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The current study aims to analyze the principles of integrated technology of explosion to tackle the problems of coal seam high gas content and pressure, developed faults, complex structure, low coal seam permeability, and high outburst risk. Based on this, we found through numerical simulation that as the inclination of the coal seam increases, the risk of coal and gas outburst increases during the tunneling process. Therefore, it is necessary to take measures to reduce the risk of coal and gas outburst. We conducted field engineering experiments. Our results show that the synergistic antireflection technology of hydraulic fracturing and deep-hole presplitting blasting has a significant antireflection effect in low-permeability coal seams. After implementing this technology, the distribution of coal moisture content was relatively uniform and improved the influence range of direction and tendency. Following 52 days of extraction, the average extraction concentration was 2.9 times that of the coal seam gas extraction concentration under the original technology. The average scalar volume of single hole gas extraction was increased by 7.7 times. Through field tests, the purpose of pressure relief and permeability enhancement in low-permeability coal seams was achieved. Moreover, the effect of gas drainage and treatment in low-permeability coal seams was improved, and the applicability, effectiveness, and safety of underground hydraulic fracturing and antireflection technology in low-permeability coal seams were verified. The new technique is promising for preventing and controlling gas hazards in the future.

Cetrorelix, a potent third generation of luteinizing hormone releasing hormone (LHRH) antagonist, is a synthetic decapeptide used for treatment of infertility, prostatic hypertrophy and sexual hormone-dependent tumors. The approved drug of cetrorelix (Cetrotide, Asta Medica AG, Frankfurt, Germany.), was used for prevention of premature ovulation in patients undergoing a controlled ovarian stimulation (COS), followed by oocyte pick-up and assisted reproductive techniques, and has been shown safe and effective in controlled ovarian stimulation. Nevertheless, the study of aggregation products of cetrorelix was rarely reported. A simple liquid chromatography mass spectrometry (LC-MS/MS) method was developed for separation, identification and characterization of a new cetrorelix methylene dimer impurity in cetrorelix. The chromatographic separation was achieved on an XSelect Peptide CSH ™C18 column (150 × 4.6 mm, 3.5 μm particle size) using gradient elution with a mobile phase of ammonium formate buffer (pH 3.0, 20 mM), acetonitrile at a flow rate 1.0 mL min-1, and an ultraviolet detection wavelength of 226 nm. The new cetrorelix methylene dimer impurity was characterized by LC-MS/MS and it characteristic fragment ions were summarized. A simple, fast and accurate method was established for the determination of the molecular weight and structure of the new cetrorelix methylene dimer impurity. In this study, the results showed that the cetrorelix was highly unstable in formaldehyde conditions. In addition, it is proposed that the impact of formaldehyde in the environment on the quality of cetrorelix acetate for Injection should be evaluated during the production process.

In order to keep the display apparatus reliability of reading braille point, reduce the production cost, improve the penetration rate, based on the mini stepper motor as the driving mechanism, we design a based on the STM32 braille display device. This paper first describes the overall design scheme of the blind to read and the assembly plan, and the hardware design and the function of each module is introduced, at the same time, the embedded software development and implementation process. And sets up a physical model for verification, the apparatus succeeds in converting English characters into corresponding braille raised dots, resulting in helping the blind to read electronic texts.

The establishment of the indicator system is an important process that helps enterprises to carry out benchmarking on energy efficiency, and is a ligament to link all procedures of benchmarking. According to energy consumption status of molybdenum enterprise, this paper is collecting the factors which have influences on the energy efficiency level. Then the indexes are screened using interpretative structural model, and the energy efficiency index system based on energy consumption of the main process is designed and optimized.