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4 results on '"John Farrel"'

1. List of contributors

Author

Margarida Abrantes, Raquel Alves, Sharath Anugula, Veronica Aran, Lina Badimon, Jorge N. Barreto, Grzegorz Bartosz, Fernanda Borges, Consuelo Borrás, Maria Filomena Botelho, Jean Bousquet, António M.D. Brehm, Gerly A.C. Brito, Daan Bultje, Ana Cristina Cabral, André Caetano, Helena Canhão, Isabel Marques Carreira, Ana Maria Carriazo, Cristina Carvalho, Eugenia Carvalho, Margarida Castel-Branco, Yaohua Chen, João M. Coelho-Filho, Vera Constâncio, António Correia e Silva, Deiziane V.S. Costa, Elísio Costa, Inês Costa, Teresa Cunha-Oliveira, Paulo de Carvalho, Vicenzo De Luca, Edoardo R. de Natale, Jorge Dias, Ronaldo P. Dias, Ana I. Duarte, John Farrel, Fernando Fernandez-Llimos, Lino Ferreira, Luigi Ferrucci, Isabel Vitoria Figueiredo, Jamie K. Ford, Claudio Franceschi, Alex A. Freitas, Maja Furlan de Brito, Karla C. Giacomin, Henrique Girao, Ilias Gkikas, Bárbara Gomes, Rodrigo M. Gomes, Ana Cristina Gonçalves, Peter Goulden, Marcus Grant, Luís F. Grilo, Nick Guldemond, Jorge Henriques, Manoela Heringer, Maddalena Illario, Carmen Jerónimo, John G. Jones, Joana Jorge, Yaschar Kabiri, Agnieszka Karkucinska-Wieckowska, George Kelly, James L. Kirkland, Kristina Kitaeva, Andrey Kiyasov, Viktor I. Korolchuk, Mafalda Laranjo, Thomas J. LaRocca, Marta Lavrador, Magdalena Lebiedzinska-Arciszewska, Zhiquan Li, Yuezhong Liu, Alexandre Lourenço, Lina Ma, João O. Malva, Christopher R. Martens, Cristina Mas-Bargues, Paulo Matafome, Joana Barbosa Melo, Maria L. Lima Mendonça, Athanasios Metaxakis, Lefkos T. Middleton, Paula I. Moreira, Judite M. Nascimento, Vivaldo M. Neto, Paulo J. Oliveira, Alessandro Ori, Reinaldo B. Oriá, Susan E. Ozanne, Miguel Padeiro, Teresa Padro, Carlos M. Palmeira, Yiming Pan, Simão Paredes, João F. Passos, Edith Pereira, Francisco B. Pereira, Susana P. Pereira, Paolo Pinton, Joana F. Pires, Salomé Pires, M. Cristina Polidori, Marios Politis, Nuno Raimundo, João Ramalho-Santos, Lene Juel Rasmussen, Fernando J. Regateiro, Dario D. Reis, Caio Ribeiro, Ilda Patrícia Ribeiro, Teresa M. Ribeiro-Rodrigues, Albert Rizvanov, Teresa Rocha, Susanne Röhr, Anabela P. Rolo, Aurora Román-Domínguez, Roman Romero-Ortuno, Manuel Santos Rosa, Catrin Rutland, Izabela Sadowska-Bartosz, Paula Santana, Deolinda Santinha, Marcos Santos, Ana Bela Sarmento Ribeiro, Deisa S.R.C. Semedo, João Sequeira, Felipe Sierra, Maria Natalina L. Silva, Rafael Solana, Valeriya Solovyeva, Hélder Spínola, Renata S. Tavares, Nektarios Tavernarakis, Tamar Tchkonia, Yin-Leng Theng, Vicente Traver-Salcedo, Chi Udeh-Momoh, Rakhi Verma, Stella Victorelli, Andreia Vilaça, Gemma Vilahur, José Viña, Thomas von Zglinicki, Devin Wahl, Berenice Maria Werle, Mariusz R. Wieckowski, Heather Wilson, Erin O. Wissler Gerdes, Lucyna A. Wozniak, Barbara Zavan, Yi Zhu, and Hans Zischka

Published
2023
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3. Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model

Author

Monique P. Gelderman, Michael Brad Strader, John Farrel, Emily M. A. Lewis, Sandeep N. Shah, Abdu I. Alayash, Jaroslav G. Vostal, and Francine Wood

Subjects
0301 basic medicine, Erythrocytes, Blood transfusion, Physiology, medicine.medical_treatment, Cellular differentiation, CD34, lcsh:Medicine, Antigens, CD34, Mice, SCID, 030204 cardiovascular system & hematology, Pharmacology, Biochemistry, Mice, 0302 clinical medicine, Animal Cells, Red Blood Cells, Medicine and Health Sciences, lcsh:Science, Cells, Cultured, Multidisciplinary, Cell Differentiation, Animal Models, Hematology, Fetal Blood, Clinical Laboratory Sciences, Body Fluids, Chemistry, Blood, Cord blood, Physical Sciences, Cellular Types, Anatomy, Stem cell, Research Article, Chemical Elements, Cell Physiology, Mouse Models, Biology, Research and Analysis Methods, 03 medical and health sciences, Model Organisms, Diagnostic Medicine, In vivo, medicine, Animals, Humans, Blood Transfusion, Hemoglobin, Blood Cells, Transfusion Medicine, Cell Enucleation, lcsh:R, Biology and Life Sciences, Proteins, Mesenchymal Stem Cells, Cell Biology, Oxygen, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, lcsh:Q, Ex vivo, Developmental Biology
Abstract

Reliance on volunteer blood donors can lead to transfusion product shortages, and current liquid storage of red blood cells (RBCs) is associated with biochemical changes over time, known as 'the storage lesion'. Thus, there is a need for alternative sources of transfusable RBCs to supplement conventional blood donations. Extracorporeal production of stem cell-derived RBCs (stemRBCs) is a potential and yet untapped source of fresh, transfusable RBCs. A number of groups have attempted RBC differentiation from CD34+ cells. However, it is still unclear whether these stemRBCs could eventually be effective substitutes for traditional RBCs due to potential differences in oxygen carrying capacity, viability, deformability, and other critical parameters. We have generated ex vivo stemRBCs from primary human cord blood CD34+ cells and compared them to donor-derived RBCs based on a number of in vitro parameters. In vivo, we assessed stemRBC circulation kinetics in an animal model of transfusion and oxygen delivery in a mouse model of exercise performance. Our novel, chronically anemic, SCID mouse model can evaluate the potential of stemRBCs to deliver oxygen to tissues (muscle) under resting and exercise-induced hypoxic conditions. Based on our data, stem cell-derived RBCs have a similar biochemical profile compared to donor-derived RBCs. While certain key differences remain between donor-derived RBCs and stemRBCs, the ability of stemRBCs to deliver oxygen in a living organism provides support for further development as a transfusion product.

Published
2016
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4. Deep fascial space infection of the neck: a continuing challenge

Author

Nashaat S. Hamza, John Farrel, Melvin Strauss, and Robert A. Bonomo

Subjects
Male, medicine.medical_specialty, Endotracheal intubation, Anterior mediastinum, Severity of Illness Index, Diabetes Complications, medicine, Humans, Submental space, In patient, Fasciitis, Necrotizing, Fascial space, Fascia, Fasciitis, Soft palate, business.industry, Soft Tissue Infections, General Medicine, Middle Aged, medicine.disease, Surgery, Fasciotomy, medicine.anatomical_structure, business, Airway, Neck
Abstract

We present our clinical experience with two complex cases of deep fascial space infections of the neck. The first was a case of cervical necrotizing fasciitis involving the submental space. The second was an infection beginning at the soft palate and extending to the anterior mediastinum. Both infections emanated from an oral source in patients with diabetes mellitus, and both patients required multiple surgical debridements and endotracheal intubation for airway protection. Despite the declining incidence of deep space neck infections, our cases illustrate the challenging diagnostic and treatment dilemmas for the clinician managing patients with diabetes.

Published
2003

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