1. Pre-Pregnancy Body Mass Index and Weight Gain During Pregnancy: Relations with Gestational Diabetes and Hypertension, and Birth Outcomes
- Author
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Monique Kaminski, Anne Forhan, Olivier Thiebaugeorges, Marie-Aline Charles, Michel Schweitzer, Bernard Foliguet, Guillaume Magnin, Valérie Goua, Barbara Heude, Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de Foetopathologie et placentologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Service de gynécologie et obstétrique [Poitiers], Université de Poitiers-Centre hospitalier universitaire de Poitiers ( CHU Poitiers ), Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants ( UMR_S 953 ), Université Paris-Sud - Paris 11 ( UP11 ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), We acknowledge all the funding sources for the EDEN study: Fondation pour la Recherche Médicale (FRM), French Ministry of Research: IFR and Cohort program, INSERM Nutrition Research Program, French Ministry of Health Perinatality Program, French Agency for Environment Security (AFFSET), French National Institute for Population Health Surveillance (INVS), Paris-Sud University, French National Institute for Health Education (INPES), Nestlé, Mutuelle Générale de l'Education Nationale (MGEN), French speaking association for the study of diabetes and metabolism (Alfediam), National Agency for Research (ANR non thematic program), National Institute for Research in Public Health (IRESP: TGIR cohorte santé 2008 program), and EDEN Mother-Child Cohort Study group
- Subjects
Epidemiology ,Weight Gain ,Body Mass Index ,Fetal Macrosomia ,0302 clinical medicine ,Pregnancy ,Risk Factors ,Birth Weight ,MESH : Female ,030212 general & internal medicine ,2. Zero hunger ,MESH : Pregnancy Outcome ,030219 obstetrics & reproductive medicine ,Obstetrics ,Pregnancy Outcome ,Obstetrics and Gynecology ,Gestational age ,MESH : Weight Gain ,MESH : Infant ,[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH : Adult ,MESH : Maternal Age ,MESH : Risk Factors ,3. Good health ,Gestational diabetes ,MESH : Hypertension, Pregnancy-Induced ,Gestation ,MESH : Obesity ,Female ,gestational diabetes ,medicine.symptom ,Maternal Age ,Adult ,medicine.medical_specialty ,hypertension ,Birth weight ,Gestational Age ,Article ,03 medical and health sciences ,medicine ,Fetal macrosomia ,Humans ,Obesity ,business.industry ,MESH : Humans ,Public Health, Environmental and Occupational Health ,Infant ,MESH : Birth Weight ,Hypertension, Pregnancy-Induced ,medicine.disease ,MESH : Pregnancy ,MESH : Body Mass Index ,Diabetes, Gestational ,MESH : Fetal Macrosomia ,Pediatrics, Perinatology and Child Health ,MESH : Diabetes, Gestational ,business ,Body mass index ,Weight gain ,MESH : Gestational Age - Abstract
International audience; To study the relationship between pre-pregnancy body mass index (BMI) and weight gain during pregnancy with pregnancy and birth outcomes, with a focus on gestational diabetes and hypertension and their role in the association with fetal growth. We studied 1,884 mothers and offspring from the Eden mother-child cohort. Weight before pregnancy (W1) and weight after delivery (W2) were collected and we calculated BMI and net gestational weight gain (netGWG = (W2 - W1)/(weeks of gestation)). Gestational diabetes, hypertension gestational age and birth weight were collected. We used multivariate linear or logistic models to study the association between BMI, netGWG and pregnancy and birth outcomes, adjusting for center, maternal age and height, parity and average number of cigarettes smoked per day during pregnancy. High BMI was more strongly related to the risk of giving birth to a large-for-gestational-age (LGA) baby than high netGWG (odds ratio OR [95% CI] of 3.23 [1.86-5.60] and 1.61 [0.91-2.85], respectively). However, after excluding mothers with gestational diabetes or hypertension the ORs for LGA, respectively weakened (OR 2.57 [1.29-5.13]) for obese women and strengthened for high netGWG (OR 2.08 [1.14-3.80]). Low in comparison to normal netGWG had an OR of 2.18 [1.20-3.99] for pre-term birth, which became stronger after accounting for blood pressure and glucose disorders (OR 2.70 [1.37-5.34]). Higher net gestational weight gain was significantly associated with an increased risk of LGA only after accounting for blood pressure and glucose disorders. High gestational weight gain should not be neglected in regard to risk of LGA in women without apparent risk factors.
- Published
- 2011
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