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2. Carbon nanotube substrates enhance SARS-CoV-2 spike protein ion yields in matrix assisted laser desorption-ionization mass spectrometry

Author

T. Schenkel, A. M. Snijders, K. Nakamura, P. A. Seidl, B. Mak, L. Obst-Huebl, H. Knobel, I. Pong, A. Persaud, J. van Tilborg, T. Ostermayr, S. Steinke, E. A. Blakely, Q. Ji, A. Javey, R. Kapadia, C. G. R. Geddes, and E. Esarey

Subjects
Technology, Emerging Infectious Diseases, Engineering, Physics and Astronomy (miscellaneous), Biological Physics (physics.bio-ph), Physical Sciences, Nanotechnology, FOS: Physical sciences, Bioengineering, Physics - Biological Physics, Physics - Applied Physics, Applied Physics (physics.app-ph), Applied Physics
Abstract

Nanostructured surfaces enhance ion yields in matrix-assisted laser desorption–ionization mass spectrometry (MALDI-MS). The spike protein complex, S1, is one fingerprint signature of Sars-CoV-2 with a mass of 75 kDa. Here, we show that MALDI-MS yields of Sars-CoV-2 spike protein ions in the 100 kDa range are enhanced 50-fold when the matrix–analyte solution is placed on substrates that are coated with a dense forest of multi-walled carbon nanotubes, compared to yields from uncoated substrates. Nanostructured substrates can support the development of mass spectrometry techniques for sensitive pathogen detection and environmental monitoring.

Published
2022
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