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Olive tree pruning production is almost 30Mt/year and highly concentrated in the south of Spain. This agricultural residue is mostly burned or crushed in-site with considerable economic and environmental costs. Due to its abundancy ad concentration in specific locations and the current trend in the food and pharma industries using natural raw materials, olive tree pruning can be considered as potential feedstock to obtain high value-added products. This paper presents a conceptual design of an advanced biorefinery design combining state-of-the-art technology for producing antioxidants together with a biochemical platform for lignocellulosic ethanol production and waste treatment. The biorefinery also includes energy integration and a cogeneration stage (steam and electricity). Economic and operational conditions are identified for the biorefinery to be profitable, considering the role of the different processing stages as well as the tradeoff involved in using this feedstock for producing high value-added products in small amounts versus producing large amounts of low-profit products., Proceedings of the 24th European Biomass Conference and Exhibition, 6-9 June 2016, Amsterdam, The Netherlands, pp. 1033-1039