1. The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation
- Author
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Raphael Carapito, Ismail Aouadi, Martin Verniquet, Meiggie Untrau, Angélique Pichot, Thomas Beaudrey, Xavier Bassand, Sébastien Meyer, Loic Faucher, Juliane Posson, Aurore Morlon, Irina Kotova, Florent Delbos, Alexandre Walencik, Alice Aarnink, Anne Kennel, Caroline Suberbielle, Jean-Luc Taupin, Benedict M. Matern, Eric Spierings, Nicolas Congy-Jolivet, Arnaud Essaydi, Peggy Perrin, Antoine Blancher, Dominique Charron, Nezih Cereb, Myriam Maumy-Bertrand, Frédéric Bertrand, Valérie Garrigue, Vincent Pernin, Laurent Weekers, Maarten Naesens, Nassim Kamar, Christophe Legendre, Denis Glotz, Sophie Caillard, Marc Ladrière, Magali Giral, Dany Anglicheau, Caner Süsal, Seiamak Bahram, Süsal, Caner, Carapito, Raphael, Aouadi, Ismail, Verniquet, Martin, Untrau, Meiggie, Pichot, Angelique, Beaudrey, Thomas, Bassand, Xavier, Meyer, Sebastien, Faucher, Loic, Posson, Juliane, Morlon, Aurore, Kotova, Irina, Delbos, Florent, Walencik, Alexandre, Aarnink, Alice, Kennel, Anne, Suberbielle, Caroline, Taupin, Jean-Luc, Matern, Benedict M., Spierings, Eric, Congy-Jolivet, Nicolas, Essaydi, Arnaud, Perrin, Peggy, Blancher, Antoine, Charron, Dominique, Cereb, Nezih, Maumy-Bertrand, Myriam, Bertrand, Frederic, Garrigue, Valerie, Pernin, Vincent, Weekers, Laurent, Naesens, Maarten, Kamar, Nassim, Legendre, Christophe, Glotz, Denis, Caillard, Sophie, Ladriere, Marc, Giral, Magali, Anglicheau, Dany, Bahram, Seiamak, and School of Medicine
- Subjects
Graft Rejection ,Biochemistry & Molecular Biology ,Science & Technology ,HLA ANTIBODIES ,Biochemistry and molecular biology ,Cell biology ,Medicine ,Graft Survival ,Histocompatibility Antigens Class I ,Cell Biology ,General Medicine ,Research & Experimental Medicine ,Kidney Transplantation ,General Biochemistry, Genetics and Molecular Biology ,Antibodies ,Kidney transplantation ,Alloantibody ,Medicine, Research & Experimental ,REJECTION ,Humans ,Life Sciences & Biomedicine - Abstract
The identity of histocompatibility loci, besides human leukocyte antigen (HLA), remains elusive. The major histocompatibility complex (MHC) class I MICA gene is a candidate histocompatibility locus. Here, we investigate its role in a French multicenter cohort of 1,356 kidney transplants. MICA mismatches were associated with decreased graft survival (hazard ratio (HR), 2.12; 95% confidence interval (CI): 1.45-3.11; P < 0.001). Both before and after transplantation anti-MICA donor-specific antibodies (DSA) were strongly associated with increased antibody-mediated rejection (ABMR) (HR, 3.79; 95% CI: 1.94-7.39; P < 0.001; HR, 9.92; 95% CI: 7.43-13.20; P < 0.001, respectively). This effect was synergetic with that of anti-HLA DSA before and after transplantation (HR, 25.68; 95% CI: 3.31-199.41; P = 0.002; HR, 82.67; 95% CI: 33.67-202.97; P < 0.001, respectively). De novo-developed anti-MICA DSA were the most harmful because they were also associated with reduced graft survival (HR, 1.29; 95% CI: 1.05-1.58; P = 0.014). Finally, the damaging effect of anti-MICA DSA on graft survival was confirmed in an independent cohort of 168 patients with ABMR (HR, 1.71; 95% CI: 1.02-2.86; P = 0.041). In conclusion, assessment of MICA matching and immunization for the identification of patients at high risk for transplant rejection and loss is warranted., ‘Laboratoire d’Excellence’ (LabEx) TRANSPLANTEX; IdEx Unistra; SFRI-STRAT’US; INSERM; European Union (EU); European Regional Development Fund; INTERREG V Program; France’s National Research Agency (Agence Nationale de Recherche; ANR); Investment for the Future Program (Programme des Investissements d’Avenir; PIA); Strasbourg’s Interdisciplinary Thematic Institute (ITI) for Precision Medicine; TRANSPLANTEX NG; ITI 2021–2028 Program of the University of Strasbourg; CNRS; Institut Universitaire de France (IUF); Fédération Hospitalo-Universitaire (FHU) OMICARE; MSD Avenir ‘Autogen’
- Published
- 2021