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Additional file 2.

Additional file 1: SF1. Expression of XBP1 in tumour and normal samples from different human cancers. SF2. Higher expression of XBP1 in breast tumour tissue. SF3. XBP1 expression in different molecular subtypes of breast cancer. SF4. Expression of XBP1 mRNA in TCGA breast dataset grouped according to ER status. SF5. Screening of XBP1 Knockout single cell clones in MCF7 cells. SF6. Confirmation of correct integration of XBP1 homology arm in XBP1 KO cells. SF7. Determination of optimal dose of estrogen, tamoxifen and fulvestrant for MCF7 cells. SF8. Loss of XBP1 attenuates induction of estrogen-responsive genes. Supplementary Table 1. XBP1-target genes shortlisted after the analysis of Gene Expression Omnibus dataset (GSE49955). SF9. Validation of XBP1 regulated genes. SF 10. ESR1 and XBP1-binding sites in the proximal promoter region of RRM2, CDC6, and TOP2A. SF11. Association between XBP1-gene signature and outcome in Basal and HER2-enriched breast cancer. SF12. Expression of RRM2, CDC6 and TOP2A in two breast cancer patient datasets pre- and post-endocrine treatment.