1. Prohedonic properties of gamma-hydroxybutyrate are associated with changes in limbic resting-state functional connectivity
- Author
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Dario Dornbierer, Robin von Rotz, Rainer Kraehenmann, Fabrizio Esposito, Philipp Staempfli, Oliver G. Bosch, Erich Seifritz, Boris B. Quednow, University of Zurich, Bosch, Oliver G, Bosch, O. G., Esposito, F., Dornbierer, D., von Rotz, R., Kraehenmann, R., Staempfli, P., Quednow, B. B., and Seifritz, E.
- Subjects
Male ,libido ,Euphoriant ,2738 Psychiatry and Mental Health ,0302 clinical medicine ,Limbic System ,2736 Pharmacology (medical) ,Medicine ,Pharmacology (medical) ,10064 Neuroscience Center Zurich ,Cerebral Cortex ,Cross-Over Studies ,Cross-Over Studie ,Euphoria ,Magnetic Resonance Imaging ,anhedonia ,Psychiatry and Mental health ,2728 Neurology (clinical) ,medicine.anatomical_structure ,Neurology ,medicine.symptom ,sodium oxybate ,Human ,Adult ,medicine.medical_specialty ,Clinical Neurology ,610 Medicine & health ,Gyrus Cinguli ,Young Adult ,03 medical and health sciences ,mania ,Double-Blind Method ,liquid ecstasy ,Internal medicine ,Connectome ,Humans ,Paracentral lobule ,Anterior cingulate cortex ,Resting state fMRI ,business.industry ,Anhedonia ,Gamma hydroxybutyrate ,GABA-B Receptor Agonist ,030227 psychiatry ,Endocrinology ,nervous system ,Superior frontal gyrus ,10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics ,2808 Neurology ,GABA-B Receptor Agonists ,Neurology (clinical) ,business ,Insula ,030217 neurology & neurosurgery - Abstract
Objective: Gamma-hydroxybutyrate (GHB) is an endogenous GHB-/GABA-B receptor agonist and a narcolepsy treatment. However, GHB is also abused for its prohedonic effects. On a neuronal level, it was shown that GHB increases regional cerebral blood flow in limbic areas such as the right anterior insula (rAI) and the anterior cingulate cortex (ACC). We aimed to further explore the association between the subjective and neuronal signatures of GHB. Method: We assessed subjective effects and resting-state functional connectivity (rsFC) of an rAI- and an ACC-seed in 19 healthy male subjects after GHB (35mg/kg p.o.) using a placebo-controlled, double-blind, randomized, cross-over functional magnet resonance imaging design. Results: GHB increased subjective ratings for euphoria (p 
- Published
- 2018
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