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Additional file 1. Data on exposure to triadimefon, expressed as concentrations in surface waters including rivers, lakes, reservoirs were collected from literature published in China and abroad and unpublished data from recent monitoring results by the authors (Table S1 and Table S2). Data on half-lives to triadimefon were also collected from literature published in China and abroad (Table S3). Toxicity data for the triadimefon were collected from the ECOTOX Knowledgebase developed by US EPA ( https://cfpub.epa.gov/ecotox/search.cfm ), following the principles of accuracy, relevance and reliability (Table S4). Toxicity data based on various assessment end points sets for triadimefon were tested for normality by use of Anderson���Darling text, HC5 and PNEC were derived by curves fitting (Table S5). Finally, sensitivity distributions base on different end points were compared by use of the two-sample Kolmogorov���Smirnov test, using the SPSS software version 26 (Table S6). ECOTOX Knowledgebase. https://cfpub.epa.gov/ecotox/search.cfm Accessed 20 April 2021.

Additional file 1: Table S1. List of the 140 selected pharmaceuticals and personal care products (PPCPs): chemical .name and CAS. Table S2. Toxicity potencies for target PPCPs in aquatic organisms Table S3. Toxicity values for caffeine, carbamazepine, diethyltoluamide, and sulfamethoxazole in aquatic organisms.