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Supplemental material, sj-docx-1-tar-10.1177_17534666231172917 for Validation of the Rome proposal for severity of acute exacerbation of chronic obstructive pulmonary disease by Hyo Jin Lee, Jung-Kyu Lee, Tae Yun Park, Eun Young Heo, Deog Kyeom Kim and Hyun Woo Lee in Therapeutic Advances in Respiratory Disease

Supplemental material, sj-docx-1-tar-10.1177_17534666231172917 for Validation of the Rome proposal for severity of acute exacerbation of chronic obstructive pulmonary disease by Hyo Jin Lee, Jung-Kyu Lee, Tae Yun Park, Eun Young Heo, Deog Kyeom Kim and Hyun Woo Lee in Therapeutic Advances in Respiratory Disease

Additional file 1. SPIRIT checklist

Additional file 1: Table S1. Baseline characteristics of total and propensity score-matched patients with respiratory adverse events. Data are expressed as mean (± standard deviation), median (IQR), or number (percentage). PYs, pack-years; SD, standard deviation; IQR, interquartile range. Table S2. Clinical features before bronchoscopy in total and propensity score-matched patients with respiratory adverse events. Data are expressed as mean (± standard deviation), median (IQR), or number (percentage). FVC, forced vital capacity; FEV1, forced expiratory volume in one second; BDR, bronchodilator test; DLCO, diffusion capacity of the lung for carbon monoxide; DLCO/VA, diffusion capacity of the lung for carbon monoxide per unit alveolar volume; SD, standard deviation; IQR, interquartile range. aBronchodilator response was assessed in 342 patients, and DLCO was assessed in 360 patients. Table S3. Parameters and procedures during bronchoscopy in patients with respiratory adverse events. Data are expressed as mean (± standard deviation) or number (percentage). EBUS-TBNA, endobronchial ultrasound-guided transbronchial needle aspiration; TBLB, transbronchial lung biopsy. Table S4. Post-bronchoscopy adverse events and clinical outcomes in patients with respiratory adverse events. Data are expressed as median (IQR) or number (percentage). ICU, intensive care unit; IQR, interquartile range. Table S5. Risk factors of post-bronchoscopy respiratory adverse events in the total population. CI, confidence interval; OR, odds ratio; SF ratio, SpO2/FiO2 ratio. Covariables were selected according to the rule of thumb. Table S6. Sensitivity analysis to evaluate the relationship between the duration of low oxygen saturation and post-bronchoscopy respiratory adverse events. CI, confidence interval; OR, odds ratio; SF ratio, SpO2/FiO2 ratio.