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This article presents an analysis of the film Out of the Furnace by Scott Cooper from the aesthetic and historical points of view rage and will to sacrifice oneself are the main emotions or attitudes in this 21th-century drama taking place in a depressed industrial Pennsylvania area near Pittsburgh at the time of the wars against Irak. Actors gestures and expressions; role of the soundtrack in enhancing the sense of destiny of the characters. Both resignation and spirit of revenge, and action of vindication characterize the main character interpreted by Christian Bale. The atmosphere is similar to that of William Faulkner novels. The film also clearly alludes to the cult movie from the 1970, Deer Hunter by Michael Cimino.

Langerhans cell histiocytosis (LCH) is a myeloid neoplasm characterized by a clonal proliferation of CD1a+/CD207+ dendritic cells. Although individuals of any age can be affected, the disease is most common in infants younger than 5 years of age, especially males. A wide range of manifestations, from asymptomatic to aggressive, have been described, along with multiorgan involvement. Even though the majority of bone lesions are observed, skin, lymph nodes, brain and lungs can also be involved. The involvement of hematopoietic system, including bone marrow, liver and spleen, is less frequent yet associated with worse prognosis, due to a worse treatment response. Diagnosis of LCH is based on the integration of clinical, laboratory, and radiological data; however, only histopathological examination might confirm it. As far as the spleen involvement is concerned, according to literature, it has been reported in about 15% patients with multisystem involvement, nonetheless only a few cases show parenchymal lesions. The present study reports the case of an infant with LCH with multisystem involvement, including bone, skin, liver, and spleen, with evidence of parenchymal lesions.