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BACKGROUND: Coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) are the main treatment methods for left main artery disease (LMAD) and triple-vessel coronary artery disease (TVCAD). OBJECTIVE: This study aimed to evaluate the five-year post-treatment effects of CABG and PCI in patients with severe coronary vasculopathy. METHODS: A total of 430 patients with LMAD and/or triple-vessel coronary artery disease from November 2014 to July 2015 were enrolled retrospectively in the affiliated cardiovascular hospital of Shanxi Medical University and divided into the CABG group and PCI group. The living conditions of the patients were obtained through medical records and telephonic follow-ups five years after the surgery date. The independent risk factors for major adverse cardiovascular and cerebrovascular events (MACCE) were analyzed using logistic regression analysis. The effects of the two treatment methods were followed up and evaluated to measure the predictive ability of the Global Risk Classification (GRC) scoring system for MACCE after five years. RESULTS: There were 212 cases in the CABG group and 218 cases in the PCI group. Smoking (P= 0.047), diabetes (P= 0.031), LVEF (P= 0.020), LMAD (P= 0.008), and anterior descending branch lesions (P= 0.038) were significantly correlated with MACCE. The prevalence of MACCE in the CABG group and PCI group had no significant difference (P= 0.549). The GRC scoring system received an AUC of 0.701 for predicting MACCE. CONCLUSION: For patients with severe coronary artery disease, there was no significant difference in the prevalence of MACCE between the CABG and the PCI groups. Several independent risk factors for MACCE were found. The GRC scoring system showed a strong predictive ability for MACCE after five years of revascularization.

The hepatitis B virus (HBV) is one of the major viral infection problems worldwide in public health. The exclusive proprietary Chinese medicine Ganweikang (GWK) tablet has been marketed for years in the treatment of chronic hepatitis B (CHB). However, the pharmacodynamic material basis and underlying mechanism of GWK are not completely clear. This study is aimed at investigating the pharmacological mechanism of the GWK tablet in the treatment of CHB. The chemical ingredient information was obtained from the Traditional Chinese Medicine Database and Analysis Platform (TCMSP), Traditional Chinese Medicines Integrated Database (TCMID), and Shanghai Institute of Organic Chemistry of CAS. Ingredients and disease-related targets were defined by a combination of differentially expressed genes from CHB transcriptome data and open-source databases. Target-pathway-target (TPT) network analysis, molecular docking, and chemical composition analysis were adopted to further verify the key targets and corresponding active ingredients of GWK. Eight herbs of GWK were correlated to 330 compounds with positive oral bioavailability, and 199 correlated targets were identified. The TPT network was constructed based on the 146 enriched targets by KEGG pathway analysis, significantly associated with 95 pathways. Twenty-five nonvolatile components and 25 volatile components in GWK were identified in UPLC-QTOF/MS and GC-MS chromatograms. The key active ingredients of GWK include ferulic acid, oleanolic acid, ursolic acid, tormentic acid, 11-deoxyglycyrrhetic acid, dibenzoyl methane, anisaldehyde, wogonin, protocatechuic acid, psoralen, caffeate, dimethylcaffeic acid, vanillin, β-amyrenyl acetate, formonentin, aristololactam IIIa, and 7-methoxy-2-methyl isoflavone, associated with targets CA2, NFKB1, RELA, AKT1, JUN, CA1, CA6, IKBKG, FOS, EP300, CREB1, STAT1, MMP9, CDK2, ABCB1, and ABCG2.

Luminescent cuprous complexes are an important class of coordination compounds due to their relative abundance, low cost and ability to display excellent luminescence. The title heteroleptic cuprous complex, [2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl-κ2 P,P′](2-phenylpyridine-κN)copper(I) hexafluoridophosphate, rac-[Cu(C44H32P2)(C11H9N)]PF6, conventionally abbreviated rac-[Cu(BINAP)(2-PhPy)]PF6 (I), where BINAP and 2-PhPy represent 2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl and 2-phenylpyridine, respectively, is described. In this complex, the asymmetric unit consists of a hexafluoridophosphate anion and a heteroleptic cuprous complex cation, in which the cuprous centre in a CuP2N coordination triangle is coordinated by two P atoms from the BINAP ligand and by one N atom from the 2-PhPy ligand. Time-dependent density functional theory (TD–DFT) calculations show that the UV–Vis absorption of I should be attributed to ligand-to-ligand charge transfer (LLCT) characteristic excited states. It was also found that the paper-based film of this complex exhibited obvious luminescence light-up sensing for pyridine.

The electrical microenvironment plays an important role in bone repair. However, the underlying mechanism by which electrical stimulation (ES) promotes bone regeneration remains unclear, limiting the design of bone microenvironment-specific electroactive materials. Herein, by simple co-incubation in aqueous suspensions at physiological temperatures, biocompatible regenerated silk fibroin (RSF) is found to assemble into nanofibrils with a β-sheet structure on MXene nanosheets, which has been reported to inhibit the restacking and oxidation of MXene. An electroactive hydrogel based on RSF and bioencapsulated MXene is thus prepared to promote efficient bone regeneration. This MXene/RSF hydrogel also acts as a piezoresistive pressure transducer, which can potentially be utilized to monitor the electrophysiological microenvironment. RNA sequencing is performed to explore the underlying mechanisms, which can activate Ca

Исследуется дискретная иерархия КП с ограничениями двух типов, а именно с условием на тау-функцию и условием на калибровочное преобразование. Для этой иерархии показана эквивалентность условия $(L^k)_{

Aeschynanthus smaragdinus F.Wen & J.Q.Qin, a new species of Gesneriaceae from the monsoon rain forest in Mangbang township, Tengchong City, Yunnan Province, China, is described and illustrated here. It morphologically resembles A. chiritoides C.B.Clarke in size, shape and hairs on the leaf blades. But it can easily be distinguished from the latter by the green corolla limb with brownish-red to maroon lower lobes. At the same time, the hairs of the pedicel and calyx lobes, the length of the staminode and the size of the seed grain can also help distinguish both. It is provisionally assessed as Data Deficient (DD), according to the IUCN Red List Categories and Criteria, because field surveys for this new taxon have not been completed.

The trawler winch is a main winching tool in the fishing operation of trawler. The disturbing influence of various factors such as sea wind and waves, change in the size of the catch and the turning of the fishing vessel during the operation of the trawler will cause unbalanced force on the wire rope of the two winches, which will easily cause the deformation and damage of the fishing net facilities and directly affect the improvement of the fishing yield and increase the harvest. In order to compensate for the change of the tension of the winch tractor during the operation of the trawler, the change of the load tension caused by the wave, or the rotation direction of the fishing vessel, and to ensure the good shape of the net opening, an electro-hydraulic control technology was used to design an automatic trawler tension controller. The tension control method of the trawler is investigated. The tension sensor is used as the input information of the electrical signal of the trawler's left and right trawler, which is measured indirectly and transmitted to the controller for logical operation, and the output torque of the hydraulic motor is changed by controlling the pilot overflow, which drives the trawler winch to adjust the tension of the left and right trawler to achieve the dynamic balance of the control system. In order to solve the problem of the tension of the trawl and the influence of the length change on the trawl, we designed an intelligent control system combining PLC control system and hydraulic system and used AMEsim hydraulic simulation software system to model and simulate it, the results show that without PLC control the torque of hydraulic motor 1 is 2387.7NM, the torque of hydraulic motor 9 is 2148.64NM the difference is 239.06 NM uneven force on both sides of the trailing platform, after adding PLC adjustment torque is obviously controlled torque to maintain about 2300NM, within a certain range to play a reliable adjustment effect.

This paper introduces the rapid automatic control module of trawler based on the hydraulic system of ‘Zhejiang fishery scientific research ship No.2’.The hydraulic simulation model of double motor winch system is built in AMESim software, and SIMULINK module in MATLAB software designed closed loop fuzzy PID controller for hydraulic system simulation. through fuzzy PID control technology drives the hydraulic winch to quickly adjust the tension of the traction, maintain the stable balance of the traction force, maintain the optimization of network horizontal expansion, not only improve the fishing efficiency, but also timely and effective protection mesh. the technical achievements formed by the research will enable small and medium-sized trawlers to adjust the tension under various working conditions through the fuzzy PID control system to stabilize the opening shape of the trawl, so as to improve the automation level and fishing efficiency of related trawling equipment, and provide technical support for precision fishing.

Even though various studies have been conducted to investigate the relationship between trace metals and sleep, few epidemiological studies have evaluated the relationship between trace metals and sleep disorders in American adults.This study intended to evaluate the associations of serum zinc (Zn), copper (Cu), selenium (Se), Zn/Cu, Zn/Se, and Cu/Se ratios with sleep disorders in American adults.We conducted a cross-sectional analysis of 3660 adults aged ≥18 years old who participated in the National Health and Nutrition Examination Survey (NHANES) 2011-2016. Binary logistic regression was employed to calculate the odds ratio (OR) and 95 % confidence interval (CI) of either serum trace metals or serum trace metals ratios with risks among sleep disorder phenotypes. The restricted cubic spline (RCS) model was additionally utilized to check the dose-response relationships between serum trace metals, serum trace metals ratios, and sleep disorders.Logistic regression demonstrated that higher serum Zn (OR: 0.70, 95 % CI: 0.51-0.97, p = 0.035), Zn/Cu (OR: 0.62, 95 % CI: 0.45-0.87, p = 0.007), and Zn/Se (OR: 0.68, 95 % CI: 0.49-0.95, p = 0.025) were related to a decreased likelihood of self-reported sleep disorders, and dose-response relationships were detected by the RCS models, after adjustment for sociodemographic, behavioral, and health characteristics. No associations between serum Cu, Se, Cu/Se, and sleep disorders were observed. The findings in the sensitivity analyses were consistent with these results.Our study revealed that serum Zn, Zn/Cu, and Zn/Se were inversely associated with the risk of self-reported sleep disorders in US adults.

Hydrogen emission lines can provide extensive information about star-forming galaxies in both the local and high-redshift Universe. We present a detailed Lyman continuum (LyC), Lyman-alpha (Ly{\alpha}), and Balmer line (H{\alpha} and H\b{eta}) radiative transfer study of a high-resolution isolated Milky-Way simulation using the Arepo-RT radiation hydrodynamics code with the SMUGGLE galaxy formation model. The realistic framework includes stellar feedback, non-equilibrium thermochemistry, and dust grain evolution in the interstellar medium (ISM). We extend our Cosmic Ly{\alpha} Transfer (COLT) code with photoionization equilibrium Monte Carlo radiative transfer for self-consistent end-to-end (non-)resonant line predictions. Accurate LyC reprocessing to recombination emission requires modelling pre-absorption by dust (27.5%), helium ionization (8.7%), and anisotropic escape fractions (7.9%), as these reduce the available budget for hydrogen line emission (55.9%). We investigate the role of the multiphase dusty ISM, disc geometry, gas kinematics, and star formation activity in governing the physics of emission and escape, focusing on the time variability, gas phase structure, and spatial, spectral, and viewing angle dependence of the emergent photons. Isolated disc simulations are well-suited for comprehensive observational comparisons with local H{\alpha} surveys, but would require a proper cosmological circumgalactic medium (CGM) environment as well as less dust absorption and rotational broadening to serve as analogs for high-redshift Ly{\alpha} emitting galaxies. Future applications of our framework to next-generation cosmological simulations of galaxy formation including radiation-hydrodynamics that resolve, Comment: 28 pages, 32 figures, MNRAS, in press