Search

Your search keyword '"Levi, Giovanni"' showing total 18 results
Start Over Author "Levi, Giovanni" Language undetermined
18 results on '"Levi, Giovanni"'

2. Microhistorias.

Author

Levi, Giovanni and Levi, Giovanni

Abstract

Microhistorias es una compilación de ensayos del reconocido historiador italiano Giovanni Levi que cubren alrededor de cincuenta años de su trabajo intelectual. En esta edición en español se ha querido conservar la relación de estos textos con el tiempo en el cual fueron escritos; siguen un recorrido que va desde la reinterpretación crítica de la demografía histórica hasta la definición gradual del método microhistórico. La microhistoria de Levi surge como una crítica a una historiografía que apunta a generalizar las conclusiones, olvidándose del hecho específico o local. Según sus propias palabras, la demografía fue el primer campo en el cual se concentró su malestar, dado que la demografía histórica tendía a hacer hincapié en los hechos más frecuentes y a dejar de lado los comportamientos parentemente menos difundidos. Así, su instrumento profesional ha sido un metafórico microscopio que le ha ayudado a revelar lo que no se hacía evidente con otras metodologías.

Published
2019

7. Los historiadores, el psicoanálisis y la verdad

Author

Levi, Giovanni

Subjects
Ciencias sociales. Generalidades, UNESCO::CIENCIAS DE LAS ARTES Y LAS LETRAS, CIENCIAS DE LAS ARTES Y LAS LETRAS [UNESCO], Humanidades. Generalidades, Humanidades, Ciencias sociales
Published
2003

13. Giovanni Levi: contra la deslegitimación universal del pasado

Author

Furió, Antoni, Muñoz, Gustau, and Levi, Giovanni

Subjects
Ciencias sociales. Generalidades, UNESCO::CIENCIAS DE LAS ARTES Y LAS LETRAS, CIENCIAS DE LAS ARTES Y LAS LETRAS [UNESCO], Humanidades. Generalidades, Humanidades, Grupo C, Ciencias sociales, Grupo D
Published
1999

18. Dlx5 and Dlx6 control uterine adenogenesis during post-natal maturation: possible consequences for endometriosis

Author

Luca Mastracci, Nicolas Narboux-Nême, Paolo Garagnani, Anne Bachelot, Evelyne Duvernois-Berthet, Anastasia Fontaine, Ottavia Barbieri, Giovanni Levi, Chiara Pirazzini, Brice Bellessort, Gladys Alfama, Marine Le Cardinal, Vincent Jonchere, Evolution des régulations endocriniennes (ERE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Endocrinologie moléculaire, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut du Fer à Moulin, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Department of Experimental Medicine, University of Genova, Istituto Nazionale per la Ricerca sul Cancro, Universita degli studi di Genova, Department of Anatomic Pathology, Pathologies biliaires, fibrose et cancer du foie [CHU Saint-Antoine], Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Genova = University of Genoa (UniGe), Pathologies biliaires, fibrose et cancer du foie [CRSA], Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Muséum national d'Histoire naturelle (MNHN), Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Levi, Giovanni

Subjects
0301 basic medicine, Mullerian Ducts, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Endometriosis, Uterus, Biology, Endometrium, Epithelium, Andrology, 03 medical and health sciences, Mice, Downregulation and upregulation, [SDV.BDD] Life Sciences [q-bio]/Development Biology, Genetics, medicine, Homeobox, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Embryo Implantation, [SDV.BDD]Life Sciences [q-bio]/Development Biology, Molecular Biology, [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology, ComputingMilieux_MISCELLANEOUS, Genetics (clinical), Homeodomain Proteins, Leydig cell, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Genes, Homeobox, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, General Medicine, medicine.disease, Molecular biology, 030104 developmental biology, medicine.anatomical_structure, Genes, Gene Expression Regulation, In utero, embryonic structures, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, Transcriptome
Abstract

Dlx5 and Dlx6 are two closely associated homeobox genes which code for transcription factors involved in the control of steroidogenesis and reproduction. Inactivation of Dlx5/6 in the mouse results in a Leydig cell defect in the male and in ovarian insufficiency in the female. DLX5/6 are also strongly expressed by the human endometrium but their function in the uterus is unknown. The involvement of DLX5/6 in human uterine pathology is suggested by their strong downregulation in endometriotic lesions and upregulation in endometrioid adenocarcinomas. We first show that Dlx5/6 expression begins in Mullerian ducts epithelia and persists then in the uterine luminal and glandular epithelia throughout post-natal maturation and in the adult. We then use a new mouse model in which Dlx5 and Dlx6 can be simultaneously inactivated in the endometrium using a Pgr(cre/+) allele. Post-natal inactivation of Dlx5/6 in the uterus results in sterility without any obvious ovarian involvement. The uteri of Pgr(cre/+); Dlx5/6(flox/flox) mice present very few uterine glands and numerous abnormally large and branched invaginations of the uterine lumen. In Dlx5/6 mutant uteri, the expression of genes involved in gland formation (Foxa2) and in epithelial remodelling during implantation (Msx1) is significantly reduced. Furthermore, we show that DLX5 is highly expressed in human endometrial glandular epithelium and that its expression is affected in endometriosis. We conclude that Dlx5 and Dlx6 expression determines uterine architecture and adenogenesis and is needed for implantation. Given their importance for female reproduction, DLX5 and DLX6 must be regarded as interesting targets for future clinical research.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results