1. A longitudinal approach to biological psychiatric research: The PsyCourse study
- Author
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Monika Budde, Janos Kalman, Harald Scherk, Martin von Hagen, Fabian U. Lang, Markus Jäger, Jens Wiltfang, Georg Juckel, Udo Dannlowski, Manfred Koller, Fanny Senner, Katrin Gade, Kristina Adorjan, Eva Z. Reininghaus, Eva C. Schulte, Ida Sybille Haußleiter, Anna Gryaznova, Andreas J. Fallgatter, Till F. M. Andlauer, Ion-George Anghelescu, Markus Reitt, Here Folkerts, Sybille Schulz, Urs Heilbronner, Jens Reimer, Marcella Rietschel, Max Schmauß, Christian Figge, Maria Hake, Sebastian Stierl, Andreas Thiel, Laura Flatau, Markus M. Nöthen, Stephanie H. Witt, Moritz E. Wigand, Detlef E. Dietrich, Heike Anderson-Schmidt, Ashley L. Comes, Carsten Spitzer, Thomas Becker, Volker Arolt, Daniela Reich-Erkelenz, Bernhard T. Baune, Kim Bartholdi, Milena Meyers, Thomas G. Schulze, Vanessa Nieratschker, Barbara Emons, Franziska Degenhardt, Peter Falkai, Carsten Konrad, Silke Quast, Sabrina K. Schaupp, Jörg Zimmermann, Sophia Stegmaier, Andreas J. Forstner, Sergi Papiol, and Farah Klöhn-Saghatolislam
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Male ,Research design ,Bipolar Disorder ,diagnosis ,psychology [Psychotic Disorders] ,diagnosis [Schizophrenia] ,0302 clinical medicine ,psychosis ,Longitudinal Studies ,Research Articles ,psychology [Bipolar Disorder] ,Genetics (clinical) ,Psychopathology ,Mental Disorders ,Middle Aged ,3. Good health ,Diagnostic and Statistical Manual of Mental Disorders ,Psychiatry and Mental health ,Phenotype ,Research Design ,Schizophrenia ,diagnosis [Psychotic Disorders] ,Female ,Schizophrenic Psychology ,Research Article ,Clinical psychology ,Adult ,Psychosis ,medicine.medical_specialty ,diagnosis [Mental Disorders] ,methods [Psychopathology] ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,RDoC ,medicine ,Humans ,ddc:610 ,Bipolar disorder ,diagnosis [Bipolar Disorder] ,Psychiatry ,Kraepelinian dichotomy ,Aged ,affective disorder ,medicine.disease ,Mental health ,030227 psychiatry ,Psychotic Disorders ,psychology [Mental Disorders] ,polygenic risk score ,030217 neurology & neurosurgery - Abstract
In current diagnostic systems, schizophrenia and bipolar disorder are still conceptualized as distinct categorical entities. Recently, both clinical and genomic evidence have challenged this Kraepelinian dichotomy. There are only few longitudinal studies addressing potential overlaps between these conditions. Here, we present design and first results of the PsyCourse study (N = 891 individuals at baseline), an ongoing transdiagnostic study of the affective-to-psychotic continuum that combines longitudinal deep phenotyping and dimensional assessment of psychopathology with an extensive collection of biomaterial. To provide an initial characterization of the PsyCourse study sample, we compare two broad diagnostic groups defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) classification system, that is, predominantly affective (n = 367 individuals) versus predominantly psychotic disorders (n = 524 individuals). Depressive, manic, and psychotic symptoms as well as global functioning over time were contrasted using linear mixed models. Furthermore, we explored the effects of polygenic risk scores for schizophrenia on diagnostic group membership and addressed their effects on nonparticipation in follow-up visits. While phenotypic results confirmed expected differences in current psychotic symptoms and global functioning, both manic and depressive symptoms did not vary between both groups after correction for multiple testing. Polygenic risk scores for schizophrenia significantly explained part of the variability of diagnostic group. The PsyCourse study presents a unique resource to research the complex relationships of psychopathology and biology in severe mental disorders not confined to traditional diagnostic boundaries and is open for collaborations.
- Published
- 2018
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