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4 results on '"Lee, Kyung-Hun"'

1. Additional file 6 of Longitudinal multi-omics study of palbociclib resistance in HR-positive/HER2-negative metastatic breast cancer

Author

Park, Yeon Hee, Im, Seock-Ah, Park, Kyunghee, Wen, Ji, Lee, Kyung-Hun, Choi, Yoon-La, Lee, Won-Chul, Min, Ahrum, Bonato, Vinicius, Park, Seri, Ram, Sripad, Lee, Dae-Won, Kim, Ji-Yeon, Lee, Su Kyeong, Lee, Won-Woo, Lee, Jisook, Kim, Miso, Kim, Hyun Seon, Weinrich, Scott L., Ryu, Han Suk, Kim, Tae Yong, Dann, Stephen, Kim, Yu-Jin, Fernandez, Diane R., Koh, Jiwon, Wang, Shuoguo, Park, Song Yi, Deng, Shibing, Powell, Eric, Ravi, Rupesh Kanchi, Bienkowska, Jadwiga, Rejto, Paul A., Park, Woong-Yang, and Kan, Zhengyan

Abstract

Additional file 6. Fig. S1. Kaplan-Meier plots of poor prognostic biomarkers. Fig. S2. Characteristics of the HRD-high cluster. Fig. S3. Characteristics of HRD-high tumors co-occurring with TP53 mutation. Fig. S4. Kaplan-Meier plots of expression-based prognosis markers. Fig. S5. Proliferative cluster enriched in poor prognostic markers. Fig. S6. Integrative analysis identified distinct prognostic clusters. Fig. S7. Molecular characteristics of integrative clusters. Fig. S8. Subtype switching driven by changes in PAM50 score composition. Fig. S9. Increased tumor growth and proliferation at PD. Fig. S10. IHC analysis of cell cycle markers. Fig. S11. Landscape of PD-specific genomic alterations. Fig. S12. RB1 LOF associated with increased APOBEC signature at PD. Fig. S13. APOBEC signature enriched in PD-specific tumor subclones.

Published
2023
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2. Additional file 1 of HER2 expression, copy number variation and survival outcomes in HER2-low non-metastatic breast cancer: an international multicentre cohort study and TCGA-METABRIC analysis

Author

Tan, Ryan Shea Ying Cong, Ong, Whee Sze, Lee, Kyung-Hun, Lim, Abner Herbert, Park, Seri, Park, Yeon Hee, Lin, Ching-Hung, Lu, Yen-Shen, Ono, Makiko, Ueno, Takayuki, Naito, Yoichi, Onishi, Tatsuya, Lim, Geok-Hoon, Tan, Su-Ming, Lee, Han-Byoel, Ryu, Han Suk, Han, Wonshik, Tan, Veronique Kiak Mien, Wong, Fuh-Yong, Im, Seock-Ah, Tan, Puay Hoon, Chan, Jason Yongsheng, and Yap, Yoon-Sim

Subjects
skin and connective tissue diseases, neoplasms
Abstract

Additional file 1: Table S1. Database information and details of HER2 testing by study centre. Table S2. Sensitivity analysis of relapse-free survival and overall survival by HER2 and hormone receptor status. Figure S1. Flowchart of patients included in the ABCCG cohort analysis. Figure S2. Estimated heterogeneity between study centres in (A) relapse-free survival, and (B) overall survival (based on pooling univariable HR estimate from each centre with a random effect restricted maximum likelihood estimation model. HR, hazard ratio; I2, index of heterogeneity). Figure S3. Association of ERBB2 mRNA expression with HER2 IHC and ERBB2 CNV by hormone receptor status (TCGA-BRCA): (A-D) Hormone receptor-positive subgroup of TCGA-BRCA dataset: ERBB2 mRNA expression by (A) HER2-low and HER2-zero, (B) HER2 IHC score, (C) ERBB2 CNV; (D) ERBB2 CNV against HER2 IHC. (E-H) Hormone receptor-negative subgroup of TCGA-BRCA dataset: ERBB2 mRNA expression by (E) HER2-low and HER2-zero, (F) HER2 IHC score, (G) ERBB2 CNV; (H) ERBB2 CNV against HER2 IHC. Figure S4. Relapse-free survival by ERBB2 mRNA expression levels in combined TCGA-BRCA and METABRIC dataset (Quartile 1: lowest; Quartile 4: highest)

Published
2022
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3. Additional file 1 of A first-in-human phase 1/2 study of FGF401 and combination of FGF401 with spartalizumab in patients with hepatocellular carcinoma or biomarker-selected solid tumors

Author

Chan, Stephen L., Schuler, Martin, Kang, Yoon-Koo, Yen, Chia-Jui, Edeline, Julien, Choo, Su Pin, Lin, Chia-Chi, Okusaka, Takuji, Weiss, Karl-Heinz, Macarulla, Teresa, Cattan, Stéphane, Blanc, Jean-Frederic, Lee, Kyung-Hun, Maur, Michela, Pant, Shubham, Kudo, Masatoshi, Assenat, Eric, Zhu, Andrew X., Yau, Thomas, Lim, Ho Yeong, Bruix, Jordi, Geier, Andreas, Guillén-Ponce, Carmen, Fasolo, Angelica, Finn, Richard S., Fan, Jia, Vogel, Arndt, Qin, Shukui, Riester, Markus, Katsanou, Vasiliki, Chaudhari, Monica, Kakizume, Tomoyuki, Gu, Yi, Porta, Diana Graus, Myers, Andrea, and Delord, Jean-Pierre

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
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4. Additional file 2 of A first-in-human phase 1/2 study of FGF401 and combination of FGF401 with spartalizumab in patients with hepatocellular carcinoma or biomarker-selected solid tumors

Author

Chan, Stephen L., Schuler, Martin, Kang, Yoon-Koo, Yen, Chia-Jui, Edeline, Julien, Choo, Su Pin, Lin, Chia-Chi, Okusaka, Takuji, Weiss, Karl-Heinz, Macarulla, Teresa, Cattan, Stéphane, Blanc, Jean-Frederic, Lee, Kyung-Hun, Maur, Michela, Pant, Shubham, Kudo, Masatoshi, Assenat, Eric, Zhu, Andrew X., Yau, Thomas, Lim, Ho Yeong, Bruix, Jordi, Geier, Andreas, Guillén-Ponce, Carmen, Fasolo, Angelica, Finn, Richard S., Fan, Jia, Vogel, Arndt, Qin, Shukui, Riester, Markus, Katsanou, Vasiliki, Chaudhari, Monica, Kakizume, Tomoyuki, Gu, Yi, Porta, Diana Graus, Myers, Andrea, and Delord, Jean-Pierre

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2022
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