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2. Thunderstorm allergy and asthma: state of the art

Author

Gennaro D'Amato, Isabella Annesi-Maesano, Marilyn Urrutia-Pereira, Stefano Del Giacco, Nelson A. Rosario Filho, Herberto J. Chong-Neto, Dirceu Solé, Ignacio Ansotegui, Lorenzo Cecchi, Alessandro Sanduzzi Zamparelli, Emma Tedeschini, Benedetta Biagioni, Margarita Murrieta-Aguttes, Maria D'Amato, Salvy-Córdoba, Nathalie, High Speciality Hospital A. Cardarelli, 'Federico II' University of Naples Medical School, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Federal University of Pampa (UNIPAMPA), University of Cagliari, Federal University of Technology - Paraná (UTFPR), Federal University of Sao Paulo (Unifesp), Hospital Quirónsalud Bizkaia [Bilbao], Università degli Studi di Firenze = University of Florence (UniFI), High Speciality Hospital 'V. Monaldi' [Napoli, Italy], Università degli Studi di Perugia = University of Perugia (UNIPG), Sant'Orsola-Malpighi Polyclinic [Bologna, Italy], and SANOFI Recherche

Subjects
Pulmonary and Respiratory Medicine, allergic rhinitis, food and beverages, Review, Thunderstorm-asthma, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, pollen allergy, otorhinolaryngologic diseases, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, mould allergy, near fatal asthma, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, allergic asthma, [SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology, acute asthma attacks
Abstract

International audience; Thunderstorm-triggered asthma (TA) can be defined as the occurrence of acute asthma attacks immediately following a thunderstorm during pollen seasons. Outbreaks have occurred across the world during pollen season with the capacity to rapidly inundate a health care service, resulting in potentially catastrophic outcomes for allergicpatients. TA occurs when specific meteorological and aerobiological factors combine to affect predisposed atopic patients with IgE-mediated sentitization to pollen allergens. Thunderstorm outflows can concentrate aeroallergens, most commonly grass pollen but also other pollens such as Parietaria and moulds in TA, at ground level to release respirable allergenic particles after rupture by osmotic shock related to humidity and rainfall. Inhalation of high concentrations of these aeroallergens by sensitized individuals can induce early asthmatic responses which can be followed by a late inflammatory phase. There is evidence that, during pollen season, thunderstorms can induce allergic asthma outbreaks, sometimes also severe asthma crisis and sometimes deaths in patients suffering from pollen allergy. It has been observed that changes in the weather such as rain or humidity may induce hydratation of pollen grains during pollen seasons and sometimes also their fragmentation which generates atmospheric biological aerosols carrying allergens. Asthma attacks are induced for the high concentration at ground level of pollen grains which may release allergenic particles of respirable size after rupture by osmotic shock. In other words, it is a global health problem observed in several cities and areas of the world that can strike without sufficient warning, inducing sometimes severe clinical consequences also with deaths of asthma patients. Due to constant climate change, future TA events are likely to become more common, more disastrous and more unpredictable, as a consequence it is important to have deep knowledge on this topic to prevent asthma attacks. Other environmental factors, such as rapid changes in temperature and agricultural practices, also contribute to causing TA.

Published
2021
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3. Definition, aims, and implementation of GA

Author

Marcus, Maurer, Werner, Aberer, Rosana, Agondi, Mona, Al-Ahmad, Maryam Ali, Al-Nesf, Ignacio, Ansotegui, Rand, Arnaout, Luisa Karla, Arruda, Riccardo, Asero, Emel, Aygören-Pürsün, Aleena, Banerji, Andrea, Bauer, Moshe, Ben-Shoshan, Alejandro, Berardi, Jonathan A, Bernstein, Stephen, Betschel, Carsten, Bindslev-Jensen, Mojca, Bizjak, Isabelle, Boccon-Gibod, Konrad, Bork, Laurence, Bouillet, Henrik Balle, Boysen, Nicholas, Brodszki, Sigurd, Broesby-Olsen, Paula, Busse, Thomas, Buttgereit, Anette, Bygum, Teresa, Caballero, Régis A, Campos, Mauro, Cancian, Ivan, Cherrez-Ojeda, Danny M, Cohn, Célia, Costa, Timothy, Craig, Paulo Ricardo, Criado, Roberta F, Criado, Dorottya, Csuka, Joachim, Dissemond, Aurélie, Du-Thanh, Luis Felipe, Ensina, Ragıp, Ertaş, José E, Fabiani, Claudio, Fantini, Henriette, Farkas, Silvia Mariel, Ferrucci, Ignasi, Figueras-Nart, Natalia L, Fili, Daria, Fomina, Atsushi, Fukunaga, Asli, Gelincik, Ana, Giménez-Arnau, Kiran, Godse, Mark, Gompels, Margarida, Gonçalo, Maia, Gotua, Richard, Gower, Anete S, Grumach, Guillermo, Guidos-Fogelbach, Michihiro, Hide, Natalia, Ilina, Naoko, Inomata, Thilo, Jakob, Dario O, Josviack, Hye-Ryun, Kang, Allen, Kaplan, Alicja, Kasperska-Zając, Constance, Katelaris, Aharon, Kessel, Andreas, Kleinheinz, Emek, Kocatürk, Mitja, Košnik, Dorota, Krasowska, Kanokvalai, Kulthanan, M Sendhil, Kumaran, José Ignacio, Larco Sousa, Hilary J, Longhurst, William, Lumry, Andrew, MacGinnitie, Markus, Magerl, Michael P, Makris, Alejandro, Malbrán, Alexander, Marsland, Inmaculada, Martinez-Saguer, Iris V, Medina, Raisa, Meshkova, Martin, Metz, Iman, Nasr, Jan, Nicolay, Chikako, Nishigori, Isao, Ohsawa, Kemal, Özyurt, Nikolaos G, Papadopoulos, Claudio A S, Parisi, Jonathan Grant, Peter, Wolfgang, Pfützner, Todor, Popov, Nieves, Prior, German D, Ramon, Adam, Reich, Avner, Reshef, Marc A, Riedl, Bruce, Ritchie, Heike, Röckmann-Helmbach, Michael, Rudenko, Andaç, Salman, Mario, Sanchez-Borges, Peter, Schmid-Grendelmeier, Faradiba S, Serpa, Esther, Serra-Baldrich, Farrukh R, Sheikh, William, Smith, Angèle, Soria, Petra, Staubach, Urs C, Steiner, Marcin, Stobiecki, Gordon, Sussman, Anna, Tagka, Simon Francis, Thomsen, Regina, Treudler, Solange, Valle, Martijn, van Doorn, Lilian, Varga, Daniel O, Vázquez, Nicola, Wagner, Liangchun, Wang, Christina, Weber-Chrysochoou, Young-Min, Ye, Anna, Zalewska-Janowska, Andrea, Zanichelli, Zuotao, Zhao, Yuxiang, Zhi, Torsten, Zuberbier, Ricardo D, Zwiener, and Anthony, Castaldo

Subjects
Urticaria, Humans, Angioedema
Published
2020

5. Establishing the place in therapy of bilastine in the treatment of allergic rhinitis according to ARIA: evidence review

Author

Ignacio Ansotegui, Román Valiente, Dermot Ryan, Piotr Kuna, Torsten Zuberbier, Jean Bousquet, Carlos E. Baena-Cagnani, G. Walter Canonica, Sandra Nora González, Claus Bachert, Joaquim Mullol, Martin K. Church, Mário Morais-Almeida, Mario Sánchez-Borges, and Alvaro A. Cruz

Subjects
Adult, Allergy, medicine.medical_specialty, Rhinitis, Allergic, Perennial, Adolescent, Symptomatic treatment, Alternative medicine, MEDLINE, chemistry.chemical_compound, Piperidines, Quality of life, Anti-Allergic Agents, medicine, Humans, Clinical efficacy, Child, Asthma, Bilastine, business.industry, General Medicine, medicine.disease, Dermatology, chemistry, Practice Guidelines as Topic, Immunology, Benzimidazoles, business
Abstract

The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines development group examined the properties of oral H(1)-antihistamines and made proposals about an 'optimal' drug. Several criteria should be met by oral H(1)-antihistamines in terms of their pharmacological, and clinical efficacy and safety profiles.Bilastine, a new H(1)-antihistamine, has been approved in 28 European countries for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria in adults and children older than 12 years. To determine its potential place in therapy in the treatment of allergic rhinitis, this manuscript examines whether bilastine meets the criteria defined in the European Academy of Allergy and Clinical Immunology (EAACI)/ARIA proposals for oral H(1)-antihistamines.The optimal properties of oral H(1)-antihistamines and current ARIA recommendations for their use in allergic rhinitis are presented, as well as relevant pharmacological and clinical data for bilastine obtained from the published literature that specifically address the defined criteria.Bilastine is a potent inhibitor of the histamine H(1) receptor. Data from preclinical studies have confirmed its selectivity for the histamine H(1) receptor over other receptors, and demonstrated antihistaminic properties in vitro and in vivo. Bilastine does not interfere with the cytochrome P450 system and is devoid of cardiac side effects. Studies in healthy volunteers and patients have shown that bilastine does not affect driving ability, cardiac conduction or alertness. In large pivotal randomized, placebo-controlled trials (RCTs), bilastine had a favourable safety profile. Bilastine 20 mg once daily improved all nasal and ocular symptoms of allergic rhinitis with greater efficacy than placebo and comparable to that of cetirizine and desloratadine. Moreover, bilastine was shown to improve quality of life, an important outcome of RCTs in allergic diseases. There were no significant changes in laboratory tests, electrocardiograms or vital signs. A potential limitation of this assessment of bilastine is that it is a literature-based review and the findings are dependent upon the quality of the published evidence.Bilastine meets current EAACI/ARIA criteria for medications used in the treatment of allergic rhinitis.

Published
2011
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6. 2019 ARIA Care pathways for allergen immunotherapy

Author

Luigi Caraballo, Giorgio W. Canonica, Moises A. Calderon, Jan Brozek, Isabelle Bosse, Sinthia Bosnic‐Anticevich, Karl‐Christian Bergmann, Anna Bedbrook, Claus Bachert, Josep M. Anto, Ioana Agache, Ioanna Tsiligianni, Nikolaos G. Papadopoulos, Ignacio Ansotegui, Holger J. Schünemann, Alkis Togias, Oliver Pfaar, and Jean Bousquet

Subjects
0303 health sciences, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, General Medicine, 030304 developmental biology
Published
2019
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7. Sub-lingual immunotherapy: World Allergy Organization Position Paper 2009

Author

G Walter, Canonica, Jean, Bousquet, Thomas, Casale, Richard F, Lockey, Carlos E, Baena-Cagnani, Ruby, Pawankar, Paul C, Potter, Philippe J, Bousquet, Linda S, Cox, Stephen R, Durham, Harold S, Nelson, Giovanni, Passalacqua, Dermot P, Ryan, Jan L, Brozek, Enrico, Compalati, Ronald, Dahl, Luis, Delgado, Roy Gerth, van Wijk, Richard G, Gower, Dennis K, Ledford, Nelson Rosario, Filho, Erkka J, Valovirta, Osman M, Yusuf, Torsten, Zuberbier, Wahiduzzaman, Akhanda, Raul Castro, Almarales, Ignacio, Ansotegui, Floriano, Bonifazi, Jan, Ceuppens, Tomás, Chivato, Darina, Dimova, Diana, Dumitrascu, Luigi, Fontana, Constance H, Katelaris, Ranbir, Kaulsay, Piotr, Kuna, Dèsirée, Larenas-Linnemann, Manolis, Manoussakis, Kristof, Nekam, Carlos, Nunes, Robyn, O'Hehir, José M, Olaguibel, Nerin Bahceciler, Onder, Jung Won, Park, Alfred, Priftanji, Robert, Puy, Luis, Sarmiento, Glenis, Scadding, Peter, Schmid-Grendelmeier, Ester, Seberova, Revaz, Sepiashvili, Dirceu, Solé, Alkis, Togias, Carlo, Tomino, Elina, Toskala, Hugo, Van Beever, and Stefan, Vieths

Subjects
Allergy, medicine.medical_specialty, medicine.medical_treatment, Immunology, Placebo-controlled study, MEDLINE, Administration, Sublingual, law.invention, Randomized controlled trial, Meta-Analysis as Topic, law, Internal medicine, medicine, Immunology and Allergy, Humans, Child, Rhinitis, House dust mite, Clinical Trials as Topic, biology, business.industry, Immunotherapy, Allergens, medicine.disease, biology.organism_classification, Asthma, Practice Guidelines as Topic, Position paper, business, Food Hypersensitivity
Abstract

Udgivelsesdato: 2009-Dec

Published
2010
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