1. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis
- Author
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Tim D. Spector, Guangju Zhai, Victor Abkevich, Albert Hofman, Feng Zhang, Frank P. Luyten, Ana M. Valdes, John Loughlin, Lorraine Southam, Rainer J. Egli, Rik Lories, Jerry S. Lanchbury, Michael Doherty, Sally Doherty, Kirsten Timms, Dongliang Ge, Scott Wilson, Joyce J B van Meurs, Alexander Gutin, Deborah J. Hart, André G. Uitterlinden, Epidemiology, and Internal Medicine
- Subjects
Oncology ,medicine.medical_specialty ,Linkage disequilibrium ,Arthritis ,Osteoarthritis ,Biology ,Polymorphism, Single Nucleotide ,Linkage Disequilibrium ,Article ,Cohort Studies ,03 medical and health sciences ,Chondrocytes ,0302 clinical medicine ,Risk Factors ,Polymorphism (computer science) ,Internal medicine ,medicine ,Genetics ,Humans ,Genetic Predisposition to Disease ,Genetics(clinical) ,RNA, Messenger ,Allele ,Risk factor ,Alleles ,Genetics (clinical) ,Aged ,DNA Primers ,Oligonucleotide Array Sequence Analysis ,030304 developmental biology ,Aged, 80 and over ,030203 arthritis & rheumatology ,0303 health sciences ,Base Sequence ,Group IV Phospholipases A2 ,Case-control study ,Genetic Variation ,Genomics ,Odds ratio ,Middle Aged ,Osteoarthritis, Knee ,medicine.disease ,3. Good health ,Cyclooxygenase 2 ,Case-Control Studies ,Female - Abstract
Osteoarthritis (OA), the most prevalent form of arthritis in the elderly, is characterized by the degradation of articular cartilage and has a strong genetic component. Our aim was to identify genetic variants involved in risk of knee OA in women. A pooled genome-wide association scan with the Illumina550 Duo array was performed in 255 controls and 387 cases. Twenty-eight variants with p < 1 x 10(-5) were estimated to have probabilities of being false positives
- Published
- 2008