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Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is one of the most fatal complications of hematopoietic cell transplantation (HCT), and defibrotide is the only curative drug. We conducted this study to confirm the survival rate of VOD/SOS patients diagnosed in Korea and assess the efficacy of defibrotide.Patients diagnosed with VOD/SOS after allogenic HCT between 2003 and 2020 were enrolled. We investigated day +100 survival rates and associated risk factors in patients who satisfied the modified Seattle criteria within 50 days of HCT.A total of 110 patients satisfied the modified Seattle criteria, of which 65.5% satisfied the Baltimore criteria. Thirty-seven patients were treated with defibrotide. The day +100 survival rate of the 110 patients was 65.3%. The survival rates in patients who did not meet the Baltimore criteria and in those who did were 86.8% and 53.7%, respectively (p = 0.001). The day +100 survival rate of patients treated with defibrotide was 50.5%. Among the patients receiving defibrotide, those whose creatinine levels were more than 1.2 times the baseline had a significantly lower survival rate at 26.7% (p = 0.014). On multivariate regression analysis, the hazard ratio of satisfaction of the Baltimore criteria was 4.54 (95% confidence interval [CI], 1.69 to 12.21; p = 0.003). In patients treated with defibrotide, the hazard ratio was 8.70 (95% CI, 2.26 to 33.45; p = 0.002), when creatinine was more than 1.2 times the baseline on administration.The day +100 survival rate was significantly lower when the Baltimore criteria were satisfied, and when there was an increase in creatinine at the time of defibrotide administration.

Reinforced Concrete (RC) structures are common in earthquake-prone areas. During an earthquake, the steel reinforcement is subjected to cyclic strain histories which lead to inelastic response. In the case of rare, strong earthquakes, inelastic buckling and even rupture due to low-cycle fatigue can also occur. The understanding and characterization of the performance of RC structures under earthquake hazards requires the accurate simulation of the inelastic hysteretic behavior of steel reinforcement by means of appropriate constitutive models. Several uniaxial material models have been developed for reinforcing steel. Existing material models sacrifice efficiency for accuracy or vice versa. Conceptually simple and numerically efficient models do not accurately capture the hysteretic response and ignore rupture or buckling. On the other hand, more refined material models are characterized by iterative stress update procedures which can significantly increase the computational cost of an analysis. Additionally, experience suggests that refined models attempting for the effect of inelastic buckling tend to lead to numerical convergence problems in the stress update procedure. The goal of the present study is the formulation and implementation of an accurate and computationally efficient constitutive model for steel reinforcement under cyclic loading. A previously developed model, capable of capturing the inelastic hysteretic response of reinforcing steel in the absence of buckling and rupture, is used as a starting point in this study. The model is enhanced by replacing its original, iterative stress update procedure with an equally accurate, non-iterative one. Additionally, the model is enhanced to capture the effects of inelastic buckling and of rupture. The accuracy of the model and the efficiency of the non-iterative stress update algorithm are demonstrated by means of validation analyses. Master of Science