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In this work we report the temperature and doping-level evolution of the crystallographic and magnetic properties of the Sr-doped cobaltates Ca1−xSrxBaCo4O7. The noncollinear ferrimagnetic phase known for the magnetoelectric parent compound is found to persist only for a small amount of Sr doping (x=0.02) and is accompanied by a strong unit cell distortion. In turn, further Sr doping blurs this distortion of lattice parameters and favors other magnetic arrangements. In particular, this work focuses on an intermediate temperature region 62K, This work is part of a research project supported by ANPCyT (Argentina) under Grant No. PICT-2017-0725, and by CONICET under Grant PIP 490 /2012, Universidad Nacional de Cuyo under Grant No. SECTyP UNCuyo 06/C592, Laboratorio Argentino de Haces de Neutrones and MinCyT. J.C. would like to acknowledge the use of Servicio General de Apoyo a la Investigación-SAI, Universidad de Zaragoza and support from grants PGC-2018-099024-B-I00 -ChiMag from the Ministerio de Ciencia e Innovación de España and i-COOPB20319 from CSIC. Additional support from Diputación General de Aragón (DGA-M4) is also acknowledged. This work is partly based on experiments performed at the Swiss spallation neutron source SINQ, Paul Scherrer Institute, Villigen, Switzerland. We also acknowledge ILL and their staff for the beamtime allocation and technical assistance. G.A. and M.K. acknowledge the Swiss Leading House for the Latin American region for a Seed Money Grant. G.A. is deeply grateful to the IUPAP for a travel grant for Woman in Science that allowed her to attend the superb 2019 Erice School on Magnetic Crystallography, which made a big part of this work possible.

The overall objective of these guidelines is to provide evidence-based recommendations for the diagnosis and management of immunoglobulin G4 (IgG4)-related digestive disease in adults and children. IgG4-related digestive disease can be diagnosed only with a comprehensive work-up that includes histology, organ morphology at imaging, serology, search for other organ involvement, and response to glucocorticoid treatment. Indications for treatment are symptomatic patients with obstructive jaundice, abdominal pain, posterior pancreatic pain, and involvement of extra-pancreatic digestive organs, including IgG4-related cholangitis. Treatment with glucocorticoids should be weight-based and initiated at a dose of 0.6-0.8 mg/kg body weight/day orally (typical starting dose 30-40 mg/day prednisone equivalent) for 1 month to induce remission and then be tapered within two additional months. Response to initial treatment should be assessed at week 2-4 with clinical, biochemical and morphological markers. Maintenance treatment with glucocorticoids should be considered in multi-organ disease or history of relapse. If there is no change in disease activity and burden within 3 months, the diagnosis should be reconsidered. If the disease relapsed during the 3 months of treatment, immunosuppressive drugs should be added.

Introduction Positive fluid balance during abdominal surgery has been associated with increased morbidity. We hypothesized that administration of large volumes of intravenous fluids in cardiac surgery is associated with increased mortality. Methods Retrospective analysis of data on 1358 patients who underwent cardiac surgery from 2001 to 2005 at two major hospitals in Western New York. Patients were divided in to those who received intravenous fluids above the median volume (3.9 L) and those who received less than the median volume of intra-operative fluid. Acute Kidney Injury Network criteria based on serum creatinine were used to define Acute Kidney injury. Results Logistic regression and Cox-proportional models showed increased 90 day mortality (HR -2.8, 95% CI -1.16-7.01) in those patients who received greater than the median volume of intravenous during cardiac surgery. This was confirmed with propensity score analysis. Furthermore, the marginal effects analysis revealed that after about 4.0 liters of intravenous fluid, the survival probability falls significantly in cardiac surgery patients. Conclusions Administration of large volumes of intra-operative intravenous fluid is independently associated with an increase in 90 day mortality in cardiac surgery.

Background: 2017 International and 2018 European guidelines are the most recent guidelines for intraductal papillary mucinous neoplasms management. Aim: to evaluate the diagnostic accuracy of these guidelines in identifying malignant IPMN. Methods: data from resected patients with IPMN were collected in two referral centers. Features of risk associated to cancerous degeneration described in International and European guidelines were retrospectively applied. Sensitivity, specificity, positive and negative predictive value in detecting malignant disease were calculated. Results: the study includes 627 resected patients. European guidelines suggest resection in any patient with at least one feature of moderate-risk. International guidelines suggest that patients with moderate risk features undergo endoscopic ultrasound before surgery. European guidelines had a higher sensitivity (99.2% vs. 83%) but a lower positive predictive value (59.5% vs. 65.8%) and Specificity (2% vs. 37.5%). European guidelines detected almost all malignancies, but 40% of resected patients had low-grade dysplasia. 297 patients underwent endoscopic ultrasound before surgery. 31/116 (26.7%) tumors radiologically classified as "worrisome features" were reclassified as "high-risk stigmata" by endoscopic ultrasound and 24/31 were malignant IPMN. Conclusions: European and International guidelines have a relatively low diagnostic accuracy, being European guidelines more aggressive. Endoscopic ultrasound can improve guidelines accuracy in patients with moderate-risk features. (c) 2021 Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

The EU is working towards providing 2 MW, coaxial-cavity, CW, 170 GHz gyrotrons for ITER. Their design is based on results from an experimental pre-prototype tube in operation at FZK for several years, having a pulse length of several milliseconds. The first industrial prototype tube is designed for CW operation, but, in a first phase, will be tested out to Is at the European Gyrotron Test Facility in Lausanne, Switzerland as part of a phased testing/development program (1s, 60 s, CW). It is known that RF beam profile shaping, stray radiation handling, and collector cooling at these high power levels are three issues for the gyrotron. The gyrotron, magnet and body power supply have been delivered and successfully installed at the test stand, hosted by the CRPP. The main high voltage power supply delivery is delayed, so one of the power supplies dedicated to 3 of 9 gyrotrons in the TCV EC system is being used as a backup power source (all 3 TCV power sources can be interfaced with the test stand). Cathode conditioning began in November 2007 followed by collector conditioning in December. Parasitic low frequency oscillations have not hindered operation, and the tests have progressed to conditioning out to 0.14 s pulses by March 2008. During this period, the performance concerning microwave generation has been characterised and the RF beam profile has been measured at several planes to allow reconstruction of the phase and amplitude profile at the gyrotron window and to provide the necessary information permitting proper alignment of the compact RF loads prior to pulse extension. The power will be measured, according to the pulse length, using either a very-short pulse (