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Additional file 1: Supplementary data. Supplementary data associated with this article can be found in the table S1, S2. Table S1. Calibration curves, detection limits, and quantification limits for the chemical compounds. Table S2. MS/MS parameters for the target compounds. Table S3. Concentrations of chemical compounds detected in the mainstream smoke of IQOS using Tenax GR cartridge and CFP (μg/stick) (n=3). n.d. means not determined. Table S4. Concentrations of chemical compounds detected in the mainstream smoke of glo using Tenax GR cartridge and CFP (μg/stick) (n=3). n.d. means not determined. Table S5. Concentrations of chemical compounds detected in the mainstream smoke of ploom S using Tenax GR cartridge and CFP (μg/stick) (n=3). n.d. means not determined.