1. Additional file 1 of Serum neurofilament light chain level as a predictor of cognitive stage transition
- Author
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Lee, Eun-Hye, Kwon, Hyuk Sung, Koh, Seong-Ho, Choi, Seong Hye, Jin, Jeong-Hwa, Jeong, Jee Hyang, Jang, Jae-Won, Park, Kyung Won, Kim, Eun-Joo, Kim, Hee Jin, Hong, Jin Yong, Yoon, Soo Jin, Yoon, Bora, Kang, Ju-Hee, Lee, Jong-Min, Park, Hyun-Hee, and Ha, Jungsoon
- Abstract
Additional file 1: Supplementary Table 1. Baseline characteristics of the total participants according to the initial serum NFL levels. Supplementary Table 2. Multivariate Cox regression analysis of the factors for cognitive stage transition in total participants. Supplementary Table 3. Clinical characteristics of participants based on cognitive stage transition over the study period in mild cognitive impairment participants (n = 53). Supplementary Table 4. Clinical characteristics of participants based on cognitive stage transition over the study period in cognitively unimpaired participants (n = 146). Supplementary Table 5. Correlation between cortical thickness and neurofilament light chain levels in the serum. The cortical thickness of specific brain regions, including the hippocampus, globus pallidus, accumbens, putamen, and thalamus, were significantly negatively correlated with serum NFL levels. Supplementary Table 6. Clinical characteristics of participants with negative amyloid pathology according to the initial serum NFL levels (n = 135). Higher serum NFL levels in individuals with negative amyloid pathology were associated with cognitive stage transition (P = 0.003).
- Published
- 2022
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