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1. Successful treatment of disseminated fusariosis with posaconazole during neutropenia and subsequent allogeneic hematopoietic stem cell transplantation

Author

Donna Ball, June Kwon-Chung, A.D. Proefrock, Nikolaos G. Almyroudis, Barbara Bambach, Pamela Paplham, Sameer Gupta, M. Battiwalla, Brahm H. Segal, A. Varma, and Philip L. McCarthy

Subjects
Posaconazole, Antifungal Agents, Neutropenia, Adolescent, medicine.medical_treatment, Disease, Hematopoietic stem cell transplantation, Myelogenous, Fusarium, Humans, Medicine, Transplantation, business.industry, Hematopoietic Stem Cell Transplantation, Secondary prophylaxis, Disseminated Fusariosis, Triazoles, medicine.disease, Leukemia, Myeloid, Acute, Leukemia, Infectious Diseases, Mycoses, Immunology, Female, business, medicine.drug
Abstract

We report the case of a 16-year-old girl with acute myelogenous leukemia with disseminated fusariosis, who responded to salvage posaconazole therapy. She subsequently received additional cytotoxic chemotherapy and allogeneic hematopoietic stem cell transplantation with posaconazole continued as secondary prophylaxis. Despite intensive immunosuppressive therapy for graft-versus-host disease, no recrudescence of infection occurred.

Published
2007
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