355 results on '"Junbai Li"'
Search Results
2. Multistep Desolvation as a Fundamental Principle Governing Peptide Self-Assembly Through Liquid–Liquid Phase Separation
- Author
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Chengqian Yuan, Ruirui Xing, Jie Cui, Wei Fan, Junbai Li, and Xuehai Yan
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General Chemistry - Abstract
Biomolecular self-assembly based on peptides and proteins is a general phenomenon encountered in natural and synthetic systems. Liquid‒liquid phase separation (LLPS) is intimately involved in biomolecular self-assembly, yet the key factors at a molecular scale activating or modulating such a process remain largely elusive. Herein, we discovered that multistep desolva-tion is fundamental to the formation and evolution of peptide-rich droplets. The first step is partial desolvation of peptides to form peptide clusters, and the second step is selective desolvation of hydrophobic groups within clusters to trigger LLPS and the formation of peptide-rich droplets, followed by the complete desolvation of droplets, initiating the nucleation of peptide self-assembly. Manipulation of the degree of desolvation at different stages is an effective strategy to control the self-assembly pathways and polymorphisms. This study sheds light on the molecular origin of LLPS-mediated self-assembly dis-tinct from classical one-step self-assembly and paves the way for the precise control of supramolecular self-assembly.
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- 2023
3. Assembled Photosensitizers Applied for Enhanced Photodynamic Therapy
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Jie Zhao, Xia Xu, Yang Yang, and Junbai Li
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General Chemistry - Published
- 2023
4. Long afterglow particle enables spectral and temporal light management to boost photosynthetic efficiency
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Zhenzhen Dong, Jinbo Fei, Tonghui Wang, and Junbai Li
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Biomaterials ,Colloid and Surface Chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2023
5. Self-assembling nanoarchitectonics of size-controllable celastrol nanoparticles for efficient cancer chemotherapy with reduced systemic toxicity
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Yilin Liu and Junbai Li
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Biomaterials ,Colloid and Surface Chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2023
6. Schiff base nanoarchitectonics for supramolecular assembly of dipeptide as drug carriers
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Aoli, Wu, Yongxian, Guo, Xianbao, Li, Qi, Li, Guixin, Chen, Hengchang, Zang, and Junbai, Li
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Biomaterials ,Drug Carriers ,Colloid and Surface Chemistry ,Phenylalanine ,Dipeptides ,Schiff Bases ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Abstract
Development of peptide-based supramolecular materials with hierarchical morphology and tunable guest loading displays broad potential as drug carrier in view of biocompatibility and biodegradability. Herein, we report a facile Schiff base nanoarchitectonic for supramolecular assembly of diphenylalanine (FF) metastable gel. The addition of trace glutaraldehyde (GA)/H
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- 2023
7. Functional chromopeptide nanoarchitectonics: molecular design, self-assembly and biological applications
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Rui Chang, Luyang Zhao, Ruirui Xing, Junbai Li, and Xuehai Yan
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General Chemistry - Abstract
An overview of chromopeptide self-assembly is presented to systematically understand this kind of newly emerging peptide building block.
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- 2023
8. Biogenic sensors based on dipeptide assemblies
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Qi Li, Mingjun Xuan, Anhe Wang, Yi Jia, Shuo Bai, Xuehai Yan, and Junbai Li
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General Materials Science - Published
- 2022
9. Enhanced Bioenergy Transformation by Metal-Free Electrozyme-Based Mitochondrion Nanoarchitectonics
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Tonghui Wang, Jinbo Fei, Zhenzhen Dong, Xia Xu, Weiguang Dong, and Junbai Li
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General Chemistry - Published
- 2022
10. Controlled-Alignment Patterns of Dipeptide Micro- and Nanofibers
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Xingcen Liu, José Danglad-Flores, Stephan Eickelmann, Bingbing Sun, Jingcheng Hao, Hans Riegler, Junbai Li, and Bio-Organic Chemistry
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assembly ,microfiber/nanofiber ,Ammonia ,dip coating ,Nanofibers ,Solvents ,General Engineering ,General Physics and Astronomy ,controlled alignment ,General Materials Science ,Dipeptides ,dipeptide - Abstract
Ordered assemblies of the peptide diphenylalanine (FF) are produced and deposited on planar substrates. The FF aggregate growth is achieved through precipitation from aqueous ammonia solutions induced by solvent evaporation. The applied dip-coating technique confines the FF assembly growth to a narrow zone near the three-phase contact. The growth was observed online by optical microscopy and was investigated systematically as a function of the process parameters. Depending on the external gas flow (to influence solvent evaporation), the withdrawal speed, the initial FF, and the initial ammonia concentrations, FF forms long, straight, and rigid microfibers and/or shorter, curved nanofibers. Under certain process conditions, the FF fibers can also aggregate into stripes. These can be deposited as large arrays of uniform stripes with regular widths and spacings. Scenarios leading to the various types of fibers and the stripe formation are presented and discussed in view of the experimental findings.
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- 2022
11. Steering phase-separated droplets to control fibrillar network evolution of supramolecular peptide hydrogels
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Peng Zhou, Ruirui Xing, Qi Li, Junbai Li, Chengqian Yuan, and Xuehai Yan
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History ,Polymers and Plastics ,General Materials Science ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2023
12. Monitoring the distribution of internalized silica nanoparticles inside cells via direct stochastic optical reconstruction microscopy
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Nan Sun, Yi Jia, Chenlei Wang, Jiarui Xia, Hongqian Cao, Luru Dai, Chunmei Li, Xiaoming Zhang, and Junbai Li
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Biomaterials ,Mice ,Drug Delivery Systems ,Colloid and Surface Chemistry ,Microscopy, Fluorescence ,Animals ,Humans ,Nanoparticles ,Silicon Dioxide ,Porosity ,HeLa Cells ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Abstract
Understanding the exact localization of nanoparticles within cell is of particular importance for rational design of high-effective nanomedicines. In the present study, direct stochastic optical reconstruction microscopy (dSTORM) is employed to elucidate the precise localization of nanoparticles within cells owing to its superiority of nanometric resolution, multicolour ability and minimal invasiveness. The localization of the Cy5 labelled mesoporous silica nanoparticles (MSNs-Cy5) in MCF-7 cells are monitored by dSTORM and conventional fluorescence microscopy, respectively. The dSTORM images demonstrate much higher spatial resolution for locating MSNs-Cy5 within cells compared to that of the conventional fluorescence images. Moreover, the distribution of MSNs-Cy5 within three cell lines over time are obtained. For the MCF-7 and HeLa cells, MSNs-Cy5 nanoparticles distribute nearly all around the cytoplasm after 5 h incubation. In contrast, MSNs-Cy5 nanoparticles within NIH 3T3 cells are quite different that they are found to be either attached to or embedded into cell membranes, without penetrating into the cytoplasm. Overall, we provide a practical method to reveal the in situ precise imaging of nanoparticles in cells with nanometric resolution precision. This method may open up new opportunities for organelle-specific targeting drug delivery to achieve maximum therapeutic benefit.
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- 2022
13. Black Phosphorus Nanosheets Enhance Photophosphorylation by Positive Feedback
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Zhenzhen Dong, Jinbo Fei, Tonghui Wang, Xia Xu, Weiguang Dong, and Junbai Li
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General Chemistry - Published
- 2022
14. Microfabrication of peptide self-assemblies: inspired by nature towards applications
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Jiahao Zhang, Yancheng Wang, Brian J. Rodriguez, Rusen Yang, Bin Yu, Deqing Mei, Junbai Li, Kai Tao, and Ehud Gazit
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Microtechnology ,General Chemistry ,Peptides - Abstract
Peptide self-assemblies show intriguing and tunable physicochemical properties, and thus have been attracting increasing interest over the last two decades. However, the micro/nano-scale dimensions of the self-assemblies severely restrict their extensive applications. Inspired by nature, to genuinely realize the practical utilization of the bio-organic super-architectures, it is beneficial to further organize the peptide self-assemblies to integrate the properties of the individual supermolecules and fabricate higher-level organizations for smart functional devices. Therefore, cumulative studies have been reported on peptide microfabrication giving rise to diverse properties. This review summarizes the recent development of the microfabrication of peptide self-assemblies, discussing each methodology along with the diverse properties and practical applications of the engineered peptide large-scale, highly-ordered organizations. Finally, the current limitations of the state-of-the-art microfabrication strategies are critically assessed and alternative solutions are suggested.
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- 2022
15. Cell membrane covered polydopamine nanoparticles with two-photon absorption for precise photothermal therapy of cancer
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Hongqian Cao, Mingming Zhao, Yang Yang, Jiarui Xia, Bo Jiang, Junbai Li, Xibao Gao, and Nan Sun
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Indoles ,Materials science ,Photothermal Therapy ,Polymers ,Cell Membrane ,education ,Photothermal effect ,Nanoparticle ,Nanotechnology ,Phototherapy ,Photothermal therapy ,Fluorescence ,Two-photon absorption ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Biomaterials ,Cell membrane ,Colloid and Surface Chemistry ,Membrane ,medicine.anatomical_structure ,Neoplasms ,Cancer cell ,medicine ,Nanoparticles - Abstract
Hypothesis In view of the photothermal effect of polydopamine (PDA) nanoparticles and their internal D-π-D structures during assembly, the two-photon excited properties of PDA were studied toward the biomedical application. Further, the PDA molecules were coordinated with Mn2+ and the assembled nanoparticles were covered by cancer cell membranes, the complex system could be used directly for the treatment of cancer with photothermal and chemodynamic therapy. Experiments The two-photon excited PDA-Mn2+ nanoparticles were used for the photothermal therapy combined with chemodynamic therapy. The complexes were coated with cancer cell membranes in order to enhance the tumor homologous efficiency. Multi-modal bioimaging and anti-tumor detections were carried out both in vitro and in vivo. Findings PDA nanoparticles were demonstrated to have both good two-photon excited fluorescence and photothermal efficiency. The assembled nanoparticles modified with Mn2+ and cancer cell membranes have an obvious targeting and synergetic anti-cancer efficiency. The system creates a simple way for a precise operation with multi-modal imaging function.
- Published
- 2021
16. Gas-Induced Phase Transition of Dipeptide Supramolecular Assembly
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Jinbo Fei, Junbai Li, Aoli Wu, Xia Xu, and Huimin Xue
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Crystal ,chemistry.chemical_classification ,Phase transition ,Crystallography ,chemistry.chemical_compound ,Materials science ,Dipeptide ,chemistry ,Peptide ,General Chemistry ,Supramolecular assembly - Abstract
The manipulation of supramolecular assembly enables single-component architectures to possess diverse structures and functions. Here, we report directed phase transitions of dipeptide supramolecula...
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- 2021
17. CO 2 Induces Symmetry Breaking in Layered Dipeptide Crystals
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Xianbao Li, Qi Li, Aoli Wu, and Junbai Li
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General Chemistry ,General Medicine ,Catalysis - Published
- 2022
18. Super Light‐Sensitive Photosensitizer Nanoparticles for Improved Photodynamic Therapy against Solid Tumors
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Jie Zhao, Yuguang Yang, Xia Xu, Hongyan Li, Jinbo Fei, Yilin Liu, Xiaoming Zhang, and Junbai Li
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Mice ,Photosensitizing Agents ,Photochemotherapy ,Singlet Oxygen ,Neoplasms ,Cell Line, Tumor ,Animals ,Nanoparticles ,General Chemistry ,General Medicine ,Catalysis - Abstract
Photodynamic therapy (PDT) is an effective method for superficial cancer treatment. However, the limited light intensity in tissues, tumor hypoxia, and the low accumulation efficiency of photosensitizers (PSs) in tumors are still major challenges. Herein, we introduce super light-sensitive PS nanoparticles (designated HR NPs) that can increase singlet oxygen (
- Published
- 2022
19. CO
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Xianbao, Li, Qi, Li, Aoli, Wu, and Junbai, Li
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Dipeptides ,Carbon Dioxide - Abstract
Control of symmetry breaking of materials provides large opportunities to regulate their properties and functions. Herein, we report breaking the symmetry of layered dipeptide crystals by utilizing CO
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- 2022
20. Cu-boosted one-pot nanoarchitectonics for synthesis of polydopamine membranes as reusable laccase mimic
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Fan Gao, Zhuzhu Xiong, Yi Jia, Hong Li, and Junbai Li
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Biomaterials ,Colloid and Surface Chemistry ,Indoles ,Polymers ,Laccase ,Benzoquinones ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Hydroquinones - Abstract
As a good alternative for natural enzyme, enzyme mimics with artificial functional materials have attracted considerable attention. However, it remains a great challenge to develop a facile method to design laccase mimic with high catalytic activity, long-term stability and reusability. In this report, we propose the one-pot synthesis of reusable paper filter templated Cu-doped polydopamine membranes (PF@PDA/Cu) with laccase-like activity. Compared with the natural laccase, the PF@PDA/Cu membrane exhibits enhanced catalytic activity for the chemical conversion of hydroquinone into benzoquinone. Interestingly, these membranes present good tolerance to high temperature and the catalytic activity increases with the increase of temperature. Moreover, these membranes could be stored for 7 days and recycled for 5 times with negligible loss of catalytic activity. This work provides a promising paradigm for rational design and practical applications of metal-loading PDA materials based on one-pot synthesis methodology.
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- 2022
21. The power of super-resolution microscopy in modern biomedical science
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Nan Sun, Yi Jia, Shiwei Bai, Qi Li, Luru Dai, and Junbai Li
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Colloid and Surface Chemistry ,Surfaces and Interfaces ,Physical and Theoretical Chemistry - Published
- 2023
22. Schiff Base Mediated Dipeptide Assembly toward Nanoarchitectonics
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Yi Jia, Xuehai Yan, and Junbai Li
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General Medicine ,General Chemistry ,Dipeptides ,Peptides ,Catalysis ,Schiff Bases - Abstract
Dynamic covalent chemistry (DCC) is fascinating because of its dual nature. It perfectly combines the reversible nature of noncovalent bonds with the robustness of covalent bonds, effectively enhancing the stability of assemblies and meanwhile giving rise to unprecedented properties. Therefore, integration of DCC with supramolecular chemistry has emerged as a versatile and an extraordinarily useful approach in directing peptide assembly. This Minireview focuses on a recent strategy, which exploits dynamic Schiff base chemistry in combination with supramolecular chemistry, to mediate dipeptide assembly toward nanoarchitectonics. Diversified structures, new emergent properties, and their related applications are highlighted. Lastly, the opportunities and prospects in this exciting field are also introduced.
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- 2022
23. Boric Acid‐Fueled ATP Synthesis by F o F 1 ATP Synthase Reconstituted in a Supramolecular Architecture
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Junbai Li, Xia Xu, Huimin Xue, Weiguang Dong, Guangle Li, Jinbo Fei, and Youqian Xu
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ATP synthase ,biology ,010405 organic chemistry ,Supramolecular chemistry ,Photosynthetic phosphorylation ,General Chemistry ,Oxidative phosphorylation ,General Medicine ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,Catalysis ,0104 chemical sciences ,Supramolecular assembly ,Boric acid ,chemistry.chemical_compound ,chemistry ,biology.protein ,Lipid bilayer ,Electrochemical gradient - Abstract
Significant strides toward producing biochemical fuels have been achieved by mimicking natural oxidative and photosynthetic phosphorylation. Here, different from these strategies, we explore boric acid as a fuel for tuneable synthesis of energy-storing molecules in a cell-like supramolecular architecture. Specifically, a proton locked in boric acid is released in a modulated fashion by the choice of polyols. As a consequence, controlled proton gradients across the lipid membrane are established to drive ATP synthase embedded in the biomimetic architecture, which facilitates tuneable ATP production. This strategy paves a unique route to achieve highly efficient bioenergy conversion, holding broad applications in synthesis and devices that require biochemical fuels.
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- 2021
24. Pt@polydopamine nanoparticles as nanozymes for enhanced photodynamic and photothermal therapy
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Xibao Gao, Nan Sun, Junbai Li, Hongqian Cao, Yang Yang, Yuntian Ma, and Minghui Liang
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Indoles ,Infrared Rays ,Photothermal Therapy ,Polymers ,medicine.medical_treatment ,Mice, Nude ,Nanoparticle ,Photodynamic therapy ,Nanotechnology ,Catalysis ,Mice ,Cell Line, Tumor ,Neoplasms ,Materials Chemistry ,medicine ,Animals ,Humans ,Platinum ,Photosensitizing Agents ,Chemistry ,technology, industry, and agriculture ,Metals and Alloys ,General Chemistry ,Photothermal therapy ,Xenograft Model Antitumor Assays ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Photochemotherapy ,Therapy Effect ,Reagent ,Ceramics and Composites ,Nanoparticles - Abstract
Polydopamine nanoparticles were used to stabilize a nano-Pt catalyst to relieve tumour hypoxia in photodynamic therapy (PDT). Polydopamine not only provides a platform for carrying nano-Pt and photosensitizers but is also used as a photothermal reagent for photothermal therapy (PTT). The system presented an enhanced anti-tumor therapy effect through a combined PDT and PTT mechanism.
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- 2021
25. Advance in ATP-involved active self-assembled systems
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Jinbo Fei and Junbai Li
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Colloid and Surface Chemistry ,Polymers and Plastics ,Surfaces and Interfaces ,Physical and Theoretical Chemistry - Published
- 2023
26. Covalently triggered self-assembly of peptide-based nanodrugs for cancer theranostics
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Yamei Liu, Ruirui Xing, Junbai Li, and Xuehai Yan
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Multidisciplinary - Abstract
Covalently triggered peptide self-assembly is achieved through sequential integration of spontaneous covalent reaction and noncovalent interactions, thus both enhancing the physiological stability and extending unexpected functionality of the resulting peptide-based assemblies, different from popular supramolecular peptide self-assembly merely associated with noncovalent interactions. This review summarizes the recent progress on the development of covalently triggered peptide self-assembly for cancer theranostics. Especially, we propose the fundamental design principle of covalently triggered peptide self-assembly for constructing a variety of peptide-based assemblies including nanoparticles, nanofibers, hollow nanospheres, and other nanoarchitectures. Subsequently, the discussion is anchored in an overview of representative covalently assembled peptide-based nanodrugs for the cancer theranostics. Finally, the challenges and perspectives on the clinical potential of the covalently assembled peptide-based nanodrugs are highlighted. This review will provide new insights into construction of peptide-based nanodrugs through combination of covalent reaction and noncovalent self-assembly and prompt their clinical applications in cancer diagnosis and therapeutics.
- Published
- 2023
27. Oriented Nanoarchitectonics of Bacteriorhodopsin for Enhancing ATP Generation in a F o F 1 ‐ATPase‐Based Assembly System
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Zibo Li, Xia Xu, Fanchen Yu, Jinbo Fei, Qiang Li, Mingdong Dong, and Junbai Li
- Subjects
energy conversion ,ATP production ,artificial biomimetic system ,General Chemistry ,General Medicine ,co-assembly ,proton gradient ,Catalysis - Abstract
Energy conversion plays an important role in the metabolism of photosynthetic organisms. Improving energy transformation by promoting a proton gradient has been a great challenge for a long time. In the present study, we realize a directional proton migration through the construction of oriented bacteriorhodopsin (BR) microcapsules coated by FoF1-ATPase molecular motors through layer-by-layer (LBL) assembly. The changes in the conformation of BR under illumination lead to proton transfer in a radial direction, which generates a higher proton gradient to drive the synthesis of adenosine triphosphate (ATP) by FoF1-ATPase. Furthermore, to promote the photosynthetic activity, optically matched quantum dots were introduced into the artificial coassembly system of BR and FoF1-ATPase. Such a design creates a new path for the use of light energy.
- Published
- 2022
28. Tunable Mechanical and Optoelectronic Properties of Organic Cocrystals by Unexpected Stacking Transformation from H- to J- and X-Aggregation
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Hui Yuan, Rusen Yang, Mingsu Si, Xuehai Yan, Yi Cao, Wei Ji, Syed A. M. Tofail, Linda J. W. Shimon, Chengqian Yuan, Ehud Gazit, Wei Wang, Damien Thompson, Bin Xue, Santu Bera, Qing Ma, Qi Li, Yanqing Liu, Junbai Li, Evan Kiely, Sarah Guerin, ERC, SFI, ICHEC, National Natural Science Foundation of China, and Natural Science Foundation of Jiangsu province
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Supramolecular chirality ,Materials science ,Band gap ,Supramolecular chemistry ,Stacking ,General Physics and Astronomy ,02 engineering and technology ,Crystal structure ,010402 general chemistry ,01 natural sciences ,Cocrystal ,Article ,optoelectronic materials ,supramolecular chemistry ,Crystal ,molecular stacking ,coassembly ,General Materials Science ,business.industry ,General Engineering ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,mechanical property ,organic crystals ,Optoelectronics ,0210 nano-technology ,business ,Single crystal - Abstract
peer-reviewed Molecular stacking modes, generally classified as H-, J-, and X-aggregation, play a key role in determining the optoelectronic properties of organic crystals. However, the control of stacking transformation of a specific molecule is an unmet challenge, and a priori prediction of the performance in different stacking modes is extraordinarily difficult to achieve. In particular, the existence of hybrid stacking modes and their combined effect on physicochemical properties of molecular crystals are not fully understood. Herein, unexpected stacking transformation from H- to J- and X-aggregation is observed in the crystal structure of a small heterocyclic molecule, 4,4'-bipyridine (4,4'-Bpy), upon coassembly with N-acetyl-l-alanine (AcA), a nonaromatic amino acid derivative. This structural transformation into hybrid stacking mode improves physicochemical properties of the cocrystals, including a large red-shifted emission, enhanced supramolecular chirality, improved thermal stability, and higher mechanical properties. While a single crystal of 4,4'-Bpy shows good optical waveguiding and piezoelectric properties due to the uniform elongated needles and low symmetry of crystal packing, the significantly lower band gap and resistance of the cocrystal indicate improved conductivity. This study not only demonstrates cocrystallization-induced packing transformation between H-, J-, and X-aggregations in the solid state, leading to tunable mechanical and optoelectronic properties, but also will inspire future molecular design of organic functional materials by the coassembly strategy. ACCEPTED peer-reviewed
- Published
- 2020
29. Nanoarchitectonics beyond Self‐Assembly: Challenges to Create Bio‐Like Hierarchic Organization
- Author
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Junbai Li, David Tai Leong, Xiaofang Jia, Yi Jia, Jonathan P. Hill, Katsuhiko Ariga, and Jingwen Song
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Structural organization ,010405 organic chemistry ,Computer science ,Nanoarchitectonics ,Nanotechnology ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Catalysis ,Scientific disciplines ,0104 chemical sciences - Abstract
Incorporation of non-equilibrium actions in the sequence of self-assembly processes would be an effective means to establish bio-like high functionality hierarchical assemblies. As a novel methodology beyond self-assembly, nanoarchitectonics, which has as its aim the fabrication of functional materials systems from nanoscopic units through the methodological fusion of nanotechnology with other scientific disciplines including organic synthesis, supramolecular chemistry, microfabrication, and bio-process, has been applied to this strategy. The application of non-equilibrium factors to conventional self-assembly processes is discussed on the basis of examples of directed assembly, Langmuir-Blodgett assembly, and layer-by-layer assembly. In particular, examples of the fabrication of hierarchical functional structures using bio-active components such as proteins or by the combination of bio-components and two-dimensional nanomaterials, are described. Methodologies described in this review article highlight possible approaches using the nanoarchitectonics concept beyond self-assembly for creation of bio-like higher functionalities and hierarchical structural organization.
- Published
- 2020
30. Nanoarchitektonik als ein Ansatz zur Erzeugung bioähnlicher hierarchischer Organisate
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Jonathan P. Hill, Junbai Li, David Tai Leong, Xiaofang Jia, Yi Jia, Katsuhiko Ariga, and Jingwen Song
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Materials science ,General Medicine - Published
- 2020
31. Dynamic Detection of Active Enzyme Instructed Supramolecular Assemblies In Situ via Super-Resolution Microscopy
- Author
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Junbai Li, Yuan Gao, Chenlei Wang, Qingxin Yao, Meifang Fu, and Luru Dai
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Super-resolution microscopy ,Chemistry ,General Engineering ,Supramolecular chemistry ,General Physics and Astronomy ,02 engineering and technology ,Cell fate determination ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Small molecule ,0104 chemical sciences ,Supramolecular assembly ,Membrane ,Nanofiber ,Biophysics ,General Materials Science ,0210 nano-technology ,Intracellular - Abstract
Inspired by the self-assembly phenomena in nature, the instructed self-assembly of exogenous small molecules in a biological environment has become a prevalent process to control cell fate. Despite mounting examples of versatile bioactivities, the underlying mechanism remains less understood, which is in large hindered by the difficulties in the identification of those dynamic assemblies in situ. Here, with direct stochastic optical reconstruction microscopy, we are able to elucidate the dynamic morphology transformation of the enzyme-instructed supramolecular assemblies in situ inside cancer cells with a resolution below 50 nm. It indicates that the assembling molecules endure drastically different pathways between cell lines with different phosphatase activities and distribution. In HeLa cells, the direct formation of intracellular supramolecular nanofibers showed slight cytotoxicity, which was due to the possible cellular secretory pathway to excrete those exogenous molecules assemblies. In contrast, in Saos-2 cells with active phosphatase on the cell surface, assemblies with granular morphology first formed on the cell membranes, followed by a transformation into nanofibers and accumulation in cells, which induced Saos-2 cell death eventually. Overall, we provided a convenient method to reveal the in situ dynamic nanomorphology transformation of the supramolecular assemblies in a biological environment, in order to decipher their diverse biological activities.
- Published
- 2020
32. Reconstitution of Motor Proteins through Molecular Assembly
- Author
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Xiyun Feng, Jieling Li, Mingjun Xuan, Yi Jia, Junbai Li, and Li Duan
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Motor protein ,Chemistry ,General Chemistry ,Cell biology - Published
- 2019
33. Assembled cationic dipeptide-gold nanoparticle hybrid microspheres for electrochemical biosensors with enhanced sensitivity
- Author
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Huimin Xue, Ziruo Li, Keqing Wang, Youqian Xu, Jie Zhao, Junbai Li, Chenlei Wang, Wei Cui, and Shuo Zhang
- Subjects
Cholesterol oxidase ,Biocompatibility ,Surface Properties ,Metal Nanoparticles ,Nanoparticle ,Biosensing Techniques ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Catalysis ,Biomaterials ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,Chlorides ,Limit of Detection ,Cations ,Electrodes ,Dipeptide ,Cholesterol Oxidase ,Chemistry ,Cationic polymerization ,Reproducibility of Results ,Dipeptides ,Electrochemical Techniques ,Enzymes, Immobilized ,021001 nanoscience & nanotechnology ,Gold Compounds ,Microspheres ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Cholesterol ,Chemical engineering ,Colloidal gold ,Electrode ,Chloroauric acid ,lipids (amino acids, peptides, and proteins) ,Gold ,0210 nano-technology - Abstract
Molecular assemblies of cationic dipeptide-gold nanoparticle (CDP-AuNP) hybrid microspheres were used to modify cholesterol oxidase electrodes for high-sensitivity cholesterol detection. The cationic dipeptide used here serves as a functional molecule for adsorbing chloroauric acid based on electrostatic interactions and assembly into spherical structures, providing a platform for loading gold nanoparticles (AuNPs), increasing the immobilization load of the enzyme and maintaining the activity of the enzyme as a result of excellent biocompatibility. Moreover, the CDP-AuNP modified cholesterol oxidase electrode has a higher electrocatalytic activity to cholesterol with obvious enhancement in the current response, exhibiting a current response 13 times higher than that of the controlled electrode. The outstanding biocompatibility and increased enzyme load by hybrid microspheres and the good charge-transfer ability of AuNPs in the peptide-based electrode indicate a very attractive perspective in the field of biodevices.
- Published
- 2019
34. Oriented Nanoarchitectonics of Bacteriorhodopsin for Enhancing ATP Generation in a F
- Author
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Zibo, Li, Xia, Xu, Fanchen, Yu, Jinbo, Fei, Qiang, Li, Mingdong, Dong, and Junbai, Li
- Subjects
Adenosine Triphosphatases ,Adenosine Triphosphate ,Bacteriorhodopsins ,Molecular Conformation ,Protons - Abstract
Energy conversion plays an important role in the metabolism of photosynthetic organisms. Improving energy transformation by promoting a proton gradient has been a great challenge for a long time. In the present study, we realize a directional proton migration through the construction of oriented bacteriorhodopsin (BR) microcapsules coated by F
- Published
- 2021
35. Dopamine-Based Materials: Recent Advances in Synthesis Methods and Applications
- Author
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Hong Li and Junbai Li
- Subjects
Bioelectronics ,Materials science ,Biocompatibility ,Functional importance ,Synthesis methods ,Self-healing hydrogels ,Nanoparticle ,Surface modification ,Nanotechnology ,Photothermal conversion - Abstract
Dopamine-based materials have attracted considerable interests due to their unique physicochemical properties including versatile adhesion property, high chemical reactivity, strong photothermal conversion capacity, excellent biocompatibility and biodegradability, etc. Since the discovery of oxidative self-polymerization of dopamine for preparation of polydopamine, different strategies have been employed to construct fruitful polydopamine-based materials, such as nanoparticles, core/shell nanoparticles, microcapsules, films, and hydrogels. Moreover, one-pot polydopamine-assisted co-deposition could facilitate the incorporation of functional molecules into the materials during the formation process of polydopamine, thus greatly simplifying the functionalization procedure of polydopamine. This chapter is devoted to introduce recent development in dopamine-based materials and their applications. First, an overview of the different methodologies for fabrication of dopamine-based materials is summarized. We outline various polydopamine-based materials constructed with different preparation strategies and novel materials prepared via the co-assembly strategy. Thereafter, we focus on the recent advances of emerging applications of dopamine-based materials in various fields ranging from cancer theranostics, bioimaging, self-adhesive bioelectronics to removal of heavy metal ions. Finally, we discuss the critical unsolved challenges in this field and some potential opportunities for future research.
- Published
- 2021
36. DNA‐Based Dissipative Assembly toward Nanoarchitectonics (Adv. Funct. Mater. 37/2022)
- Author
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Qing Liu, Hong Li, Binhong Yu, Zhuojun Meng, Xiaoming Zhang, Junbai Li, and Lifei Zheng
- Subjects
Biomaterials ,Electrochemistry ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials - Published
- 2022
37. Recent advances in dopamine-based materials constructed via one-pot co-assembly strategy
- Author
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Bo Jiang, Hong Li, and Junbai Li
- Subjects
Computer science ,Dopamine ,Rational design ,Cancer therapy ,Nanotechnology ,Surfaces and Interfaces ,Nanostructures ,Colloid and Surface Chemistry ,Biological property ,medicine ,Co assembly ,Physical and Theoretical Chemistry ,medicine.drug - Abstract
Dopamine-based materials have attracted widespread interest due to the outstanding physicochemical and biological properties. Since the first report on polydopamine (PDA) films, great efforts have been devoted to develop new fabrication strategies for obtaining novel nanostructures and desirable properties. Among them, one-pot co-assembly strategy offers a unique pathway for integrating multiple properties and functions into dopamine-based platform in a single simultaneous co-deposition step. This review focuses on the state of the art development of one-pot multicomponent self-assembly of dopamine-based materials and summarizes various single-step co-deposition approaches, including PDA-assisted adaptive encapsulation, co-assembly of dopamine with other molecules through non-covalent interactions or covalent interactions. Moreover, emerging applications of dopamine-based materials in the fields ranging from sensing, cancer therapy, catalysis, oil/water separation to antifouling are outlined. In addition, some critical remaining challenges and opportunities are discussed to pave the way towards the rational design and applications of dopamine-based materials.
- Published
- 2021
38. Hierarchically oriented organization in supramolecular peptide crystals
- Author
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Ehud Gazit, Wei Ji, Xuehai Yan, Ruirui Xing, Junbai Li, and Chengqian Yuan
- Subjects
General Chemical Engineering ,Complex system ,Supramolecular chemistry ,Hierarchical organization ,Nanotechnology ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,0210 nano-technology ,01 natural sciences ,Functional system ,0104 chemical sciences - Abstract
Hierarchical self-assembly and crystallization with long-range ordered spatial arrangement is ubiquitous in nature and plays an essential role in the regulation of structures and biological functions. Inspired by the multiscale hierarchical structures in biology, tremendous efforts have been devoted to the understanding of hierarchical self-assembly and crystallization of biomolecules such as peptides and amino acids. Understanding the fundamental mechanisms underlying the construction and organization of multiscale architectures is crucial for the design and fabrication of complex functional systems with long-range alignment of molecules. This Review summarizes the typical examples for hierarchically oriented organization of peptide self-assembly and discusses the thermodynamic and kinetic mechanisms that are responsible for this specific hierarchical organization. Most importantly, we propose the concept of hierarchically oriented organization for self-assembling peptide crystals, distinct from the traditional growth mechanism of supramolecular polymerization and crystallization based on the Ostwald ripening rule. Finally, we assess critical challenges and highlight future directions towards the mechanistic understanding and versatile application of the hierarchically oriented organization mechanism. Hierarchical self-assembly and crystallization is ubiquitous in nature and is of key importance for creation of complex superstructures. Herein, Yuan and co-workers propose that hierarchically oriented organization guides the formation of such complex systems, especially in supramolecular peptide crystals.
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- 2019
39. Assembled Vitamin B2 Nanocrystals with Optical Waveguiding and Photosensitizing Properties for Potential Biomedical Application
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Jinbo Fei, Jie Zhao, Fuping Gao, Luru Dai, and Junbai Li
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Nanostructure ,Materials science ,Riboflavin ,medicine.medical_treatment ,Melanoma, Experimental ,Optical property ,Photodynamic therapy ,Nanotechnology ,010402 general chemistry ,01 natural sciences ,Catalysis ,Mice ,medicine ,Animals ,Humans ,chemistry.chemical_classification ,Photosensitizing Agents ,010405 organic chemistry ,Biomolecule ,General Medicine ,General Chemistry ,Xenograft Model Antitumor Assays ,0104 chemical sciences ,Single tumour ,Photochemotherapy ,chemistry ,Nanocrystal ,MCF-7 Cells ,Nanoparticles ,Nanorod ,Reactive Oxygen Species ,Vitamin b2 - Abstract
Great success has been achieved in recent years in the development of synthetic or assembled nanobiomaterials. Among these, biomolecule-based nanoarchitectures with special optical property are of particular interest. Here, we demonstrate that vitamin B2 nanocrystals assembled as nanorods can be obtained with precise control. Excitingly, such one-dimensional nanostructures not only exhibit intrinsic optical waveguiding properties but also the ability to sensitize oxygen to produce reactive oxygen species. With these properties, we applied the obtained vitamin B2 nanorods under remotely localized light illumination into single tumour cells in vitro for anticancer photodynamic therapy. Further, vitamin B2 nanorods were explored for in vivo photodynamic therapy by using a tumour model. With such bionanostructures, new features and functions of vitamin B2 and its derivatives have been developed.
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- 2019
40. Reconstitution of FoF1-ATPase-based biomimetic systems
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Yi Jia and Junbai Li
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Creative design ,Physiological function ,biology ,Computer science ,General Chemical Engineering ,media_common.quotation_subject ,ATPase ,General Chemistry ,Molecular machine ,Motor protein ,Polymersome ,biology.protein ,Molecular motor ,Biochemical engineering ,Function (engineering) ,media_common - Abstract
Nature makes use of molecular machines to perform intricate functions in every significant biological process and to power macroscopic motion in organisms. Biomolecular motor proteins perform crucial tasks such as cell division, intracellular transport and mechanical actuation in biological cells. The rotary motor FoF1-ATPase is one of the most extensively studied biomolecular machines as a result of its vital physiological function. Research on the function of FoF1-ATPase can help to better understand the underlying biological processes and may also result in the development of biological molecular motor-based devices or even inspire the creative design and construction of artificial molecular machines. Recent advances in nanoscience and biotechnology have enabled engineering experiments with FoF1-ATPase that have achieved notable success. In this Review, we first outline the reconstitution of FoF1-ATPase into simple liposomes and polymersomes and then focus on recent progress in the reconstitution of FoF1-ATPase on layer-by-layer-assembled systems. The elaborate structural designs utilized in layer-by-layer-assembled systems to better mimic natural cell structures are introduced. The rational integration of functional components to achieve stimuli-responsive ATP syntheses from FoF1-ATPase-based biomimetic systems is highlighted. Finally, we address some remaining key challenges and speculate on future directions for the field. FoF1-ATPase is a vital molecular machine in organisms responsible for the catalytic synthesis of the basic energy unit ATP. In this Review, the development of FoF1-ATPase reconstitution into artificial architectures is discussed ultimately leading to the development of stimuli-responsive ATP synthesis.
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- 2019
41. Nanozyme‐Catalyzed Cascade Reactions for Mitochondria‐Mimicking Oxidative Phosphorylation
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Junbai Li, Youqian Xu, Guangle Li, Tingting Yuan, Xia Xu, and Jinbo Fei
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ATP synthase ,biology ,010405 organic chemistry ,Chemistry ,General Medicine ,General Chemistry ,Oxidative phosphorylation ,Mitochondrion ,010402 general chemistry ,01 natural sciences ,Oxidative Phosphorylation ,Catalysis ,Transmembrane protein ,Mitochondria ,0104 chemical sciences ,chemistry.chemical_compound ,Colloidal gold ,biology.protein ,Gluconic acid ,Biophysics ,Electrochemical gradient - Abstract
Multiple-enzyme-involving cascade reactions that yield bioenergy are necessary in natural oxidative phosphorylation. However, in vitro applications are hampered by the sensitivity of catalytic activity to environmental adaptation. Herein, we explore nanozyme-catalyzed cascade reactions in an assembled hybrid architecture for mitochondria-mimicking oxidative phosphorylation. Hollow silica microspheres containing trapped gold nanoparticles were synthesized to promote two enzyme-like catalytic reactions that transform glucose into gluconic acid in the presence of oxygen. The resulting transmembrane proton gradient drives natural ATP synthase reconstituted on the surface to convert ADP and inorganic phosphate into ATP. The assembled architecture possesses high activity for oxidative phosphorylation, comparable to that of natural mitochondria. This study provides a new natural-artificial hybrid prototype for exploring bioenergy supply systems and holds great promise for ATP-powered bioapplications.
- Published
- 2019
42. Thermoresponsive Polymer Brush Modulation on the Direction of Motion of Phoretically Driven Janus Micromotors
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Yingjie Wu, Xiankun Lin, Junbai Li, Yuxing Ji, Qiang He, and Hongyue Zhang
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Materials science ,Diffusion ,Brush ,General Chemistry ,General Medicine ,Polymer brush ,Lower critical solution temperature ,Catalysis ,law.invention ,Electron transfer ,Chemical engineering ,law ,Surface modification ,Janus ,Bimetallic strip - Abstract
We report a thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) brush functionalized Janus Au-Pt bimetallic micromotor capable of modulating the direction of motion with the change of the ambient temperature. The PNIPAM@Au-Pt micromotor moved along the Au-Pt direction with a speed of 8.5 μm s-1 in 1.5 % H2 O2 at 25 °C (below the lower critical solution temperature (LCST) of PNIPAM), whereas it changed the direction of motion (i.e., along the Pt-Au direction) and the speed decreased to 2.3 μm s-1 at 35 °C (above LCST). Below LCST, PNIPAM brushes grafted on the Au side were hydrophilic and swelled, which permitted the electron transfer and proton diffusion on the Au side, and thus the motion is regarded as a self-electrophoretic mechanism. However, PNIPAM brushes above LCST became hydrophobic and collapsed, and thus the driving mechanism switched to the self-diffusiophoresis like that of Pt-modified Janus silica motors. These motors could reversibly change the direction of motion with the transition of the hydrophobic and hydrophilic states of the grafted PNIPAM brushes. Such a thermoresponsive polymer brush functionalization method provides a new strategy for engineering the kinematic behavior of phoretically driven micro/nanomotors.
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- 2019
43. Covalently assembled dopamine nanoparticle as an intrinsic photosensitizer and pH-responsive nanocarrier for potential application in anticancer therapy
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Yuanyuan Zhao, Chengtun Qu, Junbai Li, Yi Jia, and Hong Li
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Drug ,Cell Survival ,Dopamine ,media_common.quotation_subject ,Catechols ,Nanoparticle ,010402 general chemistry ,01 natural sciences ,Catalysis ,chemistry.chemical_compound ,Cell Line, Tumor ,Neoplasms ,Materials Chemistry ,medicine ,Humans ,Photosensitizer ,media_common ,Drug Carriers ,Photosensitizing Agents ,Singlet Oxygen ,010405 organic chemistry ,Metals and Alloys ,General Chemistry ,Hydrogen-Ion Concentration ,Boronic Acids ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Cancer treatment ,Photochemotherapy ,chemistry ,Covalent bond ,Ceramics and Composites ,Genipin ,Biophysics ,Nanoparticles ,Nanocarriers ,medicine.drug - Abstract
We report a novel nanophotosensitizer via one-step covalent assembly of dopamine and genipin. This is the first report unveiling the photodynamic effect of dopamine-based materials. These nanophotosensitizers can also act as pH-responsive drug nanocarriers via a catechol-boronate linkage, thus achieving combined PDT and chemotherapy for highly efficient cancer treatment.
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- 2019
44. DNA‐Based Dissipative Assembly toward Nanoarchitectonics
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Qing Liu, Hong Li, Binhong Yu, Zhuojun Meng, Xiaoming Zhang, Junbai Li, and Lifei Zheng
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Biomaterials ,Electrochemistry ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials - Published
- 2022
45. Photosystem II-based biomimetic assembly for enhanced photosynthesis
- Author
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Junbai Li and Mingjun Xuan
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photosynthesis ,Multidisciplinary ,Photosystem II ,AcademicSubjects/SCI00010 ,biomimetic assembly ,Chemistry ,Materials Science ,artificial chloroplast ,photosystem II ,Nanotechnology ,Review ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photosynthesis ,01 natural sciences ,0104 chemical sciences ,Synthetic materials ,Electron transfer ,Molecular level ,Water splitting ,photoelectrobiological chemistry ,AcademicSubjects/MED00010 ,0210 nano-technology ,Photocatalytic water splitting - Abstract
Photosystem II (PSII) is a fascinating photosynthesis-involved enzyme, participating in sunlight-harvest, water splitting, oxygen release, and proton/electron generation and transfer. Scientists have been inspired to couple PSII with synthetic hierarchical structures via biomimetic assembly, facilitating attainment of natural photosynthesis processes, such as photocatalytic water splitting, electron transfer and ATP synthesis, in vivo. In the past decade, there has been significant progress in PSII-based biomimetic systems, such as artificial chloroplasts and photoelectrochemical cells. The biomimetic assembly approach helps PSII gather functions and properties from synthetic materials, resulting in a complex with partly natural and partly synthetic components. PSII-based biomimetic assembly offers opportunities to forward semi-biohybrid research and synchronously inspire optimization of artificial light-harvest micro/nanodevices. This review summarizes recent studies on how PSII combines with artificial structures via molecular assembly and highlights PSII-based semi-natural biosystems which arise from synthetic parts and natural components. Moreover, we discuss the challenges and remaining problems for PSII-based systems and the outlook for their development and applications. We believe this topic provides inspiration for rational designs to develop biomimetic PSII-based semi-natural devices and further reveal the secrets of energy conversion within natural photosynthesis from the molecular level., This review collects the recent contributions on PSII coupling with artificial structures via molecular assembly, and highlights how PSII-based semi-natural systems realize enhanced photosynthesis.
- Published
- 2021
46. Disassembly and reassembly of diphenylalanine crystals through evaporation of solvent
- Author
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Hongqian Cao, Jiarui Xia, Chenlei Wang, Bingbing Sun, Junbai Li, Yang Yang, Nan Sun, and Yi Jia
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Work (thermodynamics) ,Materials science ,Hexagonal crystal system ,02 engineering and technology ,Crystal structure ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Evaporation (deposition) ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Biomaterials ,Solvent ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,Monomer ,chemistry ,Chemical engineering ,Self-assembly ,Diphenylalanine ,0210 nano-technology - Abstract
Hypothesis Crystalline self-assemblies of diphenylalanine (FF) are since long back considered to be related to Alzheimer's disease. An improved understanding of the mechanism behind the formation of such structures can lead to strategies for investigating the dynamic processes of assembly and disassembly of FF. Experiment The assembly, disassembly and reassembly of FF crystals are influenced by the solvent composition and can be triggered by evaporation of solvent. In this work these processes are directly monitored, and the structures obtained are analyzed. Findings The role of the solvent for assembly, disassembly and reassembly of diphenylalanine crystals has been demonstrated. The initial crystal structure formed via self-assembly of FF monomers can be transformed into needle-like crystals and further to hollow hexagonal microtubes through evaporation of the solvent. It is shown that all the assembly-disassembly processes are spontaneous and driven by thermodynamics. It is also found that some of the crystalline structures exhibit optical waveguiding properties.
- Published
- 2021
47. Two-photon excited peptide nanodrugs for precise photodynamic therapy
- Author
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Lei Wang, Yanfei Qi, Yang Yang, Xibao Gao, Junbai Li, Hongqian Cao, Zi Jin Wei, Hao Wang, and Jiarui Xia
- Subjects
medicine.medical_treatment ,Tumor target ,Photodynamic therapy ,Peptide ,Catalysis ,chemistry.chemical_compound ,Mice ,Two-photon excitation microscopy ,Cell Line, Tumor ,Neoplasms ,Materials Chemistry ,medicine ,Human Umbilical Vein Endothelial Cells ,Animals ,Humans ,Photosensitizer ,chemistry.chemical_classification ,Reactive oxygen species ,Photons ,Photosensitizing Agents ,Pyrenes ,Metals and Alloys ,General Chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry ,Photochemotherapy ,Excited state ,Ceramics and Composites ,Biophysics ,Pyrene ,Nanoparticles ,Peptides ,Reactive Oxygen Species - Abstract
A novel peptide nanodrug composed of three functional motifs, bis(pyrene), FFVLK and CREKA, was used as a two-photon excited photosensitizer for precise photodynamic therapy (PDT). The system presented excellent two-photon imaging ability, tumor target effect and high reactive oxygen species productivity for improving treatment precision and efficiency in PDT.
- Published
- 2021
48. Embedment of Quantum Dots and Biomolecules in a Dipeptide Hydrogel Formed In Situ Using Microfluidics
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Nicolas Hauck, Junbai Li, Andreas Fery, Yue Li, Julian Thiele, Soo Sang Chae, Himanshu P. Patel, Max J. Männel, and Günter K. Auernhammer
- Subjects
Materials science ,Nanostructure ,Microfluidics ,Nanoparticle ,Nanotechnology ,010402 general chemistry ,01 natural sciences ,7. Clean energy ,Catalysis ,Supramolecular assembly ,chemistry.chemical_compound ,nanostructures ,dipeptides ,Research Articles ,chemistry.chemical_classification ,Microchannel ,Dipeptide ,010405 organic chemistry ,Embedment ,Biomolecule ,General Chemistry ,General Medicine ,continuous-flow microfluidics ,0104 chemical sciences ,chemistry ,Quantum dot ,Supramolecular Assembly ,Self-healing hydrogels ,microchannel-confined assembly ,Self-assembly ,Research Article - Abstract
As low‐molecular‐weight hydrogelators, dipeptide hydrogel materials are suited for embedding multiple organic molecules and inorganic nanoparticles. Herein, a simple but precisely controllable method is presented that enables the fabrication of dipeptide‐based hydrogels by supramolecular assembly inside microfluidic channels. Water‐soluble quantum dots (QDs) as well as premixed porphyrins and a dipeptide in dimethyl sulfoxide (DMSO) were injected into a Y‐shaped microfluidic junction. At the DMSO/water interface, the confined fabrication of a dipeptide‐based hydrogel was initiated. Thereafter, the as‐formed hydrogel flowed along a meandering microchannel in a continuous fashion, gradually completing gelation and QD entrapment. In contrast to hydrogelation in conventional test tubes, microfluidically controlled hydrogelation led to a tailored dipeptide hydrogel regarding material morphology and nanoparticle distribution., A dipeptide hydrogel was obtained by dynamic assembly in the confined space of continuous‐flow microfluidics. Organic porphyrins and inorganic quantum dots (QDs) were integrated in the system for energy transfer, and dynamic structural control over hydrogel formation and QD integration occurred within the microchannel network (see picture).
- Published
- 2021
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49. Boric Acid-Fueled ATP Synthesis by F
- Author
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Xia, Xu, Jinbo, Fei, Youqian, Xu, Guangle, Li, Weiguang, Dong, Huimin, Xue, and Junbai, Li
- Subjects
Membrane Lipids ,Adenosine Triphosphate ,Boric Acids ,Photophosphorylation ,Recombinant Fusion Proteins ,Molecular Conformation ,Phosphatidylglycerols ,Mitochondrial Proton-Translocating ATPases ,Protons ,Dimyristoylphosphatidylcholine ,Oxidation-Reduction ,Fluorescent Dyes - Abstract
Significant strides toward producing biochemical fuels have been achieved by mimicking natural oxidative and photosynthetic phosphorylation. Here, different from these strategies, we explore boric acid as a fuel for tuneable synthesis of energy-storing molecules in a cell-like supramolecular architecture. Specifically, a proton locked in boric acid is released in a modulated fashion by the choice of polyols. As a consequence, controlled proton gradients across the lipid membrane are established to drive ATP synthase embedded in the biomimetic architecture, which facilitates tuneable ATP production. This strategy paves a unique route to achieve highly efficient bioenergy conversion, holding broad applications in synthesis and devices that require biochemical fuels.
- Published
- 2020
50. pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy
- Author
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Yi Jia, Yuanyuan Zhao, Hong Li, Junbai Li, Gang Chen, and Junxia Peng
- Subjects
Porphyrins ,Dopamine ,Nanoparticle ,Antineoplastic Agents ,Catalysis ,chemistry.chemical_compound ,Cell Line, Tumor ,polycyclic compounds ,Materials Chemistry ,medicine ,Tumor Microenvironment ,Humans ,Doxorubicin ,Chlorin e6 ,Photosensitizer ,Schiff Bases ,Tumor microenvironment ,Drug Carriers ,Schiff base ,Photosensitizing Agents ,Chlorophyllides ,Metals and Alloys ,Drug Synergism ,General Chemistry ,Hydrogen-Ion Concentration ,Combinatorial chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Drug Liberation ,chemistry ,Ceramics and Composites ,Drug release ,Nanoparticles ,medicine.drug - Abstract
The dynamic Schiff base bond is exploited to construct monodisperse dopamine-based nanoparticles with autofluorescence and pH-sensitivity. This allows facile monitoring and pH-responsive drug release in the acidic tumor microenvironment. Anticancer drugs doxorubicin and a photosensitizer chlorin e6 are further loaded into the nanoparticles and synergistic anticancer efficacy is achieved.
- Published
- 2020
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