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We study lepton flavor violation (LFV) within the Littlest Higgs Model with T parity (LHT) realizing an inverse seesaw (ISS) mechanism of type I. In this scenario there appear new $\mathcal{O}$(TeV) Majorana neutrinos, driving LFV. We are analyzing the heavy Majorana neutrinos effects on LFV processes: $\ell \to \ell' \gamma$, $Z \to \bar{\ell}\ell'$, $L \to 3 \ell$ decays and $\mu \to e$ conversion in nuclei but we emphasize Type III decay channel of $L \to 3 \ell$ which are known as "wrong-sign": $\ell \rightarrow \ell' \ell'' \Bar{\ell}'''$ satisfying $\ell \neq \ell' = \ell'' \neq \ell'''$, since these processes vanish in the traditional LHT. First, we get values to $| \theta_{ej} \theta^{\dagger}_{\mu j}|$, $| \theta_{ej} \theta^{\dagger}_{\tau j}|$, and $| \theta_{\mu j} \theta^{\dagger}_{\tau j}|$ through $\ell \to \ell' \gamma$. With aid of these limits for mixing matrices, we can demonstrate that results for branching ratios of wrong sign processes yield within one order of magnitude below present bounds. We do not expect large correlations among the two wrong-sign decay modes. Also, we see that the mean values of heavy Majorana neutrino masses for all LFV processes are quasi-degenerate around 4 TeV.

[Background]: Ticks are obligate hematophagous arthropods that synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) associated with the alpha-gal syndrome (AGS) or allergy to mammalian meat consumption., [Research design and methods]: In this study, we used a proteomics approach to characterize tick proteins in salivary glands (sialome SG), secreted saliva (sialome SA) and with α-Gal modification (alphagalactome SG and SA) in model tick species associated with the AGS in the United States (Amblyomma americanum) and Australia (Ixodes holocyclus). Selected proteins reactive to sera (IgE) from patients with AGS were identified to advance in the identification of possible proteins associated with the AGS. For comparative analysis, the α-Gal content was measured in various tick species., [Results]: The results confirmed that ticks produce proteins with α-Gal modifications and secreted into saliva during feeding. Proteins identified in tick alphagalactome SA by sera from patients with severe AGS symptomatology may constitute candidate disease biomarkers., [Conclusions]: The results support the presence of tick-derived proteins with α-Gal modifications in the saliva with potential implications in AGS and other disorders and protective capacity against tick infestations and pathogen infection. Future research should focus on the characterization of the function of tick glycoproteins with α-Gal in tick biology and AGS., This work was supported by the State Research Agency, Spain, project BIOGAL [PID2020-116761GB-I00], the Spanish Research Council Grant [2020AEP123] and Consejería de Educación, Cultura y Deportes, JCCM, Spain, project CCM17-PIC-036 (SBPLY/17/180501/000185). Ixodes holocyclus saliva and salivary gland collections was supported by the Australian Research Council Linkage Grant [LP120200836 (2013-2018)]. MV was supported by the University of Castilla La Mancha, UCLM, Spain, and the Fondo Europeo de Desarrollo Regional, FEDER, EU.

Understanding the origin of ticks is essential for evaluating the risk of tick-borne disease introduction into new territories. However, when collecting engorged ticks from a host, it is virtually impossible to identify the geographical location where this tick was acquired. Recently, the elementome of tick exoskeleton was characterized by using scanning electron microscopy (SEM) and energy dispersive spectroscopy analysis (EDS). The objective of our preliminary proof-of-concept study was to evaluate the use of SEM-EDS for the analysis of tick exoskeleton elementome to gain insight into the tick geographic and host origin. For this preliminary analysis we used 10 samples of engorged ticks (larvae and nymphs of six species from three genera) collected from various resident hosts and locations. The elementome of the tick exoskeleton was characterized in dorsal and ventral parts with three scans on each part using an EDS 80 mm2 detector at 15 kV in a field emission scanning electron microscope. We used principal component analysis (PCA) (varimax rotation) to reduce the redundancy of data under the premise of losing information as little as possible. The PCA was used to test whether the different variables (tick species, stages, hosts, or geographic locations) differ in the composition of exoskeleton elementome (C, O, P, Cl, and Na). Analyses were carried out using SPSS. The PCA analysis explained a high percentage of variance using the first two factors, C and O (86.13%). The first PC (PC-1; 63.12%) was positively related to P, Cl, and Na, and negatively related to C. The second principal component (23.01%) was mainly positively related to C. In the space defined by the two extracted PC (PC-1 and PC-2), the elementome of tick samples was clearly associated with tick species, but not with developmental stages, hosts or geographic locations. A differentiated elementome pattern was observed within Romanian regions (CJ and TL) for the same tick species. The use of the SEM-EDS methodological approach provided additional information about the tick exoskeleton elementome with possible applications to the identification of tick origin host and location., This research was partially supported by the Consejería de Educación, Cultura y Deportes, JCCM, Spain, project CCM17-PIC-036 (SBPLY/17/180501/000185). For AM, the samples were collected in the frame of the UEFISCDI project PCCDI 57/2018.

Humans evolved by losing the capacity to synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which resulted in the development of a protective response mediated by anti-α-Gal IgM/IgG/IgA antibodies against pathogens containing this modification on membrane proteins. As an evolutionary trade-off, humans can develop the alpha-Gal syndrome (AGS), a recently diagnosed disease mediated by anti-α-Gal IgE antibodies and associated with allergic reactions to mammalian meat consumption and tick bites. However, the anti-α-Gal antibody response may be associated with other immune-mediated disorders such as those occurring in patients with COVID-19 and Guillain-Barré syndrome (GBS). Here, we provide a dataset (209 entries) on the IgE/IgM/IgG/IgA anti-α-Gal antibody response in healthy individuals and patients diagnosed with AGS, tick-borne allergies, GBS and COVID-19. The data allows correlative analyses of the anti-α-Gal antibody response with factors such as patient and clinical characteristics, record of tick bites, blood group, age and sex. These analyses could provide insights into the role of anti-α-Gal antibody response in disease symptomatology and possible protective mechanisms.

Objectives. To interpret the motives of pregnancy in girls and the re-signification of their life’s course. Materials and methods. In the cities of Bogota, Cali, Cartagena and Medellin, 18 life stories of adolescents under 15 years old with experience of pregnancy were made during 2012 and 2013. A phenomenological analytical framework was used to reveal the motives and meanings. Results. The “because motives” and “in order to motives” of adolescents life course, are redefined by the moral control of families, couples, education and health professionals based on common sense and professional habitus. Conclusion. In the real “because motives” it is found that common sense assigns blame and responsibility to teens for their pregnancy. In the educational context there is a device that excludes them and promotes dropouts. In the field of health, human rights abuses are used as a control and punishment mechanism.

La vicuña es una especie emblemática de la conservación de fauna en el Perú. La población de vicuñas se recuperó después de varios años de medidas oportunas para su conservación, pasando al apéndice II del CITES. En la actualidad existen vicuñas que se mantienen libres (silvestría) y poblaciones mantenidas encerradas en cercos permanentes (cautiverio). Durante 2018 se realizaron 58 capturas programadas (llamadas Chacus) en la Región Cusco, capturando 6777 animales, correspondiendo 3229 y 3548 cabezas para silvestría y cautividad, respectivamente. La distribución etaria en el caso de juveniles fue mayor en silvestría (18.08%) con respecto al sistema de cautividad (7.2%), lo cual estaría evidenciando la existencia de mayor mortalidad en esta población. El censo nacional de 2012 indica una mayor proporción de hembras en la población general de la Región Cusco; sin embargo, en este trabajo se encontraron poblaciones similares por sexo en ambos sistemas de crianza. La proporción de vicuñas esquiladas respecto a las capturadas fue de 52.95 y 30.21% para silvestría y cautividad, respectivamente, en tanto que la producción de fibra fue de 172.4 y 156.7 g por animal en promedio para silvestría y cautividad, respectivamente. Estos resultados conllevan a la posibilidad de replantear el uso de cercos permanentes en la crianza de vicuñas en cautiverio para la producción de fibra, considerando los menores niveles productivos obtenidos en este sistema de manejo.

This primer focuses on a recently diagnosed tick-borne allergic disease known as the alpha-Gal syndrome (AGS). Tick bites induce in humans high levels of IgE antibodies against the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) present on tick salivary glycoproteins and tissues of non-catarrhine mammals, leading to the AGS in some individuals. This immune response evolved as a conflict and cooperation between ticks and human hosts including their gut microbiota. The conflict is characterized by the AGS that mediate delayed anaphylaxis to red meat consumption and certain drugs such as cetuximab, and immediate anaphylaxis to tick bites. The cooperation is supported by the capacity of anti-α-Gal IgM and IgG antibody response to protect against pathogens with α-Gal on their surface. Despite the growing diagnosis of AGS in all world continents, many questions remain to be elucidated on the tick proteins and immune mechanisms triggering this syndrome, and the protective response against pathogen infection elicited by anti-α-Gal antibodies. The answer to these questions will provide information for the evaluation of risks, diagnosis and prevention of the AGS, and the possibility of using the carbohydrate α-Gal to develop vaccines for the control of major infectious diseases., The preparation of this manuscript was partially supported by the Consejería de Educación, Cultura y Deportes, JCCM, Spain, project CCM17-PIC-036 (SBPLY/17/180501/000185). MV was supported by the University of Castilla La Mancha, Spain.

El embarazo adolescente tiene un alto impacto socioeconómico. El objetivo de esta investigaciónfue interpretar los significados de la sexualidad y el embarazo de niñas menores de 15 añoscon experiencia de embarazo. Se realizó un estudio cualitativo interpretativo desde el enfoquefenomenológico de Alfred Schütz sobre el sentido común. Se realizaron 18 relatos de vidacon adolescentes menores de 15 años con experiencia de embarazo en las ciudades de Bogotá,Cali, Cartagena y Medellín. Los significados de la menarquia, el inicio de relaciones sexuales,la unión en pareja, el uso de anticonceptivos y la atención del parto están influenciados por laagencia moral social e institucional. La empresa moral circula por los espacios de socializaciónde las adolescentes: madres, padres, hogares, instituciones y profesionales del sector de la saludy educativo clasifican, de acuerdo con su sentido común, lo que está bien o es “normal” paralas niñas adolescentes.

To interpret the motives of pregnancy in girls and the re-signification of their life's course.In the cities of Bogota, Cali, Cartagena and Medellin, 18 life stories of adolescents under 15 years old with experience of pregnancy were made during 2012 and 2013. A phenomenological analytical framework was used to reveal the motives and meanings.The "because motives" and "in order to motives" of adolescents life course, are redefined by the moral control of families, couples, education and health professionals based on common sense and professional habitus.In the real "because motives" it is found that common sense assigns blame and responsibility to teens for their pregnancy. In the educational context there is a device that excludes them and promotes dropouts. In the field of health, human rights abuses are used as a control and punishment mechanism.

OBJECTIVE To describe and understand the meanings that adolescents give to sexuality and how they are created and influence adolescents' reproductive health and sexual practices. MATERIAL AND METHODS The research was conducted in three different regions within Bogoa city. Twenty focus groups were selected and 20 life stories of boys and girls between 10 and 14 years old were transcribed. From inductive and deductive categorization of the transcripts of the oral histories, an interpretative analysis was carried out in order to generate concepts and relations that comprise plausible hypotheses about the meanings that circulate in the adolescents' symbolic universe. RESULTS There are notable differences between the meanings that boys and girls give to sexuality, the ways in which such meanings are created, and the factors that contribute to its configuration. These findings imply dissimilar constructions related with reproductive and sexual health risks. CONCLUSIONS The cultural constructions resulting from sexual differences that is, gender suggest the meanings that are given to sexuality in the groups studied and define ways of interacting with the social environment. Girls relate sexuality with reproduction and they experience it as negative. For boys, the possibility of a positive and pleasant experience of sexuality exists, marked by a context that encourages having sexual relations as a way of maintaining manhood.

Objetivos. Describir y comprender los significados que tiene la sexualidad en los adolescentes , y cómo se construyen e influyen en sus prácticas sexuales y salud reproductiva. Material y métodos. La investigación se llevó a cabo en tres zonas de la ciudad de Bogotá. Se seleccionaron 20 grupos focales y se tomaron 20 relatos de vida de adolescentes mujeres y varones entre 10 y 14 años. Mediante la categorización deductiva e inductiva de las transcripciones de los discursos verbales, se procedió a un análisis de tipo interpretativo para generar conceptos y relaciones que configuran hipótesis plausibles sobre las significaciones que circulan en el universo simbólico adolescente. Resultados. Existen diferencias en los significados que tienen los varones y las mujeres sobre la sexualidad, la forma en que los construyen y los agentes que contribuyen a su conformación. Estos hallazgos suponen articulaciones distintas en relación con los riesgos en salud sexual y reproductiva Conclusiones. La construcción cultural que se hace de la diferencia sexual –el género– marca los significados que se dan a la sexualidad en los grupos estudiados y establece formas de interactuar con su entorno social. Las mujeres relacionan la sexualidad con el ejercicio reproductivo y la viven como una experiencia negativa. Para los varones existe la posibilidad positiva y placentera de la sexualidad, enmarcada en un contexto que los impulsa a tener relaciones sexuales como forma de sustentar su masculinidad. Objective. To describe and understand the meanings that adolescents give to sexuality and how they are created and influence adolescents' reproductive health and sexual practices. Material and Methods. The research was conducted in three different regions within Bogotá city. Twenty focus groups were selected and 20 life stories of boys and girls between 10 and 14 years old were transcribed. From inductive and deductive categorization of the transcripts of the oral histories, an interpretative analysis was carried out in order to generate concepts and relations that comprise plausible hypotheses about the meanings that circulate in the adolescents' symbolic universe. Results. There are notable differences between the meanings that boys and girls give to sexuality, the ways in which such meanings are created, and the factors that contribute to its configuration. These findings imply dissimilar constructions related with reproductive and sexual health risks. Conclusions. The cultural constructions resulting from sexual differences that is, gender suggest the meanings that are given to sexuality in the groups studied and define ways of interacting with the social environment. Girls relate sexuality with reproduction and they experience it as negative. For boys, the possibility of a positive and pleasant experience of sexuality exists, marked by a context that encourages having sexual relations as a way of maintaining manhood.