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6. K index utility as diagnostic and prognostic biomarker in the assessment of patients with suspected Multiple Sclerosis

Author

Claudia, Cutellè, Claudia, Balducci, Diletta, Cereda, Maria Letizia, Fusco, Davide, Iacobucci, Jacopo, Perugini, Fiammetta, Pirro, Rinaldo, Brivio, Davide Paolo, Bernasconi, Carlo, Ferrarese, Maura, Frigo, Guido, Cavaletti, Cutelle, C, Balducci, C, Cereda, D, Fusco, M, Iacobucci, D, Perugini, J, Pirro, F, Brivio, R, Bernasconi, D, Ferrarese, C, Frigo, M, and Cavaletti, G

Subjects
Multiple Sclerosis, κ index, Prognosi, Immunology, Biomarker, Prognosis, Immunoglobulin kappa-Chains, Cerebrospinal fluid, Neurology, Multiple Sclerosi, Humans, Immunology and Allergy, Neurology (clinical), Immunoglobulin free light chain, Biomarkers
Abstract

The aim of the present study is to evaluate the composite role of k index in the initial assessment of Multiple Sclerosis (MS) patients and to select useful cut-offs exportable in clinical practice. We analysed CSF/serum samples of 140 patients and followed-up the CIS/MS subgroup for 7 years. Our results suggest κ index as a quantitative diagnostic and prognostic biomarker in MS, significantly associated to baseline lesion load and to successive clinical course. We propose k index ≥106 as a prognostic cut-off to select patients at major risk of relapse, potentially influencing initial therapeutic decisions.

Published
2022
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