4 results on '"Manola, Šime"'
Search Results
2. Functional coronary testing in acute coronary syndromes: can we defer that easily?
- Author
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Hadžibegović, Irzal, Pavlović, Nikola, Šipić, Tomislav, Pavlov, Marin, Jurin, Ivana, Blivajs, Aleksandar, Vrbanić, Matija, Lisičić, Ante, Antolković, Luka, and Manola, Šime
- Subjects
acute coronary syndrome ,percutaneous coronary intervention ,invasive functional test ,Cardiology and Cardiovascular Medicine - Published
- 2023
3. Clinical effectiveness of primary prevention implantable cardioverter-defibrillators: results of the EU-CERT-ICD controlled multicentre cohort study
- Author
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Zabel, Markus, Willems, Rik, Lubinski, Andrzej, Bauer, Axel, Brugada, Josep, Conen, David, Flevari, Panagiota, Hasenfuß, Gerd, Svetlosak, Martin, Huikuri, Heikki V, Malik, Marek, Pavlović, Nikola, Schmidt, Georg, Sritharan, Rajevaa, Schlögl, Simon, Szavits-Nossan, Janko, Traykov, Vassil, Tuinenburg, Anton E, Willich, Stefan N, Harden, Markus, Friede, Tim, Svendsen, Jesper Hastrup, Sticherling, Christian, Merkely, Béla, Perge, Peter, Sallo, Zoltan, Szeplaki, Gabor, Szegedi, Nandor, Nagy, Klaudia Vivien, Lüthje, Lars, Sritharan, R, Haarmann, Helge, Bergau, Leonard, Seegers, Joachim, Munoz- Exposito, Pascal, Tichelbäcker, Tobias, Kirova, Aleksandra, Hnatkova, Katerina, Vos, Marc A, Reinhold, Thomas, Vandenberk, Bert, Klinika, Magdalena, Rotkvić, L, Flevari, Panayota, Katsimardos, Andreas, Katsaras, Dimitrios, Hatala, Robert, Kuczejko, Tomasz, Hansen, Jim, Manola, Šime, Vinter, Ozren, Benko, Ivica, Tuinenburg, Anton, Sprenkeler, David, Smoczynska, A, Vos, M A, Meyer-Zürn, Christine, Eick, Christian, Arbelo, Elena, Kaliska, Gabriela, Martinek, Jozef, Dommasch, Michael, Steger, Alexander, Kääb, Stefan, Sinner, Moritz F, Rizas, Konstantinos D, Hamm, Wolfgang, Traykov, V, Cygankiewicz, Iwona, Ptaszyński, Pawel, Kaczmarek, K, Poddebska, I, Iovev, Svetoslav, Novotný, Tomáš, Kozak, Milan, Huikuri, Heikki, Kenttä, Tuomas, Pelli, Ari, Kasprzak, Jaroslaw D, Qavoq, Dariusz, Brusich, Sandro, Avdovic, Ervin, Klasan, Marina, Galuszka, Jan, Taborsky, Milos, Velchev, Vasil, Dissmann, Rüdiger, Shalganov, T, Guzik, P, Krauze, T, Bimmel, Dieter, Lieberz, Christiane, Ludwigsburg, Klinikum, Stefanow, Stefan, Rüb, Norman, Wolpert, Christian, Meier, Lars S, Behrens, Steffen, Jurisic, Zrinka, Braunschweig, Frieder, Blaschke, Florian, Pieske, Burkert, Bakotic, Zoran, Anic, Ante, Weiden, Klinikum, Schwinger, Robert H G, Platonov, Pyotr, Grönefeld, Gerian, Klingenheben, Thomas, and EU-CERT-ICD Study Investigators
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Implantable cardioverter-defibrillator ,Risk factors ,Mortality ,Sudden cardiac death ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,Cohort Studies ,EU-CERT-ICD Study Investigators ,03 medical and health sciences ,0302 clinical medicine ,Clinical Research ,Internal medicine ,medicine ,Clinical endpoint ,Humans ,AcademicSubjects/MED00200 ,Prospective Studies ,030212 general & internal medicine ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine ,1102 Cardiorespiratory Medicine and Haematology ,Aged ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina ,Heart Failure ,Ejection fraction ,Ischemic cardiomyopathy ,business.industry ,Hazard ratio ,Stroke Volume ,1103 Clinical Sciences ,Dilated cardiomyopathy ,medicine.disease ,Confidence interval ,Defibrillators, Implantable ,3. Good health ,Europe ,Primary Prevention ,Death, Sudden, Cardiac ,Treatment Outcome ,Cardiovascular System & Hematology ,Implantable cardioverter-defibrillator, Risk factors, Mortality, Sudden cardiac death ,Cardiology and Cardiovascular Medicine ,business ,Cohort study - Abstract
Aims The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was conducted in 44 centres and 15 European countries. It aimed to assess current clinical effectiveness of primary prevention ICD therapy. Methods and results We recruited 2327 patients with ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and guideline indications for prophylactic ICD implantation. Primary endpoint was all-cause mortality. Clinical characteristics, medications, resting, and 12-lead Holter electrocardiograms (ECGs) were documented at enrolment baseline. Baseline and follow-up (FU) data from 2247 patients were analysable, 1516 patients before first ICD implantation (ICD group) and 731 patients without ICD serving as controls. Multivariable models and propensity scoring for adjustment were used to compare the two groups for mortality. During mean FU of 2.4 ± 1.1 years, 342 deaths occurred (6.3%/years annualized mortality, 5.6%/years in the ICD group vs. 9.2%/years in controls), favouring ICD treatment [unadjusted hazard ratio (HR) 0.682, 95% confidence interval (CI) 0.537–0.865, P = 0.0016]. Multivariable mortality predictors included age, left ventricular ejection fraction (LVEF), New York Heart Association class Conclusion In contemporary ICM/DCM patients (LVEF ≤35%, narrow QRS), primary prophylactic ICD treatment was associated with a 27% lower mortality after adjustment. There appear to be patients with less survival advantage, such as older patients or diabetics.
- Published
- 2020
4. Utjecaj atrioventrikulskog intervala na interventrikulsku disinkroniju i udarni volumen u bolesnika s totalnim AV blokom i implantiranim DDD elektrostimulatorom srca
- Author
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Manola, Šime, Pintarić, Hrvoje, and dostupno, nije
- Subjects
medicine ,AV blok ,DDD elektrostimulator srca ,AV interval ,interventrikularna disinkronija - Abstract
Stimulacija iz desnog ventrikula u prošlosti je smanjila smrtnost i spasila veliki broj života, ali asinkrona električna aktivnost kao njena posljedica rezultira značajnim hemodinamskim i elektrofiziološkim promjenama u srcu. Asinkrona kontrakcija uzrokuje redukciju ejekcijskog vremena i smanjuje vrijeme povećanja i smanjenja tlaka u lijevom ventrikulu, povećava trajanje izovolumne kontrakcije i izovolumne relaksacije. I upravo su to hemodinamska objašnjenja negativnog učinka stimulacije iz vrška desnog ventrikla. Asinkrona električna aktivacija dovodi do diskordinirane kontrakcije. Diskordinirana kontrakcija smanjuje snagu srčane pumpe. Poslije toga, diskordinirana kontrakcija uzrokuje regionalne mehaničke razlike, a regionalne mehaničke razlike uzrokuju asimetričnu hipertrofiju. Također dolazi do promjena na staničnoj razini koje dodatno oštećuju srčanu funkciju. Reducirana srčana pumpa za posljedicu ima dilataciju ventrikula, a dilatacija ventrikula povećava napetost stijenke koja dodatno smanjuje snagu srčane pumpe. I upravo je to mehanizam gdje kao posljedica stimulacije dolazi do slabljenja srčane funkcije i razvoja srčane insuficijencije u gotovo 25% bolesnika koji do tada srčanu insuficijenciju nisu imali. Osnovni cilj našeg rada bio je saznati da li postoji neki programabilni parametar kojim možemo smanjiti interventrikulsku disinkroniju i utjecati na dijastoličku i sistoličku funkciju lijevog ventrikula te tako spriječiti razvoj srčanog zatajenja. Postavljena hipoteza bila je da li se individualnom optimizacijom atrioventrikulskog intervala može direktno utjecati na smanjenje interventrikulske disinkronije, poboljšati dijastolička funkcija te povećati udarni volumen, odnosno sistolička funkcija lijevog ventrikula i samim tim postići pozitivan hemodinamski učinak. U ovo istraživanje uključeni su bolesnici sa strukturno zdravim srcem koji imaju implantiran dvokomornim elektrostimulatorom srca zbog totalnog atriventrikulskog bloka koji se liječe i kontroliraju na Zavodu za kardiovaskularne bolesti Klinike za internu medicinu Kliničke bolnice «Sestre milosrdnice». Za analizu razlika kvantitativnih vrijednosti između skupina upotrijebljeni su parametrijski testovi (nezavisni t-test) ili neparametrijeski ekvivalenti (Mann-Whitney U test). Chi-square testom su između ispitivanih skupina ustanovljene razlike u kvalitativnim vrijednostima. Pri analizi zavisnih varijabli (početak istraživanja – nakon 6 mjeseci) primijenjeni su zavisni t-test ili neparametrijski Wilcoxonov test. Za procjenu utjecaja kliničkih i laboratorijskih čimbenika na razinu disinkronije i udarnog volumena provedena je binarna logistička regresija. P vrijednosti ispod 0.05 smatrane su statistički značajnim. Naši su rezultati pokazali da je u akutnom pokusu optimizacije AV intervala, značajan broj bolesnika (71,7%) je smanjio interventrikulsku disinkroniju te povećao udarni volumen (81,7%). Gotovo dvije trećine bolesnika (63,3%) je istovremeno smanjilo interventrikulsku disinkroniju i povećalo udarni volumen. Analizom kvantitativnih i kvalitativnih parametara te pročavanjem njihove povezanosti sa smanjenem interventrikulske disinkronije i povećanjem udarnog volumena zaključili smo da ne postoji statitstički značajne povezanosti u akutnom pokusu. Svega 15% bolesnika značajno smanjuje disinkroniju za više od 10%, dok samo 11,6% ima značajno poćanje UV (> 10%) kao odgovor na akutnu optimizaciju AV intervala. Analiza bazalnih parametara kod tih bolesnika s jako dobrim odgovorom pokazuje da su ti bolesnici statistički značajno mlađi (p=0,046) i imaju veći postotak od maksimalne potrošnje kisika (p=0,039). Mi smo, osim toga, u naših bolesnika analizirali kvantitativne parametre između dvije grupe: grupa 1 odnosno nominalni i grupa 2 optimalni atrioventrikulski interval nakon perioda praćenja od 6 mjeseci. Bolesnici u optimalnoj skupini su mršaviji (p=0,008); imaju veću ejekcijsku frakciju lijevog ventrikula (p=0,001); imaju veći UV (p, Although right ventricle pacing reduced mortalitiy and has saved lives since it's been in use, still, asynchronous electircal activity results in significant haemodynamical and electrophysiologic changes in the heart. Asynchronous contraction causes shortening in the ejection time and reduces duration of pressure elevation and reduction in the left ventricle and also increases the duration of isometric contraction and relaxation. Those are the reasons for negative haemodynamic effect of right ventricle apex stimulation. Asynchornous electrical activation leads to asynchoronous contraction which then reduces the stroke volume. Also asynchronous contraction leads to asymmetric hypertrophy. All of these cause ventricular dilatation which then leads to increased wall tension. This is the short description of processes that lead to heart failure in almost 25% of patients who are implanted with cardiac pacemaker with right ventricle apex stimulation. The aim of our study was to evaluate individual AV interval optimization as a programmable parameter that could reduce interventricular dyssynchrony and influence on diastolic and systolic function of the left ventricle. We included patients with structurally normal heart who were implanted dual chamber pacemaker for complete AV block in University Hospital ''Sestre milosrdnice'' in Zagreb, Croatia. In the acute phase of optimization, significant number of patients (71,7%) reduced interventricular dyssynchrony and also had higher stroke volume (81,7%). Total of 63,3% both reduced interventricular dyssynchrony while also raising the stroke volume. Further analysis showed no significant difference between patients in acute phase. Only 15% of patients reduced interventricular dyssynchrony for more than 10%, while only 11,6% patients had rise in stroke volume for more than 10% as a response on acute optimisation of AV interval. Patients who responded better in the acute phase were significantly younger (p=0,046) and had higher oxygen consumption values (p=0,039). Patients were divided in two groups, one with nominal and other with optimal AV interval. Patients were followed for 6 months. Patients with optimal AV were thinner (p=0,008), had higher values of ejection fraction (p=0,001), higher stroke volumes (p
- Published
- 2010
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