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Medicinal plants have played an important influence in the development of human society; they were always at the forefront of all cultures and civilizations as a source of medicine. Medicinal plants are considered rich sources of secondary compounds, and many modern medications are derived from them. Hammada scoparia is a medicinal plant that belongs to the Chenopodiaceae family. It is currently found in North Africa (Morocco, Algeria, Libya, and Egypt) and has many medicinal properties used as folk medicine. The present research discusses the phytochemical components and biological activities of Hammada scoparia. The corresponding data were collected from various online databases, new research, and published resources. Different secondary compounds from the species have been documented, including flavonoids, tannins, alkaloids, terpenoids, and saponins. Pharmacological research has demonstrated that the major bioactives have antimicrobial, antioxidant, cytotoxic, and antimalarial activities and anticancer, reno-protective, and hepatoprotective effects. In conclusion, this study provides much information about the interests of vegetal species: Hammada scoparia.