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Background. Global warming is a growing threat in the world today mainly due to the emission of CO2 caused by the burning of fossil fuel. Consequently, countries are being forced to seek potential alternative sources of energy such as wind, solar, and photovoltaic among many others. However, the realization of their benefits is faced with challenges. Though wind stands a chance to solve this problem, the lack of adequate site profiles, long-term behavioural information, and specific data information that enables informed choice on site selection, turbine selection, and expected power output has remained a challenge to its exploitation. In this research, Weibull and Rayleigh models are adopted. Wind speeds were analyzed and characterized in the short term and then simulated for a long-term measured hourly series data of daily wind speeds at a height of 10 m. The analysis included daily wind data which was grouped into discrete data and then calculated to represent the mean wind speed, diurnal variations, daily variations, and monthly variations. To verify the models, statistical tools of Chi square, RMSE, MBE, and correlational coefficient were applied. Also, the method of measure, correlate, and predict was adopted to check for the reliability of the data used. The wind speed frequency distribution at the height of 10 m was found to be 2.9 ms-1 with a standard deviation of 1.5. From the six months’ experiments, averages of wind speeds at hub heights of 10 m were calculated and found to be 1.7 m/s, 2.4 m/s, and 1.3 m/s, for Ikobe, Kisii University, and Nyamecheo stations, respectively. The wind power density of the region was found to be 29 W/m2. By a narrow margin, Rayleigh proves to be a better method over Weibull in predicting wind power density in the region. Wind speeds at the site are noted to be decreasing over the years. The region is shown as marginal on extrapolation to 30 m for wind energy generation hence adequate for nongrid connected electrical and mechanical applications. The strong correlation between the site wind profiles proves data reliability. The gradual decrease of wind power over the years calls for attention.

Harmful effects of synthetic chemical insecticides including vector resistance, environmental pollution and health hazards have necessitated the current significance in the search for plant-based insecticide products that are environmentally safe and effective to leishmaniases control. The insecticidal activity of Tagetes minuta Linnaeus (Asteraceae), Acalypha fruticosa Forssk (Euphorbiaceae) and Tarchonanthus camphoratus L. (Compositae) extracts were investigated against Phlebotomus duboscqi Neveu Lemaire (Diptera: Psychodidae).The extracts were prepared from dried aerial parts soaked in methanol and ethyl acetate twice until the filtrates became clear, filtered and dried out by rotary evaporation at 30-35 degrees C. The solid extracts obtained were later prepared into 2.5, 5 and 10 mg/ml. Two millilitres of the solutions were blotted on filter papers, which were dried overnight and placed into jars where adult sandflies were aspirated. Males and females were assayed separately.The extracts had significant mortality (p0.05) in both males and females bioassays but were not significantly different between sexes. The extracts of Acalypha fruticosa and Tagetes minuta had significantly higher mortality rates than those of Tarchonanthus camphoratus and the different concentrations used showed significantly different mortality rates and 10 mg/ml was the most effective concentration. Cent percent mortality was obtained at 96 h of exposure to 5 and 10 mg/ml concentrations except for Tarchonanthus camphoratus which had a mortality of only 46.7% in 10 mg/ml bioassay. These extracts were found to be insecticidal to adult sandflies.

Alkaptonuria (AKU) is a disorder of phenylalanine/tyrosine metabolism due to a defect in the enzyme homogentisate 1,2-dioxygenase (HGD). This recessive disease is caused by mutations in the HGD gene. We report a 14-year-old girl who was referred after presenting black urine. Careful examination revealed ochronosis of the conjunctiva. There was no affection of the cardiac valves. Elevated excretion of homogentisic acid in urine was found. Sequence analysis of the HGD gene from genomic DNA revealed that the patient is a compound heterozygote with a previously described mutation (c.473C > T, p.Pro158Leu), and a novel one (c.821C > T, p.Pro274Leu). Her mother is heterozygous for the novel mutation, while the brother is heterozygous for the previously described mutation. In summary, we describe an alkaptonuric patient with ocular ochronosis and a novel HGD mutation, c.821C > T, p.Pro274Leu.