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Existing data demonstrate reduced delta power during sleep in patients with depression and chronic pain. However, there has been little examination of the relationship between delta power and pain-reports, or pain-catastrophizing. We recruited female participants (n = 111) with insomnia and temporomandibular disorder, and measured nocturnal and daytime measures of pain and pain catastrophizing, and calculated relative nocturnal delta (0.5-4 Hz) power during sleep. We fit linear regression models, and further examined the moderating effect of depressive symptom severity. Lower relative delta power across the whole night was significantly associated with greater nocturnal pain (B = -20.276, P = .025, R

Introduction Existing data demonstrate reduced delta power during sleep in chronic pain and depressed patients. However, there has been little examination of the relationship between delta power and next-day reports of pain. We tested the extent to which nocturnal (during the concurrent sleep period) and daytime pain reports are associated with delta power during sleep, as well as the extent to which this association is moderated by depressive symptoms. We hypothesised that reduced delta power and SWS would be associated with increased pain, pain catastrophising, and pain sensitivity. Methods 149 female participants with insomnia and temporomandibular joint pain (TMD) were recruited. We examined nocturnal and daytime measures of pain (pain severity, average pain), pain catastrophizing, and objective pain sensitivity (obtained through quantitative sensory testing (QST)), and calculated relative nocturnal delta (0.5-3.4 Hz) power using polysomnography. We fit linear regression models correcting for depressive symptom severity, age, and total sleep time, and further examined the moderating effect of depression severity on these measures. Results reduced delta power was associated with increased average nocturnal pain (Unstandardized β = -17.67, p= 0.02), morning pain (Unstandardized β = -15.67, p=0.02), and average next-day pain (Unstandardized β = -16.74, p= 0.03). Depression severity did not moderate these relationships. Delta power was not significantly associated with objective pain-sensitivity, nocturnal, or daytime pain catastrophising. However the association between nocturnal pain catastrophising and delta power was moderated by depressive symptom severity (p = 0.04). Simple slopes analysis revealed that when participants had low depressive symptoms ( Discussion These findings demonstrate that delta power during sleep is associated with both nocturnal and daytime experience of pain in patients with TMD. In patients with TMD and low depressive symptoms, reduced delta power was associated with increased nocturnal pain catastrophising.

Introduction There is an established link between tinnitus (an auditory symptom affecting sound in the ear or head, in the absence of auditory stimulus) and depression in adults. However, there is a lack of research into the effect of tinnitus on sleep architecture in this depression. Methods Female participants (n=149) with sleep disturbance and temporomandibular joint (TMJD) pain were recruited as part of a treatment trial. Data were used to identify a cohort of participants with clinically significant depressive symptoms (CES-D >16), with and without tinnitus. We examined the pre-randomization polysomnography (PSG) dataset, and calculated sleep architecture, and relative spectral power (Alpha, beta, theta, delta). We compared cohorts using independent t-tests, testing for differences in architectural and spectral sleep parameters, controlling for anxiety symptoms. Results 14 females (mean age = 41.76) reporting current tinnitus were age and depression severity matched with 14 females reporting no tinnitus (mean age = 41.27). Groups did not differ significantly in age (p = 0.91), BMI (p = 0.868), race (p = 0.328) or severity of depressive symptoms (CES-D: 23.93 No tinnitus vs 25.07 Tinnitus, p = 0.540), but the tinnitus group reported significantly higher anxiety (GAD-7: 9.43 no tinnitus vs 13.36 Tinnitus, p = 0.016). Data indicated TMJD patients with tinnitus had greater N2 sleep percentage (24.243% no tinnitus vs 57.200% Tinnitus, p = 0.033) compared with controls. There were no significant differences in N1% (4.2% No tinnitus vs 3.7% Tinnitus, p = 0.874), SWS% (23.164% No tinnitus vs 17.236% Tinnitus, p = 0.217) or REM% (26.386% No Tinnitus vs 21.88% Tinnitus, p = 0.238) between groups. Analysis of spectral data showed no significant differences in relative alpha (0.129 No tinnitus, 0.143 Tinnitus, p = 0.099), beta (0.186 No tinnitus vs 0.188 Tinnitus, p = 0.814), theta (0.123 No Tinnitus vs 0.125 Tinnitus, p = 0.069), or delta power (0.360 Tinnitus vs 0.346 Tinnitus, p = 0.399). Conclusion Our results indicate an association between tinnitus and increased N2% in TMJD participants reporting sleep disturbance and depressive symptoms. The effect of tinnitus on objective sleep parameters, in the context of depressive symptoms warrants further study. Support (If Any) This research study was supported financially by the NIH Grant R01 DE019731 (Haythornthwaite, JA and Smith, MT).[MR1] [MR1]Don’t include this in the main body, it’ll use too many words. If there’s a section on the submission portal to include this, add it. If not can just put the grant reference (as one word) in brackets after “treatment trial”

Systematic reviews should provide trustworthy guidance to decision-makers, but their credibility is challenged by the selective reporting of trial results and outcomes. Some trials are not published, and even among clinical trials that are published partially (e.g., as conference abstracts), many are never published in full. Although there are many potential sources of published and unpublished data for systematic reviews, there are no established methods for choosing among multiple reports or data sources about the same trial.We will conduct systematic reviews of the effectiveness and safety of two interventions following the Institute of Medicine (IOM) guidelines: (1) gabapentin for neuropathic pain and (2) quetiapine for bipolar depression. For the review of gabapentin, we will include adult participants with neuropathic pain who do not require ventilator support. For the review of quetiapine, we will include adult participants with acute bipolar depression (excluding mixed or rapid cycling episodes). We will compare these drugs (used alone or in combination with other interventions) with placebo or with the same intervention alone; direct comparisons with other medications will be excluded. For each review, we will conduct highly sensitive electronic searches, and the results of the searches will be assessed by two independent reviewers. Outcomes, study characteristics, and risk of bias ratings will be extracted from multiple reports by two individuals working independently, stored in a publicly available database (Systematic Review Data Repository) and analyzed using commonly available statistical software. In each review, we will conduct a series of meta-analyses using data from different sources to determine how the results are affected by the inclusion of data from multiple published sources (e.g., journal articles and conference abstracts) as well as unpublished aggregate data (e.g., "clinical study reports") and individual participant data (IPD). We will identify patient-centered outcomes in each report and identify differences in the reporting of these outcomes across sources.CRD42015014037 , CRD42015014038.

This study sought to identify reliable subgroups of patients with chronic pain based on profiles of subscale scores on the Pain Stages of Change Questionnaire (PSOCQ), a reliable and valid measure of individuals' readiness to adopt a self-management approach to chronic pain. The PSOCQ was administered to 633 people seeking treatment for chronic pain. Participants were predominantly White, averaged 48 years of age, about half were men, and about half reported back pain as the primary complaint. In a first study, cluster analysis was applied to 250 respondents. Five clusters were identified and named Precontemplation (11.0% of the sample), Contemplation (18.0%), Noncontemplative Action (12.4%), Participation (25%), and Ambivalent (33.6%). Results of a discriminant function analysis (DFA) on this sample, using the solution from the cluster analysis yielded a total error rate of 0.036. In a second study, the results of the first DFA were applied to an independent sample of 383 respondents in order to cross validate the solution from the first study. Cluster assignment proportions were very similar to the first sample and the posterior probability error rate for the second DFA was 13%. As predicted, clusters did not differ on measures of pain, disability, or demographics. Moreover, clusters differed significantly in theoretically consistent directions by scores on the Survey of Pain Attitudes, thus demonstrating criterion related validity for the clusters. Future research should examine the utility of PSOCQ profiles, relative to individual PSOCQ scale scores alone, in predicting response to self-management treatment approaches.

Adults with sickle cell disease (SCD) report experiencing discriminatory behavior from some healthcare providers. The impact of discrimination on health outcomes in SCD, including adherence to physician recommendations, is not known.Our aim was to evaluate the association between perceived discrimination from healthcare providers and nonadherence to physician recommendations among persons with SCD, and to test the potentially mediating role of patient trust.Patients with SCD (age 15 years and older) participating in the Improving Patient Outcomes with Respect and Trust (IMPORT) Study.Perceived discrimination from healthcare providers and reported adherence to physician recommendations were assessed by patient self-report using items from the 2001 Commonwealth Fund Health Survey. Interpersonal trust in medical professionals was assessed using the short form of the Wake Forest Trust in Medical Professionals instrument.We used a cross-sectional analysis of IMPORT participant data. Multivariable Poisson regression models were used to test the independent association of discrimination with adherence and to test patient trust as a potential mediator.Among 273 SCD patients with complete data on all variables of interest, patients reporting experiences of discrimination in the healthcare system were 53% more likely to also report being nonadherent to physician recommendations. Trust in medical professionals appeared to mediate the discrimination/nonadherence relationship, accounting for 50% of the excess prevalence of nonadherence among those experiencing discrimination.SCD patient perceptions of discriminatory experiences from healthcare providers are associated with greater nonadherence to physician recommendations, and may be a potential factor contributing to disparities in health and health quality among this patient population. Perceived discrimination appears to affect adherence behaviors through the pathway of patient trust. Improving relationships between healthcare providers and SCD patients may improve the trust that SCD patients have in medical professionals, which in turn may improve other outcomes among this underserved patient population.

J. W. Brehm and his associates ( J. W. Brehm, R. A. Wright, S. Solomon, L. Silka, & J. Greenberg, 1983 , Journal of Experimental Social Psychology, 19, 21–48) recently argued that the magnitude of goal valence (the attractiveness or unattractiveness of a potential outcome) varies directly with motivational arousal level. Motivational arousal, in turn, is thought to be a function of the perceived difficulty of goal attainment. This formulation was tested in the present study by examining the relationship between goal attractiveness ratings and performance on an anagram task. According to the Yerkes-Dodson law ( R. M. Yerkes & J. D. Dodson, 1908 , Journal of Comparative Neurological Psychology, 18, 459–482), the relationship between motivational arousal and performance should be curvilinear; optimal performance is usually observed for moderate levels of motivation relative to either low or very high motivation levels. Consistent with the Brehm et al. hypothesis, optimum performance in the present study was observed for subjects who reported moderate levels of goal attractiveness relative to subjects who reported either low or high levels of goal attractiveness. Anticipatory ratings of the difficulty of the anagrams were also congruent with the Brehm et al. model. These findings converge with data from other studies supporting the utility of goal attractiveness as an index of motivational arousal and provide an additional dimension of support for the model proposed by Brehm et al.

The purpose of this study was to examine the relative contributions of sets of descriptive, organic, and psychosocial variables to a prediction of nocturnal penile rigidity among a group of men presenting with significant erectile dysfunction. Seventy veterans referred for evaluation of their erectile dysfunction completed several standardized questionnaires and two nights of nocturnal penile rigidity monitoring (NPRM) using the snap gauge technique. Results suggest that each set of variables uniquely contributes to a prediction of NPRM. Findings support the view that a biopsychosocial approach should be used in the evaluation and treatment of erectile dysfunction.