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Additional file 1: Data 1. Candidate variants arising from whole exome sequencing analysis. Table details the variants resulting following filtering steps and details of how each variant was interpreted according to guidelines published by the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (Richards et al., 2015). Chr: chromosome; Hom: homozygous; HGVS: Human Genome Variation Society; EGF-like: epidermal growth factor-like; AF: Allele frequency; MIM: Mendelian inheritance in Man I.D. number. * Evidence and Classifications calculated according criteria from Richards et al., 2015