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Advancement in industrialization and urbanization has caused an influx of contaminants into the environment polluting the soil, water, and air. These contaminants come in various forms and structures, including heavy metals, petroleum hydrocarbons, industrial dyes, pharmaceutically active compounds, pesticides, and many other toxic chemicals. The presence of these pollutants in the environment poses a serious threat to living things, including humans. Various conventional methods have been developed to tackle this menace, though effective, are however not safe for the ecosystem. Interestingly, bioremediation has offered a cheap, effective, and environmentally safe method for the removal of recalcitrant pollutants from the environment. White-rot fungi (WRF), belonging to the basidiomycetes, have shown class and proven to be an excellent tool in the bioremediation of the most difficult organic pollutants in the form of lignin. White-rot fungi possess extracellular lignin modified enzymes (LMEs) made up of laccases (Lac), manganese peroxidase (MnP), lignin peroxidase (LiP), and versatile peroxidase (VP) that are not specific to a particular substrate, causes opening of aromatic rings and cleavage of bonds through oxidation and reduction among many other pathways. The physiology of WRF, non specificity of LMEs coupled with varying intracellular enzymes such as cytochrome P450 removes pollutants through biodegradation, biosorption, bioaccumulation, biomineralization, and biotransformation, among many other mechanisms. The application of WRF on a laboratory and pilot scale has provided positive outcomes; however, there are a couple of limitations encountered when applied in the field, which can be overcome through improvement in the genome of promising strains.&nbsp

Background: Invasive candidiasis has been recognized as a major cause of mortality and morbidity in hospital settings across the globe. Aside from C. albicans, other Candida species (C. glabarata, C. parapsilosis, and C. tropicalis) associated with invasive candidiasis have been reported as a public health challenge. Objective: This study aimed to evaluate the antifungal activities of extracts of some indigenous plants using the agar disc diffusion method. Methods: Fresh samples of the plant parts were collected, identified, air dried, pulverized and extracted using standard methods. The extracts were screened against clinical isolates of C. albicans, C. glabarata, C. parapsilosis and C. tropicalis using agar disc diffusion method. Results: All plant extracts exhibited varying inhibition zones ranging from 8.0 - 24.0 mm against the tested isolates. Fractions of Acalypha wilkesiana Macrophylla (AWRF5) showed the lowest activities against all the test isolates with zones of inhibition ranging from 10.0-13.0 mm while AWRF6 fraction of the same plant demonstrated highest antifungal activities against all the test isolates with zones of inhibition ranging from 14.0-24 mm followed by fractions of Acalypha wilkesiana Hoffmanii (AWGF6), which demonstrated high (14.0 - 20.0 mm) antifungal activities. Conclusion: The Plants understudied possessed antifungal potentials and can serve as lead in the development of phytomedicines to combat candidiasis decrease medical as well as financial burden, hence improving the management of cirrhotic patients. These predictors, however, need further work to validate reliability.