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Your search keyword '"Karin Stempelmann"' showing total 2 results
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2 results on '"Karin Stempelmann"'

1. A new tool for rapid and reliable diagnosis of HLA loss relapses after HSCT

Author

Dietrich W. Beelen, Chiara Brambati, Karin Stempelmann, Wietse Mulder, Luca Vago, Pietro Crivello, Benedetta Mazzi, Douglas A. Bost, Cinzia Pultrone, Katharina Fleischhauer, Cristina Toffalori, Fabio Ciceri, Evelien E. Bouwmans, Müberra Ahci, Ahci, Müberra, Toffalori, Cristina, Bouwmans, Evelien, Crivello, Pietro, Brambati, Chiara, Pultrone, Cinzia, Stempelmann, Karin, Bost, Dougla, Mazzi, Benedetta, Beelen, Dietrich W, Ciceri, Fabio, Mulder, Wietse, Fleischhauer, Katharina, and Vago, Luca

Subjects
Genetic Markers, medicine.medical_treatment, Genes, MHC Class II, Immunology, Medizin, Genes, MHC Class I, HLA-C Antigens, Human leukocyte antigen, Hematopoietic stem cell transplantation, Polymerase Chain Reaction, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Antigen, Antigens, Neoplasm, Recurrence, Inside BLOOD Commentary, MHC class I, Humans, Medicine, HLA-DP beta-Chains, Health Services Needs and Demand, MHC class II, Leukemia, HLA-A Antigens, biology, business.industry, Haplotype, Hematopoietic Stem Cell Transplantation, Cell Biology, Hematology, Histocompatibility, surgical procedures, operative, Haplotypes, Tumor Escape, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, biology.protein, business, Gene Deletion, 030215 immunology
Abstract

In this issue of Blood, Ahci and colleagues describe a simple and robust method for identifying the phenomenon of leukemic HLA loss often associated with treatment failure of hematopoietic stem cell transplantation from haploidentical donors (haplo-HSCT).1

Published
2017
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2. Biological responses of workplace particles and their association with adverse health effects on miners

Author

Steffeni Rehn, Herbert Diederichs, Karin Stempelmann, Joachim Bruch, Weihong Chen, and Bernd Rehn

Subjects
Male, China, Lung Neoplasms, Cell Survival, Guinea Pigs, chemistry.chemical_element, Corundum, Air Pollutants, Occupational, Management, Monitoring, Policy and Law, engineering.material, Oxygen, Mining, Cohort Studies, chemistry.chemical_compound, Cause of Death, Occupational Exposure, Lactate dehydrogenase, Macrophages, Alveolar, Toxicity Tests, medicine, Animals, Humans, Particle Size, Rats, Wistar, Quartz, Cells, Cultured, chemistry.chemical_classification, Reactive oxygen species, Tumor Necrosis Factor-alpha, Pneumoconiosis, Metallurgy, Radiochemistry, Public Health, Environmental and Occupational Health, Dust, General Medicine, medicine.disease, In vitro, Rats, chemistry, Tin, engineering, Tumor necrosis factor alpha, Reactive Oxygen Species
Abstract

Epidemiological research has demonstrated the relationship between exposure to quartz dust and an elevated risk of pneumoconiosis and possible elevated risk of cancer. The current study was designed to evaluate the biological responses of workplace particles containing crystalline silica using an in vitro cell test. Respirable particle samples were sampled from four tin mines, where the standardized mortality ratio (SMR) for pneumoconiosis was 51.6 and SMR for lung cancer was 2.2 in dust-exposed miners. Alveolar macrophages (AM) are considered as the target cells for primary dust effects. The samples were then measured at 15, 30, 60 and 120 microg particle per 10(6) AM for cytoxicity with the release of glucuronidase, lactate dehydrogenase, for reactive oxygen damage with H(2)O(2) release, and for ability to induce fibrosis using the secretion of tumor necrosis factor-alpha (TNF-alpha). Pure quartz (DQ12) and corundum were used as controls. The results showed the samples from tin mines caused a higher cytoxicity when compared to corundum, yet lower when compared to quartz. However, reactive oxygen species release (148-177 nmol/3 x 10(5) AM in high concentration of 120 microg/10(6) AM) induced by the samples were significantly higher than that induced by quartz (57 nmol/3 x 10(5) AM) and corundum (62 nmol/3 x 10(5) AM). Furthermore, particle samples induced higher TNF-alpha secretion than corundum, the samples from Limu tin mine induced much higher TNF-alpha levels than that induced by DQ12 quartz. The results from the in vitro tests help elucidate the degree of hazard of dust particles in tin mines. The in vitro reaction patterns of AM also constitute a powerful tool to monitor biological and pathogenic responses of humans following dust particle exposure.

Published
2004
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