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1. Lung SBRT credentialing in the Canadian OCOG-LUSTRE randomized trial

Author

Anand Swaminath, Marcin Wierzbicki, Sameer Parpia, Vijayananda Kundapur, Sergio Faria, Naseer Ahmed, Alexis Bujold, Khalid Hirmiz, Timothy Owen, Nelson Leong, Kevin Ramchandar, Edith Filion, Harold Lau, Robert Thompson, Brian Yaremko, Zsolt Gabos, Selma Mehiri, James R. Wright, Theodoros K. Tsakiridis, Kathryn Cline, and Timothy J. Whelan

Subjects
Oncology, Radiology, Nuclear Medicine and imaging
Abstract

To report on the Stereotactic Body Radiation Therapy (SBRT) credentialing experience during the Phase III Ontario Clinical Oncology Group (OCOG) LUSTRE trial for stage I non-small cell lung cancer.Three credentialing requirements were required in this process: (a) An institutional technical survey; (b) IROC (Imaging and Radiation Oncology Core) thoracic phantom end-to-end test; and (c) Contouring and completion of standardized test cases using SBRT for one central and one peripheral lung cancer, compared against the host institution as the standard. The main hypotheses were that unacceptable variation would exist particularly in OAR definition across all centres, and that institutions with limited experience in SBRT would be more likely to violate per-protocol guidelines.Fifteen Canadian centres participated of which 8 were new, and 7 were previously established (≥2 years SBRT experience), and all successfully completed surveys and IROC phantom testing. Of 30 SBRT test plans, 10 required replanning due to major deviations, with no differences in violations between new and established centres (p = 0.61). Mean contouring errors were highest for brachial plexus in the central (C) case (12.55 ± 6.62 mm), and vessels in the peripheral (P) case (13.01 ± 12.55 mm), with the proximal bronchial tree (PBT) (2.82 ± 0.78 C, 3.27 ± 1.06 P) as another variable structure. Mean dice coefficients were lowest for plexus (0.37 ± 0.2 C, 0.37 ± 0.14 P), PBT (0.77 ± 0.06 C, 0.75 ± 0.09 P), vessels (0.69 ± 0.29 C, 0.64 ± 0.31 P), and esophagus (0.74 ± 0.04 C, 0.76 ± 0.04 P). All plans passed per-protocol planning target volume (PTV) coverage and maximum/volumetric organs-at-risk constraints, although variations existed in dose gradients within and outside the target.Clear differences exist in both contouring and planning with lung SBRT, regardless of centre experience. Such an exercise is important for studies that rely on high precision radiotherapy, and to ensure that implications on trial quality and outcomes are as optimal as possible.

Published
2022

2. Coronary sinus venoarterial CO2 difference in different hemodynamic states

Author

G, Vretzakis, E, Ferdi, B, Papaziogas, C, Dragoumanis, J, Pneumatikos, I, Tsangaris, K, Tsakiridis, and F, Konstantinou

Subjects
Male, Cardiac Catheterization, Central Venous Pressure, Myocardium, Partial Pressure, Hemodynamics, Blood Pressure, Stroke Volume, Carbon Dioxide, Coronary Vessels, Head-Down Tilt, Oxygen, Hemoglobins, Oxygen Consumption, Heart Rate, Catheterization, Swan-Ganz, Coronary Circulation, Humans, Female, Vascular Resistance, Cardiac Output, Coronary Artery Bypass, Aged
Abstract

Myocardial metabolic rate and coronary flow are closely related limiting thus the diagnostic value of coronary sinus saturation monitoring as an indicator of flow. Regional venoarterial CO2 gradient was found elevated during low flow in various clinical and experimental conditions, in animals and humans. This study was undertaken to examine the impact of the variations of cardiac mechanical work on veno-arterial CO2 content and partial pressure difference (deltaPCO2) of the coronary sinus blood. Twenty-seven patients of either sex (m/f = 21/6), undergoing coronary artery bypass grafting under extracorporeal circulation, were studied. Monitoring included a Swan-Ganz catheter and a coronary sinus line. The correct position of the late was verified by the waveform displayed in the monitor. Immediately after cannulae placement, a hemodynamic profile was obtained and simultaneous arterial and coronary sinus sampling for blood gas analysis was done in an ABL 720 (Radiometer Copenhagen) analyzer. A second collection of the same data was obtained five minutes later with the patients in a slight "head-down" position. Conditions for exclusion was intersample variation of hemoglobin's concentration greater than 15% and sodium ion concentration difference greater than 10% of the greater value. Arteriovenous oxygen partial pressure difference (deltaP(a-cs)O2), veno-arterial carbon dioxide partial pressure difference (deltaP(cs-a)CO2), O2CO2 content difference and heart's respiratory quotient were calculated and correlated to cardiac output (CO) and the other hemodynamic parameters. Statistical analysis employed t-paired test and linear regression. No ischemia was detected during sampling. "Head-down" position had a significant impact to all hemodynamic parameters except heart rate. In both data rows, although CO ranged widely and altered significantly, coronary sinus oxygen saturation and arteriovenous O2 content difference were stable and showed insignificant correlations to all the hemodynamic parameters that were studied. Carbon dioxide content difference (coronary sinus-arterial) showed a trending of decrease with higher flow. DeltaP(cs-a)CO2 appeared stable and independent of flow. Finally, respiratory quotient decreased significantly from 0.91 +/- 0.4 to 0.86 +/- 0.4 (mean +/- SD; p0.05). The heart's high basal oxygen consumption and the almost near hemoglobin's desaturation transcoronary extraction of oxygen limits the value of coronary sinus saturation monitoring as indicator of coronary flow. Heart's little extraction reserve is faced with coronary flow reserve. In the physiologic range and under the conditions of anesthesia, elevated CO2 production is accompanied with increased coronary flow. Under these circumstances, deltaP(cs-a)CO2 appears stable and is not suitable for clinical decisions concerning heart's coronary flow.

Published
2004

3. ATORVASTATIN EFFECTS ON INFLAMMATION AND PLATELET ACTIVATION MARKERS FOLLOWING DRUG ELUTING STENTING IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE

Author

G. Moschos, E. Hatzinikolaou-Kotsakou, Th. Beleveslis, K. Tsakiridis, E. Reppas, G. Bobotis, A. Chantas, and A. Mavrogiani

Subjects
Drug, medicine.medical_specialty, business.industry, media_common.quotation_subject, Atorvastatin, Inflammation, General Medicine, medicine.disease, Coronary artery disease, Internal medicine, Internal Medicine, medicine, Cardiology, In patient, Platelet activation, medicine.symptom, Cardiology and Cardiovascular Medicine, business, media_common, medicine.drug
Published
2008
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4. Poster Session 2

Author

T. Andersson, A. Magnusson, I.- L. Bryngelsson, O. Frobert, K. M. Henriksson, N. Edvardsson, D. Poci, M. Polovina, T. Potpara, M. Licina, N. Mujovic, A. Kocijancic, D. Simic, M. C. Ostojic, R. A. Providencia, A. Botelho, J. Trigo, J. Nascimento, N. Quintal, P. Mota, A. M. Leitao-Marques, R. F. Bosch, W. Kirch, L. Rosin, S. N. Willich, D. Pittrow, H. Bonnemeier, M. C. Valenza, L. Martin, T. Munoz Casaubon, G. Valenza, M. Botella, M. Serrano, B. Valenza, I. Cabrera, K. Anderson, B. S. Benzaquen, N. Koziolova, J. Nikonova, Y. Shilova, D. Scherr, S. Narayan, M. Wright, D. Krummen, A. Jadidi, P. Jais, M. Haissaguerre, M. Hocini, R. Hunter, Y. Liu, Y. Lu, W. Wang, R. J. Schilling, S. Bernstein, B. Wong, R. Rooke, C. Vasquez, R. Shah, S. Rosenberg, L. Chinitz, G. Morley, M. Bashir Choudhary, F. Holmqvist, J. Carlson, H.- J. Nilsson, P. G. Platonov, A. S. Jadidi, H. Cochet, S. Miyazaki, A. J. Shah, N. Marrouche, N. Calvo, M. Nadal, D. Andreu, D. Tamborero, F. E. Diaz, A. Berruezo, J. Brugada, L. Mont, S. Fichtner, G. Hessling, H. L. Estner, C. Jilek, T. Reents, S. Ammar, J. Wu, I. Deisenhofer, H. Nakanishi, K. Kashiwase, A. Hirata, M. Wada, Y. Ueda, J. Skoda, P. Neuzil, J. Popelova, J. Petru, L. Sediva, V. Y. Reddy, L. Uldry, A. Forclaz, N. Virag, J.- M. Vesin, L. Kappenberger, R. Sehra, C. Briggs, W.- J. Rappel, M. Janotka, M. Chovanec, K. Yamashiro, K. Takami, Y. Sakamoto, K. Satoh, T. Suzuki, H. Nakagawa, A. Romanov, E. Pokushalov, S. Artemenko, V. Shabanov, I. Stenin, D. Elesin, A. Turov, A. Yakubov, M. Hioki, S. Matsuo, K. Ito, R. Narui, S. Yamashita, K. Sugimoto, M. Yoshimura, T. Yamane, L. Di Biase, J. D. Gallinghouse, K. Rajappan, J. Kautzner, A. Dello Russo, C. Tondo, F. Lorgat, A. Natale, O. Balta, K. Buenz, M. Paessler, H. Anders, M. Horlitz, T. Deneke, L. Lickfett, I. Liberman, M. Linhart, R. Andrie, E. Mittmann-Braun, F. Stockigt, G. Nickenig, J. Schrickel, R. Tilz, A. Rillig, B. Feige, A. Metzner, A. Fuernkranz, A. Burchard, E. Wissner, F. Ouyang, T. R. Betts, M. A. Jones, K. C. K. Wong, N. Qureshi, Y. Bashir, G. Corbucci, D. Losik, V. Selina, M. A. Crandall, C. Daniels, E. Daoud, S. Kalbfleisch, H. Yamaji, T. Murakami, H. Kawamura, M. Murakami, K. Hina, S. Kusachi, G. Dakos, V. Vassilikos, S. Paraskevaidis, A. Mantziari, S. Theophylogiannakos, I. Chouvarda, I. Chatzizisis, I. Styliadis, T. Kimura, K. Fukumoto, N. Nishiyama, Y. Aizawa, Y. Fukuda, T. Sato, S. Miyoshi, S. Takatsuki, A. J. Navarrete Casas, I. Ali, F. C. Conte, M. Moran, B. G. Graham, O. Kalejs, R. Lacis, P. Stradins, A. Koris, I. Putnins, M. Vikmane, A. Lejnieks, A. Erglis, A. Estrada, A. Perez Silva, S. Castrejon, D. Doiny, J. L. Merino, A. Baranchuk, I. Greiss, C. S. Simpson, H. Abdollah, D. P. Redfearn, M. Buys-Topart, R. Nitzsche, B. Thibault, S. Kathan, C. Kolb, S. Reif, S. Schade, J. Taggeselle, A. Frey, A. Birkenhagen, S. Kohler, M. Schmidt, O. Cano Perez, F. Buendia, B. Igual, J. M. Osca, J. M. Sanchez, M. J. Sancho-Tello, J. M. Olague, A. Salvador, J. M. Tolosana, J. Fernandez-Armenta, M. Matas, M. C. Barbarin, M. Habibovic, K. C. Van Den Broek, D. A. M. J. Theuns, L. Jordaens, M. Alings, P. H. Van Der Voort, S. S. Pedersen, G. Pupita, S. Molini, M. Brambatti, A. Capucci, S. Molodykh, E. M. Idov, O. V. Belyaev, L. Segreti, E. Soldati, G. Zucchelli, A. Di Cori, S. Viani, L. Paperini, R. De Lucia, M. G. Bongiorni, L. Binner, M. Taborsky, D. Bello, H. Heuer, B. Ramza, I. Jenniskens, W. B. Johnson, M. S. Silvetti, L. Rava', M. S. Russo, C. Di Mambro, A. Ammirati, G. Gimigliano, M. Prosperi, F. Drago, A. R. Santos, B. Picarra, P. Semedo, P. Dionisio, R. Matos, M. Leitao, A. Jacinto, M. Trinca, P. Mazzone, G. Ciconte, A. Marzi, G. Paglino, P. Vergara, N. Sora, S. Gulletta, P. Della Bella, P. Koppitz, A. Fach, S. Hobbiesiefken, E. Fiehn, R. Hambrecht, J. Sperzel, M. Jung, J. Schmitt, D. Pajitnev, H. Burger, G. Goebel, W. Ehrlich, T. Walther, T. Ziegelhoeffer, V. Vancura, D. Wichterle, V. Melenovsky, M. Glikson, G. Goldenberg, A. Segev, D. Dvir, J. Kuzniec, A. Finkelstein, I. Hay, V. Guetta, W. K. Choo, S. Gupta, R. Kirkfeldt, J. Johansen, E. Nohr, M. Moller, P. Arnsbo, J. Nielsen, M. Banha, P. Stojanov, S. Raspopovic, D. Vasic, D. Savic, G. Nikcevic, V. Jovanovic, P. Defaye, B. Mondesert, A. Mbaye, R. Cassagneau, V. Gagniere, J. Jacon, V. Sanfins, H. R. Reis, J. N. Nobre, V. M. Martins, L. D. Duarte, C. M. Morais, J. C. Conceicao, M. Hero, J. L. Rey, A. Ducharme, C. Simpson, C. Stuglin, L. Blier, M. Senaratne, Y. Khaykin, A. Pinter, A. Mlynarska, R. Mlynarski, M. Sosnowski, J. Wilczek, C. Iorgulescu, S. Bogdan, D. Constantinescu, C. Caldararu, M. Dorobantu, A. Radu, R.- G. Vatasescu, S. Yusu, T. Ikeda, H. Mera, Y. Miwa, A. Abe, M. Miyakoshi, T. Tsukada, H. Yoshino, V. Nayar, P. Cantelon, A. Rawling, M. R. D. Belham, P. J. Pugh, J. Osca Asensi, O. Cano, D. Tejada, B. Munoz, M. Rodriguez, J. Olague, L. Wecke, A. Van Hunnik, T. Thompson, L. Di Carlo, M. Zdeblick, A. Auricchio, F. Prinzen, A. Doltra Magarolas, B. Bijnens, E. Silva, D. Penela, M. Sitges, P. Ofman, L. Navaravong, J. Leng, A. Peralta, P. Hoffmeister, R. Levine, J. Cook, M. Stoenescu, M. E. Tettamanti, A. Revilla Orodea, J. Lopez Diaz, L. De La Fuente Galan, R. Arnold, E. Garcia Moran, J. A. San Roman Calvar, I. Gomez Salvador, K. Nakamura, M. Takami, T. Keida, A. Mesato, S. Higa, M. Shimabukuro, H. Masuzaki, R. Proietti, A. Sagone, G. Domenichini, H. Burri, C. Valzania, M. Biffi, H. Sunthorn, G. Gavaruzzi, H. Foulkes, G. Boriani, S. Koh, W. Hou, J. Snell, J. Poore, N. Dalal, G. Bornzin, A. Kloppe, D. Mijic, H. Bogossian, I. Ninios, M. Zarse, B. Lemke, L. Guedon-Moreau, C. Kouakam, D. Klug, C. Marquie, F. Ziglio, S. Kacet, H. Mohamed Fereig Hamed, A. M. A. L. Hamdy, A. H. M. E. D. Abd El Aziz, M. R. V. A. T. Nabih, R. E. H. A. B. Hamdy, A. Yaminisaharif, G. H. Davoudi, A. Kasemisaeid, S. Sadeghian, A. Vasheghani Farahani, P. Yazdanifard, A. Shafiee, C. Alonso, C. Grimard, G. Jauvert, A. Lazarus, L. L. Mont, J. Ortiz-Perez, T. Caralt, J. Escudero, F. Perez, K. M. Griffith, R. Ferreyra, P. Urena, M. Demas, C. Muratore, H. Mazzetti, J. Guardado, M. Fernandes, V. H. Pereira, F. Canario-Almeida, F. Ferreira, B. Rodrigues, J. Almeida, A. Sokal, E. Jedrzejczyk, R. Lenarczyk, S. Pluta, O. Kowalski, P. Pruszkowska, A. Swiatkowski, Z. Kalarus, M. Heinke, B. Ismer, H. Kuehnert, T. Heinke, R. Surber, N. Osypka, D. Prochnau, H. R. Figulla, S. Iacopino, M. Landolina, A. Proclemer, L. Padeletti, V. Calvi, A. Pierantozzi, P. Di Stefano, A. Bauer, F. Bode, F. Le Gal, J. C. Deharo, M. Delay, J. Clementy, M. Kawamura, Y. Munetsugu, K. Tanno, Y. Kobayashi, D. Cannom, J. Hosoda, T. Ishikawa, K. Andoh, M. Nobuyoshi, S. Fujii, S. Shizuta, T. Isshiki, M. A. Castel, F. Perez-Villa, B. Vidal, P. Pruszkowska-Skrzep, M. Szulik, T. Kukulski, L. Gianfranchi, K. Bettiol, F. Pacchioni, P. Alboni, R. Abu Sham'a, J. Buber, E. Nof, R. Kuperstein, M. Feinberg, D. Luria, M. Eldar, K. Parks, J. R. Stone, J. P. Singh, E. Hatzinikolaou-Kotsakou, M. Kotsakou, T. H. Beleveslis, G. Moschos, E. Reppas, P. Latsios, K. Tsakiridis, A. Kazemisaeid, G. Davoodi, A. Yamini Sharif, M. Sheikhvatan, M. Toniolo, G. Zanotto, A. Rossi, L. Tomasi, C. Vassanelli, H. Versteeg, P. M. C. Mommersteeg, G. Vergara, J. Blauer, R. Ranjan, S. Vijayakumar, E. Kholmovski, N. Volland, R. Macleod, L. E. Aguinaga Arrascue, A. Bravo, P. Garcia Freire, P. Gallardo, E. Hasbani, J. Dantur, R. Quintana, P. P. Adragao, D. Cavaco, L. Parreira, K. Reis Santos, P. Carmo, R. Miranda, S. Marcelino, D. Cabrita, P. Sommer, T. Gaspar, S. Rolf, A. Arya, C. Piorkowski, G. Hindricks, E. Valles Gras, V. Bazan, L. Portillo, F. Suarez, J. Bruguera, J. Marti, Y. Huo, S. Richter, R. Schoenbauer, N. Rivas, J. Casaldaliga, I. Roca, L. Dos, J. Perez-Rodon, A. Pijuan, D. Garcia-Dorado, A. Moya, H. B. Carter, A. Garg, J. Hegrenes, H. J. Sih, L. R. Teplitsky, K. Kuroki, H. Tada, Y. Seo, T. Ishizu, M. Igawa, Y. Sekiguchi, K. Kuga, K. Aonuma, C. Rodriguez A, J. Mejias, P. Hidalgo, J. A. Hidalgo L, M. Orczykowski, P. Derejko, F. Walczak, E. Szufladowicz, P. Urbanek, R. Bodalski, K. Bieganowska, L. Szumowski, P. Peichl, R. Cihak, I. Skalsky, P. Kubus, P. Vit, L. Zaoral, R. A. Gebauer, M. Fiala, J. Janousek, K. Hiroshima, M. Goya, M. Ohe, K. Hayashi, Y. Makihara, M. Nagashima, Y. An, M. Schloesser, T. Lawrenz, D. Meyer Zu Vilsendorf, C. Strunk-Mueller, C. Stellbrink, J. Papagiannis, D. Avramidis, C. Kokkinakis, G. Kirvassilis, G. Eidelman, A. Arenal, T. Datino, F. Atienza, E. Gonzalez Torrecilla, A. Miracle, J. Hernandez, F. Fernandez Aviles, E. Ene, P. Insulander, H. Bastani, F. Braunschweig, N. Drca, G. Kenneback, J. Schwieler, J. Tapanainen, M. Jensen-Urstad, B. Andrea, E. M. A. Andrea, W. M. Maciel, L. S. Siqueira, R. C. Cosenza, F. M. Mittidieri, S. F. Farah, J. A. Atie, E. Kanoupakis, E. Kallergis, H. Mavrakis, C. Goudis, I. Saloustros, N. Malliaraki, G. Chlouverakis, P. Vardas, J. L. Bonnes, J. Jaspers Focks, S. W. Westra, M. A. Brouwer, J. L. R. M. Smeets, G. Inama, C. Pedrinazzi, F. Oliva, M. Senni, M. Zoni Berisso, S. Mostov, M. Haim, R. Nevzorov, D. Hasadi, B. Starsberg, A. Porter, J. Kuschyk, A. Schoene, F. Streitner, C. G. Veltmann, R. Schimpf, M. Borggrefe, U. Luesebrink, A. Gardiwal, H. Oswald, T. Koenig, D. Duncker, G. Klein, R. Bastiaenen, V. Batchvarov, O. Atty, J. H. Cheng, E. R. Behr, M. M. Gallagher, A. H. Starrenburg, K. Kraaier, M. F. Scholten, J. Van Der Palen, S. Adhya, L. A. Smith, T. Zhao, C. Bannister, R. H. Kamdar, M. Martinelli, S. Siqueira, R. Greco, S. A. D. Nishioka, A. A. A. Pedrosa, R. Alkmim-Teixeira, G. L. Peixoto, R. Costa, J. C. Nielsen, P. T. Mortensen, J. B. Johansen, W. Kwasniewski, A. Filipecki, D. Urbanczyk-Swic, W. Orszulak, M. Trusz - Gluza, J. Jimenez-Candil, J. Morinigo, C. Ledesma, C. Martin-Luengo, T. Vogtmann, M. Gomer, S. Stiller, V. Kuehlkamp, G. Zach, S. Loescher, S. Kespohl, G. Baumann, J. D. Snell, N. Korsun, J. R. Snell, B. Morley, R. Bharmi, Y. Nabutovsky, M. Mollerus, L. Naslund, A. Meyer, M. Lipinski, B. Libey, K. Dornfeld, A. Martin, M. Gallego, M. K. De Bie, J. B. Van Rees, C. J. Borleffs, J. Thijssen, J. W. Jukema, M. J. Schalij, L. Van Erven, E. T. Van Der Velde, T. A. Witteman, H. Foeken, T. Szili-Torok, F. Akca, K. Caliskan, F. Ten Cate, M. Michels, D. C. Cozma, L. Petrescu, C. Mornos, S. I. Dragulescu, J. A. Groeneweg, B. K. Velthuis, M. G. P. J. Cox, P. Loh, D. Dooijes, M. J. Cramer, J. M. T. De Bakker, R. N. W. Hauer, S. D. Park, S. H. Shin, S. I. Woo, J. Kwan, K. S. Park, D. H. Kim, A. Iorio, L. Vitali Serdoz, F. Brun, E. Daleffe, M. Zecchin, M. Dal Ferro, S. Santangelo, G. F. Sinagra, S. Ouali, R. Hammemi, S. Hammas, S. Kacem, R. Gribaa, E. Neffeti, F. Remedi, E. Boughzela, P. Korantzopoulos, K. Letsas, Z. Christogiannis, K. Kalantzi, A. Ntorkos, J. Goudevenos, P. W. X. Foley, L. Yung, E. Barnes, M. Kikuchi, H. Ito, F. Miyoshi, R. Pecini, J. M. Marott, G. B. Jensen, J. Theilade, T. Mine, T. Kodani, T. Masuyama, I. M. Mozos, C. Serban, C. Costea, L. Susan, P. Barthel, A. Mueller, M. Malik, G. Schmidt, O. Karakurt, H. Kilic, D. R. Munevver Sari, D. Mroczek-Czernecka, A. Z. Pietrucha, A. Borowiec, M. Wnuk, I. Bzukala, O. Kruszelnicka, E. Konduracka, J. Nessler, Y. Kikuchi, A. Meireles, C. Gomes, D. Anjo, C. Roque, A. Pinheiro Vieira, V. Lagarto, A. Hipolito Reis, S. Torres, L. Miller, G. Vedrenne, E. Bruguiere, A. Redheuil, T. Lavergne, J. Y. Le Heuzey, E. Mousseaux, A. Hersi, K. Alhabib, H. Alfaleh, K. Sulaiman, W. Almahmeed, J. Alsuwidi, H. Amin, A. Almotarreb, H. W. K. Pang, K. Michael, E. J. Pereira, P. W. Munt, M. F. Fitzpatrick, A. S. Revishvili, G. Simonyan, T. Dzhordzhikiya, O. Sopov, V. Kalinin, E. T. Locati, A. M. Vecchi, G. Cattafi, A. Sachero, M. Lunati, S. Sayah, A. Alizadeh, N. Nazari, M. Hekmat, M. Moradi, M. Zeighami, H. Ghanji, K. Suzuki, M. Takagi, K. Maeda, H. Tatsumi, P. Vieira, H. Reis, A. Toth, H. Vago, P. Takacs, E. Edes, A. Marki, G. Y. Balazs, K. Huttl, B. Merkely, F. Lainis, M. M. Buckley, E. J. Johns, C. M. Seifer, L. Daba, K. Liebrecht, W. Piwowarska, J. Toquero Ramos, E. Perez Pereira, C. Mitroi, V. Castro Urda, J. M. Fernandez Villanueva, A. Corona Figueroa, L. Hernandez Reina, I. Fernandez Lozano, A. Bartoletti, P. Bocconcelli, S. Giuli, R. Massa, C. Svetlich, G. Tarsi, F. Tronconi, E. Vitale, P. Stryjewski, M. Wegrzynowska, A. Lousinha, J. Labandeiro, E. Antunes, S. Silva, S. Alves, A. Timoteo, M. Oliveira, R. Cruz Ferreira, and J. Jedrzejczyk-Spaho

Subjects
medicine.medical_specialty, Voltage-dependent calcium channel, business.industry, medicine.drug_class, Umbilical artery, 030204 cardiovascular system & hematology, Cyclase, 3. Good health, Low testosterone levels, 03 medical and health sciences, 0302 clinical medicine, Bkca channel, Endocrinology, Physiology (medical), Internal medicine, medicine.artery, Natriuretic peptide, Medicine, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Ionic Channels
Abstract

Inthelastdecadesseveralinvestigatorshavesuggestedtheassociationofandrogenswithhypertension. Recently, some studies have shown that the incidence of cardiovascular diseases is increased in men with low testosterone levels, suggesting a protective role of androgens. Hypertension is one of the mostcommonproblemsinpregnancythatcomplicates5-10 %ofpregnancies.Anincreaseofmorbidity wasobservedinbabiesfrompregnantwomenwithhypertension.However,thepathogenesisremains unclearandthislimitstheabilitytopreventandtreatthispathology.Thebeneficialeffectsofandrogens for vascular system are associated with their ability to cause vasorelaxation. Inhuman vessels, this non genomiceffectofandrogensappeartobeduetoactivationoflargeconductancecalcium-activatedpotassiumchannels(BKCa)andvoltagegatedpotassiumchannels(KV)whichisinducedbycGMPincrease andaconsequentactivationofcGMP-dependentproteinkinase(PKG).Ontheotherhand,thegenomic effects of androgens concerning ionic channels are almost unknown. Our previous studies suggested that androgens increase the expression of BKCa channels and decrease expression of L-type calcium channels (LTCC). The aim of this work was to analyze the genomic effects of androgens on theexpressionofotherproteinsinvolvedintheregulationofvascularcontractility,suchassolubleguanylate cyclase (sGC), the natriuretic peptide receptor-A (NPRA) and PKG. This study also aimed to compare the expression levels of these proteins in human umbilical artery (HUA) from normotensive andhypertensivepregnantwomen.ToachievethesegoalsrealtimePCRwasperformedusingsmooth

Published
2011
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5. Moderated Posters: Sudden cardiac death

Author

W. Kwasniewski, A. Filipecki, W. Orszulak, D. Urbanczyk, K. Szydlo, M. Trusz Gluza, C. J. W. Borleffs, J. B. Van Rees, G. H. Van Welsenes, L. Van Erven, R. J. Van Bommel, E. T. Van Der Velde, J. J. Bax, M. J. Schalij, J. Jimenez-Candil, M. Ruiz, J. Morinigo, A. Martin, C. Ledesma, C. Martin-Luengo, R. Cozar-Leon, E. Diaz-Infante, B. Prado-Gotor, P. Nieto, J. Maldonado, I. Borrego, J. M. Cruz, K. Satomi, Y. Yamada, H. Okamura, T. Noda, W. Shimizu, K. Suyama, N. Aihara, S. Kamakura, E. Hatzinikolaou-Kotsakou, G. Moschos, T. H. Beleveslis, E. Reppas, M. Kotsakou, K. Tsakiridis, M. F. Nageh, J. J. Kim, J. Yao, T. F. Deering, A. Epstein, D. Goldman, S. Greenberg, Y. Dalal, J. Kreuz, O. Balta, L. Lickfett, G. Nickenig, J. Schwab, F. W. Horlbeck, A. Bitzen, N. Liliegren, A. Jegorova, and J. O. Schwab

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), Internal medicine, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business, medicine.disease, Sudden cardiac death
Published
2009
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6. Poster session 3: Miscellaneous

Author

T. Potpara, M. Grujic, M. Ostojic, B. Vujisic, M. Polovina, N. Mujovic, E. Hatzinikolaou-Kotsakou, E. Reppas, T. H. Beleveslis, G. Moschos, M. Kotsakou, K. Tsakiridis, E. Simeonidou, A. Papandreou, G. Tsigas, C. Michalakeas, C. Tsitlakidis, D. Alexopoulos, J. Lekakis, D. T. Kremastinos, D. Poci, L. Backmn, T. H. Karlsson, N. Edvardsson, P.- G. Golzio, M. Vinci, C. Amellone, M. Jorfida, V. Veglio, E. Gaido, G. P. Trevi, M. G. Bongiorni, L. Ding, W. E. I. Hua, S. H. U. Zhang, K. E. P. I. N. G. Chen, F. Z. Wang, X. I. N. Chen, B. Dokumaci, A. S. Dokumaci, S. Ozyildirim, M. Yolcu, C. Uyan, S. Nicolas-Franco, J. Rodriguez Gonzalez, C. Albacete-Moreno, G. Ruiz-Villa, A. Sanchez-Martos, D. Bixquert-Genoves, P. Skoczynski, J. Gajek, D. Zysko, M. Porebska, K. Josiak, W. Mazurek, R. A. Providencia, J. Silva, L. Seca, P. L. Gomes, S. Barra, P. Mota, J. Nascimento, A. M. Leitao-Marques, Y. Kikuchi, P. A. Brady, P. Erne, J. Val-Mejias, J. Schwab, R. Schimpf, M. Orlov, T. Mattioni, J. Amlie, F. Sacher, B. Lahitton, J. Laborderie, M. Wright, M. Haissaguerre, T. Berger, R. Zwick, W. Dichtl, M. Stuehlinger, O. Pachinger, F. Hintringer, K. Toli, K. Koutras, J. Stauropoulos, S. Vichos, J. Mantas, C. R. Rodriguez Artuza, J. A. Hidalgo L, A. Garcia, P. Fumero, A. Perez, I. Rangel, S. Perl, P. Stiegler, A. Kollmann, B. Rotman, P. Lercher, M. Anelli-Monti, K. H. Tscheliessnigg, B. M. Pieske, K. Nakamura, S. Naito, K. Kumagai, K. Goto, J. Iwamoto, N. Funabashi, S. Oshima, I. Komuro, J. Stavropoulos, D. Koutras, L. Di Biase, S. Beheiry, R. Hongo, R. Horton, K. Morganti, S. Hao, J. Javier Sanchez, A. Natale, G. Digby, B. Parfrey, F. Morriello, L. Lim, W. M. Hopman, C. S. Simpson, D. P. Redfearn, A. Baranchuk, T. Madsen, E. B. Schmidt, E. Toft, J. H. Christensen, D. Patel, M. Shaheen, K. Sonne, P. Mohanty, L. Dibiase, R. P. Horton, J. E. Sanchez, T. Krynski, S. M. Stec, A. Stanke, A. Baszko, P. Kulakowski, E. Rondano, M. Bortnik, E. Occhetta, G. Teodori, P. P. Caimmi, P. N. Marino, P. Osmancik, Z. Peroutka, D. Herman, P. Stros, P. Budera, Z. Straka, D. Petrac, V. Radeljic, D. Delic-Brkljacic, S. Manola, N. Pavlovic, G. Inama, C. Pedrinazzi, P. Adragao, F. Arribas, M. Landolina, J. L. Merino, J. De Sousa, M. Gulizia, P. Neuzil, F. Holy, J. Skoda, J. Petru, L. Sediva, S. Kralovec, J. Brada, M. Taborsky, M. Takami, A. Yoshida, K. Fukuzawa, K. Takami, H. Kumagai, S. Tanaka, M. Itoh, K. Hirata, F. Jacques, J. Champagne, D. Doyle, E. Charbonneau, F. Dagenais, P. Voisine, E. Dumont, A. Aboelhoda, M. Nawar, I. Khadragui, M. Loutfi, B. Ramadan, G. Makboul, L. Gianfranchi, F. Pacchioni, K. Bettiol, P. Alboni, R. Gallardo Lobo, R. Pap, G. Bencsik, A. Makai, G. Marton, L. Saghy, T. Forster, M. Stockburger, F. Trautmann, A. Nitardy, M. Just-Teetzmann, S. Schade, O. Celebi, A. Krebs, R. Dietz, C. A. Pastore, R. A. Douglas, N. Samesima, M. Martinelli Filho, S. A. D. Nishioka, A. Pastor Fuentes, J. Perea, N. Tur, B. Berzal, L. H. Boldt, M. Polotzki, M. G. Posch, A. Perrot, M. Lohse, S. Rolf, C. Ozcelik, W. Haverkamp, L. G. Tunyan, S. V. Grigoryan, A. Barsheshet, R. Abu Sham'a, R. Kuperstein, M. S. Feinberg, A. Sandach, D. Luria, M. Eldar, M. Glikson, R.- G. Vatasescu, A. Berruezo, C. Iorgulescu, A. Fruntelata, M. Dorobantu, A. Chaumeil, F. Philippon, G. O'hara, L. Blier, F. Molin, M. Gilbert, U. Paslawska, A. Noszczyk-Nowak, P. Skrzypczak, J. Nicpon, S. Chevallier, A. Van Oosterom, E. Pruvot, A. Iga, M. Igarashi, H. Itou, T. Fujino, T. Tsubota, J. Yamazaki, K. Yoshihara, P. Arsenos, K. Gatzoulis, P. Dilaveris, T. Gialernios, T. Papaioannou, K. Masoura, S. Archontakis, C. Stefanadis, G. M. Nasr, A. Khashaba, H. Osman, M. El-Barbary, M. Heinke, T. Heinke, B. Ismer, H. Kuehnert, R. Surber, and H. R. Figulla

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), Medicine, Medical physics, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2009
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7. Poster Session 4: ECG

Author

D. Rollando, R. Pap, F. Fernandez-Aviles, N. Davidson, R. Weber, A. H. Christensen, E. Stoica, G. P. Bezante, P. Saravanan, A. Tardin, S. Apiyasawat, T. Papaioannou, L. Getaz, F. Gonzalez Llopis, G. Bertero, B. Moise, L. Paredes, A. Antoniadis, C. Stefanadis, J. Osca Asensi, M. Haissaguerre, A. Forclaz, P. Serrano Aguilar, M. Trusz-Gluza, E. Tsaritsaniotis, I. Nault, E. Arbelo Lainez, A. Matsumura, A. Filipecki, P. Dilaveris, J. L. Rojo Alvarez, T. Forster, M. Ito, J. A. Giner-Caro, J. Martinez-Sanchez, J. H. Svendsen, S. Yamazato, Everss, E. Modonesi, M. Suzuki, J. Carlson, K. Letsas, S. Sugiura, J. D. Luporsi, R. M. W. Hofstra, F. Holmqvist, P. Kaminsky, A. Bikias, S. O'neill, S. Led, E. Themeles, Y. Jackson, D. Coriu, A. Salvador Sanz, J. J. Sanchez-Munoz, T. Arentz, E. Gonzalez-Torrecilla, E. Reppas, F. Chappuis, G. Tsiliki, O. Chioncel, G. Katsaris, M. Senga, G. Manis, T. H. Beleveslis, L. Haman, A. Michelucci, Z. Tabor, J. Sztajzel, A. Jadidi, K. Tsakiridis, M. Kotsakou, C. Militaru, S. Haunso, S. Archontakis, C. Macarie, F. Atienza Fernandez, M. Nieri, A. Makai, K. Wita, P. Reilly, E. Fujii, I. Donoiu, P. Chandanamattha, M. Ezekowitz, S. Connolly, G. Moschos, G. Galanti, J. D. H. Jongbloed, H. Dostalova, M. Hocini, O. Cano Perez, J. Olague De Ros, S. Yusuf, A. Scopinaro, S. Sideris, A. Arenal Maiz, S. Terrades, E. Zorio Grima, L. Caselli, A. Garcia Quintana, M. Gatley, J. Oldgren, S. Miyazaki, I. Delithanasis, N. Fragakis, I. Tatsis, E. Hatzinikolaou-Kotsakou, M. Wright, J. Navarro Manchon, A. Giuca, L. Garcia Perez, M. L. Castilla San Jose, P. Penafiel-Verdu, S. Narayan, T. Gialernios, E. Caballero Dorta, A. Barsotti, D. D. Ionescu, M. Valdes-Chavarri, C. Brunelli, A. Garcia-Alberola, G. Klausz, T. Ngarmukos, J. Almendral Garrote, O. Londono Sanchez, B. Brembilla-Perrot, M. Nakamura, L. Wallentin, M. A. Arnau Vives, J. Gaspoz, Y. Hashimoto, P. Van Der Zwaag, K. Szydlo, G. Bencsik, F. J. Pastor-Perez, P. Parizek, P. G. Platonov, S. Vignini, M. P. Van Den Berg, V. Santeladze, P. Arsenos, K. Gatzoulis, K. Likittanasombat, M. Ohno, L. Saghy, A. Medina Fernandez-Aceytuno, W. Nagahori, D. Kalusche, L. Serrano Arriezu, A. Parekh, N. N. Al-Shawabkeh, J P Van Tintelen, K. Astheimer, M. Stridh, and N. Sadoul

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), Physical therapy, medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2009
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8. HYPERCHOLESTEROLEMIA IN DILATED CARDIOMYOPATHY: THE LEVELS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 COULD BE A DETERMINANT INDEPENDENT RISK FACTOR FOR CAD

Author

A. Chantas, K. Tsakiridis, E. Reppas, Th. Beleveslis, E. Hatzinikolaou-Kotsakou, G. Moschos, and M. Kotsakou

Subjects
medicine.medical_specialty, business.industry, Lipoprotein-associated phospholipase A2, CAD, Dilated cardiomyopathy, General Medicine, medicine.disease, Internal medicine, Internal Medicine, Cardiology, Medicine, Risk factor, Cardiology and Cardiovascular Medicine, business, A determinant
Published
2008
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