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Additional file 1: Figure S1. Two-dimensional 1H,15 N correlation spectrum obtained for ZGM1. (HSQC, 1H NMR at 500 Hz, 13C NMR at 125 Hz in CDCl3). Figure S2. ZGM1 concentration in mouse tissue over time after administration. (a) ZGM1 concentration in blood plasma or brain homogenate after administration at a dose of 250 mg/kg. (b) ZGM1 concentration in brain homogenate after administration at a dose of 40 mg/kg, 120 mg/kg and 250 mg/kg. Figure S3. Western blotting analyses of learning- and memory-related proteins in mouse brains. Table S1. NMR data of the ZGM series. Table S2. Escape latency and significance (p value) of the hidden platform test in the Morris water maze.