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The multi-decision support model is developed and demontrated to minimise the cost of transport and treatment of municipal solid waste under the effected of socio and environment. The tool is simple, easy to upgrade to fit with the local condition, easy and fast running (some minutes). The model is used to compare the operation of MSW system if there are some changes in impact factors. The results of model show: (1) the distribution of amount of MSW from sources to treatment plants, (2) the selected treatment technologies, its capacity and location, (3) cost analysis of transport, treatment of MSW and the income. In the current situation of HCMC (case study 2), the model proposed 2 treatment tecnologies in 20 years planning, called bath anaerobic digestion technology and bioreactor landfill, with the treatment amount of 70% and 30%, respectively. In case of the planned land for treatment zone is not reached as case study 2, incineration technology will be a good choice.