1. Diffuse tensor imaging of lower extremities: a novel MR imaging technique for chemotherapy-induced peripheral neuropathy
- Author
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Jenn Segar, Hninyee Win, Pavani Chalasani, Lana H. Gimber, Michele Chu-Pilli, Denise J. Roe, Sima Ehsani, Betsy C. Wertheim, Kiah J. Farr, and Mihra S. Taljanovic
- Subjects
0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Antineoplastic Agents ,Breast Neoplasms ,Asymptomatic ,03 medical and health sciences ,0302 clinical medicine ,Fractional anisotropy ,Humans ,Medicine ,Effective diffusion coefficient ,Prospective Studies ,medicine.diagnostic_test ,business.industry ,Peripheral Nervous System Diseases ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Diffusion Tensor Imaging ,030104 developmental biology ,Peripheral neuropathy ,Lower Extremity ,Oncology ,Chemotherapy-induced peripheral neuropathy ,030220 oncology & carcinogenesis ,Biomarker (medicine) ,Female ,Radiology ,medicine.symptom ,business ,Diffusion MRI - Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is caused by drug-induced damage to the axons which is not detected easily due to lack of reliable, clinically applicable modalities. Diffuse tensor imaging (DTI) allows for quantitative measurements of fractional anisotropy (FA) and apparent diffusion coefficient (ADC), which have been shown to detect nerve injury by Magnetic Resonance Imaging (MRI). We sought to evaluate if DTI could be used for detection of CIPN in patients with breast cancer treated with a taxane. Patients with h/o exposure to neurotoxic chemotherapy, diabetes, or peripheral neuropathy were excluded. Patients completed pre- and post-chemotherapy MRI of bilateral legs and FACT&GOG-Ntx. Genotyping of single-nucleotide variations (SNVs) was performed to detect known associations with CIPN. We had 14 evaluable patients in this prospective trial. Mean FA values post-chemotherapy were significantly lower than baseline at mid-calf (p more...
- Published
- 2020
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