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2. UK Phosphorus Transformation Strategy: Towards a circular UK food system

Author

Cordell D, Jacobs B, Anderson A, Camargo-Valero M, Doody D, Forber K, Lyon C, Mackay E, Marshall R, Martin-Ortega J, May L, Okumah M, Rothwell S, Shahvi S, Sherry E, Spears B, and Withers P

Subjects
Phosphorus, Food System, Agriculture, United Kingdom
Abstract

This report sets out the UK’s first comprehensive national phosphorus transformation strategy, based on extensive stakeholder consultation across the UK food system, in addition to economic modelling and biophysical analyses. The UK’s food system is in transition, driven in part by major changes to agricultural policy. It is also under pressure from climate change, land use change, Brexit uncertainties, and unforeseen shocks like COVID-19. However one critical challenge that has not been sufficiently addressed is the secure supply and sustainable use of phosphorus. Phosphorus is a lynchpin of the food system and has no substitute. Yet its mismanagement has led to serious risks of compromising future food and water security in the UK and globally.This Strategy forms part of a larger, 3-year, UKRI-funded research effort, the RePhoKUs project.

Published
2022
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3. Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury: a CENTER TBI study

Author

Sewalt C. A., Gravesteijn B. Y., Menon D., Lingsma H. F., Maas A. I. R., Stocchetti N., Venema E., Lecky F. E., Akerlund C., Amrein K., Andelic N., Andreassen L., Anke A., Antoni A., Audibert G., Azouvi P., Azzolini M. L., Bartels R., Barzo P., Beauvais R., Beer R., Bellander B. -M., Belli A., Benali H., Berardino M., Beretta L., Blaabjerg M., Bragge P., Brazinova A., Brinck V., Brooker J., Brorsson C., Buki A., Bullinger M., Cabeleira M., Caccioppola A., Calappi E., Calvi M. R., Cameron P., Lozano G. C., Carbonara M., Chevallard G., Chieregato A., Citerio G., Cnossen M., Coburn M., Coles J., Cooper D. J., Correia M., Covic A., Curry N., Czeiter E., Czosnyka M., Dahyot-Fizelier C., Dawes H., De Keyser V., Degos V., Corte F. D., Boogert H., Depreitere B., Dilvesi D., Dixit A., Donoghue E., Dreier J., Duliere G. -L., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V. L., Foks K., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gantner D., Gao G., George P., Ghuysen A., Giga L., Glocker B., Golubovic J., Gomez P. A., Gratz J., Gravesteijn B., Grossi F., Gruen R. L., Gupta D., Haagsma J. A., Haitsma I., Helbok R., Helseth E., Horton L., Huijben J., Hutchinson P. J., Jacobs B., Jankowski S., Jarrett M., Jiang J. -Y., Jones K., Karan M., Kolias A. G., Kompanje E., Kondziella D., Koraropoulos E., Koskinen L. -O., Kovacs N., Lagares A., Lanyon L., Laureys S., Lecky F., Lefering R., Legrand V., Lejeune A., Levi L., Lightfoot R., Lingsma H., Castano-Leon A. M., Maegele M., Majdan M., Manara A., Manley G., Martino C., Marechal H., Mattern J., McMahon C., Melegh B., Menovsky T., Mulazzi D., Muraleedharan V., Murray L., Nair N., Negru A., Nelson D., Newcombe V., Nieboer D., Noirhomme Q., Nyiradi J., Olubukola O., Oresic M., Ortolano F., Palotie A., Parizel P. M., Payen J. -F., Perera N., Perlbarg V., Persona P., Peul W., Piippo-Karjalainen A., Pirinen M., Ples H., Polinder S., Pomposo I., Posti J. P., Puybasset L., Radoi A., Ragauskas A., Raj R., Rambadagalla M., Real R., Rhodes J., Richardson S., Richter S., Ripatti S., Rocka S., Roe C., Roise O., Rosand J., Rosenfeld J. V., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Rueckert D., Rusnak M., Sahuquillo J., Sakowitz O., Sanchez-Porras R., Sandor J., Schafer N., Schmidt S., Schoechl H., Schoonman G., Schou R. F., Schwendenwein E., Sewalt C., Skandsen T., Smielewski P., Sorinola A., Stamatakis E., Stanworth S., Kowark A., Stevens R., Stewart W., Steyerberg E. W., Sundstrom N., Synnot A., Takala R., Tamas V., Tamosuitis T., Taylor M. S., Ao B. T., Tenovuo O., Theadom A., Thomas M., Tibboel D., Timmers M., Tolias C., Trapani T., Tudora C. M., Vajkoczy P., Vallance S., Valeinis E., Vamos Z., Van der Steen G., van der Naalt J., van Dijck J. T. J. M., van Essen T. A., Van Hecke W., van Heugten C., Van Praag D., Vyvere T. V., Vanhaudenhuyse A., van Wijk R. P. J., Vargiolu A., Vega E., Velt K., Verheyden J., Vespa P. M., Vik A., Vilcinis R., Volovici V., von Steinbuchel N., Voormolen D., Vulekovic P., Wang K. K. W., Wiegers E., Williams G., Wilson L., Winzeck S., Wolf S., Yang Z., Ylen P., Younsi A., Zeiler F. A., Zelinkova V., Ziverte A., Zoerle T., Sewalt, Charlie Aletta [0000-0003-3270-4814], Apollo - University of Cambridge Repository, Public Health, Anesthesiology, Neurology, Amrein, Krisztina, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Koraropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Lagares, Alfonso, Lanyon, Linda, Andelic, Nada, Laureys, Steven, Lecky, Fiona, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I. R., Castaño-León, Ana M., Andreassen, Lasse, Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Martino, Costanza, Maréchal, Hugues, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David, Anke, Audny, Menovsky, Tomas, Mulazzi, Davide, Muraleedharan, Visakh, Murray, Lynnette, Nair, Nandesh, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Noirhomme, Quentin, Antoni, Anna, Nyirádi, József, Olubukola, Otesile, Oresic, Matej, Ortolano, Fabrizio, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Audibert, Gérard, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Azouvi, Philippe, Raj, Rahul, Rambadagalla, Malinka, Real, Ruben, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Azzolini, Maria Luisa, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Bartels, Ronald, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Skandsen, Toril, Barzó, Pál, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Kowark, Ana, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Beauvais, Romuald, Synnot, Anneliese, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Beer, Ronny, Timmers, Marjolein, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Vajkoczy, Peter, Vallance, Shirley, Valeinis, Egils, Vámos, Zoltán, Van der Steen, Gregory, van der Naalt, Joukje, Bellander, Bo-Michael, van Dijck, Jeroen T. J. M., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, Vyvere, Thijs Vande, Vanhaudenhuyse, Audrey, van Wijk, Roel P. J., Vargiolu, Alessia, Vega, Emmanuel, Belli, Antonio, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K. W., Benali, Habib, Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederik A., Zelinkova, Veronika, Berardino, Maurizio, Ziverte, Agate, Zoerle, Tommaso, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Cnossen, Maryse, Coburn, Mark, Coles, Jonathan, Cooper, D. Jamie, Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Corte, Francesco Della, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubovic, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Åkerlund, Cecilia, Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Molecular Neuroscience and Ageing Research (MOLAR), Ročka, Saulius, Tamošuitis, Tomas, CENTER TBI Participants Investigators, Section Neuropsychology, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: FPN NPPP I, „Springer Nature' grupė, Sewalt, C, Gravesteijn, B, Menon, D, Lingsma, H, Maas, A, Stocchetti, N, Venema, E, Lecky, F, Akerlund, C, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Antoni, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Barzo, P, Beauvais, R, Beer, R, Bellander, B, Belli, A, Benali, H, Berardino, M, Beretta, L, Blaabjerg, M, Bragge, P, Brazinova, A, Brinck, V, Brooker, J, Brorsson, C, Buki, A, Bullinger, M, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Lozano, G, Carbonara, M, Chevallard, G, Chieregato, A, Citerio, G, Cnossen, M, Coburn, M, Coles, J, Cooper, D, Correia, M, Covic, A, Curry, N, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dawes, H, De Keyser, V, Degos, V, Corte, F, Boogert, H, Depreitere, B, Dilvesi, D, Dixit, A, Donoghue, E, Dreier, J, Duliere, G, Ercole, A, Esser, P, Ezer, E, Fabricius, M, Feigin, V, Foks, K, Frisvold, S, Furmanov, A, Gagliardo, P, Galanaud, D, Gantner, D, Gao, G, George, P, Ghuysen, A, Giga, L, Glocker, B, Golubovic, J, Gomez, P, Gratz, J, Grossi, F, Gruen, R, Gupta, D, Haagsma, J, Haitsma, I, Helbok, R, Helseth, E, Horton, L, Huijben, J, Hutchinson, P, Jacobs, B, Jankowski, S, Jarrett, M, Jiang, J, Jones, K, Karan, M, Kolias, A, Kompanje, E, Kondziella, D, Koraropoulos, E, Koskinen, L, Kovacs, N, Lagares, A, Lanyon, L, Laureys, S, Lefering, R, Legrand, V, Lejeune, A, Levi, L, Lightfoot, R, Castano-Leon, A, Maegele, M, Majdan, M, Manara, A, Manley, G, Martino, C, Marechal, H, Mattern, J, Mcmahon, C, Melegh, B, Menovsky, T, Mulazzi, D, Muraleedharan, V, Murray, L, Nair, N, Negru, A, Nelson, D, Newcombe, V, Nieboer, D, Noirhomme, Q, Nyiradi, J, Olubukola, O, Oresic, M, Ortolano, F, Palotie, A, Parizel, P, Payen, J, Perera, N, Perlbarg, V, Persona, P, Peul, W, Piippo-Karjalainen, A, Pirinen, M, Ples, H, Polinder, S, Pomposo, I, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Real, R, Rhodes, J, Richardson, S, Richter, S, Ripatti, S, Rocka, S, Roe, C, Roise, O, Rosand, J, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Rueckert, D, Rusnak, M, Sahuquillo, J, Sakowitz, O, Sanchez-Porras, R, Sandor, J, Schafer, N, Schmidt, S, Schoechl, H, Schoonman, G, Schou, R, Schwendenwein, E, Skandsen, T, Smielewski, P, Sorinola, A, Stamatakis, E, Stanworth, S, Kowark, A, Stevens, R, Stewart, W, Steyerberg, E, Sundstrom, N, Synnot, A, Takala, R, Tamas, V, Tamosuitis, T, Taylor, M, Ao, B, Tenovuo, O, Theadom, A, Thomas, M, Tibboel, D, Timmers, M, Tolias, C, Trapani, T, Tudora, C, Vajkoczy, P, Vallance, S, Valeinis, E, Vamos, Z, Van der Steen, G, van der Naalt, J, van Dijck, J, van Essen, T, Van Hecke, W, van Heugten, C, Van Praag, D, Vyvere, T, Vanhaudenhuyse, A, van Wijk, R, Vargiolu, A, Vega, E, Velt, K, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Volovici, V, von Steinbuchel, N, Voormolen, D, Vulekovic, P, Wang, K, Wiegers, E, Williams, G, Wilson, L, Winzeck, S, Wolf, S, Yang, Z, Ylen, P, Younsi, A, Zeiler, F, Zelinkova, V, Ziverte, A, Zoerle, T, Sewalt, C. A., Gravesteijn, B. Y., Menon, D., Lingsma, H. F., Maas, A. I. R., Stocchetti, N., Venema, E., Lecky, F. E., Akerlund, C., Amrein, K., Andelic, N., Andreassen, L., Anke, A., Antoni, A., Audibert, G., Azouvi, P., Azzolini, M. L., Bartels, R., Barzo, P., Beauvais, R., Beer, R., Bellander, B. -M., Belli, A., Benali, H., Berardino, M., Beretta, L., Blaabjerg, M., Bragge, P., Brazinova, A., Brinck, V., Brooker, J., Brorsson, C., Buki, A., Bullinger, M., Cabeleira, M., Caccioppola, A., Calappi, E., Calvi, M. R., Cameron, P., Lozano, G. C., Carbonara, M., Chevallard, G., Chieregato, A., Citerio, G., Cnossen, M., Coburn, M., Coles, J., Cooper, D. J., Correia, M., Covic, A., Curry, N., Czeiter, E., Czosnyka, M., Dahyot-Fizelier, C., Dawes, H., De Keyser, V., Degos, V., Corte, F. D., Boogert, H., Depreitere, B., Dilvesi, D., Dixit, A., Donoghue, E., Dreier, J., Duliere, G. -L., Ercole, A., Esser, P., Ezer, E., Fabricius, M., Feigin, V. L., Foks, K., Frisvold, S., Furmanov, A., Gagliardo, P., Galanaud, D., Gantner, D., Gao, G., George, P., Ghuysen, A., Giga, L., Glocker, B., Golubovic, J., Gomez, P. A., Gratz, J., Gravesteijn, B., Grossi, F., Gruen, R. L., Gupta, D., Haagsma, J. A., Haitsma, I., Helbok, R., Helseth, E., Horton, L., Huijben, J., Hutchinson, P. J., Jacobs, B., Jankowski, S., Jarrett, M., Jiang, J. -Y., Jones, K., Karan, M., Kolias, A. G., Kompanje, E., Kondziella, D., Koraropoulos, E., Koskinen, L. -O., Kovacs, N., Lagares, A., Lanyon, L., Laureys, S., Lecky, F., Lefering, R., Legrand, V., Lejeune, A., Levi, L., Lightfoot, R., Lingsma, H., Castano-Leon, A. M., Maegele, M., Majdan, M., Manara, A., Manley, G., Martino, C., Marechal, H., Mattern, J., Mcmahon, C., Melegh, B., Menovsky, T., Mulazzi, D., Muraleedharan, V., Murray, L., Nair, N., Negru, A., Nelson, D., Newcombe, V., Nieboer, D., Noirhomme, Q., Nyiradi, J., Olubukola, O., Oresic, M., Ortolano, F., Palotie, A., Parizel, P. M., Payen, J. -F., Perera, N., Perlbarg, V., Persona, P., Peul, W., Piippo-Karjalainen, A., Pirinen, M., Ples, H., Polinder, S., Pomposo, I., Posti, J. P., Puybasset, L., Radoi, A., Ragauskas, A., Raj, R., Rambadagalla, M., Real, R., Rhodes, J., Richardson, S., Richter, S., Ripatti, S., Rocka, S., Roe, C., Roise, O., Rosand, J., Rosenfeld, J. V., Rosenlund, C., Rosenthal, G., Rossaint, R., Rossi, S., Rueckert, D., Rusnak, M., Sahuquillo, J., Sakowitz, O., Sanchez-Porras, R., Sandor, J., Schafer, N., Schmidt, S., Schoechl, H., Schoonman, G., Schou, R. F., Schwendenwein, E., Sewalt, C., Skandsen, T., Smielewski, P., Sorinola, A., Stamatakis, E., Stanworth, S., Kowark, A., Stevens, R., Stewart, W., Steyerberg, E. W., Sundstrom, N., Synnot, A., Takala, R., Tamas, V., Tamosuitis, T., Taylor, M. S., Ao, B. T., Tenovuo, O., Theadom, A., Thomas, M., Tibboel, D., Timmers, M., Tolias, C., Trapani, T., Tudora, C. M., Vajkoczy, P., Vallance, S., Valeinis, E., Vamos, Z., Van der Steen, G., van der Naalt, J., van Dijck, J. T. J. M., van Essen, T. A., Van Hecke, W., van Heugten, C., Van Praag, D., Vyvere, T. V., Vanhaudenhuyse, A., van Wijk, R. P. J., Vargiolu, A., Vega, E., Velt, K., Verheyden, J., Vespa, P. M., Vik, A., Vilcinis, R., Volovici, V., von Steinbuchel, N., Voormolen, D., Vulekovic, P., Wang, K. K. W., Wiegers, E., Williams, G., Wilson, L., Winzeck, S., Wolf, S., Yang, Z., Ylen, P., Younsi, A., Zeiler, F. A., Zelinkova, V., Ziverte, A., Zoerle, T., Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Institute for Molecular Medicine Finland, University of Helsinki, HUS Neurocenter, Neurokirurgian yksikkö, Statistical and population genetics, Biostatistics Helsinki, Clinicum, Helsinki University Hospital Area, Faculty Common Matters (Faculty of Social Sciences), Samuli Olli Ripatti / Principal Investigator, and Complex Disease Genetics

Subjects
medicine.medical_specialty, Brain Injuries, Traumatic/diagnosis, Referral, IMPACT, Traumatic brain injury, traumatic brain injury, referral, transfer, trauma system, Glasgow Outcome Scale, GUIDELINES, Critical Care and Intensive Care Medicine, 3124 Neurology and psychiatry, 03 medical and health sciences, 0302 clinical medicine, Case mix index, Midline shift, Brain Injuries, Traumatic, medicine, EPIDEMIOLOGY, Humans, In patient, Glasgow Coma Scale, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Referral and Consultation, Original Research, OUTCOMES, RC86-88.9, business.industry, MORTALITY, 3112 Neurosciences, HEAD-INJURY, Medical emergencies. Critical care. Intensive care. First aid, PREHOSPITAL MANAGEMENT, Trauma system, CARE, 3126 Surgery, anesthesiology, intensive care, radiology, medicine.disease, 3. Good health, Transfer, Emergency medicine, Emergency Medicine, Human medicine, business, SYSTEM, 030217 neurology & neurosurgery
Abstract

Scandinavian journal of trauma, resuscitation and emergency medicine 29(1), 113 (2021). doi:10.1186/s13049-021-00930-1, Published by BioMed Central, London

Published
2021

4. Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis

Author

Bohm J. K., Guting H., Thorn S., Schafer N., Rambach V., Schochl H., Grottke O., Rossaint R., Stanworth S., Curry N., Lefering R., Maegele M., Akerlund C., Amrein K., Andelic N., Andreassen L., Anke A., Antoni A., Audibert G., Azouvi P., Azzolini M. L., Bartels R., Barzo P., Beauvais R., Beer R., Bellander B., Belli A., Benali H., Berardino M., Beretta L., Blaabjerg M., Bragge P., Brazinova A., Brinck V., Brooker J., Brorsson C., Buki A., Bullinger M., Cabeleira M., Caccioppola A., Calappi E., Calvi M. R., Cameron P., Lozano G. C., Carbonara M., Cavallo S., Chevallard G., Chieregato A., Citerio G., Ceyisakar I., Clusmann H., Coburn M., Coles J., Cooper J., Correia M., Covic A., Czeiter E., Czosnyka M., Dahyot-Fizelier C., Dark P., Dawes H., Keyser V., Degos V., Corte F. D., Boogert H. d., Depreitere B., Dilvesi B., Dixit A., Donoghue E., Dreier J., Duliere G., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V., Foks K., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gantner D., Gao G., George P., Ghuysen A., Giga L., Glocker B., Golubovic J., Gomez P., Gratz J., Gravesteijn B., Grossi F., Gruen R., Gupta D., Haagsma J., Haitsma I., Helbok R., Helseth E., Horton L., Huijben J., Hutchinson P., Jacobs B., Jankowski S., Jarrett M., Jiang J., Johnson F., Jones K., Karan M., Kolias A., Kompanje E., Kondziella D., Koraropoulos E., Koskinen L., Kovacs N., Kowark A., Lagares A., Lanyon L., Laureys S., Lecky F., Ledoux D., Legrand V., Lejeune A., Levi L., Lightfoot R., Lingsma H., Maas A., M. Castano-Leon A., Majdan M., Manara A., Manley G., Martino C., Marechal H., Mattern J., McMahon C., Melegh B., Menon D., Menovsky T., Mikolic A., Misset B., Muraleedharan V., Murray L., Negru A., Nelson D., Newcombe V., Nieboer D., Nyiradi J., Olubukola O., Oresic M., Ortolano F., Palotie A., Parizel P., Payen J., Perera N., Perlbarg V., Persona P., Peul W., Piippo-Karjalainen A., Pirinen M., Ples H., Polinder S., Pomposo I., Posti J., Puybasset L., Radoi A., Ragauskas A., Raj R., Rambadagalla M., Rhodes J., Richardson S., Richter S., Ripatti S., Rocka S., Roe C., Roise O., Rosand J., Rosenfeld J., Rosenlund C., Rosenthal G., Rossi S., Rueckert D., Rusnak M., Sahuquillo J., Sakowitz O., Sanchez-Porras R., Sandor J., Schmidt S., Schoechl H., Schoonman G., Schou R. F., Schwendenwein E., Sewalt C., Skandsen T., Smielewski P., Sorinola A., Stamatakis E., Stevens R., Stewart W., Steyerberg E., Stocchetti N., Sundstrom N., Synnot A., Takala R., Tamas V., Tamosuitis T., Taylor M. S., Ao B. T., Tenovuo O., Theadom A., Thomas M., Tibboel D., Timmers M., Tolias C., Trapani T., Tudora C. M., Unterberg A., Vajkoczy P., Vallance S., Valeinis E., Vamos Z., Jagt M., Steen G., Naalt J., Dijck J., Essen T., Hecke W. V., Heugten C. v., Praag D. V., Vyvere T. V., Wijk R., Vargiolu A., Vega E., Velt K., Verheyden J., Vespa P., Vik A., Vilcinis R., Volovici V., von Steinbuchel N., Voormolen D., Vulekovic P., Wang K., Wiegers E., Williams G., Wilson L., Winzeck S., Wolf S., Yang Z., Ylen P., Younsi A., Zeiler F., Zelinkova V., Ziverte A., Zoerle T., Grottke, Oliver [0000-0002-0722-3122], Apollo - University of Cambridge Repository, Böhm, Julia K, Güting, Helge, Thorn, Sophie, Schäfer, Nadine, Rambach, Victoria, Schöchl, Herbert, Grottke, Oliver, Rossaint, Rolf, Stanworth, Simon, Curry, Nicola, Lefering, Rolf, Maegele, Marc (CENTER-TBI Participants and Investigators), Beretta, Luigi, Section Neuropsychology, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: FPN NPPP I, Ragauskas, Arminas, Ročka, Saulius, Tamošuitis, Tomas, Vilcinis, Rimantas, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, Helsinki Institute for Information Technology, Statistical and population genetics, Department of Mathematics and Statistics, Biostatistics Helsinki, Department of Public Health, Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, HUS Neurocenter, Neurokirurgian yksikkö, Clinicum, Helsinki University Hospital Area, Molecular Neuroscience and Ageing Research (MOLAR), Rocka, Saulius, Tamosuitis, Tomas, „Springer Nature' grupė, Bohm, J, Guting, H, Thorn, S, Schafer, N, Rambach, V, Schochl, H, Grottke, O, Rossaint, R, Stanworth, S, Curry, N, Lefering, R, Maegele, M, Akerlund, C, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Antoni, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Barzo, P, Beauvais, R, Beer, R, Bellander, B, Belli, A, Benali, H, Berardino, M, Beretta, L, Blaabjerg, M, Bragge, P, Brazinova, A, Brinck, V, Brooker, J, Brorsson, C, Buki, A, Bullinger, M, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Lozano, G, Carbonara, M, Cavallo, S, Chevallard, G, Chieregato, A, Citerio, G, Ceyisakar, I, Clusmann, H, Coburn, M, Coles, J, Cooper, J, Correia, M, Covic, A, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dark, P, Dawes, H, Keyser, V, Degos, V, Corte, F, Boogert, H, Depreitere, B, Dilvesi, B, Dixit, A, Donoghue, E, Dreier, J, Duliere, G, Ercole, A, Esser, P, Ezer, E, Fabricius, M, Feigin, V, Foks, K, Frisvold, S, Furmanov, A, Gagliardo, P, Galanaud, D, Gantner, D, Gao, G, George, P, Ghuysen, A, Giga, L, Glocker, B, Golubovic, J, Gomez, P, Gratz, J, Gravesteijn, B, Grossi, F, Gruen, R, Gupta, D, Haagsma, J, Haitsma, I, Helbok, R, Helseth, E, Horton, L, Huijben, J, Hutchinson, P, Jacobs, B, Jankowski, S, Jarrett, M, Jiang, J, Johnson, F, Jones, K, Karan, M, Kolias, A, Kompanje, E, Kondziella, D, Koraropoulos, E, Koskinen, L, Kovacs, N, Kowark, A, Lagares, A, Lanyon, L, Laureys, S, Lecky, F, Ledoux, D, Legrand, V, Lejeune, A, Levi, L, Lightfoot, R, Lingsma, H, Maas, A, M. Castano-Leon, A, Majdan, M, Manara, A, Manley, G, Martino, C, Marechal, H, Mattern, J, Mcmahon, C, Melegh, B, Menon, D, Menovsky, T, Mikolic, A, Misset, B, Muraleedharan, V, Murray, L, Negru, A, Nelson, D, Newcombe, V, Nieboer, D, Nyiradi, J, Olubukola, O, Oresic, M, Ortolano, F, Palotie, A, Parizel, P, Payen, J, Perera, N, Perlbarg, V, Persona, P, Peul, W, Piippo-Karjalainen, A, Pirinen, M, Ples, H, Polinder, S, Pomposo, I, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Rhodes, J, Richardson, S, Richter, S, Ripatti, S, Rocka, S, Roe, C, Roise, O, Rosand, J, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossi, S, Rueckert, D, Rusnak, M, Sahuquillo, J, Sakowitz, O, Sanchez-Porras, R, Sandor, J, Schmidt, S, Schoechl, H, Schoonman, G, Schou, R, Schwendenwein, E, Sewalt, C, Skandsen, T, Smielewski, P, Sorinola, A, Stamatakis, E, Stevens, R, Stewart, W, Steyerberg, E, Stocchetti, N, Sundstrom, N, Synnot, A, Takala, R, Tamas, V, Tamosuitis, T, Taylor, M, Ao, B, Tenovuo, O, Theadom, A, Thomas, M, Tibboel, D, Timmers, M, Tolias, C, Trapani, T, Tudora, C, Unterberg, A, Vajkoczy, P, Vallance, S, Valeinis, E, Vamos, Z, Jagt, M, Steen, G, Naalt, J, Dijck, J, Essen, T, Hecke, W, Heugten, C, Praag, D, Vyvere, T, Wijk, R, Vargiolu, A, Vega, E, Velt, K, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Volovici, V, von Steinbuchel, N, Voormolen, D, Vulekovic, P, Wang, K, Wiegers, E, Williams, G, Wilson, L, Winzeck, S, Wolf, S, Yang, Z, Ylen, P, Younsi, A, Zeiler, F, Zelinkova, V, Ziverte, A, Zoerle, T, Public Health, Pediatric Surgery, Neurology, Neurosurgery, and Intensive Care

Subjects
Neurologi, INTRACRANIAL HEMORRHAGE, PREINJURY WARFARIN, CENTER-TBI, Critical Care and Intensive Care Medicine, 0302 clinical medicine, Traumatic brain injury, Coagulopathy, Brain Injuries, Traumatic, Prospective Studies, RISK, Anticoagulant, Head injury, Blood Coagulation Disorders, 3. Good health, Neurology, CLOPIDOGREL, Neurosurgery, Blood Coagulation Tests, Original Work, medicine.medical_specialty, medicine.drug_class, Subgroup analysis, 03 medical and health sciences, MORBIDITY, TRANSFUSION, medicine, Humans, VDP::Medisinske Fag: 700, Glasgow Coma Scale, OLDER-ADULTS, coagulopathy, risk factors, traumatic brain injury, HYPOTHERMIA, business.industry, MORTALITY, 3112 Neurosciences, HEAD-INJURY, 030208 emergency & critical care medicine, medicine.disease, VDP::Medical disciplines: 700, Risk factors, Emergency medicine, Base excess, Risk factor, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Background Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated coagulopathy is poorly understood. Methods This analysis, embedded in the prospective, multi-centred, observational Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, aimed to characterise the coagulopathy of TBI. Emphasis was placed on the acute phase following TBI, primary on subgroups of patients with abnormal coagulation profile within 4 h of admission, and the impact of pre-injury anticoagulant and/or antiplatelet therapy. In order to minimise confounding factors, patients with isolated TBI (iTBI) (n = 598) were selected for this analysis. Results Haemostatic disorders were observed in approximately 20% of iTBI patients. In a subgroup analysis, patients with pre-injury anticoagulant and/or antiplatelet therapy had a twice exacerbated coagulation profile as likely as those without premedication. This was in turn associated with increased rates of mortality and unfavourable outcome post-injury. A multivariate analysis of iTBI patients without pre-injury anticoagulant therapy identified several independent risk factors for coagulopathy which were present at hospital admission. Glasgow Coma Scale (GCS) less than or equal to 8, base excess (BE) less than or equal to − 6, hypothermia and hypotension increased risk significantly. Conclusion Consideration of these factors enables early prediction and risk stratification of acute coagulopathy after TBI, thus guiding clinical management.

Published
2021

5. Ontsluieringen in de Oost (1935)

Author

Jacobs, B, Jansen, R.H.T., Heerma van Voss, A.F., Bouras, N., Hart, M. 't, Heijden, M.P.C. van der, and Lucassen, L.A.C.J.

Subjects
Foundational principles & fundamental rights (transition), Grondslagen van het publiekrecht, Principles of Public Law, Dragende beginselen & fundamentele rechten (overgangssituatie)
Abstract

Contains fulltext : 282834.pdf (Publisher’s version ) (Open Access)

Published
2022

6. Ontsluieringen in de Oost (1935)

Author

Jacobs, B, Jansen, R.H.T., Heerma van Voss, A.F., Bouras, N., Hart, M. 't, Heijden, M.P.C. van der, and Lucassen, L.A.C.J.

Published
2022

7. Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

Author

Storm, Catherine S., Kia, Demis A., Almramhi, Mona M., Bandres-Ciga, Sara, Finan, Chris, Noyce, A. J., Kaiyrzhanov, R., Middlehurst, B., Tan, M., Houlden, H., Morris, H. R., Plun-Favreau, H., Holmans, P., Hardy, J., Trabzuni, D., Quinn, J., Bubb, V., Mok, K. Y., Kinghorn, K. J., Lewis, P., Schreglmann, S. R., Lovering, R., R'Bibo, L., Manzoni, C., Rizig, M., Ryten, M., Guelfi, S., Escott-Price, V., Chelban, V., Foltynie, T., Williams, N., Morrison, K. E., Clarke, C., Harvey, K., Jacobs, B. M., Brice, Alexis, Danjou, F., Lesage, S., Corvol, J. C., Martinez, M., Schulte, C., Brockmann, K., Simón-Sánchez, J., Heutink, P., Rizzu, P., Sharma, M., Gasser, T., Schneider, S. A., Cookson, M. R., Blauwendraat, C., Craig, D. W., Billingsley, K., Makarious, M. B., Narendra, D. P., Faghri, F., Gibbs, J. R., Hernandez, D. G., Van Keuren-Jensen, K., Shulman, J. M., Iwaki, H., Leonard, H. L., Nalls, M. A., Robak, L., Bras, J., Guerreiro, R., Lubbe, S., Troycoco, T., Finkbeiner, S., Mencacci, N. E., Lungu, C., Singleton, A. B., Scholz, S. W., Reed, X., Uitti, R. J., Ross, O. A., Grenn, F. P., Moore, A., Alcalay, R. N., Wszolek, Z. K., Gan-Or, Z., Rouleau, G. A., Krohn, L., Mufti, K., van Hilten, J. J., Marinus, J., Adarmes-Gómez, A. D., Aguilar Barberà, Miquel, Álvarez Angulo, Iñaki, Alvarez, V., Barrero, F. J., Yarza, J. A. B., Bernal-Bernal, I., Blázquez Estrada, M, Bonilla-Toribio, M., Botía, J. A., Boungiorno, M. T., Buiza-Rueda, Dolores, Cámara, A., Carrillo, F., Carrión-Claro, M., Cerdan, D., Clarimón, Jordi, Compta, Y., Diez-Fairen, M., Dols-Icardo, Oriol, Duarte, J., Duran, R., Escamilla-Sevilla, F., Ezquerra, M., Feliz, C., Fernández, M., Fernández-Santiago, R., Garcia, C., García-Ruiz, P., Gómez-Garre, P., Heredia, M. J. G., Gonzalez-Aramburu, I., Pagola, A. G., Hoenicka, J., Infante, J., Jesús, S., Jimenez-Escrig, A., Kulisevsky, Jaime, Labrador-Espinosa, M. A., Lopez-Sendon, J. L., de Munain Arregui, A. L., Macias, D., Torres, I. M., Marín, J., Marti, M. J., Martínez-Castrillo, J. C., Méndez-del-Barrio, C., González, M. M., Mata, M., Mínguez, A., Mir, P., Rezola, E. M., Muñoz, E., Pagonabarraga, J., Pastor, P., Errazquin, F. P., Periñán-Tocino, T., Ruiz-Martínez, J., Ruz, C., Rodriguez, A. S., Sierra, M., Suarez-Sanmartin, E., Tabernero, C., Tartari, J. P., Tejera-Parrado, C., Tolosa, E., Valldeoriola, F., Vargas-González, L., Vela, Lydia, Vives, F., Zimprich, A., Pihlstrom, L., Toft, M., Taba, P., Koks, S., Hassin-Baer, S., Majamaa, K., Siitonen, A., Tienari, P., Okubadejo, N. U., Ojo, O. O., Shashkin, C., Zharkinbekova, N., Akhmetzhanov, V., Kaishybayeva, G., Karimova, A., Khaibullin, T., Lynch, T. L., Hingorani, Aroon, Wood, Nicholas W.., Universitat Autònoma de Barcelona, Rosetrees Trust, John Black Charitable Foundation, University College London, King Abdulaziz University, National Institute for Health Research (UK), Universidad de Cantabria, HUS Neurocenter, Department of Neurosciences, and Clinicum

Subjects
Aging, Science, Quantitative Trait Loci, General Physics and Astronomy, Neurodegenerative, 3124 Neurology and psychiatry, General Biochemistry, Genetics and Molecular Biology, Article, Cohort Studies, Risk Factors, Genetics research, Genetics, 2.1 Biological and endogenous factors, Humans, Genetic Predisposition to Disease, Aetiology, Multidisciplinary, Genome, Parkinson's Disease, Genome, Human, Prevention, 3112 Neurosciences, Neurosciences, Brain, Genetic Variation, Parkinson Disease, General Chemistry, Mendelian Randomization Analysis, International Parkinson’s Disease Genomics Consortium, Brain Disorders, Good Health and Well Being, Gene Expression Regulation, Neurology, 5.1 Pharmaceuticals, Case-Control Studies, Neurological, Disease Progression, Development of treatments and therapeutic interventions, Human, Biotechnology
Abstract

Parkinson’s disease is a neurodegenerative movement disorder that currently has no disease-modifying treatment, partly owing to inefficiencies in drug target identification and validation. We use Mendelian randomization to investigate over 3,000 genes that encode druggable proteins and predict their efficacy as drug targets for Parkinson’s disease. We use expression and protein quantitative trait loci to mimic exposure to medications, and we examine the causal effect on Parkinson’s disease risk (in two large cohorts), age at onset and progression. We propose 23 drug-targeting mechanisms for Parkinson’s disease, including four possible drug repurposing opportunities and two drugs which may increase Parkinson’s disease risk. Of these, we put forward six drug targets with the strongest Mendelian randomization evidence. There is remarkably little overlap between our drug targets to reduce Parkinson’s disease risk versus progression, suggesting different molecular mechanisms. Drugs with genetic support are considerably more likely to succeed in clinical trials, and we provide compelling genetic evidence and an analysis pipeline to prioritise Parkinson’s disease drug development., There is currently no disease-modifying treatment for Parkinson’s disease, a common neurodegenerative disorder. Here, the authors use genetic variation associated with gene and protein expression to find putative drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome.

Published
2021

8. Advies publieke waarden voor het onderwijs

Author

Bok, C., Brunsveld, N., Dijck, J. van, Prins, C., Jacobs, B., Skeikh, H., Heuvel, B van den, Fikkers, D.J., Stolk, R., Regien, I., and Verstappen, J.

Subjects
Digital Security
Abstract

Contains fulltext : 239960.pdf (Publisher’s version ) (Open Access) 63 p.

Published
2021

9. Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury: a CENTER TBI study

Author

Sewalt, CA, Gravesteijn, BY, Menon, D, Lingsma, HF, Maas, AIR, Stocchetti, N, Venema, E, Lecky, FE, Åkerlund, C, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Antoni, A, Audibert, G, Azouvi, P, Azzolini, ML, Bartels, R, Barzó, P, Beauvais, R, Beer, R, Bellander, BM, Belli, A, Benali, H, Berardino, M, Beretta, L, Blaabjerg, M, Bragge, P, Brazinova, A, Brinck, V, Brooker, J, Brorsson, C, Buki, A, Bullinger, M, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, MR, Cameron, P, Lozano, GC, Carbonara, M, Chevallard, G, Chieregato, A, Citerio, G, Cnossen, M, Coburn, M, Coles, J, Cooper, DJ, Correia, M, Covic, A, Curry, N, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dawes, H, De Keyser, V, Degos, V, Corte, FD, Boogert, HD, Depreitere, B, Ðilvesi, Ð, Dixit, A, Donoghue, E, Dreier, J, Dulière, GL, Ercole, A, Esser, P, Ezer, E, Fabricius, M, Feigin, VL, Foks, K, Frisvold, S, Furmanov, A, Gagliardo, P, Galanaud, D, Gantner, D, Gao, G, George, P, Ghuysen, A, Giga, L, Glocker, B, Golubovic, J, Gomez, PA, Gratz, J, Grossi, F, Gruen, RL, Gupta, D, Haagsma, JA, Haitsma, I, Helbok, R, Helseth, E, Horton, L, Huijben, J, Hutchinson, PJ, Jacobs, B, Jankowski, S, Jarrett, M, Jiang, JY, Jones, K, and Synnot, Anneliese

Subjects
Uncategorized
Abstract

Full list of CENTER TBI Participants and Investigators can be found in publication (p.8-11): https://sjtrem.biomedcentral.com/articles/10.1186/s13049-021-00930-1#Abs1Background: Prehospital care for patients with traumatic brain injury (TBI) varies with some emergency medical systems recommending direct transport of patients with moderate to severe TBI to hospitals with specialist neurotrauma care (SNCs). The aim of this study is to assess variation in levels of early secondary referral within European SNCs and to compare the outcomes of directly admitted and secondarily transferred patients. Methods: Patients with moderate and severe TBI (Glasgow Coma Scale < 13) from the prospective European CENTER-TBI study were included in this study. All participating hospitals were specialist neuroscience centers. First, adjusted between-country differences were analysed using random effects logistic regression where early secondary referral was the dependent variable, and a random intercept for country was included. Second, the adjusted effect of early secondary referral on survival to hospital discharge and functional outcome [6 months Glasgow Outcome Scale Extended (GOSE)] was estimated using logistic and ordinal mixed effects models, respectively. Results: A total of 1347 moderate/severe TBI patients from 53 SNCs in 18 European countries were included. Of these 1347 patients, 195 (14.5%) were admitted after early secondary referral. Secondarily referred moderate/severe TBI patients presented more often with a CT abnormality: mass lesion (52% vs. 34%), midline shift (54% vs. 36%) and acute subdural hematoma (77% vs. 65%). After adjusting for case-mix, there was a large European variation in early secondary referral, with a median OR of 1.69 between countries. Early secondary referral was not associated with functional outcome (adjusted OR 1.07, 95% CI 0.78–1.69), nor with survival at discharge (1.05, 0.58–1.90). Conclusions: Across Europe, substantial practice variation exists in the proportion of secondarily referred TBI patients at SNCs that is not explained by case mix. Within SNCs early secondary referral does not seem to impact functional outcome and survival after stabilisation in a non-specialised hospital. Future research should identify which patients with TBI truly benefit from direct transportation.

Published
2021
Full Text
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10. Neurofascin-155 CIDP patients: Clinical, immunological and biomarker features

Author

Martin-Aguilar, L, Lleixa, C, Pascual-Goni, E, Caballero, M, Martinez-Martinez, L, Diaz-Manera, J, Rojas, R, Cortes-Vicente, E, de Luna, N, Suarez-Calvet, X, Gallardo, E, Rajabally, Y, Scotton, S, Jacobs, B, Baars, A, Cortese, A, Vegezzi, E, Hoftberger, R, Zimprich, F, Roesler, C, Nobile-Orazio, E, Liberatore, G, Liong, HF, Martinez-Pineiro, A, Carvajal, A, Pinar-Morales, R, Uson-Martin, M, Alberti, O, Lopez-Perez, MA, Marquez, F, Pardo-Fernandez, J, Cabrera-Serrano, M, Munoz-Delgado, L, Ortiz, N, Duman, O, Bartolome, M, Bril, V, Segura-Chavez, D, Pitarokoili, K, Steen, C, Illa, I, and Querol, L

Subjects
neurofascin-155 (NF155), neurofilament light chain (NfL), Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), NF155 antibody titers
Published
2021

11. Steps and Traces

Author

Jacobs, B., Levy, P., Rot, J., Cirstea, C., and Cirstea, C.

Subjects
FOS: Computer and information sciences, Computer Science - Logic in Computer Science, Logic, 010102 general mathematics, 0102 computer and information sciences, 01 natural sciences, Theoretical Computer Science, Logic in Computer Science (cs.LO), Arts and Humanities (miscellaneous), 010201 computation theory & mathematics, Hardware and Architecture, Software Science, 0101 mathematics, Digital Security, Software
Abstract

In the theory of coalgebras, trace semantics can be defined in various distinct ways, including through algebraic logics, the Kleisli category of a monad or its Eilenberg–Moore category. This paper elaborates two new unifying ideas: (i) coalgebraic,draftrules trace semantics is naturally presented in terms of corecursive algebras, and (ii) all three approaches arise as instances of the same abstract setting. Our perspective puts the different approaches under a common roof and allows to derive conditions under which some of them coincide.

Published
2020
Full Text
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14. Friction for privacy: Why privacy by design needs user experience design

Author

Jacobs, B., Schraffenberger, H.K., Wekke, K. van der, and Wekke, K. van der

Subjects
Digital Security
Abstract

Contains fulltext : 219344.pdf (Publisher’s version ) (Open Access) IRMA is an open source identity platform that is run by the not-for-profit Privacy by Design foundation in The Netherlands. It grew out of academic research at Radboud University Nijmegen - and originally at IBM Research at Zurich in the 1990s. IRMA is now clearly gaining momentum and is being integrated in various ways, especially in healthcare, (local) government, and also in commercial areas such as insurance. The techniques underlying IRMA have been developed with privacy protection as explicit goal. This article explores the impact of this privacy focus on the user experience (UX) and on the ongoing (re)design of the interface of the IRMA app. The authors are both closely involved in the development of IRMA.

Published
2020

15. Rethinking surgical readmissions

Author

Machesney M, Hadjittofi C, Davies J, Taylor F, and Jacobs B

Subjects
medicine.medical_specialty, business.industry, General surgery, General Medicine, 030230 surgery, humanities, body regions, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Retrospective analysis, Medicine, General hospital, business
Abstract

A retrospective analysis of 289 general surgery patients readmitted in a district general hospital

Published
2018

16. Learning to Coordinate

Author

Heerdt, G. Ter, Jacobs, B., Kappé, T., Silva, A., Boer, F. de, Bonsangue, M., Rutten, J., Boer, F. de, Bonsangue, M., and Rutten, J.

Subjects
Visual language, Computer science, Programming language, 020204 information systems, Component (UML), 0202 electrical engineering, electronic engineering, information engineering, 020207 software engineering, 02 engineering and technology, Digital Security, computer.software_genre, Composition (language), computer, Automaton
Abstract

Reo is a visual language of connectors that originated in component-based software engineering. It is a flexible and intuitive language, yet powerful and capable of expressing complex patterns of composition. The intricacies of the language resulted in many semantic models proposed for Reo, including several automata-based ones.

Published
2018

17. A Recipe for State-and-Effect Triangles

Author

Jacobs, B., Moss, L., and Moss, L.

Subjects
FOS: Computer and information sciences, Computer Science - Logic in Computer Science, 000 Computer science, knowledge, general works, TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, Computer Science::Logic in Computer Science, Mathematics::Category Theory, Computer Science, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Computer Science::Programming Languages, Digital Security, Leibniz International Proceedings in Informatics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Logic in Computer Science (cs.LO)
Abstract

In the semantics of programming languages one can view programs as state transformers, or as predicate transformers. Recently the author has introduced state-and-effect triangles which capture this situation categorically, involving an adjunction between state- and predicate-transformers. The current paper exploits a classical result in category theory, part of Jon Beck's monadicity theorem, to systematically construct such a state-and-effect triangle from an adjunction. The power of this construction is illustrated in many examples, covering many monads occurring in program semantics, including (probabilistic) power domains., Logical Methods in Computer Science ; Volume 13, Issue 2 ; 1860-5974

Published
2017

19. Causal Inference by String Diagram Surgery

Author

Jacobs, B., Zanasi, Fabio, Kissinger, A., Bojanczyk, M., and Bojanczyk, M.

Subjects
FOS: Computer and information sciences, Computer Science - Logic in Computer Science, Computer Science - Machine Learning, FOS: Mathematics, Mathematics - Category Theory, Category Theory (math.CT), Digital Security, Logic in Computer Science (cs.LO), Machine Learning (cs.LG)
Abstract

Extracting causal relationships from observed correlations is a growing area in probabilistic reasoning, originating with the seminal work of Pearl and others from the early 1990s. This paper develops a new, categorically oriented view based on a clear distinction between syntax (string diagrams) and semantics (stochastic matrices), connected via interpretations as structure-preserving functors. A key notion in the identification of causal effects is that of an intervention, whereby a variable is forcefully set to a particular value independent of any prior propensities. We represent the effect of such an intervention as an endofunctor which performs `string diagram surgery' within the syntactic category of string diagrams. This diagram surgery in turn yields a new, interventional distribution via the interpretation functor. While in general there is no way to compute interventional distributions purely from observed data, we show that this is possible in certain special cases using a calculational tool called comb disintegration. We demonstrate the use of this technique on a well-known toy example, where we predict the causal effect of smoking on cancer in the presence of a confounding common cause. After developing this specific example, we show this technique provides simple sufficient conditions for computing interventions which apply to a wide variety of situations considered in the causal inference literature., Comment: 17 pages

Published
2019

20. Electronic Identities in Europe

Author

Jacobs, B.

Subjects
Digital Security
Abstract

Item does not contain fulltext Electronic Identities in Europe, 21 februari 2019

Published
2019

21. Thoughts on the linguistic history of Curaçao: how Papiamentu got the better of Dutch

Author

Jacobs, B., Jacobs B., and Jacobs B.

Subjects
Long lasting, Linguistics and Language, History, Vocabulary, Literature and Literary Theory, media_common.quotation_subject, Creole language, Ethnic group, Social class, Colonialism, Language and Linguistics, Linguistics, Spite, Ethnology, media_common
Abstract

Papiamentu has borrowed considerably from Dutch with up to 30% of the vocabulary having Dutch roots. However, an important and hitherto insufficiently addressed historical-and socio-linguistic question is why Dutch itself did not creolize on Curaçao or otherwise become the principal language of the island’s society at large, in spite of it being the principal European language on the island from start to present, and even though its presence there (from the 1630s onwards) predates that of Papiamentu (from the 1650s onwards). Most colonial languages in the Caribbean have had a vast, long lasting linguistic impact in their respective colonies, either ‘ producing’ creoles (e. g. English on Jamaica or French on Haiti) or otherwise becoming the main vehicle of communication (e. g. Spanish on Cuba). Not, though, on Curaçao. On this island, the language of all social classes and ethnicities is Papiamentu, a creole with an Iberian lexical base. The present article explores this issue which, in the literature, is also known as the ‘ Curaçao Paradox’., 30% de son vocabulaire est d’origine néerlandaise. Cependant, une question historique et sociolinguistique qui a jusqu’à ce jour été relativement peu ou insuffisamment débatue est pourquoi le néerlandais lui-même ne s’est pas creolisé a Curaçao, ou au moins n’est pas devenu la langue principale de la société locale, quand bien même il a été la langue européenne principale sur l’île du début de son histoire coloniale jusqu’à aujourd’hui (dès les années 160) et sa présence est plus ancienne que celle du papiamentu (attesté dès les années 1650). La plupart des puissances coloniales européennes dans les Caraïbes eu un vaste et durable impact linguistique local, soit en produisant des créoles (e. g. l’anglais en Jamaïque ou le français à Haïti), ou autrement en devenant le principal biais de communication (e. g. l’espagnol à Cuba). Ce ne fut pas le cas à Curaçao. Sur cette île, la langue socialement et ethniquement la plus répandue est le papiamentu, un créole de base lexicale ibérienne. Le présent article tente de répondre à la question (le ‘ Paradoxe de Curaçao’) pourquoi la langue coloniale, le néerlandais, n’a pas été approprié par la population locale, et pourquoi, au lieu de cela, le papiamentu a pu prendre forme, se diffuser et consolider sa position sur l’île., Op Aruba, Bonaire en Curaçao is het Papiaments, een op het Spaans en Portugees gebaseerde creooltaal, de taal van het grootste deel van de bevolking, ongeacht sociale klasse. Maarliefst 30% van de Papiamentse woordenschat is weliswaar aan het Nederlands ontleend, tegelijk moet men zich echter de historische en sociolinguistische vraag stellen hoe het Papiaments zich zo sterk heeft kunnen manifesteren en waarom het Nederlands zelf op Curaçao geen sterkere impact heeft gehad. Het Nederlands was immers de taal van de kolonisatoren en werd op het eiland eerder gesproken (vanaf 1634) dan het Papiaments (vanaf de tweede helft van de 17e eeuw). Bij wijze van contrast : het Engels, Frans en Spaans hebben een veel dieper gaande, langdurigere impact gehad in ‘ hun’ respectievelijke kolonies in het Caribisch gebied, en hetzij in gecreoliseerde vorm (denk maar aan het Jamaican Creole op Jamaica, het Haitian Creole op Haiti) of in onveranderde vorm aan de locale bevolking overge dragen (bv. het Spaans op Cuba). Zo niet op Curaçao. In dit artikel onderzoeken we deze kwestie, die in de literatuur ook wel de ‘ Curaçaosche Paradox’ wordt genoemd., Jacobs Bart. Thoughts on the linguistic history of Curaçao: how Papiamentu got the better of Dutch. In: Revue belge de philologie et d'histoire, tome 91, fasc. 3, 2013. Langues et littératures modernes Moderne taal en lettrekunde. pp. 787-806.

Published
2013

25. Climate change and food security: a Sri Lankan perspective

Author

Esham, M, Jacobs, B, Rosairo, HSR, and Siddighi, BB

Subjects
Ecology
Abstract

© 2017, Springer Science+Business Media Dordrecht. There is growing concern in Sri Lanka over the impact of climate change, variability and extreme weather events on food production, food security and livelihoods. The link between climate change and food security has been mostly explored in relation to impacts on crop production or food availability aspects of food security, with little focus on other key dimensions, namely food access and food utilization. This review, based on available literature, adopted a food system approach to gain a wider perspective on food security issues in Sri Lanka. It points to several climate-induced issues posing challenges for food security. These issues include declining agriculture productivity, food loss along supply chains, low livelihood resilience of the rural poor and prevalence of high levels of undernourishment and child malnutrition. Our review suggests that achieving food security necessitates action beyond building climate resilient food production systems to a holistic approach that is able to ensure climate resilience of the entire food system while addressing nutritional concerns arising from impacts of climate change. Therefore, there is a pressing need to work towards a climate-smart agriculture system that will address all dimensions of food security. With the exception of productivity of a few crop species, our review demonstrates the dearth of research into climate change impacts on Sri Lanka’s food system. Further research is required to understand how changes in climate may affect other components of the food system including productivity of a wider range of food crops, livestock and fisheries, and shed light on the causal pathways of climate-induced nutritional insecurity.

Published
2018

27. A Type Theory for Probabilistic and Bayesian Reasoning

Author

Adams, R., Jacobs, B., Uustalu, T., and Uustalu, T.

Subjects
FOS: Computer and information sciences, Computer Science - Logic in Computer Science, 000 Computer science, knowledge, general works, Probability (math.PR), G.3, F.4.1, F.3.1, Mathematics - Logic, Logic in Computer Science (cs.LO), Computer Science::Logic in Computer Science, Computer Science, FOS: Mathematics, Digital Security, Logic (math.LO), GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Mathematics - Probability
Abstract

This paper introduces a novel type theory and logic for probabilistic reasoning. Its logic is quantitative, with fuzzy predicates. It includes normalisation and conditioning of states. This conditioning uses a key aspect that distinguishes our probabilistic type theory from quantum type theory, namely the bijective correspondence between predicates and side-effect free actions (called instrument, or assert, maps). The paper shows how suitable computation rules can be derived from this predicate-action correspondence, and uses these rules for calculating conditional probabilities in two well-known examples of Bayesian reasoning in (graphical) models. Our type theory may thus form the basis for a mechanisation of Bayesian inference., Comment: 38 pages

Published
2018

28. Een blockchain aan je been

Author

Jacobs, B.

Subjects
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Published
2018

32. Een blockchain aan je been

Author

Jacobs, B.

Subjects
Digital Security
Abstract

Contains fulltext : 191713.pdf (Publisher’s version ) (Open Access)

Published
2018

33. An Effect-theoretic Account of Lebesgue Integration

Author

Jacobs, B., Westerbaan, B.E., Ghica, D.R., and Ghica, D.R.

Subjects
Dominated convergence theorem, Discrete mathematics, Electronic Notes in Theoretical Computer Science, General Computer Science, Measurable function, Effect algebra, Lebesgue integration, Riemann integral, Lebesgue–Stieltjes integration, Theoretical Computer Science, symbols.namesake, effect module, Sigma-algebra, Universally measurable set, Simple function, symbols, Digital Security, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Computer Science(all), Mathematics
Abstract

Effect algebras have been introduced in the 1990s in the study of the foundations of quantum mechanics, as part of a quantum-theoretic version of probability theory. This paper is part of that programme and gives a systematic account of Lebesgue integration for [0,1]-valued functions in terms of effect algebras and effect modules. The starting point is the 'indicator' function for a measurable subset. It gives a homomorphism from the effect algebra of measurable subsets to the effect module of [0,1]-valued measurable functions which preserves countable joins.It is shown that the indicator is free among these maps: any such homomorphism from the effect algebra of measurable subsets can be thought of as a generalised probability measure and can be extended uniquely to a homomorphism from the effect module of [0,1]-valued measurable functions which preserves joins of countable chains. The extension is the Lebesgue integral associated to this probability measure. The preservation of joins by it is the monotone convergence theorem.

Published
2015

34. Towards Phosphorus and Climate Smart Agriculture in Sri Lanka

Author

Cordell, DJ, Dominish, E, Esham, M, and Jacobs, B

Abstract

Two of the biggest global challenges for food security – phosphorus scarcity and climate change – are threatening farmers’ livelihoods, agricultural productivity and environmental health. Sri Lanka’s agricultural sector is comprised largely of smallholder farmers, where rainfed rice is often a staple of the diet. Climate change projections indicate rice yields could drop by 40%, affecting the majority of farmers and increasing poverty levels by up to a third. At the same time, fertiliser subsidies, which represent 2% of government spending, are currently being scaled back in a country that is dependent on fertiliser imports. This exposes farmers to future price fluctuations like the 800% phosphate fertiliser price spike that occurred in 2008. The goal of this collaborative research project is to contribute to building food system resilience to climate change and phosphorus scarcity in Sri Lanka, through adaptations from farm-scale through to policy-making. This report presents the first phase of the project investigating the capacity of smallholder farmers, policy-makers, industry and other food system stakeholders in Sri Lanka to adapt to these twin challenges, via a participatory, integrated, rapid vulnerability assessment framework.

Published
2017

35. Social network analysis: a primer on engaging communities on climate adaptation in New South Wales, Australia

Author

Cunningham, R, Jacobs, B, Measham, T, Harman, MP, and Cvitanovic, C

Abstract

A network is a group or system of interconnected people or things. Social networks connect people. Those connections provide advantages to members of the network through access to private information, diverse skills and power, which makes the understanding of networks important for the formulation and communication of policy. The Adaptive Communities Node used a network analysis methodology to understand the formal and informal knowledge channels that communicate climate change adaptation policy throughout regional communities (Harman et al, 2016; Harman et al 2015a; Harman et al 2015b). The results of case studies in these communities (centred on Shoalhaven, Bega and Orange) have been published through the UTS:ISF NSW Adaptation Research Hub (https://www.uts.edu.au/research-and-teaching/our-research/institute-sustainable-futures/our-research/climate-change/nsw). This primer serves as a companion document to those reports.

Published
2017

36. Statistical Analysis of Lumen Depreciation for LED Packages

Author

Schuld, M., van Driel, W.D., Jacobs, B., van Driel, Willem Dirk, Fan, Xuejun, and Zhang, Guo Qi

Subjects
LED degradation, Risk analysis (engineering), Computer science, Statistics, Warranty, Lumen maintenance, Statistical analysis, LM-80 data extrapolation, Acceleration model, Lumen (unit)
Abstract

Commercial claims for LED-based products in terms of lumen maintenance are fully based on TM-21 extrapolations using LM-80 data. This chapter indicates that there may be a risk in doing this as TM-21 only relies on the behavior of the average LED degradation, instead of taking into account the degradation of all individual LEDs. Therefore, we propose a more profound statistical approach in order to make the appropriate step from TM-21 extrapolation to lumen maintenance on a product level. This is needed as some commercial claims are based on 10 years of warranty and some service bids provide periods of 20–25 years of operation. This chapter reviews the different approaches currently available to perform lumen maintenance extrapolations.

Published
2017

38. Medical privacy

Author

Jacobs, B.

Subjects
Digital Security
Abstract

Item does not contain fulltext Radboud Grand Round - 58, 18 september 2017

Published
2017

40. Kijk uit, nepnieuws!

Author

Becker, M.J. and Jacobs, B.

Subjects
Digital Security, Center for Contemporary European Philosophy (CCEP)
Abstract

Item does not contain fulltext 14 januari 2017

Published
2017

41. Vertrouwen en Authenticatie

Author

Jacobs, B., Bartels, S., Jansen, C., Schuijling, B., Vermunt, N., Bartels, S., Jansen, C., Schuijling, B., and Vermunt, N.

Subjects
Digital Security, Serie Onderneming en Recht
Abstract

Contains fulltext : 181664.pdf (Publisher’s version ) (Open Access)

Published
2017

42. Introduction to Coalgebra

Author

Jacobs, B.

Subjects
Cambridge Tracts in Theoretical Computer Science, Digital Security
Abstract

The area of coalgebra has emerged within theoretical computer science with a unifying claim: to be the mathematics of computational dynamics. It combines ideas from the theory of dynamical systems and from the theory of state-based computation. Although still in its infancy, it is an active area of research that generates wide interest. Written by one of the founders of the field, this book acts as the first mature and accessible introduction to coalgebra. It provides clear mathematical explanations, with many examples and exercises involving deterministic and non-deterministic automata, transition systems, streams, Markov chains and weighted automata. The theory is expressed in the language of category theory, which provides the right abstraction to make the similarity and duality between algebra and coalgebra explicit, and which the reader is introduced to in a hands-on manner. The book will be useful to mathematicians and (theoretical) computer scientists and will also be of interest to mathematical physicists, biologists and economists.

Published
2016

43. Planning tools for strategic management of peri-urban food production

Author

Wynne, L, Cordell, D, Chong, J, and Jacobs, B

Abstract

Using Sydney as a case study, this report aims to develop an understanding of what best practice looks for land-use planning on the urban fringe. Peri-urban areas around the world have traditionally been the food bowls of our cities. Increasing urbanisation is threatening the existence of peri-urban agriculture, paving over the soils that have fed global city populations. Increasing conversion to commercial and residential uses, fragmentation, land-use conflicts and global challenges such as climate change pose a threat to the viability of food production in peri-urban areas. This report considers responses that might emerge from the planning system to address threats to peri-urban agriculture. The report focuses on the experience of peri-urban planning and food production in the Sydney Basin, in New South Wales, Australia The report reviews a range of planning responses to managing peri-urban areas for resilience and sustainability. These include strategic planning measures, financial incentives, property rights protections and improved methods for valuing the benefits that peri-urban agriculture provides to cities. For many cities, perhaps including Sydney, a large proportion of peri-urban food production has already been lost, converted to residential use and supporting infrastructure. For that which remains, and for those cities that have sustainably managed their peri-urban agricultural lands, policy and initiatives are required to ensure that food production on the urban fringe can continue to contribute to urban resilience in the future.

Published
2016

45. Relating operator spaces via adjunctions

Author

Jacobs, B., Mandemaker, J.J., Chubb, J., Eskandarian, A., Harizanov, V., Chubb, J., Eskandarian, A., and Harizanov, V.

Subjects
Functor, Computer science, Algebraic structure, Hilbert space, Lecture Notes in Logic, Monad (functional programming), Adjunction, Algebra, symbols.namesake, Operator (computer programming), Mathematics::Category Theory, Bounded function, symbols, Digital Security, Category theory
Abstract

This chapter uses categorical techniques to describe relations between various sets of operators on a Hilbert space, such as self-adjoint, positive, density, effect and projection operators. These relations, including various Hilbert-Schmidt isomorphisms of the formtr( A −), are expressed in terms of dual adjunctions, and maps between them. Of particular interest is the connection with quantum structures, via a dual adjunction between convex sets and effect modules. The approach systematically uses categories of modules, via their description as Eilenberg-Moore algebras of a monad. Introduction. There is a recent exciting line of work connecting research in the semantics of programming languages and logic, and research in the foundations of quantum physics, including quantum computation and logic, see [9] for an overview. This paper fits in that line of work. It concentrates on operators (on Hilbert spaces) and organises and relates these operators according to their algebraic structure. This is to a large extent not more than a systematic presentation of known results and connections in the (modern) language of category theory. However, the approach leads to clarifying results, like Theorem 14 that relates density operators and effects via a dual adjunction between convex sets and effect modules (extending earlier work [25]). It is in line with many other dual adjunctions and dualities that are relevant in programming logics [31, 1, 30]. Indeed, via this dual adjunction we can put the work [11] on quantum weakest preconditions in perspective (see especially Remark 15). The article begins by describing the familiar sets of operators (bounded, selfadjoint, positive) on a (finite-dimensional) Hilbert space in terms of functors to categories of modules. The dual adjunctions involved are made explicit, basically via dual operation V ⟼ V ∗ , see Section 2. Since the algebraic structure of these sets of operators is described in terms of modules over various semirings, namely over complex numbers C (for bounded operators), over real numbers R (for self-adjoint operators), and over non-negative real numbers R ≥0 (for positive operators), it is useful to have a uniform description of such modules. It is provided in Section 3, via the notion of algebra of a monad (namely the multiset monad).

Published
2016

48. The Fall of a Tiny Star

Author

Garcia, F. D., Jacobs, B., Ryan, A.P.Y., Naccache, D., Quisquater, J.-J., Ryan, A.P.Y., Naccache, D., and Quisquater, J.-J.

Subjects
Engineering, business.industry, Star (game theory), Lecture notes in computer science, Academic freedom, Access control, Computer security, computer.software_genre, Publishing, Public transport, Smart card, Digital Security, Fall of man, business, computer, Contactless smart card
Abstract

This short paper gives a combined technical-historical account of the fate of the world's most-used contactless smart card, the MIFARE Classic. The account concentrates on the years 2008 and 2009 when serious security flaws in the MIFARE Classic were unveiled. The story covers, besides the relevant technicalities, the risks of proprietary security mechanisms, the rights and morals wrt. publishing security vulnerabilities, and eventually the legal confrontation in court.

Published
2016

49. Healthiness from Duality

Author

Hino, W., Kobayashi, H., Hasuo, I., Jacobs, B., Koskinen, E., and Koskinen, E.

Subjects
Discrete mathematics, FOS: Computer and information sciences, Computer Science - Logic in Computer Science, 010102 general mathematics, Probabilistic logic, 0102 computer and information sciences, Adjunction, 01 natural sciences, Logic in Computer Science (cs.LO), Algebra, Nondeterministic algorithm, 010201 computation theory & mathematics, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, 0101 mathematics, Algebraic number, Digital Security, Category theory, Dijkstra's algorithm, Categorical variable, Mathematics, Program logic
Abstract

Healthiness is a good old question in program logics that dates back to Dijkstra. It asks for an intrinsic characterization of those predicate transformers which arise as the (backward) interpretation of a certain class of programs. There are several results known for healthiness conditions: for deterministic programs, nondeterministic ones, probabilistic ones, etc. Building upon our previous works on so-called state-and-effect triangles, we contribute a unified categorical framework for investigating healthiness conditions. We find the framework to be centered around a dual adjunction induced by a dualizing object, together with our notion of relative Eilenberg-Moore algebra playing fundamental roles too. The latter notion seems interesting in its own right in the context of monads, Lawvere theories and enriched categories., Comment: 13 pages, Extended version with appendices of a paper accepted to LICS 2016

Published
2016
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