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Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231162648 for Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS by Zsuzsanna Ament, Amit Patki, Varun M Bhave, Ninad S Chaudhary, Ana-Lucia Garcia Guarniz, Naruchorn Kijpaisalratana, Suzanne E Judd, Mary Cushman, D Leann Long, M Ryan Irvin and W Taylor Kimberly in Journal of Cerebral Blood Flow & Metabolism

Additional file 1: Supplemental Table 1. Association of VAI with incident kidney failure. Supplemental Table 2. Association of LAP with incident kidney failure. Supplemental Table 3. Association of measures of adiposity with incident kidney failure in a competing risk of death analysis. Supplemental Table 4. Association of measures of adiposity with incident kidney failure stratified by baseline CKD stages. Supplemental Table 5. Association of triglycerides and HDL with incident CKD, progressive eGFR decline, and incident kidney failure. Supplemental Table 6. Association of measures of adiposity with incident albuminuria. Supplemental Figure 1. Global Wald Chi-Square Score of Relative Importance of Measures of Adiposity to Incident Kidney Failure. Abbreviations: VAI, visceral adiposity index; BMI, body mass index; LAP, lipid accumulation product.

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231162648 for Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS by Zsuzsanna Ament, Amit Patki, Varun M Bhave, Ninad S Chaudhary, Ana-Lucia Garcia Guarniz, Naruchorn Kijpaisalratana, Suzanne E Judd, Mary Cushman, D Leann Long, M Ryan Irvin and W Taylor Kimberly in Journal of Cerebral Blood Flow & Metabolism

The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) is a national prospective study of adults comprising 14 established US prospective cohort studies. Starting as early as 1971, investigators in the C4R cohort studies have collected data on clinical and subclinical diseases and their risk factors, including behavior, cognition, biomarkers, and social determinants of health. C4R links this pre-coronavirus disease 2019 (COVID-19) phenotyping to information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute and postacute COVID-related illness. C4R is largely population-based, has an age range of 18-108 years, and reflects the racial, ethnic, socioeconomic, and geographic diversity of the United States. C4R ascertains SARS-CoV-2 infection and COVID-19 illness using standardized questionnaires, ascertainment of COVID-related hospitalizations and deaths, and a SARS-CoV-2 serosurvey conducted via dried blood spots. Master protocols leverage existing robust retention rates for telephone and in-person examinations and high-quality event surveillance. Extensive prepandemic data minimize referral, survival, and recall bias. Data are harmonized with research-quality phenotyping unmatched by clinical and survey-based studies; these data will be pooled and shared widely to expedite collaboration and scientific findings. This resource will allow evaluation of risk and resilience factors for COVID-19 severity and outcomes, including postacute sequelae, and assessment of the social and behavioral impact of the pandemic on long-term health trajectories.

Additional file 4. Logistic regression models predicting the odds of having a moderate-to-high risk wc at follow-up

Additional file 3. Logistic regression models predicting the odds of being overweight/obese at follow-up

Additional file 1. Logistic regression models predicting the odds of being overweight/obese using baseline height at follow-up

Additional file 2. Descriptive statistics for participants who were included versus excluded from the analytic sample

Supplemental Material, JAH-20-517.R1_APPENDIX_A_SUPPLEMENTAL_MODEL_TABLES_4_and_5 for The Association of Neighborhood Medical Facilities with Aging in Place and Risk of Incident Myocardial Infarction by Janene R. Brown, Jana A. Hirsch, Suzanne E. Judd, Philip M. Hurvitz, Virginia J. Howard, Monika Safford, Jeffrey Moore and Gina S. Lovasi in Journal of Aging and Health

Additional file 2. Health care experiences during the COVID-19 pandemic by race and social determinants of health among adults age ��� 58 years in the REGARDS Study.

Additional file 1. REGARDS Computer-Assisted Telephone Interview CATI ��� COVID-19. REGARDS COVID-19 module administered beginning July 6, 2020.

Supplemental material, ProNT_Supp_VascMed_18AUG for Pro-neurotensin/neuromedin N and risk of ischemic stroke: The REasons for Geographic And Racial Differences in Stroke (REGARDS) study by Charles D Nicoli, Nicholas Wettersten, Suzanne E Judd, George Howard, Virginia J Howard, Joachim Struck and Mary Cushman in Vascular Medicine

BackgroundThe majority of people with chronic kidney disease (CKD) are unaware of their kidney disease. Assessing the clinical significance of increasing CKD awareness has critical public health and healthcare delivery implications. Whether CKD awareness among persons with CKD is associated with longitudinal health behaviors, disease management, and health outcomes is unknown.MethodsWe analyzed data from participants with CKD in the REasons for Geographic And Racial Differences in Stroke study, a national, longitudinal, population-based cohort. Our predictor was participant CKD awareness. Outcomes were (1) health behaviors (smoking avoidance, exercise, and nonsteroidal anti-inflammatory drug use); (2) CKD management indicators (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use, statin use, systolic blood pressure, fasting blood glucose, and body mass index); (3) change in estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR); and (4) health outcomes (incident end-stage kidney disease [ESKD], coronary heart disease [CHD], stroke, and death). Logistic and linear regressions were used to examine the association of baseline CKD awareness with outcomes of interest, adjusted for CKD stage and participant demographic and clinical factors.ResultsOf 6,529 participants with baseline CKD, 285 (4.4%) were aware of their CKD. Among the 3,586 participants who survived until follow-up (median 9.5 years), baseline awareness was not associated with subsequent odds of health behaviors, CKD management indicators, or changes in eGFR and UACR in adjusted analyses. Baseline CKD awareness was associated with increased risk of ESKD (adjusted hazard ratio [aHR] 1.44; 95% CI 1.08-1.92) and death (aHR 1.18; 95% CI 1.00-1.39), but not with subsequent CHD or stroke, in adjusted models.ConclusionsIndividuals aware of their CKD were more likely to experience ESKD and death, suggesting that CKD awareness reflects disease severity. Most persons with CKD, including those that are high-risk, remain unaware of their CKD. There was no evidence of associations between baseline CKD awareness and longitudinal health behaviors, CKD management indicators, or eGFR decline and albuminuria.

Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update. The Statistical Update is a critical resource for researchers, clinicians, healthcare policy makers, media professionals, the lay public, and many others who seek the best available national data on heart disease, stroke, and other cardiovascular disease-related morbidity and mortality and the risks, quality of care, use of medical procedures and operations, and costs associated with the management of these diseases in a single document. Indeed, since 1999, the Statistical Update has been cited >10 500 times in the literature, based on citations of all annual versions. In 2012 alone, the various Statistical Updates were cited ≈3500 times (data from Google Scholar). In recent years, the Statistical Update has undergone some major changes with the addition of new chapters and major updates across multiple areas, as well as increasing the number of ways to access and use the information assembled. For this year's edition, the Statistics Committee, which produces the document for the AHA, updated all of the current chapters with the most recent nationally representative data and inclusion of relevant articles from the literature over the past year. This year's edition includes a new chapter on peripheral artery disease, as well as new data on the monitoring and benefits of cardiovascular health in the population, with additional new focus on evidence-based approaches to changing behaviors, implementation strategies, and implications of the AHA's 2020 Impact Goals. Below are a few highlights from this year's Update. © 2013 American Heart Association, Inc.

Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update. The Statistical Update is a critical resource for researchers, clinicians, healthcare policy makers, media professionals, the lay public, and many others who seek the best available national data on heart disease, stroke, and other cardiovascular disease-related morbidity and mortality and the risks, quality of care, use of medical procedures and operations, and costs associated with the management of these diseases in a single document. Indeed, since 1999, the Statistical Update has been cited >10 500 times in the literature, based on citations of all annual versions. In 2012 alone, the various Statistical Updates were cited ≈3500 times (data from Google Scholar). In recent years, the Statistical Update has undergone some major changes with the addition of new chapters and major updates across multiple areas, as well as increasing the number of ways to access and use the information assembled. For this year's edition, the Statistics Committee, which produces the document for the AHA, updated all of the current chapters with the most recent nationally representative data and inclusion of relevant articles from the literature over the past year. This year's edition includes a new chapter on peripheral artery disease, as well as new data on the monitoring and benefits of cardiovascular health in the population, with additional new focus on evidence-based approaches to changing behaviors, implementation strategies, and implications of the AHA's 2020 Impact Goals. Below are a few highlights from this year's Update. © 2013 American Heart Association, Inc.

Background/aimsThe association between chronic kidney disease (CKD) awareness and healthy behaviors is unknown. We examined whether CKD self-recognition is associated with healthy behaviors and achieving risk-reduction targets known to decrease risk of cardiovascular morbidity and CKD progression.MethodsCKD awareness, defined as a 'yes' response to 'Has a doctor or other health professional ever told you that you had kidney disease?', was examined among adults with CKD (eGFR

Objectives: The purpose of this study was to explore the relationship between TV/video viewing, as a measure of sedentary behavior, and risk of incident stroke in a large prospective cohort of men and women. Methods: This analysis involved 22,257 participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study who reported at baseline the amount of time spent watching TV/video daily. Suspected stroke events were identified at six-monthly telephone calls and were physician-adjudicated. Cox proportional hazards models were used to examine risk of stroke at follow-up. Results: During 7.1 years of follow-up, 727 incident strokes occurred. After adjusting for demographic factors, watching TV/video ≥. 4 h/day (30% of the sample) was associated with a hazard ratio of 1.37 increased risk of all stroke (95% confidence interval (CI), 1.10-1.71) and incident ischemic stroke (hazard ratio 1.35, CI 1.06-1.72). This association was attenuated by socioeconomic factors such as employment status, education and income. Conclusions: These results suggest that while TV/video viewing is associated with increased stroke risk, the effect of TV/video viewing on stroke risk may be explained through other risk factors. Refereed/Peer-reviewed