, Izzath, Wazim, Lavados, Pablo M., Olavarría, Veronica V., Sampaio Silva, Gisele, de Carvalho Sousa, Anna Verena, Kirmani, Jawad, Bendszus, Martin, Amano, Tatsuo, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Morris, Jane G., Griffin, Emma, Thornton, John, Lavoie, Pascale, Matouk, Charles, Hill, M. D, Demchuk, Andrew M., Killer-Oberpfalzer, Monika, Nahab, Fadi, Altschul, Dorothea, Ramos-Pachón, Anna, Pérez de la Ossa, Natalia, Kikano, Raghid, Boisseau, William, Walker, Gregory, Cordina, Steve M., Puri, Ajit, Luisa Kuhn, Anna, Gandhi, Dheeraj, Ramakrishnan, Pankajavalli, Novakovic-White, Roberta, Chebl, Alex, Kargiotis, Odysseas, Czap, Alexandra L, Zha, Alicia M, Masoud, Hesham E., Lopez, Carlos, Ozretic, David, Al-Mufti, Fawaz, Zie, Wenjie, Duan, Zhenhui, Yuan, Zhengzhou, Huang, Wenguo, Hao, Yonggang, Luo, Jun, Kalousek, Vladimir, Bourcier, Romain, Guile, Romain, Hetts, Steven, Al-Jehani, Hosam M., AlHazzani, Adel, Sadeghi-Hokmabadi, Elyar, Teleb, Mohamed, Payne, Jeremy, Lee, Jin Soo, Hong, Ji Man, Sohn, Sung-Il, Hwang, Yang-Ha, Shin, Dong Hoon, Roh, Hong Gee, Edgell, Randy, Khatri, Rakesh, Smith, Ainsley, Malik, Amer, Liebeskind, David, Herial, Nabeel, Jabbour, Pascal, Magalhaes, Pedro, Ozdemir, Atilla Ozcan, Aykac, Ozlem, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Beer-Furlan, Andre, Joshi, Krishna, Catanese, Luciana, Abud, Daniel Giansante, Neto, Octavio Giansante, Mehrpour, Masoud, Al Hashmi, Amal, Saqqur, Mahar, Mostafa, Abdulrahman, Fifi, Johanna T., Hussain, Syed, John, Seby, Gupta, Rishi, Sivan-Hoffmann, Rotem, Reznik, Anna, Sani, Achmad Fidaus, Geyik, Serdar, Akıl, Eşref, Churojana, Anchalee, Ghoreishi, Abdoreza, Saadatnia, Mohammad, Sharifipour, Ehsan, Ma, Alice, Faulder, Ken, Wu, Teddy, Leung, Lester, Malek, Adel, Voetsch, Barbara, Wakhloo, Ajay, Rivera, Rodrigo, Barrientos Iman, Danny Moises, Pikula, Aleksandra, Lioutas, Vasileios-Arsenios, Thomalla, Gotz, Birnbaum, Lee, Machi, Paolo, Bernava, Gianmarco, McDermott, Mollie, Kleindorfer, Dawn, Wong, Ken, Patterson, Mary S., Fiorot, Jose Antonio, Huded, Vikram, Mack, William, Tenser, Matthew, Eskey, Clifford, Multani, Sumeet, Kelly, Michael, Janardhan, Vallabh, Cornett, Oriana, Singh, Varsha, Murayama, Yuichi, Mokin, Maxim, Yang, Pengfei, Zhang, Xiaoxi, Yin, Congguo, Han, Hongxing, Peng, Ya, Chen, Wenhuo, Crosa, Roberto, Frudit, Michel E., Pandian, Jeyaraj D., Kulkarni, Anirudh, Yagita, Yoshiki, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonoda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Cora, Elena, Volders, David, Ducroux, Celina, Shoamanesh, Ashkan, Ospel, Johanna, Kaliaev, Artem, Ahmed, Saima, Rashid, Umair, Rebello, Leticia C., Pereira, Vitor Mendes, Fahed, Robert, Chen, Michael, Sheth, Sunil A., Palaiodimou, Lina, Tsivgoulis, Georgios, Chandra, Ronil, Koyfman, Feliks, Leung, Thomas, Khosravani, Houman, Dharmadhikari, Sushrut, Frisullo, Giovanni, Calabresi, Paolo, Tsiskaridze, Alexander, Lobjanidze, Nino, Grigoryan, Mikayel, Czlonkowska, Anna, de Sousa, Diana A., Demeestere, Jelle, Liang, Conrad, Sangha, Navdeep, Lutsep, Helmi L., Ayo-Martín, Óscar, Cruz-Culebras, Antonio, Tran, Anh D., Young, Chang Y., Cordonnier, Charlotte, Caparros, Francois, De Lecinana, Maria Alonso, Fuentes, Blanca, Yavagal, Dileep, Jovin, Tudor, Spelle, Laurent, Moret, Jacques, Khatri, Pooja, Zaidat, Osama, Raymond, Jean, Martins, Sheila, Nguyen, Thanh N, Universitat Autònoma de Barcelona, and UAM. Departamento de Medicina

Subjects
Gerontology, 2019-20 coronavirus outbreak, medicine.medical_specialty, acute ischemic stroke, Hospitals, Low-Volume, Time Factors, Coronavirus disease 2019 (COVID-19), Medicina, Clinical Neurology, Stroke care, stroke care, Global Health, mechanical thrombectomy, Pandemic, Epidemiology, Health care, Global health, Medicine, Humans, Registries, Stroke, Retrospective Studies, Thrombectomy, Science & Technology, business.industry, Research, COVID-19, medicine.disease, Hospitalization, Cross-Sectional Studies, Peripheral Vascular Disease, Neurology, Cardiovascular System & Cardiology, epidemiology, Neurosciences & Neurology, business, Life Sciences & Biomedicine, Intracranial Hemorrhages, Hospitals, High-Volume, intracranial hemorrhage
Abstract

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM, Background: The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide. Aims: We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at the height of the pandemic (1 March–31 May 2020) compared with two control three-month periods (immediately preceding and one year prior). Methods: Retrospective, observational, international study, across 6 continents, 40 countries, and 187 comprehensive stroke centers. The diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases at participating centers. Results: The hospitalization volumes for any stroke, intracranial hemorrhage, and mechanical thrombectomy were 26,699, 4002, and 5191 in the three months immediately before versus 21,576, 3540, and 4533 during the first three pandemic months, representing declines of 19.2% (95%CI, −19.7 to −18.7), 11.5% (95%CI, −12.6 to −10.6), and 12.7% (95%CI, −13.6 to −11.8), respectively. The decreases were noted across centers with high, mid, and low COVID-19 hospitalization burden, and also across high, mid, and low volume stroke/mechanical thrombectomy centers. High-volume COVID-19 centers (−20.5%) had greater declines in mechanical thrombectomy volumes than mid- (−10.1%) and low-volume (−8.7%) centers (p < 0.0001). There was a 1.5% stroke rate across 54,366 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.9% (784/20,250) of all stroke admissions. Conclusion: The COVID-19 pandemic was associated with a global decline in the volume of overall stroke hospitalizations, mechanical thrombectomy procedures, and intracranial hemorrhage admission volumes. Despite geographic variations, these volume reductions were observed regardless of COVID-19 hospitalization burden and pre-pandemic stroke/mechanical thrombectomy volumes

Published
2021

4. sj-pdf-1-wso-10.1177_17474930211041213 - Supplemental material for Outcome in Patients Treated with Intra-arterial thrombectomy: The optiMAL Blood Pressure control (OPTIMAL-BP) Trial

Author

Nam, Hyo Suk, Kim, Young Dae, Choi, Jin Kyo, Baik, Minyoul, Kim, Byung Moon, Kim, Dong Joon, Heo, JoonNyung, Shin, Dong Hoon, Lee, Kyung-Yul, Jung, Yo Han, Baek, Jang-Hyun, Hwang, Yang-Ha, Sohn, Sung-Il, Hong, Jeong-Ho, Park, Hyungjong, Kim, Chi Kyung, Kim, Gyu Sik, Seo, Kwon-Duk, Lee, Kijeong, Seo, Jung Hwa, Bang, Oh Young, Seo, Woo-Keun, Chung, Jong-Won, Chang, Jun Young, Kwon, Sun U, Lee, Jun, Kim, Jinkwon, Yoo, Joonsang, Song, Tae-Jin, Ahn, Seong Hwan, Cho, Bang-Hoon, Cho, Han-Jin, Kim, Jae Guk, Chang, Yoonkyung, Lee, Chan Joo, Park, Sungha, Park, Goeun, and Lee, Hye S

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-wso-10.1177_17474930211041213 for Outcome in Patients Treated with Intra-arterial thrombectomy: The optiMAL Blood Pressure control (OPTIMAL-BP) Trial by Hyo Suk Nam MD, PhD Young Dae Kim MD, PhD Jin Kyo Choi MD Minyoul Baik MD Byung Moon Kim MD, PhD Hye S Lee PhD in International Journal of Stroke

Published
2021
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5. Safety and optimal neuroprotection of neu2000 in acute ischemic stroke with reCanalization: study protocol for a randomized, double-blinded, placebo-controlled, phase-II trial

Author

Hong, Ji Man, Choi, Mun Hee, Sohn, Sung-Il, Hwang, Yang-Ha, Ahn, Seong Hwan, Lee, Yeong-Bae, Shin, Dong-Ick, Chamorro Sánchez, Ángel, Choi, Dennis W., SONIC investigators, and Universitat de Barcelona

Subjects
0301 basic medicine, Isquèmia cerebral, Time Factors, Medicine (miscellaneous), Brain Ischemia, Study Protocol, Disability Evaluation, 0302 clinical medicine, Modified Rankin Scale, Occlusion, Multicenter Studies as Topic, Pharmacology (medical), Prospective Studies, Cerebrovascular disease, Stroke, Randomized Controlled Trials as Topic, Thrombectomy, Computed tomography angiography, lcsh:R5-920, medicine.diagnostic_test, Endovascular Procedures, Endovascular recanalization, Cerebral ischemia, Salicylates, Neuroprotective Agents, Treatment Outcome, Anesthesia, Collateral, lcsh:Medicine (General), Malalties cerebrovasculars, Ischemia, Neuroprotectants, Placebo, Neuroprotection, Ischemia and reperfusion, 03 medical and health sciences, Clinical Trials, Phase II as Topic, Double-Blind Method, Republic of Korea, medicine, Humans, business.industry, Recovery of Function, medicine.disease, meta-Aminobenzoates, Fluorobenzenes, 030104 developmental biology, business, Reperfusion injury, 030217 neurology & neurosurgery
Abstract

Background The potential of neuroprotective agents should be revisited in the era of endovascular thrombectomy (EVT) for acute large-artery occlusion because their preclinical effects have been optimized for ischemia and reperfusion injury. Neu2000, a derivative of sulfasalazine, is a multi-target neuroprotectant. It selectively blocks N-methyl-D-aspartate receptors and scavenges for free radicals. This trial aimed to determine whether neuroprotectant administration before EVT is safe and leads to a more favorable outcome. Methods This trial is a phase-II, multicenter, three-arm, randomized, double-blinded, placebo-controlled, blinded-endpoint drug trial that enrolled participants aged ≥ 19 years undergoing an EVT attempt less than 8 h from symptom onset, with baseline National Institutes of Health Stroke Scale (NIHSS) score ≥ 8, Alberta Stroke Program Early CT score ≥ 6, evidence of large-artery occlusion, and at least moderate collaterals on computed tomography angiography. EVT-attempted patients are randomized into control, low-dose (2.75 g), and high-dose (5.25 g) Neu2000KWL over 5 days. Seventy participants per group are enrolled for 90% power, assuming that the treatment group has a 28.4% higher proportion of participants with functional independence than the placebo group. The primary outcome, based on intention-to-treat criteria is the improvement of modified Rankin Scale (mRS) scores at 3 months using a dichotomized model. Safety outcomes include symptomatic intracranial hemorrhage within 5 days. Secondary outcomes are distributional change of mRS, mean differences in NIHSS score, proportion of NIHSS score 0–2, and Barthel Index > 90 at 1 and 4 weeks, and 3 months. Discussion The trial results may provide information on new therapeutic options as multi-target neuroprotection might mitigate reperfusion injury in patients with acute ischemic stroke before EVT. Trial registration ClinicalTrials.gov, ID: NCT02831088. Registered on 13 July 2016. Electronic supplementary material The online version of this article (10.1186/s13063-018-2746-9) contains supplementary material, which is available to authorized users.

Published
2018

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