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9 results on '"Leung, K. Y."'

1. The actions of methotrexate on endothelial cells are dependent on the shear stress-induced regulation of one carbon metabolism

Author

Lang, M, Leung, K-Y, Greene, N, Malone, K, Saginc Giannoustas, G, Randi, A, Kiprianos, A, Maughan, R, Pericleous, C, and Mason, J

Abstract

Objectives: The disease-modifying anti-rheumatic drug methotrexate (MTX) is recognized to reduce cardiovascular risk in patients with systemic inflammatory diseases. However, the molecular basis for these cardioprotective effects remains incompletely understood. This study evaluated the actions of low-dose MTX on the vascular endothelium. Methods: Human endothelial cells (EC) were studied under in vitro conditions relevant to inflammatory arthritis. These included culture in a pro-inflammatory microenvironment and exposure to fluid shear stress (FSS) using a parallel plate model. Respectively treated cells were analyzed by RNA sequencing and quantitative real-time PCR for gene expression, by immunoblotting for protein expression, by phosphokinase activity arrays, by flow cytometry for cell cycle analyses and by mass spectrometry to assess folate metabolite levels. Results: In static conditions, MTX was efficiently taken up by EC and caused cell cycle arrest concurrent with modulation of cell signaling pathways. These responses were reversed by folinic acid (FA), suggesting that OCM is a predominant target of MTX. Under FSS, MTX did not affect cell proliferation or pro-inflammatory gene expression. Exposure to FSS downregulated endothelial one carbon metabolism (OCM) as evidenced by decreased expression of key OCM genes and metabolites. Conclusion: We found that FSS significantly downregulated OCM and thereby rendered EC less susceptible to the effects of MTX treatment. The impact of shear stress on OCM suggested that MTX does not directly modulate endothelial function. The cardioprotective actions of MTX likely reflect direct actions on inflammatory cells and indirect benefit on the vascular endothelium.

Published
2023

2. Measurement of the Reactor Antineutrino Flux and Spectrum at Daya Bay

Author

Daya Bay Collaboration, An, F. P., Balantekin, A. B., Band, H. R., Bishai, M., Blyth, S., Butorov, I., Cao, D., Cao, G. F., Cao, J., Cen, W. R., Chan, Y. L., Chang, J. F., Chang, L. C., Chang, Y., Chen, H. S., Chen, Q. Y., Chen, S. M., Chen, Y. X., Chen, Y., Cheng, J. H., Cheng, J., Cheng, Y. P., Cherwinka, J. J., Chu, M. C., Cummings, J. P., de Arcos, J., Deng, Z. Y., Ding, X. F., Ding, Y. Y., Diwan, M. V., Dove, J., Draeger, E., Dwyer, D. A., Edwards, W. R., Ely, S. R., Gill, R., Gonchar, M., Gong, G. H., Gong, H., Grassi, M., Gu, W. Q., Guan, M. Y., Guo, L., Guo, X. H., Hackenburg, R. W., Han, R., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Higuera, A., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, L. M., Hu, L. J., Hu, T., Hu, W., Huang, E. C., Huang, H. X., Huang, X. T., Huber, P., Hussain, G., Jaffe, D. E., Jaffke, P., Jen, K. L., Jetter, S., Ji, X. P., Ji, X. L., Jiao, J. B., Johnson, R. A., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Kwan, K. K., Kwok, M. W., Kwok, T., Langford, T. J., Lau, K., Lebanowski, L., Lee, J., Lei, R. T., Leitner, R., Leung, K. Y., Leung, J. K. C., Lewis, C. A., Li, D. J., Li, F., Li, G. S., Li, Q. J., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, P. Y., Lin, S. K., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, D. W., Liu, H., Liu, J. L., Liu, J. C., Liu, S. S., Lu, C., Lu, H. Q., Lu, J. S., Luk, K. B., Ma, Q. M., Ma, X. Y., Ma, X. B., Ma, Y. Q., Caicedo, D. A. Martinez, McDonald, K. T., McKeown, R. D., Meng, Y., Mitchell, I., Kebwaro, J. Monari, Nakajima, Y., Napolitano, J., Naumov, D., Naumova, E., Ngai, H. Y., Ning, Z., Ochoa-Ricoux, J. P., Olshevski, A., Pan, H. -R., Park, J., Patton, S., Pec, V., Peng, J. C., Piilonen, L. E., Pinsky, L., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, B., Ren, J., Rosero, R., Roskovec, B., Ruan, X. C., Shao, B. B., Steiner, H., Sun, G. X., Sun, J. L., Tang, W., Taychenachev, D., Tsang, K. V., Tull, C. E., Tung, Y. C., Viaux, N., Viren, B., Vorobel, V., Wang, C. H., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, W. W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wen, L. J., Whisnant, K., White, C. G., Whitehead, L., Wise, T., Wong, H. L. H., Wong, S. C. F., Worcester, E., Wu, Q., Xia, D. M., Xia, J. K., Xia, X., Xing, Z. Z., Xu, J. Y., Xu, J. L., Xu, J., Xu, Y., Xue, T., Yan, J., Yang, C. G., Yang, L., Yang, M. S., Yang, M. T., Ye, M., Yeh, M., Young, B. L., Yu, G. Y., Yu, Z. Y., Zang, S. L., Zhan, L., Zhang, C., Zhang, H. H., Zhang, J. W., Zhang, Q. M., Zhang, Y. M., Zhang, Y. X., Zhang, Z. J., Zhang, Z. Y., Zhang, Z. P., Zhao, J., Zhao, Q. W., Zhao, Y. F., Zhao, Y. B., Zheng, L., Zhong, W. L., Zhou, L., Zhou, N., Zhuang, H. L., and Zou, J. H.

Subjects
Physics, Range (particle radiation), Physics - Instrumentation and Detectors, Fissile material, 010308 nuclear & particles physics, Fission, Daya bay, General Physics and Astronomy, Flux, FOS: Physical sciences, Electron, Daya Bay Reactor Neutrino Experiment, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Inverse beta decay, 0103 physical sciences, Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment
Abstract

This Letter reports a measurement of the flux and energy spectrum of electron antineutrinos from six 2.9~GW$_{th}$ nuclear reactors with six detectors deployed in two near (effective baselines 512~m and 561~m) and one far (1,579~m) underground experimental halls in the Daya Bay experiment. Using 217 days of data, 296,721 and 41,589 inverse beta decay (IBD) candidates were detected in the near and far halls, respectively. The measured IBD yield is (1.55 $\pm$ 0.04) $\times$ 10$^{-18}$~cm$^2$/GW/day or (5.92 $\pm$ 0.14) $\times$ 10$^{-43}$~cm$^2$/fission. This flux measurement is consistent with previous short-baseline reactor antineutrino experiments and is $0.946\pm0.022$ ($0.991\pm0.023$) relative to the flux predicted with the Huber+Mueller (ILL+Vogel) fissile antineutrino model. The measured IBD positron energy spectrum deviates from both spectral predictions by more than 2$\sigma$ over the full energy range with a local significance of up to $\sim$4$\sigma$ between 4-6 MeV. A reactor antineutrino spectrum of IBD reactions is extracted from the measured positron energy spectrum for model-independent predictions.

Published
2015
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3. Improved Measurement of Electron Antineutrino Disappearance at Daya Bay

Author

Daya Bay Collaboration, An, F. P., An, Q., Bai, J. Z., Balantekin, A. B., Band, H. R., Beriguete, W., Bishai, M., Blyth, S., Brown, R. L., Cao, G. F., Cao, J., Carr, R., Chan, W. T., Chang, J. F., Chang, Y., Chasman, C., Chen, H. S., Chen, H. Y., Chen, S. J., Chen, S. M., Chen, X. C., Chen, X. H., Chen, X. S., Chen, Y., Chen, Y. X., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Deng, Z. Y., Ding, Y. Y., Diwan, M. V., Draeger, E., Du, X. F., Dwyer, D., Edwards, W. R., Ely, S. R., Fang, S. D., Fu, J. Y., Fu, Z. W., Ge, L. Q., Gill, R. L., Gonchar, M., Gong, G. H., Gong, H., Gornushkin, Y. A., Gu, W. Q., Guan, M. Y., Guo, X. H., Hackenburg, R. W., Hahn, R. L., Hans, S., Hao, H. F., He, M., He, Q., Heeger, K. M., Heng, Y. K., Hinrichs, P., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, T., Huang, H. X., Huang, H. Z., Huang, X. T., Huber, P., Issakov, V., Isvan, Z., Jaffe, D. E., Jetter, S., Ji, X. L., Ji, X. P., Jiang, H. J., Jiao, J. B., Johnson, R. A., Kang, L., Kettell, S. H., Kramer, M., Kwan, K. K., Kwok, M. W., Kwok, T., Lai, C. Y., Lai, W. C., Lai, W. H., Lau, K., Lebanowski, L., Lee, J., Lei, R. T., Leitner, R., Leung, J. K. C., Leung, K. Y., Lewis, C. A., Li, F., Li, G. S., Li, Q. J., Li, W. D., Li, X. B., Li, X. N., Li, X. Q., Li, Y., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S. K., Lin, Y. C., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, D. W., Liu, J. C., Liu, J. L., Liu, Y. B., Lu, C., Lu, H. Q., Luk, A., Luk, K. B., Ma, Q. M., Ma, X. B., Ma, X. Y., Ma, Y. Q., McDonald, K. T., McFarlane, M. C., McKeown, R. D., Meng, Y., Mohapatra, D., Nakajima, Y., Napolitano, J., Naumov, D., Nemchenok, I., Ngai, H. Y., Ngai, W. K., Nie, Y. B., Ning, Z., Ochoa-Ricoux, J. P., Olshevski, A., Patton, S., Pec, V., Peng, J. C., Piilonen, L. E., Pinsky, L., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Rosero, R., Roskovec, B., Ruan, X. C., Shao, B. B., Shih, K., Steiner, H., Sun, G. X., Sun, J. L., Tagg, N., Tam, Y. H., Tanaka, H. K., Tang, X., Themann, H., Torun, Y., Trentalange, S., Tsai, O., Tsang, K. V., Tsang, R. H. M., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, L. S., Wang, L. Y., Wang, L. Z., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Webber, D. M., Wei, H. Y., Wei, Y. D., Wen, L. J., Whisnant, K., White, C. G., Whitehead, L., Williamson, Y., Wise, T., Wong, H. L. H., Worcester, E. T., Wu, F. F., Wu, Q., Xi, J. B., Xia, D. M., Xing, Z. Z., Xu, J., Xu, J. L., Xu, Y., Xue, T., Yang, C. G., Yang, L., Ye, M., Yeh, M., Yeh, Y. S., Young, B. L., Yu, Z. Y., Zhan, L., Zhang, C., Zhang, F. H., Zhang, J. W., Zhang, Q. M., Zhang, S. H., Zhang, Y. C., Zhang, Y. H., Zhang, Y. X., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, Q. W., Zhao, Y. B., Zheng, L., Zhong, W. L., Zhou, L., Zhou, Z. Y., Zhuang, H. L., and Zou, J. H.

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Daya bay, FOS: Physical sciences, Astronomy and Astrophysics, Daya Bay Reactor Neutrino Experiment, Electron, Expected value, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Neutrino, Nuclear Experiment (nucl-ex), Instrumentation, Electron neutrino, Nuclear Experiment
Abstract

We report an improved measurement of the neutrino mixing angle $\theta_{13}$ from the Daya Bay Reactor Neutrino Experiment. We exclude a zero value for $\sin^22\theta_{13}$ with a significance of 7.7 standard deviations. Electron antineutrinos from six reactors of 2.9 GW$_{\rm th}$ were detected in six antineutrino detectors deployed in two near (flux-weighted baselines of 470 m and 576 m) and one far (1648 m) underground experimental halls. Using 139 days of data, 28909 (205308) electron antineutrino candidates were detected at the far hall (near halls). The ratio of the observed to the expected number of antineutrinos assuming no oscillations at the far hall is $0.944\pm 0.007({\rm stat.}) \pm 0.003({\rm syst.})$. An analysis of the relative rates in six detectors finds $\sin^22\theta_{13}=0.089\pm 0.010({\rm stat.})\pm0.005({\rm syst.})$ in a three-neutrino framework., Comment: 21 pages, 24 figures. Submitted to and accepted by Chinese Physics C. Two typos were corrected. Description improved

Published
2012
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4. Comparing two financial crises: the case of Hong Kong real estate markets

Author

LEUNG, K. Y. Charles and TANG, C. H. Edward

Subjects
jel:E50, jel:R20, jel:E60, jel:E44, regime switching, structural change, small open economy, bounded rationality, banking policy, jel:G01
Abstract

Hong Kong is no stranger to bubbles or crisis. During the Asian Financial Crisis(AFC), the Hong Kong housing price index drops more than 50% in less than a year. The same market then experiences the Internet Bubble, the SARS attack, and recently the Global Financial Crisis (GFC). This paper attempts to provide some “stylized facts” of the real estate markets and the macroeconomy, and follow the event-study methodology to examine whether the markets behave differently in the AFC and GFC, and discuss the possible linkage to the change in government policies (“learning effect”) and the flow of Chinese consumers and investors to Hong Kong (“China factor”).

Published
2011

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